4.4 Interim Financial Statements

2.1 Applicatio

Turn-by-wire: Computationally mediated physical fabrication

Advances in digital fabrication have simultaneously created new capabilities while reinforcing outdated workflows that constrain how, and by whom, these fabrication tools are used. In this paper, we investigate how a new class of hybrid-controlled machines can collaborate with novice and expert users alike to yield a more lucid making experience. We demonstrate these ideas through our system, Turn-by-Wire. By combining the capabilities of a traditional lathe with haptic input controllers that modulate both position and force, we detail a series of novel interaction metaphors that invite a more fluid making process spanning digital, model-centric, computer control, and embodied, adaptive, human control. We evaluate our system through a user study and discuss how these concepts generalize to other fabrication tools

Model checking polygonal differential inclusions using invariance kernels

Polygonal hybrid systems are a subclass of planar hybrid automata which can be represented by piecewise constant differential inclusions. Here, we identify and compute an important object of such systems’ phase portrait, namely invariance kernels. An invariant set is a set of initial points of trajectories which keep rotating in a cycle forever and the invariance kernel is the largest of such sets. We show that this kernel is a non-convex polygon and we give a non-iterative algorithm for computing the coordinates of its vertices and edges. Moreover, we present a breadth-first search algorithm for solving the reachability problem for such systems. Invariance kernels play an important role in the algorithm.peer-reviewe

Long-term and recent changes in sea level in the Falkland Islands

Mean sea level measurements made at Port Louis in the Falkland Islands in 1981-2, 1984 and 2009, together with values from the nearby permanent tide gauge at Port Stanley, have been compared to measurements made at Port Louis in 1842 by James Clark Ross. The long-term rate of change of sea level is estimated to have been +0.75 ± 0.35 mm/year between 1842 and the early 1980s, after correction for air pressure effects and for vertical land movement due to Glacial Isostatic Adjustment (GIA). The 2009 Port Louis data set is of particular importance due to the availability of simultaneous information from Port Stanley. The data set has been employed in two ways, by providing a short recent estimate of mean sea level itself, and by enabling the effective combination of measurements at the two sites. The rate of sea level rise observed since 1992, when the modern Stanley gauge was installed, has been larger at 2.51 ± 0.58 mm/year, after correction for air pressure and GIA. This rate compares to a value of 2.79 ± 0.42 mm/year obtained from satellite altimetry in the region over the same period. Such a relatively recent acceleration in the rate of sea level rise is consistent with findings from other locations in the southern hemisphere and globall

On Targets: Dropping in on American Bombing Ranges

Impact range targets in military training areas can be square, triangular, rectangular, circular, and linear. Some are designed to look like other things, like airbases, villages, convoys, industrial areas, surface-to-air missile sites, and are built out of old airoplanes, trucks, tanks, cars, buses, boats, tires, mounds of earth, and empty shipping containers. Some are meant to be bombed or strafed physically, others electronically.  The most focused type of target at these ranges, the classic target you might say, is circular, like a bullseye. Its simple geometric embrace of space defines a periphery, and centre. Though largely two-dimensional when seen from above, shown as a gallery they have a cosmological air, whether a planetary hard mass pulled in by gravity, or a solar gas in a sustained continuous explosion. The tension between being drawn inwards, toward the ground, and exploding outwards, is in equilibrium. Some people say that these days everything is a target. These, however, undoubtedly are, and they are out there for the world to see, through internet-based satellite imagery providers like Google Earth. Like framed photographs on the wall, they narrow our attention, and ask us to overlook everything else

Cagi, the Critical Assessment of Genome Interpretation, Establishes Progress and Prospects for Computational Genetic Variant Interpretation Methods

BACKGROUND: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind predictions of phenotypes from genetic data, and these were evaluated by independent assessors. RESULTS: Performance was particularly strong for clinical pathogenic variants, including some difficult-to-diagnose cases, and extends to interpretation of cancer-related variants. Missense variant interpretation methods were able to estimate biochemical effects with increasing accuracy. Assessment of methods for regulatory variants and complex trait disease risk was less definitive and indicates performance potentially suitable for auxiliary use in the clinic. CONCLUSIONS: Results show that while current methods are imperfect, they have major utility for research and clinical applications. Emerging methods and increasingly large, robust datasets for training and assessment promise further progress ahead