Aplicación del modelo SWMM 5.0 para la estimación del arrastre de depósitos de sedimentos y contaminantes asociados en sistemas de alcantarillado unitario

veles de partículas sólidas y otros contaminantes se observan en los caudales vertidos desde sistemas unitarios al medio fluvial receptor durante el período inicial de una tormenta. Las investigaciones en este campo sugieren que la principal fuente de estos contaminantes está vinculada al proceso de erosión y resuspensión de sólidos depositado s en los conductos del sistema durante el periodo seco antecedente al evento de precipitación. Este trabajo aborda el desarrollo de una metodología capaz de tratar, en una primera aproximación, el transporte de sedimentos dentro de las conducciones de un sistema de alcantarillado unitario. Su implementación se basa en la aplicación modificada, de un modelo del sistema, en el software de dominio público Storm Water Management Model (SWMM 5.0). Así, esta metodología supone una ampliación en la capacidad de trabajo del mencionado programa de simulación, al contemplar el proceso de erosión y re-suspensión de sólidos preexistentes en el interior de sistemas unitarios, que hasta ahora no se considera. Los resultados obtenidos en un estudio piloto, demuestran la aplicabilidad de la metodología de aproximación para la obtención de la evolución de la carga sólida total y contaminantes asociados, durante un evento de tormenta.Postprint (author’s final draft

Risk Analysis by Age on the Burden of Meningococcal Disease in Spain.

We conducted an age-based risk analysis of meningococcal disease in Spain to provide prospects on a rational vaccine schedule in pediatrics. We used the National Hospital Registry to estimate meningococcal hospitalization rate. Population census for each year was used as the denominator in computing the hospitalization rate. We computed the odds ratio of each age using 5-year-old children. There was a dramatic decline in risk in 1 year (OR 0.58) to 4 years of age (OR 0.21). The risk continued to decline until 13 years old. Afterward, it had a minimal upward trajectory observed at 14–17 years old (OR 0.08). Infants and adolescents are at continued risk of invasive meningococcal disease in Spain. The highest risk occurs in infants. Surveillance data, together with evidence on long-term immunogenicity and capacity for herd effect, should be considered for a more relevant immunization schedule

A COVID-19 Rehabilitation Prospective Surveillance Model for Use by Physiotherapists

[Abstract] The long-term sequelae of coronavirus disease 2019 (COVID-19) are only now beginning to be defined, but it is already known that the disease can have direct and indirect impacts mainly on the cardiorespiratory and neuromuscular systems and may affect mental health. A role for rehabilitation professionals from all disciplines in addressing COVID-19 sequelae is recognised, but it is essential that patient assessment be systematic if health complications are to be identified and treated and, if possible, prevented. The aim is to present a COVID-19 prospective surveillance model based on sensitive and easily used assessment tools, which is urgently required. Following the Oxford Centre for Evidence-Based Medicine Level of Evidence Tool, an expert team in cardiorespiratory, neuromuscular and mental health worked via telemeetings to establish a model that provides guidelines to rehabilitation professionals working with patients who require rehabilitation after suffering from COVID-19. A COVID-19 prospective surveillance model is proposed for use by rehabilitation professionals and includes both face-to-face and telematic monitoring components. This model should facilitate the early identification and management of long-term COVID-19 sequelae, thus responding to an arising need.This research was funded by the Spanish Ministry of Education Culture and Sport (FPU17/00939), the University of Granada Excellence Actions (Unit of Excellence in Exercise and Health

Effect of hip muscle strengthening exercises on pain and disability in patients with non-specific low back pain—a systematic review

Low back pain (LBP) is a health problem that affects 70–80% of the population in Western countries. Because of the biomechanical relationship between the lumbar region and the hip, it is thought that strengthening the muscles of this joint could improve the symptoms of people with LBP. The objective of this study is to evaluate the current evidence on the efficacy of hip strengthening exercises to reduce pain and disability in people with LBP. Clinical trials were collected from the PubMed, PEDro, and Scopus databases published up to September 2022. Based on the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines and using CASP and PEDro tools for methodological quality assessment, we selected studies that included hip strengthening exercises as part of LBP treatment and measured pain and/or disability parameters. Among the 966 records identified in the search, a total of 7 studies met the established selection criteria. Overall, participants who performed hip strengthening exercises had significantly improved in pain and disability. The methodological quality of the included studies was assessed as “good”. In conclusion, the addition of hip muscle strengthening exercises iterating interacted with LBP, effectively improving pain and disability

Rotavirus infection beyond the gut

The landscape of rotavirus (RV) infection has changed substantially in recent years. Autoimmune triggering has been added to clinical spectrum of this pathology, which is now known to be much broader than diarrhea. The impact of RV vaccines in these other conditions is becoming a growing field of research. The importance of host genetic background in RV susceptibility has been revealed, therefore increasing our understanding of vaccine effectiveness and giving some clues about the limited efficacy of RV vaccines in low-income settings. Also, interaction of RV with intestinal microbiota seems to play a key role in the process of infection vaccine effect. This article reviews current findings on the extraintestinal impact of RV infection and their widening clinical picture, and the recently described mechanisms of host susceptibility to infection and vaccine effectiveness. RV infection is a systemic disease with clinical and pathophysiological implications beyond the gut. We propose an “iceberg” model for this pathology with almost hidden clinical implications away from the gastrointestinal tract and eventually triggering the development of autoimmune diseases. Impact of current vaccines is being influenced by host genetics and gut microbiota interactions and these factors must be taken into account in the development of public health programs.This work was supported by grants from the Instituto de Salud Carlos III (Proyecto de Investigación en Salud, Acción Estratégica en Salud): project GePEM ISCIII/PI16/01478/Cofinanciado FEDER (AS) and project ReSVinext ISCIII/PI16/01569/Cofinanciado FEDER (FMT); Consellería de Sanidade, Xunta de Galicia (RHI07/2-intensificación actividad investigadora, PS09749 and 10PXIB918184PR), Instituto de Salud Carlos III (Intensificación de la actividad investigadora 2007-2012, PI16/01569), Fondo de Investigación Sanitaria (FIS; PI070069/PI1000540) del plan nacional de I + D + I (FMT), and 2016-PG071 Consolidación e Estructuración REDES 2016GI-1344 G3VIP (Grupo Gallego de Genética Vacunas Infecciones y Pediatría, ED341D R2016/021) (AS and FMT)S

