4,940 research outputs found
Prediction of blanket peat erosion across Great Britain under environmental change
A recently developed fluvial erosion model for blanket peatlands, PESERA-PEAT, was applied at ten sites across Great Britain to predict the response of blanket peat erosion to environmental change. Climate change to 2099 was derived from seven UKCP09 future projections and the UK Met Officeβs historical dataset. Land management scenarios were established based on outputs from earlier published investigations. Modelling results suggested that as climate changes, the response of blanket peat erosion will be spatially very variable across Great Britain. Both relative changes and absolute values of sediment yield were predicted to be higher in southern and eastern areas than in western and northern parts of Great Britain, peaking in the North York Moors of eastern England. Areas with high precipitation and low temperature were predicted to have low relative erosion changes and absolute sediment yield. The model suggested that summer desiccation may become more important for blanket peat erosion under future climate change, and that temperature was more dominant than precipitation in controlling long-term blanket peat erosion change. However, in the North York Moors, precipitation appeared to be more dominant in driving long-term erosion change. Land management measures were shown to provide a means to mitigate against the impacts of climate change on blanket peat erosion
Drawing bobbin lace graphs, or, Fundamental cycles for a subclass of periodic graphs
In this paper, we study a class of graph drawings that arise from bobbin lace
patterns. The drawings are periodic and require a combinatorial embedding with
specific properties which we outline and demonstrate can be verified in linear
time. In addition, a lace graph drawing has a topological requirement: it
contains a set of non-contractible directed cycles which must be homotopic to
, that is, when drawn on a torus, each cycle wraps once around the minor
meridian axis and zero times around the major longitude axis. We provide an
algorithm for finding the two fundamental cycles of a canonical rectangular
schema in a supergraph that enforces this topological constraint. The polygonal
schema is then used to produce a straight-line drawing of the lace graph inside
a rectangular frame. We argue that such a polygonal schema always exists for
combinatorial embeddings satisfying the conditions of bobbin lace patterns, and
that we can therefore create a pattern, given a graph with a fixed
combinatorial embedding of genus one.Comment: Appears in the Proceedings of the 25th International Symposium on
Graph Drawing and Network Visualization (GD 2017
Spin gating electrical current
We use an aluminium single electron transistor with a magnetic gate to
directly quantify the chemical potential anisotropy of GaMnAs materials.
Uniaxial and cubic contributions to the chemical potential anisotropy are
determined from field rotation experiments. In performing magnetic field sweeps
we observe additional isotropic magnetic field dependence of the chemical
potential which shows a non-monotonic behavior. The observed effects are
explained by calculations based on the kinetic
exchange model of ferromagnetism in GaMnAs. Our device inverts the conventional
approach for constructing spin transistors: instead of spin-transport
controlled by ordinary gates we spin-gate ordinary charge transport.Comment: 5 pages, 4 figure
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A Lagrangian analysis of ice-supersaturated air over the North Atlantic
Understanding the nature of air parcels that exhibit ice-supersaturation is important because they are the regions of potential formation of both cirrus and aircraft contrails, which affect the radiation balance. Ice-supersaturated air parcels in the upper troposphere and lower stratosphere over the North Atlantic are investigated using Lagrangian trajectories. The trajectory calculations use ERA-Interim data for three winter and three summer seasons, resulting in approximately 200,000 trajectories with ice-supersaturation for each season. For both summer and winter, the median duration of ice-supersaturation along a trajectory is less than 6 hours. 5% of air which becomes ice-supersaturated in the troposphere, and 23% of air which becomes ice-supersaturated in the stratosphere will remain ice-supersaturated for at least 24 hours. Weighting the ice-supersaturation duration with the observed frequency indicates the likely overall importance of the longer duration ice-supersaturated trajectories. Ice-supersaturated air parcels typically experience a decrease in moisture content while ice-supersaturated, suggesting that cirrus clouds eventually form in the majority of such air. A comparison is made between short-lived (less than 24 h) and long-lived (greater than 24 h) ice-supersaturated air flows. For both air flows, ice-supersaturation occurs around the northernmost part of the trajectory. Short-lived ice-supersaturated air flows show no significant differences in speed or direction of movement to subsaturated air parcels. However, long-lived ice-supersaturated air occurs in slower moving air flows, which implies that they are not associated with the fastest moving air through a jet stream
Design of lipid nanoparticle delivery agents for multivalent display of recombinant Env trimers in HIV vaccination
Background:
Immunization strategies that elicit antibodies capable of neutralizing diverse strains of the virus will likely be an important part of a successful vaccine against HIV. The envelope trimer is the only neutralizing target on the virus, and strategies to promote durable, high avidity antibody responses against the native intact trimer structure are lacking. We recently developed chemically-crosslinked lipid nanocapsules as carriers of molecular adjuvants and encapsulated or surface-displayed antigens, which promote follicular helper T-cell responses and elicited high-avidity, durable antibody responses to a candidate malaria antigen (Moon et al. Nat. Mater. 10 243 (2011); Moon et al. PNAS 109 1080 (2012)).
