332 research outputs found
The water supercooled regime as described by four common water models
The temperature scale of simple water models in general does not coincide
with the natural one. Therefore, in order to make a meaningful evaluation of
different water models a temperature rescaling is necessary. In this paper we
introduce a rescaling using the melting temperature and the temperature
corresponding to the maximum of the heat capacity to evaluate four common water
models (TIP4P-Ew, TIP4P-2005, TIP5P-Ew and Six-Sites) in the supercooled
regime. Although all the models show the same general qualitative behavior, the
TIP5P-Ew appears as the best representation of the supercooled regime when the
rescaled temperature is used. We also analyze, using thermodynamic arguments,
the critical nucleus size for ice growth. Finally, we speculate on the possible
reasons why atomistic models do not usually crystalize while the coarse grained
mW model do crystallize.Comment: 8 pages, 8 figure
Probing terahertz surface plasmon waves in graphene structures
Epitaxial graphene mesas and ribbons are investigated using terahertz (THz)
nearfield microscopy to probe surface plasmon excitation and THz transmission
properties on the sub-wavelength scale. The THz near-field images show
variation of graphene properties on a scale smaller than the wavelength, and
excitation of THz surface waves occurring at graphene edges, similar to that
observed at metallic edges. The Fresnel reflection at the substrate SiC/air
interface is also found to be altered by the presence of graphene ribbon
arrays, leading to either reduced or enhanced transmission of the THz wave
depending on the wave polarization and the ribbon width.Comment: accepted for publication in Applied Physics Lette
Path deviations outperform approximate stability in heterogeneous congestion games
We consider non-atomic network congestion games with heterogeneous players
where the latencies of the paths are subject to some bounded deviations. This
model encompasses several well-studied extensions of the classical Wardrop
model which incorporate, for example, risk-aversion, altruism or travel time
delays. Our main goal is to analyze the worst-case deterioration in social cost
of a perturbed Nash flow (i.e., for the perturbed latencies) with respect to an
original Nash flow. We show that for homogeneous players perturbed Nash flows
coincide with approximate Nash flows and derive tight bounds on their
inefficiency. In contrast, we show that for heterogeneous populations this
equivalence does not hold. We derive tight bounds on the inefficiency of both
perturbed and approximate Nash flows for arbitrary player sensitivity
distributions. Intuitively, our results suggest that the negative impact of
path deviations (e.g., caused by risk-averse behavior or latency perturbations)
is less severe than approximate stability (e.g., caused by limited
responsiveness or bounded rationality). We also obtain a tight bound on the
inefficiency of perturbed Nash flows for matroid congestion games and
homogeneous populations if the path deviations can be decomposed into edge
deviations. In particular, this provides a tight bound on the Price of
Risk-Aversion for matroid congestion games
Mitochondrial Glycerol Phosphate Acyltransferase Directs the Incorporation of Exogenous Fatty Acids into Triacylglycerol
The mitochondrial isoform of glycerol-3-phosphate acyltransferase (GPAT), the first step in glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via SREBP-1c, suggesting that it plays a role in triacylglycerol synthesis. To test this hypothesis, we overexpressed mitochondrial GPAT in Chinese hamster ovary (CHO) cells. When GPAT was overexpressed 3.8-fold, triacylglycerol mass was 2.7-fold higher than in control cells. After incubation with trace [14C]oleate (∼3 μM), control cells incorporated 4.7-fold more label into phospholipid than triacylglycerol, but GPAT-overexpressing cells incorporated equal amounts of label into phospholipid and triacylglycerol. In GPAT-overexpressing cells, the incorporation of label into phospholipid, particularly phosphatidylcholine, decreased 30%, despite normal growth rate and phospholipid content, suggesting that exogenous oleate was directed primarily toward triacylglycerol synthesis. Transiently transfected HEK293 cells that expressed a 4.4-fold increase in GPAT activity incorporated 9.7-fold more [14C]oleate into triacylglycerol compared with control cells, showing that the effect of GPAT overexpression was similar in two different cell types that had been transfected by different methods. When the stable, GPAT-overexpressing CHO cells were incubated with 100 μM oleate to stimulate triacylglycerol synthesis, they incorporated 1.9-fold more fatty acid into triacylglycerol than did the control cells. Confocal microscopy of CHO and HEK293 cells transfected with the GPAT-FLAG construct showed that GPAT was located correctly in mitochondria and was not present elsewhere in the cell. These studies indicate that overexpressed mitochondrial GPAT directs incorporation of exogenous fatty acid into triacylglycerol rather than phospholipid and imply that (a) mitochondrial GPAT and lysophosphatidic acid acyltransferase produce a separate pool of lysophosphatidic acid and phosphatidic acid that must be transported to the endoplasmic reticulum where the terminal enzymes of triacylglycerol synthesis are located, and (b) this pool remains relatively separate from the pool of lysophosphatidic acid and phosphatidic acid that contributes to the synthesis of the major phospholipid species.Instituto de Investigaciones Bioquímicas de La Plat
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Flexible and stretchable power sources for wearable electronics.
