Análisis del teletrabajo como forma eficaz de trabajo y como herramienta para la conciliación familiar y laboral

[ES] El uso de las nuevas tecnologías de la información y de la comunicación en el trabajo y su introducción en las empresas y en la Administración Pública ha supuesto una transformación en cuanto a su organización. El objetivo principal de este trabajo es el análisis del teletrabajo como forma eficaz de trabajo y como herramienta para la conciliación familiar y laboral. Con este fin, se analiza la legislación a nivel europeo, nacional y autonómico relacionada con el tema. Así mismo, se realiza una revisión de la literatura sobre el concepto, las modalidades de teletrabajo y las ventajas e inconvenientes que supone, tanto para los empleados como para el conjunto de la organización. En la misma línea, se analizan estadísticas oficiales, informes, artículos, etc., para comprender la situación actual del teletrabajo en España. Finalmente, se diseña y se implementa un cuestionario de elaboración propia, que ofrece resultados cuantitativos sobre el teletrabajo, sus modalidades preferidas, su carácter (obligatorio-opcional), su relación con la conciliación familiar y laboral, etc.Llácer Iborra, P. (2020). Análisis del teletrabajo como forma eficaz de trabajo y como herramienta para la conciliación familiar y laboral. http://hdl.handle.net/10251/149241TFG

Hormigón de bajo impacto ambiental elaborado con materiales activados alcalinamente para su uso en firmes compactados con rodillo

Convenios con empresa. El objetivo de este trabajo es la evaluación preliminar de la viabilidad técnica de dos formulaciones de hormigón elaboradas con residuos activados alcalinamente para el desarrollo de firmes de carretera compactados a rodillo de bajo impacto ambiental. Para lograr este objetivo, se han seguido las siguientes etapas: obtención de una dosificación optimizada con hormigón convencional, realización de ensayos con las dos formulaciones de hormigón elaboradas con residuos activados alcalinamente, y valoración de los resultados planteando soluciones a posibles resultados adversosIborra Bosch, P. (2011). Hormigón de bajo impacto ambiental elaborado con materiales activados alcalinamente para su uso en firmes compactados con rodillo. http://hdl.handle.net/10251/13098.Archivo delegad

Untargeted sequencing of circulating microRNAs in a healthy and diseased older population

We performed untargeted profiling of circulating microRNAs (miRNAs) in a well characterized cohort of older adults to verify associations of health and disease-related biomarkers with systemic miRNA expression. Differential expression analysis revealed 30 miRNAs that significantly differed between healthy active, healthy sedentary and sedentary cardiovascular risk patients. Increased expression of miRNAs miR-193b-5p, miR-122-5p, miR-885-3p, miR-193a-5p, miR-34a-5p, miR-505-3p, miR-194-5p, miR-27b-3p, miR-885-5p, miR-23b-5b, miR-365a-3p, miR-365b-3p, miR-22-5p was associated with a higher metabolic risk profile, unfavourable macro- and microvascular health, lower physical activity (PA) as well as cardiorespiratory fitness (CRF) levels. Increased expression of miR-342-3p, miR-1-3p, miR-92b-5p, miR-454-3p, miR-190a-5p and miR-375-3p was associated with a lower metabolic risk profile, favourable macro- and microvascular health as well as higher PA and CRF. Of note, the first two principal components explained as much as 20% and 11% of the data variance. miRNAs and their potential target genes appear to mediate disease- and health-related physiological and pathophysiological adaptations that need to be validated and supported by further downstream analysis in future studies.Clinical Trial Registration: ClinicalTrials.gov: NCT02796976 ( https://clinicaltrials.gov/ct2/show/NCT02796976 )

Are iodophor-impregnated drapes associated with lower intraoperative contamination compared to no adhesive drape?: A protocol for systematic review and meta analysis

