Identifying competencies for taking online courses successfully

Successful online learning if we look outside the didactics but in the field of personal development, from the anthropological bases, is in learner’s identification as an active subject of the learnin

Difficulties and limitations of paramedical personnel professional activities: the case of a nurse in the department of oral and maxillofacial surgery

The literature review focuses on the problems of the professional activities of paramedical personnel. The attention is given to the specific features of the nursing staff work. The review is based on scientific papers published on the relevant topic and regulatory documents of medical organizations

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Trans-Baikal Cossacks as a Subject of Patriotic Education of Youth

Introduction. In modern conditions, patriotic education of young people is of particular importance, the implementation of which is possible using the potential of the Russian Cossacks. The Russian Cossacks have the necessary resources for the formation of youth patriotism, including the presence of their own ideology, ethnopsychological and ethno-cultural features, behavioral models, the system of patriotic education as part of the “Cossack pedagogy”. This potential of the Cossacks should be used in the modern social practice of patriotic education from the younger generation. The purpose of the article is based on the results of the analysis of public opinion in the Trans-Baikal Territory to investigate the attitude of the population to the Cossacks and its role in the patriotic education of the younger generation. Materials and Methods. The methodology of the study is presented by the theory of social identity of V. A. Tishkov, the pedagogical theory of patriotic education of V. V. Ivanov. Within the framework of the study, the attitude of the Trans-Baikal Territory residents to the Cossacks and the opinion about the potential of the Cossacks in the patriotic education of young people are characterized. The study was conducted in 2021–2022. A survey in the form of a questionnaire was used as the main method. 500 residents of the Trans-Baikal Territory were interviewed. The method of cluster (territorial) single-stage sampling was used in the study. Results. It is revealed that in the Trans-Baikal Territory, a positive attitude to the Cossacks, their traditions and values prevails. The results obtained in the course of the study indicate that today the process of revival of the Cossacks is supported in society. It is shown that the Cossacks play an important role in the patriotic education of young people. Discussion and Conclusion. The residents of the Trans-Baikal Territory recognize the value of using the patriotic traditions of the Cossacks and the need for the participation of the Cossacks in the patriotic education of young people. The results obtained can be used in the development of programs of patriotic, spiritual and moral education of the younger generation based on the traditional values of the Cossacks

Conservative finite-difference scheme for the problem of THz pulse interaction with multilevel layer covered by disordered structure based on the density matrix formalism and 1D Maxwell's equation.

On the basis of the Crank-Nicolson method, we develop a conservative finite-difference scheme for investigation of the THz pulse interaction with a multilevel medium, covered by a disordered layered structure, in the framework of the Maxwell-Bloch equations, describing the substance evolution and the electromagnetic field evolution. For this set of the partial differential equations, the conservation laws are derived and proved. We generalize the Bloch invariant with respect to the multilevel medium. The approximation order of the developed finite-difference scheme is investigated and its conservatism property is also proved. To solve the difference equations, which are nonlinear with respect to the electric field strength, we propose an iteration method and its convergence is proved. To increase the computer simulation efficiency, we use the well-known solution of Maxwell's equations in 1D case as artificial boundary condition. It is approximated using Cabaret scheme with the second order of an accuracy. On the basis of developed finite-difference scheme, we investigate the broadband THz pulse interaction with a medium covered by a disordered structure. This problem is of interest for the substance detection and identification. We show that the disordered structure dramatically induces an appearance of the substance false absorption frequencies. We demonstrate also that the spectrum for the transmitted and reflected pulses becomes broader due to the cascade mechanism of the high energy levels excitation of molecules. It leads to the substance emission at the frequencies, which are far from the frequency range for the incident pulse spectrum. Time-dependent spectral intensities at these frequencies are weakly disturbed by the disordered cover and, hence, they can be used for the substance identification

New Possibilities of Substance Identification Based on THz Time Domain Spectroscopy Using a Cascade Mechanism of High Energy Level Excitation

Using an experiment with thin paper layers and computer simulation, we demonstrate the principal limitations of standard Time Domain Spectroscopy (TDS) based on using a broadband THz pulse for the detection and identification of a substance placed inside a disordered structure. We demonstrate the spectrum broadening of both transmitted and reflected pulses due to the cascade mechanism of the high energy level excitation considering, for example, a three-energy level medium. The pulse spectrum in the range of high frequencies remains undisturbed in the presence of a disordered structure. To avoid false absorption frequencies detection, we apply the spectral dynamics analysis method (SDA-method) together with certain integral correlation criteria (ICC)

Identifying competencies for taking online courses successfully

Successful online learning if we look outside the didactics but in the field of personal development, from the anthropological bases, is in learner’s identification as an active subject of the learnin

The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin(hCG)-receptor (LH/hCG-R) (hCG, low-molecular-weight allosteric LH/hCG-R-agonists) can be used to restore them. The aim was to study effectiveness of separate and combined administration of metformin, hCG and 5-amino-N-tert-butyl-2-(methylsulfanyl)-4-(3-(nicotinamido)phenyl)thieno[2,3-d]pyrimidine-6-carboxamide (TP3) on steroidogenesis and spermatogenesis in male rats with T2DM. hCG (15 IU/rat/day) and TP3 (15 mg/kg/day) were injected in the last five days of five-week metformin treatment (120 mg/kg/day). Metformin improved testicular steroidogenesis and spermatogenesis and restored LH/hCG-R-expression. Compared to control, in T2DM, hCG stimulated steroidogenesis and StAR-gene expression less effectively and, after five-day administration, reduced LH/hCG-R-expression, while TP3 effects changed weaker. In co-administration of metformin and LH/hCG-R-agonists, on the first day, stimulating effects of LH/hCG-R-agonists on testosterone levels and hCG-stimulated expression of StAR- and CYP17A1-genes were increased, but on the 3&ndash;5th day, they disappeared. This was due to reduced LH/hCG-R-gene expression and increased aromatase-catalyzed estradiol production. With co-administration, LH/hCG-R-agonists did not contribute to improving spermatogenesis, induced by metformin. Thus, in T2DM, metformin and LH/hCG-R-agonists restore steroidogenesis and spermatogenesis, with metformin being more effective in restoring spermatogenesis, and their co-administration improves LH/hCG-R-agonist-stimulating testicular steroidogenesis in acute but not chronic administration

Measurement and modeling of optical properties of heated adipose tissue in the terahertz range

Measurements and modeling of the optical properties of adipose tissue and its components in the terahertz range with a change in tissue temperature were carried out. It was shown that the optical density (OD) of adipose tissue samples decreases with increasing temperature, which can be mainly associated with dehydration of the sample. We can also expect some contribution to the decrease in the OD of suppression of THz wave scattering when matching the refractive indices of scatterers and their environment due to the intake of free fatty acids secreted by adipocytes due to thermally induced cell lipolysis. It is shown that in the experimental model, the difference between the THz absorption spectra of water and oil allows us to estimate the water content in adipose tissue. A comparison of the measurement results and molecular modeling in the terahertz region confirmed the hypothesis about the reasons for the change in the optical properties of heated adipose tissue

Pulses <i>E</i>_<i>refl</i> and <i>E</i>_<i>tran</i> reflected from (solid line) and transmitted through (dashed line) the medium without cover (a), and with cover (b) under averaging over 32 random realizations of disordered structure (dimensionless units).

<p>Pulses <i>E</i>_<i>refl</i> and <i>E</i>_<i>tran</i> reflected from (solid line) and transmitted through (dashed line) the medium without cover (a), and with cover (b) under averaging over 32 random realizations of disordered structure (dimensionless units).</p