Flexible and stretchable power sources represent a key technology for the realization of wearable electronics. Developing flexible and stretchable batteries with mechanical endurance that is on par with commercial standards and offer compliance while retaining safety remains a significant challenge. We present a unique approach that demonstrates mechanically robust, intrinsically safe silver-zinc batteries. This approach uses current collectors with enhanced mechanical design, such as helical springs and serpentines, as a structural support and backbone for all battery components. We show wire-shaped batteries based on helical band springs that are resilient to fatigue and retain electrochemical performance over 17,000 flexure cycles at a 0.5-cm bending radius. Serpentine-shaped batteries can be stretched with tunable degree and directionality while maintaining their specific capacity. Finally, the batteries are integrated, as a wearable device, with a photovoltaic module that enables recharging of the batteries
Mitochondrial Glycerol Phosphate Acyltransferase Directs the Incorporation of Exogenous Fatty Acids into Triacylglycerol
The mitochondrial isoform of glycerol-3-phosphate acyltransferase (GPAT), the first step in glycerolipid synthesis, is up-regulated by insulin and by high carbohydrate feeding via SREBP-1c, suggesting that it plays a role in triacylglycerol synthesis. To test this hypothesis, we overexpressed mitochondrial GPAT in Chinese hamster ovary (CHO) cells. When GPAT was overexpressed 3.8-fold, triacylglycerol mass was 2.7-fold higher than in control cells. After incubation with trace [14C]oleate (∼3 μM), control cells incorporated 4.7-fold more label into phospholipid than triacylglycerol, but GPAT-overexpressing cells incorporated equal amounts of label into phospholipid and triacylglycerol. In GPAT-overexpressing cells, the incorporation of label into phospholipid, particularly phosphatidylcholine, decreased 30%, despite normal growth rate and phospholipid content, suggesting that exogenous oleate was directed primarily toward triacylglycerol synthesis. Transiently transfected HEK293 cells that expressed a 4.4-fold increase in GPAT activity incorporated 9.7-fold more [14C]oleate into triacylglycerol compared with control cells, showing that the effect of GPAT overexpression was similar in two different cell types that had been transfected by different methods. When the stable, GPAT-overexpressing CHO cells were incubated with 100 μM oleate to stimulate triacylglycerol synthesis, they incorporated 1.9-fold more fatty acid into triacylglycerol than did the control cells. Confocal microscopy of CHO and HEK293 cells transfected with the GPAT-FLAG construct showed that GPAT was located correctly in mitochondria and was not present elsewhere in the cell. These studies indicate that overexpressed mitochondrial GPAT directs incorporation of exogenous fatty acid into triacylglycerol rather than phospholipid and imply that (a) mitochondrial GPAT and lysophosphatidic acid acyltransferase produce a separate pool of lysophosphatidic acid and phosphatidic acid that must be transported to the endoplasmic reticulum where the terminal enzymes of triacylglycerol synthesis are located, and (b) this pool remains relatively separate from the pool of lysophosphatidic acid and phosphatidic acid that contributes to the synthesis of the major phospholipid species.Instituto de Investigaciones Bioquímicas de La Plat
A Decade of Experience Using mTor Inhibitors in Liver Transplantation
Some studies suggest that Sirolimus (SRL) is associated with an increased risk of death in liver transplant recipients compared to treatment with calcineurin inhibitors (CNIs). We compared patients who received SRL or CNI in the first year after liver transplant. Our database included 688 patients who received a liver transplant. The patients were divided into groups. (1) CNI + MPS (mycophenolate sodium) at time of discharge. (2) CNI + MPS at time of discharge; SRL was added within the first 6 months and continued through the first year. (3) CNI + MPS at time of discharge; SRL was added within the first 6 months and discontinued before the first year. (4) SRL as primary immunosuppression. (5) SRL as primary immunosuppression and discontinued before the first year. We used mortality and graft loss as the primary measures of outcome. We also quantified renal function using the change in glomerular filtration rate (GFR), the presence of biopsy proven acute cellular reject (ACR), and steroid-resistant rejection (SRR). There were no significant differences in mortality or graft loss. There was no difference in patient or graft survival. Patients that received SRL as primary immunosuppression had 50% less rejection compared to controls
Resonantly enhanced second-harmonic generation using III-V semiconductor all-dielectric metasurfaces
Nonlinear optical phenomena in nanostructured materials have been challenging
our perceptions of nonlinear optical processes that have been explored since
the invention of lasers. For example, the ability to control optical field
confinement, enhancement, and scattering almost independently, allows nonlinear
frequency conversion efficiencies to be enhanced by many orders of magnitude
compared to bulk materials. Also, the subwavelength length scale renders phase
matching issues irrelevant. Compared with plasmonic nanostructures, dielectric
resonator metamaterials show great promise for enhanced nonlinear optical
processes due to their larger mode volumes. Here, we present, for the first
time, resonantly enhanced second-harmonic generation (SHG) using Gallium
Arsenide (GaAs) based dielectric metasurfaces. Using arrays of cylindrical
resonators we observe SHG enhancement factors as large as 104 relative to
unpatterned GaAs. At the magnetic dipole resonance we measure an absolute
nonlinear conversion efficiency of ~2X10^(-5) with ~3.4 GW/cm2 pump intensity.
The polarization properties of the SHG reveal that both bulk and surface
nonlinearities play important roles in the observed nonlinear process
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