Background:Surgical site infection (SSI) is one of the most frightening complications after surgery. Adhesive drapes (AD) are widely used as an infection prevention tool. They can be non-impregnated or iodophor-impregnated, although non-impregnated are less used as they might be related to higher number of infections. One of the most common ways to study their efficacy is by analyzing the intraoperative contamination, which is a useful primary endpoint as it does not need follow-up and it has been strongly associated with infections. Therefore, we believe a systematic review (SR) and meta-analysis is needed to determine which is the literature available about this topic and to explore their results. Methods:All randomized controlled trials (RCT) published since 1984 through to January 15, 2023 will be included. Non-human and experimental studies will be excluded. We will only include studies written in English. We will conduct searches in the following electronic databases: MEDLINE (via PubMed), SCOPUS and Web Of Science. The protocol of the SR was registered in PROSPERO under the number CRD42023391651 and was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol guidelines. Discussion:The evidence regarding the benefits of using iodophor-impregnated adhesive drapes (IIAD) is scarce. Therefore, this SR and meta-analysis is required to determine if they are related with a lower intraoperative contamination incidence, compared to no AD

A High Fundamental Frequency (HFF)-based QCM Immunosensor for Tuberculosis Detection

Tuberculosis, one of the oldest diseases affecting human beings, is still considered as a world public health problem by the World Health Organization. Therefore, there is a need for new and more powerful analytical methods for early illness diagnosis. With this idea in mind, the development of a High Fundamental Frequency (HFF) piezoelectric immunosensor for the sensitive detection of tuberculosis was undertaken. A 38 kDa protein secreted by Mycobacterium tuberculosis was first selected as the target biomarker. Then, specific monoclonal antibodies (MAbs) were obtained. Myc-31 MAb, which showed the highest affinity to the analyte, was employed to set up a reference enzyme-linked immunosorbent assay (ELISA) with a limit of detection of 14 ng mL-1 of 38 kDa antigen. For the development of the HFF piezoelectric immunosensor, 100 MHz quartz crystals were used as transducer elements. The gold electrode surface was functionalized by covalent immobilization of the target biomarker through mixed self-assembled monolayers (mSAM) of carboxylic alkane thiols. A competitive immunoassay based on Myc-31 MAb was integrated with the transducer as sensing bio-recognition event. Reliable assay signals were obtained using low concentrations of antigen for functionalization and MAb for the competitive immunoassay. Under optimized conditions, the HFF immunosensor calibration curve for 38 kDa determination showed a limit of detection as low as 11 ng mL-1 of the biomarker. The high detectability attained by this immunosensor, in the picomolar range, makes it a promising tool for the easy, direct and sensitive detection of the tuberculosis biomarker in biological fluids such as sputum.This study was supported by COLCIENCIAS (Colombia), Project no. 13335212865) and by AWSensors (Valencia, Spain). All of the authors: A. Montoya, C. March, Y.J. Montagut, M.J. Moreno, J.J. Manclus, A. Arnau, Y. Jimenez, M. Jaramillo, P. A. Marin and R.A. Torres declare that they have no conflict of interest.Montoya Baides, Á.; March Iborra, MDC.; Montagut Ferizzola, YJ.; Moreno Tamarit, MJ.; Manclus Ciscar, JJ.; Arnau Vives, A.; Jiménez Jiménez, Y.... (2017). A High Fundamental Frequency (HFF)-based QCM Immunosensor for Tuberculosis Detection. Current Topics in Medicinal Chemistry. 17(14):1623-1630. https://doi.org/10.2174/1568026617666161104105210S16231630171

Hidradenitis suppurativa and autoinflammatory syndrome. A case report.

