Interview with George and Margaret Isaacson by Andrea L’Hommedieu

Biographical NoteGeorge Steven Isaacson was born in New York on October 20, 1948, and grew up in Auburn, Maine. His father worked in a lumber business in Livermore Falls with his uncles. George was graduated from Bowdoin College and attended law school at the University of Pennsylvania, where he met his future wife, Margaret. After graduating, he clerked for Judge Thomas E. Delahanty and then went to work for a law firm in Portland, Maine. George Mitchell interviewed him for an attorney’s position with Jensen Baird law firm. At the time of this interview, he was a senior partner at Brann and Isaacson in Lewiston, Maine, an adjunct professor at Bowdoin College, and a lecturer at the University of Maine School of Law. Margaret (McGaughey) Isaacson was born in Detroit, Michigan, on May 29, 1948. She lived in New York, attended college in California and law school at the University of Pennsylvania. Margaret practiced law in Boston for four years and then accepted a clerkship with Frank Coffin in Maine. When George Mitchell was appointed U.S. attorney and permitted a third assistant U.S. attorney position, Margaret was hired. At the time of this interview, Margaret had served in the U.S. Attorney’s Office for thirty-two years. SummaryInterview includes discussion of: George’s childhood in Auburn; growing up Jewish in Auburn; Margaret’s childhood; their meeting in law school; George’s clerkship in Maine; George’s recollections of Mitchell at Jensen Baird; Margaret’s moving to Maine for a clerkship with Frank Coffin and then as assistant U.S. attorney under Mitchell; the U.S. Attorney’s Office and Jim Brannigan; Mitchell’s management style; anecdote about Margaret’s working on drug cases with Mitchell; Mitchell’s appointment to federal judgeship; Mitchell’s 1974 gubernatorial campaign; Mitchell and rumors about the Supreme Court; Mitchell’s talent for litigation and his process in preparing a case; and Bowdoin College

What Drives Car Attitudes: An Analysis of How Demographics and Environmental Views Relate to Car Attitudes

Successfully marketing new, clean, car technologies to consumers requires an advertising strategy that fits consumers’ priorities and attitudes towards cars. We created a survey to study how attitudes towards cars are associated with demographics and environmental views. Our study examined car preferences and environmental concerns of a sample of Gettysburg College students in comparison to a national sample obtained from Amazon’s Mechanical Turk. Overall, we concluded that environmental beliefs are a significantly better prediction of car behaviors than demographics. We found that on average people would pay more for a car with a higher fuel economy, but not enough to cover the higher price of newer, cleaner technologies, such as hybrid cars. Gettysburg College students’ environmental concern scores were significantly higher on average than that of the general American population. Survey respondents from both samples supported devoting more research and resources to hybrid, electric, and biofuel technologies. However, in regards to their personal purchases they ranked safety and other qualities of the car as higher priorities than greenhouse gas emissions or fuel economy. According to our results, marketing electric cars as safe and reliable is a better strategy than marketing their high fuel economy

Metacognitive Knowledge Monitoring in Post-Secondary Education: The Consequences of Poor Knowledge Monitoring and a Program to Facilitate It

One of the most frustrating teaching dilemmas in post-secondary education is helping students who claim to have mastered the course content but are unable to demonstrate their understanding. These students are often convinced they have a command of the material and may even be able to persuade their instructor that their failure is due to the test. But instructors who carefully question these students realize that most of these students have not mastered the material. This paper will briefly report on research from the last decade on metacognitive knowledge monitoring, and then present a program that teaches both self-regulated learning (SRL) and metacognition. Over the past five years the author has researched the relationship between metacognitive knowledge monitoring (MKM) and classroom learning and has developed a program in his educational psychology class which compels students to regulate their own learning and develops metacognitive skills

Airspace Technology Demonstration 3 (ATD-3): Dynamic Routes for Arrivals in Weather (DRAW) Technology Transfer Document Summary Version 2.0