Methods:
To apply this system to the delivery of HIV antigens, we developed a strategy to anchor recombinant envelope trimers to the surfaces of these particles under conditions preserving the antigenic integrity of the trimers, allowing multivalent display of these immunogens for immunization. To anchor trimers in their native orientation, gp140 trimers with terminal his-tags were anchored to the surface of lipid nanocapsules via Ni-NTA-functionalized lipids.
Results:
Owing to their significant size (409 kDa) and heavy glycosylation, we found that liquid-ordered and/or gel-phase lipid compositions were required to stably anchor trimers to particle membranes. Trimer-loaded nanocapsules carrying monophosphoryl lipid A elicited durable antibody responses with titers comparable to a Complete Freundβs Adjuvant (CFA)-like emulsion in mice, without the toxic inflammation associated with the latter adjuvant. Further, nanocapsules elicited strong helper T-cell responses associated with a steadily increasing avidity of trimer-binding antibody over 90 days, which was not replicated by other adjuvants.
Conclusion:
These results suggest that nanoparticles displaying HIV trimers in an oriented, multivalent presentation can promote key aspects of the humoral response against Env immunogens.National Institutes of Health (U.S.) (AI095109)Massachusetts Institute of Technology. Ragon Institute of MGH, MIT, and Harvar
Projected free energies for polydisperse phase equilibria
A `polydisperse' system has an infinite number of conserved densities. We
give a rational procedure for projecting its infinite-dimensional free energy
surface onto a subspace comprising a finite number of linear combinations of
densities (`moments'), in which the phase behavior is then found as usual. If
the excess free energy of the system depends only on the moments used, exact
cloud, shadow and spinodal curves result; two- and multi-phase regions are
approximate, but refinable indefinitely by adding extra moments. The approach
is computationally robust and gives new geometrical insights into the
thermodynamics of polydispersity.Comment: 4 pages, REVTeX, uses multicol.sty and epsf.sty, 1 postscript figure
include
Reconfigurable Boolean Logic using Magnetic Single-Electron Transistors
We propose a novel hybrid single-electron device for reprogrammable low-power
logic operations, the magnetic single-electron transistor (MSET). The device
consists of an aluminium single-electron transistors with a GaMnAs magnetic
back-gate. Changing between different logic gate functions is realized by
reorienting the magnetic moments of the magnetic layer which induce a voltage
shift on the Coulomb blockade oscillations of the MSET. We show that we can
arbitrarily reprogram the function of the device from an n-type SET for
in-plane magnetization of the GaMnAs layer to p-type SET for out-of-plane
magnetization orientation. Moreover, we demonstrate a set of reprogrammable
Boolean gates and its logical complement at the single device level. Finally,
we propose two sets of reconfigurable binary gates using combinations of two
MSETs in a pull-down network
The Cooperative Participatory Evaluation of Renewable Technologies on Ecosystem Services (CORPORATES)
Publisher PD
Climatic versus biotic constraints on carbon and water fluxes in seasonally drought-affected ponderosa pine ecosystems
We investigated the relative importance of climatic versus biotic controls on gross primary production (GPP) and water vapor fluxes in seasonally drought-affected ponderosa pine forests. The study was conducted in young (YS), mature (MS), and old stands (OS) over 4 years at the AmeriFlux Metolius sites. Model simulations showed that interannual variation of GPP did not follow the same trends as precipitation, and effects of climatic variation were smallest at the OS (50%), and intermediate at the YS (<20%). In the young, developing stand, interannual variation in leaf area has larger effects on fluxes than climate, although leaf area is a function of climate in that climate can interact with age-related shifts in carbon allocation and affect whole-tree hydraulic conductance. Older forests, with well-established root systems, appear to be better buffered from effects of seasonal drought and interannual climatic variation. Interannual variation of net ecosystem exchange (NEE) was also lowest at the OS, where NEE is controlled more by interannual variation of ecosystem respiration, 70% of which is from soil, than by the variation of GPP, whereas variation in GPP is the primary reason for interannual changes in NEE at the YS and MS. Across spatially heterogeneous landscapes with high frequency of younger stands resulting from natural and anthropogenic disturbances, interannual climatic variation and change in leaf area are likely to result in large interannual variation in GPP and NEE
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