Analisis Kinerja Simpang Steger Tak Bersinyal Pada Jl. Buah Batu - Jl. Solontongan - Jl. Suryalaya Kota Bandung

Berdekatan. Simpang merupakan pertemuan antara beberapa jalan menjadi satu. Pada simpangsering terjadi konflik kendaraan bermotor, khususnya simpang tidak bersinyal. Kecenderunganpengguna kendaraan bermotor pada saat ini selalu ingin cepat dan ingin menang sendiri dan seringmengakibatkan konflik di persimpangan. Akibat terjadinya konflik dan hambatan padapersimpangan, maka meningkatnya juga tundaan dan derajat kejenuhan (DS) di simpang tersebut.Analisis dilakukan pada simpang empat steger tak bersinyal, tepatnya pada jl.Buahbatu–jl.Solontongan–jl.Suryalaya. Data diperoleh dari survei lapangan berupa geometri simpang, aruslalulintas pada waktu pagi, siang dan sore selama 3 jam kemudian diambil peakhour, polapergerakan kendaraan pada jam tertentu, kecepatan dan keadaan hambatan samping secara visualpada simpang tersebut. Analisis terhadap simpang empat steger tak bersinyal ini dilakukan denganmengunakan metode MKJI yaitu simpang empat bersinyal, Simpang tiga tak bersinyal dansimpang tiga bersinyal. Analisis awal dilakukan dengan menggunakan metode MKJI simpang tigatak bersinyal untuk mengetahui kinerja simpang tersebut dan menghasilkan DS>1. Alternatif yangdianalisis sebanyak 3 alternatif dan menghasilkan data tundaan dan derajat kejenuhan. Dari ketigaalternatif tersebut didapatkan Alternatif terpilih yaitu alternatif 3 dengan cara menggunakanseparator pada area disekitar simpang tersebut sepanjang 300 m dan menghasilkan derajatkejenuhan rata–rata < 0,6.

Pengaruh Penggunaan PS Ball Terhadap Balok Beton Bertulang Dengan Pembebanan Monotonik Dan Pembebanan Siklik

PS Ball sebagai bahan pengganti pasir dan bahan pengisi telah dilakukan dan disimpulkan dapat digunakan sebagai bahan konstruksi bangunan. PS Ball sebagai bahan konstruksi bangunan lebih unggul dibanding pasir dalam hal kuat tekan, kekerasan, dan anti-weathering. Saat ini, bahankonstruksi bangunan yang sering digunakan adalah beton. Inovasi untuk menciptakan bahan penyusun beton yang ramah lingkungan sangat diperlukan sehingga dilakukan penelitian pengaruh penggunaan PS Ball pada balok beton bertulang dengan pembebanan monotonik dan pembebanansiklik.Tujuan penelitian adalah mengevaluasi pengaruh penggunaan PS Ball terhadap elemen struktur beton bertulang dengan pembebanan monotonik dan pembebanan siklik sertamenganalisis perilaku elemen struktur setelah dibebani beban monotonik dan beban siklik. Pengujian dilakukan dengan metode eksperimental. Berdasarkan hasil analisis diperoleh beton bertulang menggunakan PS Ball dapat menahanbeban sebesar 90 kN sedangkan beton bertulang tanpa PS Ball sebesar 79 kN pada saat pembebanan monotonik. Pada pembebanan siklik, disipasi energi kumulatif beton bertulangmenggunakan PS Ball kinerjanya lebih baik daripada beton bertulang tanpa PS Ball dan kurva histerisis beton bertulang menggunakan PS Ball lebih stabil dan tidak terjadi pinching

Differential Changes in QTc Duration during In-Hospital Haloperidol Use

Aims: To evaluate changes in QT duration during low-dose haloperidol use, and determine associations between clinical variables and potentially dangerous QT prolongation. Methods: In a retrospective cohort study in a tertiary university teaching hospital in The Netherlands, all 1788 patients receiving haloperidol between 2005 and 2007 were studied; ninety-seven were suitable for final analysis. Rate-corrected QT duration (QTc) was measured before, during and after haloperidol use. Clinical variables before haloperidol use and at the time of each ECG recording were retrieved from hospital charts. Mixed model analysis was used to estimate changes in QT duration. Risk factors for potentially dangerous QT prolongation were estimated by logistic regression analysis. Results: Patients with normal before-haloperidol QTc duration (male <= 430 ms, female <= 450 ms) had a significant increase in QTc duration of 23 ms during haloperidol use; twenty-three percent of patients rose to abnormal levels (male >= 450 ms, female >= 470 ms). In contrast, a significant decrease occurred in patients with borderline (male 430-450 ms, female 450-470 ms) or abnormal before-haloperidol QTc duration (15 ms and 46 ms, respectively); twenty-three percent of patients in the borderline group, and only 9% of patients in the abnormal group obtained abnormal levels. Potentially dangerous QTc prolongation was independently associated with surgery before haloperidol use (OR(adj) 34.9, p = 0.009) and before-haloperidol QTc duration (OR(adj) 0.94, p = 0.004). Conclusion: QTc duration during haloperidol use changes differentially, increasing in patients with normal before-haloperidol QTc duration, but decreasing in patients with prolonged before-haloperidol QTc duration. Shorter before-haloperidol QTc duration and surgery before haloperidol use predict potentially dangerous QTc prolongatio

The 28th International Cosmic Ray Conference Expected Event Rate of Subhundred-GeV Gamma Ray Bursts using the Tibet-III Air Shower Array with Single Particle Counting Technique The Tibet ASγ Collaboration

Abstract We calculate the expected event rate of subhundred-GeV gamma-ray bursts using the Tibet-III air shower array with single particle counting technique. The calculation is done under reasonable assumptions that the attenuation effect of gamma rays in the intergalactic space as well as the distributions of redshift, luminosity and emission time of GRBs

Expected Event Rate of Subhundred-GeV Gamma Ray Bursts using the Tibet-III Air Shower Array with Single Particle Counting Technique The Tibet ASγ Collaboration

Abstract We calculate the expected event rate of subhundred-GeV gamma-ray bursts using the Tibet-III air shower array with single particle counting technique. The calculation is done under reasonable assumptions that the attenuation effect of gamma rays in the intergalactic space as well as the distributions of redshift, luminosity and emission time of GRBs

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity