25 research outputs found
Epigrafía funeraria inédita de un área romana inédita: Tafalla y el valle del río Cidacos (Navarra)
El presente artículo pretende revisar la estructura de poblamiento romano en la Navarra Media, prestando especial atención a la presencia romana en la ciudad de Tafalla, analizando sus vestigios, su relación con otras poblaciones y revisando la red viaria en época romana. Junto a ello presentamos tres nuevos hallazgos epigráficos, uno en el término municipal de Tafalla, otro en Pueyo y el tercero en Olite. Finalmente se integra a Tafalla dentro del antiguo poblamiento vascón, proponiendo, de acuerdo con las fuentes, la identificación antigua de esta ciudad
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program
Altres ajuts: This work was supported by the Obra Social "La Caixa" (to M. Esteller).Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of aberrant RNA modification landscapes in the so-called epitranscriptome. Here, we report that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine. In this setting, NSUN5 exhibits tumor-suppressor characteristics in vivo glioma models. We also found that NSUN5 loss generates an unmethylated status at the C3782 position of 28S rRNA that drives an overall depletion of protein synthesis, and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress. Interestingly, NSUN5 epigenetic inactivation also renders these gliomas sensitive to bioactivatable substrates of the stress-related enzyme NQO1. Most importantly, NSUN5 epigenetic inactivation is a hallmark of glioma patients with long-term survival for this otherwise devastating disease
Small-scale solar magnetic fields
As we resolve ever smaller structures in the solar atmosphere, it has become
clear that magnetism is an important component of those small structures.
Small-scale magnetism holds the key to many poorly understood facets of solar
magnetism on all scales, such as the existence of a local dynamo, chromospheric
heating, and flux emergence, to name a few. Here, we review our knowledge of
small-scale photospheric fields, with particular emphasis on quiet-sun field,
and discuss the implications of several results obtained recently using new
instruments, as well as future prospects in this field of research.Comment: 43 pages, 18 figure
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
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The Sunrise Mission
The first science flight of the balloon-borne Sunrise telescope took place in June 2009 from ESRANGE (near Kiruna/Sweden) to Somerset Island in northern Canada. We describe the scientific aims and mission concept of the project and give an overview and a description of the various hardware components: the 1-m main telescope with its postfocus science instruments (the UV filter imager SuFI and the imaging vector magnetograph IMaX) and support instruments (image stabilizing and light distribution system ISLiD and correlating wavefront sensor CWS), the optomechanical support structure and the instrument mounting concept, the gondola structure and the power, pointing, and telemetry systems, and the general electronics architecture. We also explain the optimization of the structural and thermal design of the complete payload. The preparations for the science flight are described, including AIV and ground calibration of the instruments. The course of events during the science flight is outlined, up to the recovery activities. Finally, the in-flight performance of the instrumentation is discussed. © 2010 The Author(s)
Sunspots: from small-scale inhomogeneities towards a global theory
The penumbra of a sunspot is a fascinating phenomenon featuring complex
velocity and magnetic fields. It challenges both our understanding of radiative
magneto-convection and our means to measure and derive the actual geometry of
the magnetic and velocity fields. In this contribution we attempt to summarize
the present state-of-the-art from an observational and a theoretical
perspective.Comment: Accepted for publication in Space Science Review
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The European Solar Telescope
The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l'Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems
Epigrafía funeraria inédita de un área romana inédita: Tafalla y el valle del río Cidacos (Navarra)
El presente artículo pretende revisar la estructura de poblamiento romano en la Navarra Media, prestando especial atención a la presencia romana en la ciudad de Tafalla, analizando sus vestigios, su relación con otras poblaciones y revisando la red viaria en época romana. Junto a ello presentamos tres nuevos hallazgos epigráficos, uno en el término municipal de Tafalla, otro en Pueyo y el tercero en Olite. Finalmente se integra a Tafalla dentro del antiguo poblamiento vascón, proponiendo, de acuerdo con las fuentes, la identificación antigua de esta ciudad
Epigrafía funeraria inédita de un área romana inédita: Tafalla y el valle del río Cidacos (Navarra)
El presente artículo pretende revisar la estructura de poblamiento romano en la Navarra Media, prestando especial atención a la presencia romana en la ciudad de Tafalla, analizando sus vestigios, su relación con otras poblaciones y revisando la red viaria en época romana. Junto a ello presentamos tres nuevos hallazgos epigráficos, uno en el término municipal de Tafalla, otro en Pueyo y el tercero en Olite. Finalmente se integra a Tafalla dentro del antiguo poblamiento vascón, proponiendo, de acuerdo con las fuentes, la identificación antigua de esta ciudad
The promise of machine learning in predicting treatment outcomes in psychiatry
For many years, psychiatrists have tried to understand factors involved in response to medications or psychotherapies, in order to personalize their treatment choices. There is now a broad and growing interest in the idea that we can develop models to personalize treatment decisions using new statistical approaches from the field of machine learning and applying them to larger volumes of data. In this pursuit, there has been a paradigm shift away from experimental studies to confirm or refute specific hypotheses towards a focus on the overall explanatory power of a predictive model when tested on new, unseen datasets. In this paper, we review key studies using machine learning to predict treatment outcomes in psychiatry, ranging from medications and psychotherapies to digital interventions and neurobiological treatments. Next, we focus on some new sources of data that are being used for the development of predictive models based on machine learning, such as electronic health records, smartphone and social media data, and on the potential utility of data from genetics, electrophysiology, neuroimaging and cognitive testing. Finally, we discuss how far the field has come towards implementing prediction tools in real-world clinical practice. Relatively few retrospective studies to-date include appropriate external validation procedures, and there are even fewer prospective studies testing the clinical feasibility and effectiveness of predictive models. Applications of machine learning in psychiatry face some of the same ethical challenges posed by these techniques in other areas of medicine or computer science, which we discuss here. In short, machine learning is a nascent but important approach to improve the effectiveness of mental health care, and several prospective clinical studies suggest that it may be working already