A counterstamped coin of the Habsburgs in the Iberian Iron Age architectural complex at Cerro de la Merced (Cabra, Córdoba)

Se analiza una moneda resellada por última vez bajo Felipe IV circa 1659 d.C., hallada en una gran zanja fechable así en el siglo XVII en el complejo aristocrático ibérico del Cerro de la Merced (Cabra, Córdoba). Esta es una excepcional corroboración arqueológica de la búsqueda de tesoros en el s. XVII, bien documentada en fuentes como procesos de Inquisición, relacionada con el exilio y posterior expulsión de los moriscosWe analyze a counterstamped coin, last time under Philip IV of Spain c. 1659 AD, found in a big excavation trench thus dated to the mid 17th c. AD, in the Iberian Iron Age aristocratic complex at Cerro de la Merced (Cabra, Córdoba). This is a most unusual archaeological corroboration of 17th c. treasury-hunting digs, well documented in Inquisition procedures, and connected with the inner exile and later banishment from Spain of the moriscosTrabajo realizado en el marco del Proyecto I+D+i HAR 2017-82806-P del MINECO “Ciudades y complejos aristocráticos ibéricos”

Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomics

This study received support from Instituto de Salud Carlos III (ISCIII): GePEM (PI16/01478/Cofinanciado FEDER; A.S.), DIAVIR (DTS19/00049/Cofinanciado FEDER, A.S.), Resvi-Omics (PI19/01039/Cofinanciado FEDER, A.S.), Agencia Gallega de Innovación (GAIN): Grupos con Potential de Crecimiento (IN607B 2020/08, A.S.); Agencia Gallega para la Gestión del Conocimiento en Salud (ACIS): BI-BACVIR (PRIS-3, A.S.), and CovidPhy (SA 304C, A.S.); ReSVinext (PI16/01569/Cofinanciado FEDER, F.M.T.), Enterogen (PI19/01090/Cofinanciado FEDER, F.M.T.) and consorcio Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CB21/06/00103; F.M.T.); GEN-COVID (IN845D 2020/23, F.M-T.) and Grupos de Referencia Competitiva (IIN607A2021/05, F.M-T). The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publicationThere is abundant epidemiological data indicating that the incidence of severe cases of coronavirus disease (COVID-19) is significantly higher in males than females worldwide. Moreover, genetic variation at the X-chromosome linked TLR7 gene has been associated with COVID-19 severity. It has been suggested that the sex-biased incidence of COVID-19 might be related to the fact that TLR7 escapes X-chromosome inactivation during early embryogenesis in females, thus encoding a doble dose of its gene product compared to males. We analyzed TLR7 expression in two acute phase cohorts of COVID-19 patients that used two different technological platforms, one of them in a multi-tissue context including saliva, nasal, and blood samples, and a third cohort that included different post-infection timepoints of long-COVID-19 patients. We additionally explored methylation patterns of TLR7 using epigenomic data from an independent cohort of COVID-19 patients stratified by severity and sex. In line with genome-wide association studies, we provide supportive evidence indicating that TLR7 has altered CpG methylation patterns and it is consistently downregulated in males compared to females in the most severe cases of COVID-19S

Understanding genetic diversity of relict forests. Linking long-term isolation legacies and current habitat fragmentation in Abies pinsapo Boiss

Increasing variability and uncertainty regarding future climate provide new challenges for the conservation of endangered tree species. For example, threat status can be impacted by genetic diversity, where forest trees show reduced geographic range size, isolated populations and fragmented distribution. We place the conservation insights of population genetic structure in a climate change context, using as experimental system a relict drought-sensitive fir (Abies pinsapo Boiss.). Nuclear (nSSR, ISSR) and chloroplast (cpSSR) markers were analysed to investigate the extent to that A. pinsapo evidences ongoing genetic erosion, isolation and divergent genetic diversity, among populations, elevations and cohorts (young, adult and old trees). We obtained contrasting patterns among chloroplast and nuclear markers. Based on cpSSRs, the highest genetic distances were found in the western portion of the distribution, while based on both nSSRs and ISSRs, differentiation appeared in the eastern portion of the distribution. Evidence for bottlenecks and genetic drift were found in all the studied populations, as well as low among-population genetic differentiation. Land use legacies e.g. impacting current forest structural diversity might be related to observed genetic diversity. No evidence of demographic genetic erosion among cohorts was found. Conservation efforts should focus on reducing the probability of occurrence of stochastic events such as fires and habitat loss due to human impacts or climate change to maximise A. pinsapo population sizes. Further research on adaptive potential should focus on identifying active genetic management strategies that might improve adaptation to future climates in such endangered relict species