A high-fat diet containing whole walnuts (Juglans regia) reduces tumour size and growth along with plasma insulin-like growth factor 1 in the transgenic adenocarcinoma of the mouse prostate model.

Prostate cancer (PCa) has been linked to fat intake, but the effects of both different dietary fat levels and types remain inconsistent and incompletely characterised. The effects on PCa in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model of an elevated fat (20 % of energy as fat) diet containing 155 g of whole walnuts were compared to those of an elevated fat (20 % of energy as soyabean oil) diet with matched macronutrients, tocopherols as well as a low-fat (8 % of energy as soyabean oil) diet. Mice, starting at 8 weeks of age, consumed one of the three different diets ad libitum; and prostates, livers and blood were obtained after 9, 18 or 24 weeks of feeding. No differences were observed in whole animal growth rates in either high-fat (HF) diet group, but prostate tumour weight and growth rate were reduced in the walnut diet group. Walnut diet group prostate weight, plasma insulin-like growth factor 1, resistin and LDL were lower at 18 weeks, while no statistically significant prostate weight differences by diet were seen at 9 or 24 weeks. Multiple metabolites in the livers differed by diet at 9 and 18 weeks. The walnut diet's beneficial effects probably represent the effects of whole walnuts' multiple constituents and not via a specific fatty acid or tocopherols. Moreover, as the two HF diets had dissimilar effects on prostate tumour growth rate and size, and yet had the same total fat and tocopherol composition and content, this suggests that these are not strongly linked to PCa growth

Critical issue to consider while developing SQL injection prevention mechanism

SQL injection vulnerability is the one of the most common web-based application vulnerabilities that can be exploited by SQL injection attack to gain access to restricted data, bypass authentication mechanism and execute unauthorized data manipulation language. Defensive coding is the simple and affordable way to tackle this problem, by applying secure coding in each an every queries used in application. In this paper we provide a detailed background of SQLI attack, we classify defensive coding into different categories, review existing techniques that are related to each technique, and also evaluate such techniques based on number of attacks they were able to stop.We also evaluated each category of approach based on it's deployment requirement related to inheritance. Currently, to the best of our knowledge no papers have classied defensive coding as we do

On the practical utility of a continuum traffic flow model on curvy highways in adverse weather conditions

The macroscopic continuum traffic flow models are being investigated to predict and ameliorate traffic more efficiently. These models are beneficial implementation tools to comprehend and complement the shortfalls in traffic evolution. Despite the significant enhancements in devising the traffic dynamics, the practical utilization of these macroscopic models is not being fully explored. In this study, the Non-Homogeneous Stimulus-Response Model (NHSRM) (Imran et al., 2023) is investigated for its application in forecasting traffic flow on a curvy highway during various weather conditions. The weather impact, in the specific, dry, light rainfall, moderate rainfall, and heavy rainfall on the travel time, velocity, and density spatiotemporal evolution on a curvy highway is analyzed. The flow during different weather conditions is investigated over two curved roads with 120 m, and 500 m radii. As evident from the results, significant velocity breakdowns during heavy rainfall impact the upstream traffic which contributes to congestion development. The average velocity of traffic depletes significantly, and the congestion formation upstream is significant. While the travel time of particular highway segments elevates sharply during heavy rainfall. A comprehensive understanding of the insights, and the critically associated with the parameters of the model, in particular, on the choice of the maximum velocity of the highway has been presented for NHSRM

Финансовое обеспечение деятельности туристического предприятия

Целью статьи является разработка рекомендаций по повышению эффективности финансового обеспечения деятельности туристического предприятия, определение приоритетных путей совершенствования финансовых показателей его деятельности

Comparative study of safety and efficacy of pregabalin and gabapentin in management of neuropathic pain associated with chronic lumbar radiculopathy

Background: Chronic lumbar radiculopathy a clinical condition in which there is back and leg pain associated with sensory, reflex, or motor deficits in the area of nerve root distribution lasting for more than 12 weeks. The prevalence of lumbar radiculopathy has been reported to be 5.3% in men and 3.7% in women. Pregabalin and gabapentin, which fit in to a new category of drugs called as alpha-2-delta (α2δ) modulators, have been discovered to be effective in the treatment of neuropathic pain related with multiple conditions. So this study was done to compare safety and efficacy of pregabalin and gabapentin in management of pain associated with chronic lumbar radiculopathy.Methods: This was a randomized two arm comparative prospective study. Total 160 patients were enrolled and randomized equally into 2 groups. Group A patients were given capsule pregabalin 75 mg two times a day orally, Group B patients were given tablet gabapentin 300 mg two times a day. Pain intensity was assessed at the start of study i.e. at baseline (0 week), at 6 weeks and at 12 weeks of starting the treatment using numeric pain rating scale.Results: There was significant reduction in pain at the end of 12 weeks in both the groups (p<0.0001), but there was no significant difference between these two groups. The incidence of adverse effects was also more in group A.Conclusions: Both the drugs are having comparable efficacy but gabapentin is more tolerable in such cases

Analysis of C-shape slotted MSPA for 5G sub band applications on three different substrates

A comparative analysis of a compact planar Squarepatch Microstrip Multiband antenna on three different substratesis proposed. The proposed design has a C-shaped slot etched on thesquare radiating part and the antenna is energized usingmicrostrip feed line. RT Duroid