Airspace Technology Demonstration 3 (ATD-3) is part of NASAs Airspace Operations and Safety Program (AOSP) specifically, its Airspace Technology Demonstrations (ATD) Project. ATD-3 is a multi-year research and development effort which proposes to develop and demonstrate automation technologies and operating concepts that enable air navigation service providers and airspace users to continuously assess weather, winds, traffic, and other information to identify, evaluate, and implement workable opportunities for flight plan route corrections that can result in significant flight time and fuel savings in en route airspace. In order to ensure that the products of this tech-transfer are relevant and useful, NASA has created strong partnerships with the FAA and key industry stakeholders. This summary document and accompanying technology artifacts satisfy the third Research Transition Product (RTP) defined in the Applied Traffic Flow Management (ATFM) Research Transition Team (RTT) Plan, which is Dynamic Routes for Arrivals in Weather (DRAW). This technology transfer consists of artifacts for DRAW Arrival Metering (AM) Operations delivered in June 2018, DRAW AM updates, and DRAW Extended Metering (XM) Operations. Blue highlighting indicates the new or modified deliverables. Some of the artifacts in this technology transfer have distribution restrictions that need to be followed. Distribution information is noted in each section. DRAW is a trajectory-based system that combines the legacy Dynamic Weather Routes (DWR) weather avoidance technology with an arrival-specific rerouting algorithm and arrival scheduler to improve traffic flows on weather-impacted arrival routes into major airports. First, DRAW identifies flights that could be rerouted to more efficient Standard Terminal Arrival Routes (STARs) that may have previously been impacted by weather. Second, when weather is impacting the arrival routing, DRAW proposes simple arrival route corrections that enable aircraft to stay on their flight plan while avoiding weather. The DRAW system proposes reroutes early enough to allow Time Based Flow Management (TBFM) to make the necessary schedule adjustments. As a result, metering operations can be sustained longer and more consistently in the presence of weather because the arrival schedule accounts for the dynamic routing intent of arrival flights to deviate around weather. The first DRAW tech transfer in June 2018 focused on arrival metering operations with the DRAW algorithm implemented in the NASA Center TRACON Automation System (CTAS) automation software. This tech transfer delivery includes updates for DRAW implemented in FAAs TBFM 4.7 automation software and preliminary research into DRAW for XM operations

Causality re-established

Causality never gained the status of a "law" or "principle" in physics. Some recent literature even popularized the false idea that causality is a notion that should be banned from theory. Such misconception relies on an alleged universality of reversibility of laws of physics, based either on determinism of classical theory, or on the multiverse interpretation of quantum theory, in both cases motivated by mere interpretational requirements for realism of the theory. Here, I will show that a properly defined unambiguous notion of causality is a theorem of quantum theory, which is also a falsifiable proposition of the theory. Such causality notion appeared in the literature within the framework of operational probabilistic theories. It is a genuinely theoretical notion, corresponding to establish a definite partial order among events, in the same way as we do by using the future causal cone on Minkowski space. The causality notion is logically completely independent of the misidentified concept of "determinism", and, being a consequence of quantum theory, is ubiquitous in physics. In addition, as classical theory can be regarded as a restriction of quantum theory, causality holds also in the classical case, although the determinism of the theory trivializes it. I then conclude arguing that causality naturally establishes an arrow of time. This implies that the scenario of the "Block Universe" and the connected "Past Hypothesis" are incompatible with causality, and thus with quantum theory: they both are doomed to remain mere interpretations and, as such, not falsifiable, similar to the hypothesis of "super-determinism". This article is part of a discussion meeting issue "Foundations of quantum mechanics and their impact on contemporary society".Comment: Presented at the Royal Society of London, on 11/12/ 2017, at the conference "Foundations of quantum mechanics and their impact on contemporary society". To appear on Philosophical Transactions of the Royal Society

HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab

Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition. Case presentation: We report the case of a 46 year old Zambian woman who presented with pyrexia, diarrhoea and vomiting, confusion, lymphadenopathy, and renal failure. She rapidly developed multiple organ failure following the initiation of treatment of MCD with rituximab. Following admission to intensive care (ICU), she received prompt multi-organ support. After 21 days on the ICU she returned to the haematology medical ward, and was discharged in remission from her disease after 149 days in hospital. Conclusion: Rituximab, the efficacy of which has thus far been examined predominantly in patients outside the ICU, in conjunction with extensive organ support was effective treatment for MCD with associated multiple organ failure. There is, to our knowledge, only one other published report of its successful use in an ICU setting, where it was combined with cyclophosphamide, adriamycin and prednisolone. Reports such as ours support the notion that critically unwell patients with HIV and haematological disease can benefit from intensive care

Occurrence and core-envelope structure of 1--4x Earth-size planets around Sun-like stars

Small planets, 1-4x the size of Earth, are extremely common around Sun-like stars, and surprisingly so, as they are missing in our solar system. Recent detections have yielded enough information about this class of exoplanets to begin characterizing their occurrence rates, orbits, masses, densities, and internal structures. The Kepler mission finds the smallest planets to be most common, as 26% of Sun-like stars have small, 1-2 R_e planets with orbital periods under 100 days, and 11% have 1-2 R_e planets that receive 1-4x the incident stellar flux that warms our Earth. These Earth-size planets are sprinkled uniformly with orbital distance (logarithmically) out to 0.4 AU, and probably beyond. Mass measurements for 33 transiting planets of 1-4 R_e show that the smallest of them, R < 1.5 R_e, have the density expected for rocky planets. Their densities increase with increasing radius, likely caused by gravitational compression. Including solar system planets yields a relation: rho = 2.32 + 3.19 R/R_e [g/cc]. Larger planets, in the radius range 1.5-4.0 R_e, have densities that decline with increasing radius, revealing increasing amounts of low-density material in an envelope surrounding a rocky core, befitting the appellation "mini-Neptunes." Planets of ~1.5 R_e have the highest densities, averaging near 10 g/cc. The gas giant planets occur preferentially around stars that are rich in heavy elements, while rocky planets occur around stars having a range of heavy element abundances. One explanation is that the fast formation of rocky cores in protoplanetary disks enriched in heavy elements permits the gravitational accumulation of gas before it vanishes, forming giant planets. But models of the formation of 1-4 R_e planets remain uncertain. Defining habitable zones remains difficult, without benefit of either detections of life elsewhere or an understanding of life's biochemical origins.Comment: 11 pages, 6 figures, accepted for publication Proc. Natl. Acad. Sc

Gauge Invariant Effective Stress-Energy Tensors for Gravitational Waves

It is shown that if a generalized definition of gauge invariance is used, gauge invariant effective stress-energy tensors for gravitational waves and other gravitational perturbations can be defined in a much larger variety of circumstances than has previously been possible. In particular it is no longer necessary to average the stress-energy tensor over a region of spacetime which is larger in scale than the wavelengths of the waves and it is no longer necessary to restrict attention to high frequency gravitational waves.Comment: 11 pages, RevTe

Pyrantel Pamoate in Roundworm Infestations

A controlled single-blind trial was carried out to compare the effect of single-dose therapy with pyrantel pamoate (Combantrin) and piperazine citrate in children infested with Ascaris lumbricoides. Fifty-six children were treated. Pyrantel pamoate was 96,4% effective and piperazine c::itrate 82,1% effective in eradicating Ascaris lumbricoides. ova from 3 consecutive stools taken on the 7th, 8th and 9th days after treatment. If results of stool examination on the 9th day only are considered, pyrantel pamoate was 100% effective and piperazine citrate was 89,3% effective. S. Afr. Med. J., 47, 91 (1973