246 research outputs found
Recent Advances in the Immunohistochemistry- Aided Differential Diagnosis of Benign Versus Malignant Hepatocellular Lesions
Néhány további adat a hazai karszt dolinák aszimmetriájának kialakulásához = Some Additional Data on Asymmetry in the Formation of Hungarian Karst Dolines
Data for the geoecology of solution karst dolines, with particular attention to climatic, soil and biogenic environment
The appearance and spatial distribution of the solution dolines of the temperate karsts are closely related to the climatic conditions of the temperate zone and its ecological characteristics. The basis of the classical geomorphological classification of dolines was the characteristic geological condition and the resulting form. Doline formation is shaped by the processes of complex geoecological factors (rock, climate, water, soil, vegetation). Dolines are vulnerable spots in karst areas. The environmental load originating from anthropogenic utilization endangers the natural course of corrosion and the quality of the non-renewable resources of karsts as well as karst ecosystem services, therefore, a complex assessment is necessary for revealing the changes. The study investigates the affect of some important geoecological parameters on the development of solution dolines
KristálycukorbĂłl szintetizált szĂ©ngömb templát segĂtsĂ©gĂ©vel előállĂtott TiO2 gömbhĂ©j-szerkezetek jellemzĂ©se Ă©s fotokatalitikus aktivitásuk vizsgálata
A hepatocellularis carcinoma - a makroszkópiától a molekuláris patológiáig
A hepatocellularis carcinoma (HCC) igen rossz prognĂłzisĂş daganat, azonban diagnosztikája Ă©s kezelĂ©se terĂĽletĂ©n az utĂłbbi Ă©vekben jelentĹ‘s elĹ‘rehaladás törtĂ©nt. Mindehhez hozzájárult a HCC molekuláris patogenezisĂ©nek mĂ©lyebb megismerĂ©se. A cirrhosis talaján kialakult HCC praemalignus elváltozásai a nagy regeneratĂv nodulus, az alacsony („low”) Ă©s magas („high”) fokozatĂş diszplasztikus nodulus. MikroszkĂłposan a WHO trabecularis (micro-, macrotrabecularis), acinaris (pseudoglandularis,), scirrhosus Ă©s szolid formát kĂĽlönĂt el, speciális altĂpuskĂ©nt a világos sejtes, fibrolamellaris Ă©s kevert cholangiohepatocellularis szöveti forma ismert. Ezen szövettani tĂpusok prognosztikai jelentĹ‘sĂ©ge vitatott. A fibrolamellaris, fiatalokban elĹ‘fordulĂł, nem cirrhoticus HCC-t jobb prognĂłzisĂşnak tartják, bár valĂłszĂnű, hogy ez annak a következmĂ©nye, hogy ezen tĂpust cirrhosis nem kĂsĂ©ri. A diagnĂłzist segĂthetik egyes, a szĂ©rumban Ă©s a daganatban is kimutathatĂł tumormarkerek, Ăgy a jĂłl ismert alfa-fetoprotein (AFP) mellett a glipikán-3 Ă©s a survivin, az Ăşjabban leĂrt agrin Ă©s claudinok, valamint a májsejteredetet bizonyĂtĂł hepatocytaspecifikus antigĂ©n (HSA). Ăšjabban az Ăşgynevezett mikro-RNS-ek diagnosztikus jelentĹ‘sĂ©ge, elsĹ‘sorban a májsejtspecifikus mir-122-Ă© is felmerĂĽlt. A HCC molekuláris osztályozása, a kezelĂ©s irányait is megszabĂł barcelonai beosztás (BCLC) mellett, kulcsfontosságĂş molekuláris eltĂ©rĂ©sek alapján csoportosĂtja a HCC-t. Számos olyan molekuláris alteráciĂł Ă©szlelhetĹ‘, amely minden HCC-ben megfigyelhetĹ‘, mĂg egyes eltĂ©rĂ©sek csak bizonyos tumorokban detektálhatĂłk.
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Hepatocellular carcinoma (HCC) is a tumor with rather bad prognosis. Recent years, however, have seen considerable progress in the diagnostics and treatment of this disease, contributing to better understanding of its molecular pathogenesis. Large regenerative nodules, low and high grade dysplastic nodules are premalignant alterations of HCC developing on the grounds of cirrhosis. Microscopically the WHO distinguishes trabecular, acinar (pseudoglandular), scirrhous and solid forms. Special histological subtypes are the clear cell, fibrolamellar and mixed hepato-cholangiocellular variants. The prognostic significance of these histological types is argued. The fibrolamellar, non-cirrhotic form of HCC occurring in young age is considered to be of better prognosis, but this is probably due to the fact that this type is not accompanied by cirrhosis. Certain tumor markers may help the diagnosis, such as alpha-fetoprotein (AFP), glypican-3, survivin, the recently described agrin and claudins, furthermore, the hepatocyte specific antigen (HSA), which confirms the hepatocytic origin of the tumor. Recently, the diagnostic significance of microRNAs, primarily of the hepatocyte-specific mir122 has also emerged. In addition to the Barcelona Clinic Liver Cancer (BCLC) staging classification which determines the course of therapy, the molecular classification of HCC is based on key molecular alterations, many of which are observable in all HCC cases, whereas some alterations are only detectable in certain tumors
The background of local food-based economy development in the Eger wine region
This study reveals the background situation of local food-based economy in the Eger Wine Region. Local food economy is mostly in initial phase in the region because of small scale supply, barely known local food producers and their supply, weak connections between producers and representation of interests, or major labour issues. Despite all these there are advantageous economic environment for development local food-based economy in the area, because the critical mass of producers is still active in the region and consumer’s demand is significant. Tourism provides standing demand for local goods as well. A comprehensive development of market infrastructure would increase the existence of these unique economic entities
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