Lebensqualität, Gesundheitszustand und Therapiezufriedenheit bei erfolgreich langzeitbehandelten HIV-infizierten Patienten

Lebensqualität, Gesundheitszustand und Therapiezufriedenheit bei erfolgreich Langzeitbehandelten HIV-Infizierten Patienten

ARTEFACTS: How do we want to deal with the future of our one and only planet?

The European Commission’s Science and Knowledge Service, the Joint Research Centre (JRC), decided to try working hand-in-hand with leading European science centres and museums. Behind this decision was the idea that the JRC could better support EU Institutions in engaging with the European public. The fact that European Union policies are firmly based on scientific evidence is a strong message which the JRC is uniquely able to illustrate. Such a collaboration would not only provide a platform to explain the benefits of EU policies to our daily lives but also provide an opportunity for European citizens to engage by taking a more active part in the EU policy making process for the future. A PILOT PROGRAMME To test the idea, the JRC launched an experimental programme to work with science museums: a perfect partner for three compelling reasons. Firstly, they attract a large and growing number of visitors. Leading science museums in Europe have typically 500 000 visitors per year. Furthermore, they are based in large European cities and attract local visitors as well as tourists from across Europe and beyond. The second reason for working with museums is that they have mastered the art of how to communicate key elements of sophisticated arguments across to the public and making complex topics of public interest readily accessible. That is a high-value added skill and a crucial part of the valorisation of public-funded research, never to be underestimated. Finally museums are, at present, undergoing something of a renaissance. Museums today are vibrant environments offering new techniques and technologies to both inform and entertain, and attract visitors of all demographics.JRC.H.2-Knowledge Management Methodologies, Communities and Disseminatio

Virtual implantations to transition from porcine to bovine animal models for a total artificial heart

Realheart total artificial heart (TAH) is a novel, pulsatile, four-chamber total artificial heart which had been successfully tested acutely in a porcine animal model. However, the bovine model is better suited for long-term testing and thus an evaluation of how the design would fit the bovine anatomy was required. Virtual implantation is a method that enables a computer simulated implantation based on anatomical 3D-models created from computer tomography images. This method is used clinically, but not yet adopted for animal studies. Herein, we evaluated its suitability in the redesign of the outer dimensions and vessel connections of Realheart TAH to transition from the porcine to the bovine animal model. Virtual implantations in combination with bovine cadaver studies enabled a series of successful acute bovine implantations. Virtual implantations are a useful tool to replace the use of animals in early device development and refine subsequent necessary in vivo experiments. The next steps are to carry out human virtual implantations and cadaver studies to ensure the design is optimized for all stages of testing as well as the final recipient.status: publishe

Effect of potassium fertilization on the contents of antioxidants in three cocktail tomato cultivars

Tomatoes are an important source of health beneficial phytochemicals, which act as antioxidants such as ascorbic acid, phenolic compounds, carotenoids, and tocopherols. The content of antioxidants is influenced, among others, by abiotic stress factors, like the nutritional status. Potassium (K) is a macronutrient, which is essential for several physiological functions in plants, for example, translocation of assimilates, activation of enzymes, maintenance of turgescence, and stomata regulation. The aim of this study was to investigate the effect of increasing K fertilization on the concentration of antioxidants in cocktail tomatoes. Therefore, three tomato cultivars (Primavera, Resi, and Yellow Submarine), grown in an outdoor pot experiment, were fertilized with increasing K doses for two consecutive years. It was confirmed that antioxidants in tomato fruit can be affected by the K regime, but was also shown that other factors may reduce or even inverse those effects when cultivation takes place in an uncontrolled outdoor environment. Most consistent K fertilization effects were found for naringenin, p-coumaric acid and caffeic acid. However, enrichment of tomatoes with antioxidants by K fertilization is cultivar dependent and, therefore, general statements should be avoided

Activated Protein C Resistance Does Not Increase Risk for Recurrent Stroke or Death in Stroke Patients

<div><p>Background</p><p>Activated protein C (APC) resistance is the most common inherited prothrombotic disorder. The role of APC resistance in ischemic stroke is controversially discussed.</p><p>Objectives</p><p>The aim of this single center follow up study was to investigate the effect of APC resistance on stroke recurrence and survival in stroke patients.</p><p>Patients/Methods</p><p>We retrospectively identified 966 patients who had had an ischemic stroke or transitory ischemic attack (TIA) and in whom laboratory tests for APC resistance had been conducted. These patients were contacted to determine the primary outcomes of recurrent ischemic stroke or death.</p><p>Results</p><p>A total of 858 patients with an average follow up time of 8.48 years were included. APC resistance did not influence cumulative incidence functions for stroke free and total survival. In multivariate analyses, crude and adjusted hazard ratios for recurrent stroke as well as for death where not significantly increased in patients with APC resistance. This also applies to the subgroups of young patients, patients with cryptogenic stroke and patients with atrial fibrillation.</p><p>Conclusion</p><p>APC-resistance is not a risk factor for subsequent stroke or death in patients with a first ischemic stroke or TIA. Testing for APC-resistance in stroke patients therefore cannot be routinely recommended.</p></div

Baseline data of considered patients.

<p>Baseline data of considered patients.</p