Measuring and generating social influence using mobile telephony

Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 63-68).In recent years, mobile telephony and manufactured social influence have received attention as tools for eliciting behavior change. This paper describes an experimental approach to studying the effect of these tools in combination. We demonstrate that mobile telephony can be used to generate social influence and elicit behavior change in support of a specified goal. A longitudinal experiment is conducted in a free-living environment, using mobile telephony to track and attempt to influence the activity level of a pool of 97 subjects over 62 days. Subjects receiving feedback about others' performance show a significantly greater increase in activity level than subjects receiving feedback about their own performance only, demonstrating that social influence enhances the persuasive capability of mobile telephony. A significant effect is observed of a subject's pre-existing closeness to the others whose performance he sees. Evidence is also seen that generated social ties lead to a more significant and sustained increase in activity level than existing social ties.by Cory M. Ip.S.M.in Technology and Polic

The Social fMRI: Measuring, Understanding, and Designing Social Mechanisms in the Real World

A key challenge of data-driven social science is the gathering of high quality multi-dimensional datasets. A second challenge relates to design and execution of structured experimental interventions in-situ, in a way comparable to the reliability and intentionality of ex-situ laboratory experiments. In this paper we introduce the Friends and Family study, in which a young-family residential community is transformed into a living laboratory. We employ a ubiquitous computing approach that combines extremely rich data collection in terms of signals, dimensionality, and throughput, together with the ability to conduct targeted experimental interventions with study populations. We present our mobile-phone-based social and behavioral sensing system, which has been deployed for over a year now. Finally, we describe a novel tailored intervention aimed at increasing physical activity in the subject population. Results demonstrate the value of social factors for motivation and adherence, and allow us to quantify the contribution of different incentive mechanisms.U.S. Army Research Laboratory (Cooperative Agreement Number W911NF-09-2-0053)United States. Air Force Office of Scientific Research (Award FA9550-10-1-0122

OSSOS. IV. DISCOVERY OF A DWARF PLANET CANDIDATE IN THE 9 : 2 RESONANCE WITH NEPTUNE

We report the discovery and orbit of a new dwarf planet candidate, 2015 RR245, by the Outer Solar System Origins Survey (OSSOS). The orbit of 2015 RR245 is eccentric (e = 0.586), with a semimajor axis near 82 au, yielding a perihelion distance of 34 au. 2015 RR245 has g - r = 0.59 +/- 0.11 and absolute magnitude H-r = 3.6 +/- 0.1; for an assumed albedo of p(V) = 12%, the object has a diameter of similar to 670. km. Based on astrometric measurements from OSSOS and Pan-STARRS1, we find that 2015 RR245 is securely trapped on ten-megayear timescales in the 9: 2 mean-motion resonance with Neptune. It is the first trans-Neptunian object (TNO) identified in this resonance. On hundred-megayear. timescales, particles in 2015 RR245-like orbits depart and sometimes return to the resonance, indicating that 2015 RR245 likely forms part of the long-lived metastable population of distant TNOs that drift between resonance sticking and actively scattering via gravitational encounters with Neptune. The discovery of a 9: 2 TNO stresses the role of resonances in the long-term evolution of objects in the scattering disk. and reinforces the view that distant resonances are heavily populated in the current solar system. This object further motivates detailed modeling of the transient sticking population.Peer reviewe

OSSOS. VII. 800+Trans-Neptunian Objects-The Complete Data Release

The Outer Solar System Origins Survey (OSSOS), a wide-field imaging program in 2013-2017 with the Canada-France-Hawaii Telescope, surveyed 155 deg(2) of sky to depths of m(r) = 24.1-25.2. We present 838 outer solar system discoveries that are entirely free of ephemeris bias. This increases the inventory of trans-Neptunian objects (TNOs) with accurately known orbits by nearly 50%. Each minor planet has 20-60 Gaia/Pan-STARRS-calibrated astrometric measurements made over 2-5 oppositions, which allows accurate classification of their orbits within the trans-Neptunian dynamical populations. The populations orbiting in mean-motion resonance with Neptune are key to understanding Neptune's early migration. Our 313 resonant TNOs, including 132 plutinos, triple the available characterized sample and include new occupancy of distant resonances out to semimajor axis a similar to 130 au. OSSOS doubles the known population of the nonresonant Kuiper Belt, providing 436 TNOs in this region, all with exceptionally high-quality orbits of a uncertainty sigma(a)Peer reviewe

