Extending the capability of forensic electrochemistry to the novel psychoactive substance benzylpiperazine.

Benzylpiperazine (BZP) is a novel psychoactive substance that is commonly abused in tablet form as an 'ecstasy-type' drug. Electroanalysis offers genuine potential for field testing of bulk drug samples. This research is the first to investigate the viability of voltammetric analysis of BZP. Initial cyclic voltammetry in 0.1 M KCl showed an oxidative peak at a glassy carbon electrode for BZP at approximately 0.8 V (scan rate 205 mV s− 1). Next an optimised electrode/electrolyte combination (viz. 80:20 W:W glassy carbon beads:nujol and pH 9.5, 40 mM, Britton-Robinson buffer) was developed using K3Fe(CN)6 to test the electrode material. The oxidation of BZP involves two electrons and two protons and a mechanism has been proposed. An anodic stripping square wave voltammetric method was optimised by factorial design with the conditions of deposition: − 0.8 V for 135 s, and stripping: step height 10 mV, amplitude 50 mV and frequency 13 Hz. A limit of detection of 6 μM was achieved. The resolution against 3,4-methylenedioxymethylamphetamine (MDMA) was also verified

Is null-point reconnection important for solar flux emergence?

The role of null-point reconnection in a 3D numerical MHD model of solar emerging flux is investigated. The model consists of a twisted magnetic flux tube rising through a stratified convection zone and atmosphere to interact and reconnect with a horizontal overlying magnetic field in the atmosphere. Null points appear as the reconnection begins and persist throughout the rest of the emergence, where they can be found mostly in the model photosphere and transition region, forming two loose clusters on either side of the emerging flux tube. Up to 26 nulls are present at any one time, and tracking in time shows that there is a total of 305 overall, despite the initial simplicity of the magnetic field configuration. We find evidence for the reality of the nulls in terms of their methods of creation and destruction, their balance of signs, their long lifetimes, and their geometrical stability. We then show that due to the low parallel electric fields associated with the nulls, null-point reconnection is not the main type of magnetic reconnection involved in the interaction of the newly emerged flux with the overlying field. However, the large number of nulls implies that the topological structure of the magnetic field must be very complex and the importance of reconnection along separators or separatrix surfaces for flux emergence cannot be ruled out.Comment: 26 pages, 12 figures. Added one referenc

First 3D Reconstructions of Coronal Loops with the STEREO A+B Spacecraft: IV. Magnetic Modeling with Twisted Force-Free Fields

The three-dimensional (3D) coordinates of stereoscopically triangulated loops provide strong constraints for magnetic field models of active regions in the solar corona. Here we use STEREO/A and B data from some 500 stereoscopically triangulated loops observed in four active regions (2007 Apr 30, May 9, May 19, Dec 11), together with SOHO/MDI line-of-sight magnetograms. We measure the average misalignment angle between the stereoscopic loops and theoretical magnetic field models, finding a mismatch of $\mu=19^\circ-46^\circ$ for a potential field model, which is reduced to $\mu=14^\circ-19^\circ$ for a non-potential field model parameterized by twist parameters. The residual error is commensurable with stereoscopic measurement errors ($\mu_{SE} \approx 8^\circ-12^\circ$). We developed a potential field code that deconvolves a line-of-sight magnetogram into three magnetic field components $(B_x, B_y, B_z)$, as well as a non-potential field forward-fitting code that determines the full length of twisted loops ($L \approx 50-300$ Mm), the number of twist turns (median $N_{twist}=0.06$), the nonlinear force-free $\alpha$-parameter (median $\alpha \approx 4 \times 10^{-11}$ cm$^{-1}$), and the current density (median $j_z \approx 1500$ Mx cm$^{-2}$ s$^{-1}$). All twisted loops are found to be far below the critical value for kink instability, and Joule dissipation of their currents is found be be far below the coronal heating requirement. The algorithm developed here, based on an analytical solution of nonlinear force-free fields that is accurate to second order (in the force-free parameter $\alpha$), represents the first code that enables fast forward-fitting to photospheric magnetograms and stereoscopically triangulated loops in the solar corona.Comment: The Astrophysical Journal (in press), 37 pages, 14 Figure

On Solving the Coronal Heating Problem

This article assesses the current state of understanding of coronal heating, outlines the key elements of a comprehensive strategy for solving the problem, and warns of obstacles that must be overcome along the way.Comment: Accepted by Solar Physics; Published by Solar Physic

The Met Office Forecast Ocean Assimilation Model (FOAM) using a 1/12‐degree grid for global forecasts

The Met Office Forecast Ocean Assimilation Model (FOAM) ocean–sea-ice analysis and forecasting operational system has been using an ORCA tripolar grid with 1/4° horizontal grid spacing since December 2008. Surface boundary forcing is provided by numerical weather prediction fields from the operational global atmosphere Met Office Unified Model. We present results from a 2-year simulation using a 1/12° global ocean–sea-ice model configuration while keeping a 1/4° data assimilation (DA) set-up. We also describe recent operational data assimilation enhancements that are included in our 1/4° control and 1/12° simulations: a new bias-correction term for sea-level anomaly assimilation and a revised pressure correction algorithm. The primary effect of the first is to decrease the mean and variability of sea-level anomaly increments at high latitudes, whereas the second significantly reduces the vertical velocity standard deviation in the tropical Pacific. The level of improvement achieved with the higher resolution configuration is moderate but consistently satisfactory when measured using neighbourhood verification metrics that provide fairer quantitative comparisons between gridded model fields at different spatial resolutions than traditional root-mean-square metrics. A comparison of the eddy kinetic energy from each configuration and an observation-based product highlights the regions where further system developments are most needed

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Pneumocystis jirovecii pneumonia in tropical and low and middle income countries: a systematic review and meta-regression

Objective: Pneumocystis jirovecii pneumonia (PCP), the commonest opportunistic infection in HIV-infected patients in the developed world, is less commonly described in tropical and low and middle income countries (LMIC). We sought to investigate predictors of PCP in these settings. Design Systematic review and meta-regression. METHODS: Meta-regression of predictors of PCP diagnosis (33 studies). Qualitative and quantitative assessment of recorded CD4 counts, receipt of prophylaxis and antiretrovirals, sensitivity and specificity of clinical signs and symptoms for PCP, co-infection with other pathogens, and case fatality (117 studies). RESULTS: The most significant predictor of PCP was per capita Gross Domestic Product, which showed strong linear association with odds of PCP diagnosis (p30%; treatment was largely appropriate. Prophylaxis appeared to reduce the risk for development of PCP, however 24% of children with PCP were receiving prophylaxis. CD4 counts at presentation with PCP were usually <200×10 3/ ml. CONCLUSIONS: There is a positive relationship between GDP and risk of PCP diagnosis. Although failure to diagnose infection in poorer countries may contribute to this, we also hypothesise that poverty exposes at-risk patients to a wide range of infections and that the relatively non-pathogenic P. jirovecii is therefore under-represented. As LMIC develop economically they eliminate the conditions underlying transmission of virulent infection: P. jirovecii , ubiquitous in all settings, then becomes a greater relative threat