The Outer Solar System Origins Survey : I. Design and First-Quarter Discoveries

We report the discovery, tracking, and detection circumstances for 85 trans-Neptunian objects (TNOs) from the first 42 deg(2) of the Outer Solar System Origins Survey. This ongoing r-band solar system survey uses the 0.9 deg(2) field of view MegaPrime camera on the 3.6m Canada-France-Hawaii Telescope. Our orbital elements for these TNOs are precise to a fractional semimajor axis uncertaintyPeer reviewe

Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage

Irradiation and DNA-damaging chemotherapeutic agents are commonly used in anticancer treatments. Following DNA damage FOXM1 protein levels are often elevated. In this study, we sought to investigate the potential role of FOXM1 in programmed cell death induced by DNA-damage. Human cancer cells after FOXM1 suppression were subjected to doxorubicin or γ-irradiation treatment. Our findings indicate that FOXM1 downregulation by stable or transient knockdown using RNAi or by treatment with proteasome inhibitors that target FOXM1 strongly sensitized human cancer cells of different origin to DNA-damage-induced apoptosis. We showed that FOXM1 suppresses the activation of pro-apoptotic JNK and positively regulates anti-apoptotic Bcl-2, suggesting that JNK activation and Bcl-2 down-regulation could mediate sensitivity to DNA-damaging agent-induced apoptosis after targeting FOXM1. Since FOXM1 is widely expressed in human cancers, our data further support the fact that it is a valid target for combinatorial anticancer therapy

Induction of Epithelial Mesenchimal Transition and Vasculogenesis in the Lenses of Dbl Oncogene Transgenic Mice

BACKGROUND: The Dbl family of proteins represents a large group of proto-oncogenes involved in cell growth regulation. The numerous domains that are present in many Dbl family proteins suggest that they act to integrate multiple inputs in complicated signaling networks involving the Rho GTPases. Alterations of the normal function of these proteins lead to pathological processes such as developmental disorders and neoplastic transformation. We generated transgenic mice introducing the cDNA of Dbl oncogene linked to the metallothionein promoter into the germ line of FVB mice and found that onco-Dbl expression in mouse lenses affected proliferation, migration and differentiation of lens epithelial cells. RESULTS: We used high density oligonucleotide microarray to define the transcriptional profile induced by Dbl in the lenses of 2 days, 2 weeks, and 6 weeks old transgenic mice. We observed modulation of genes encoding proteins promoting epithelial-mesenchymal transition (EMT), such as down-regulation of epithelial cell markers and up-regulation of fibroblast markers. Genes encoding proteins involved in the positive regulation of apoptosis were markedly down regulated while anti-apoptotic genes were strongly up-regulated. Finally, several genes encoding proteins involved in the process of angiogenesis were up-regulated. These observations were validated by histological and immunohistochemical examination of the transgenic lenses where vascularization can be readily observed. CONCLUSION: Onco-Dbl expression in mouse lens correlated with modulation of genes involved in the regulation of EMT, apoptosis and vasculogenesis leading to disruption of the lens architecture, epithelial cell proliferation, and aberrant angiogenesis. We conclude that onco-Dbl has a potentially important, previously unreported, capacity to dramatically alter epithelial cell migration, replication, polarization and differentiation and to induce vascularization of an epithelial tissue

Digital Rights Management (DRM) : a failure in the developed world, a danger to the developing world. A paper for the International Telecommunications Union, ITU-R Working Party 6M Report on Content Protection Technologies

This paper is part of our ongoing effort to bring some sanity to the blind march toward DRM technologies. These technologies don't work for stopping copyright infringement - their supposed function - yet they've served as an anti-competitive cudgel, a set of shackles on the public's rights in copyright, and a rubric for censoring and even jailing security researchers. EFF is delighted to be able to get this much-needed reality check before policymakers worldwide as they consider the question: 'Which DRM is best for my country?' Our answer: 'DRM will exact a punishing toll on your national interest and yield no benefit at all.' The paper explores the ways that DRM has harmed the developed world, negatively impacting scientific research, speech, innovation, competition, legitimate consumer interests, access by disabled people, archiving and library functions, and distance education. The paper goes on to examine the risks to the developing world in terms of its potential to curtail the public domain, to criminalize free and open source software projects, to enable region-based discrimination, and to lock local artists, authors, and performers into the monopoly pricing of DRM vendors. DRM has no nexus with promoting culture or stopping infringement. The rent it exacts from the nations it colonizes is too dear for anyone to bear. As you will see, the answer to "Which DRM will spur the most development in my nation?" is "None at all.