Se presenta el caso de un paciente varón de 41 años con hidradenitis supurativa de 25 años de evolución. Presenta, desde entonces, un transcurso inestable de la enfermedad que le ha impedido llevar sus actividades cotidianas con total bienestar. Las comorbilidades asociadas, las complicaciones, los cuadros clínicos producidos como efecto secundario a los tratamientos recibidos y los ingresos se han convertido en una constante en su vida. Se pretende mostrar, desde un enfoque holístico y práctico, a través de los patrones funcionales de Marjory Gordon, la evaluación y el manejo de un paciente con estas características.The case of a 41-year-old male with 25 years of evolution of hidradenitis suppurativa is presented. Since then, he presents an unstable course of the disease that has prevented him from carrying out his daily activities with total well-being. The associated comorbidities, complications, the clinic produced as a side effect of the treatments received and admissions have become a constant in his life. The aim is to show, from a holistic and practical approach, through Marjory Gordon's functional patterns, the evaluation and management of a patient with these characteristics.Medicin

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

We are grateful to members of the D.S. laboratory and Dr. E. Fernández-Malavé for discussions and critical reading of the manuscript. We appreciate the support of A. Tomás-Loba, G. Sabio, P. Martín, A. Tsilingiri, A.R. Ramiro, C.L. Abram, C.A. Lowell, J.M. García-Lobo, M. Molina, and M.C. Rodríguez for providing reagents and support. We thank the staff at the Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) facilities for technical support. M.M.-L. received a Formación de Personal Universitario (FPU) fellowship (AP2010-5935) from the Spanish Ministerio de Educación. S.I. is funded by grant SAF2015-74561-JIN from the Spanish Ministerio de Ciencia, Innovación, y Universidades (MCIU) and Fondos Europeos de Desarrollo Regional (FEDER). G.D.B and D.M.R. are supported by the Wellcome Trust and the MRC Centre for Medical Mycology at the University of Aberdeen. S.L.L. is supported by the Swiss National Science Foundation (PP00P3_150758). Work in the D.S. laboratory is funded by the CNIC and grant SAF2016-79040-R from MCIU, the Agencia Estatal de Investigación, and FEDER; B2017/BMD-3733 Immunothercan-CM from Comunidad de Madrid; RD16/0015/0018-REEM from FIS-Instituto de Salud Carlos III, MCIU, and FEDER; the Acteria Foundation; the Constantes y Vitales prize (Atresmedia); La Marató de TV3 Foundation (201723); the European Commission (635122-PROCROP H2020), and the European Research Council (ERC-2016-Consolidator Grant 725091). The CNIC is supported by the MCIU and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).Peer reviewedPublisher PD

The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial.

Background Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable with currently approved doses. There is limited evidence to support its clinical use in COVID-19 patients. We conducted a Pilot, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a single dose of ivermectin reduce the transmission of SARS-CoV-2 when administered early after disease onset. Methods Consecutive patients with non-severe COVID-19 and no risk factors for complicated disease attending the emergency room of the Clínica Universidad de Navarra between July 31, 2020 and September 11, 2020 were enrolled. All enrollments occurred within 72 h of onset of fever or cough. Patients were randomized 1:1 to receive ivermectin, 400 mcg/kg, single dose (n = 12) or placebo (n = 12). The primary outcome measure was the proportion of patients with detectable SARS-CoV-2 RNA by PCR from nasopharyngeal swab at day 7 post-treatment. The primary outcome was supported by determination of the viral load and infectivity of each sample. The differences between ivermectin and placebo were calculated using Fisher's exact test and presented as a relative risk ratio. This study is registered at ClinicalTrials.gov: NCT04390022. Findings All patients recruited completed the trial (median age, 26 [IQR 19-36 in the ivermectin and 21-44 in the controls] years; 12 [50%] women; 100% had symptoms at recruitment, 70% reported headache, 62% reported fever, 50% reported general malaise and 25% reported cough). At day 7, there was no difference in the proportion of PCR positive patients (RR 0·92, 95% CI: 0·77-1·09, p = 1·0). The ivermectin group had non-statistically significant lower viral loads at day 4 (p = 0·24 for gene E; p = 0·18 for gene N) and day 7 (p = 0·16 for gene E; p = 0·18 for gene N) post treatment as well as lower IgG titers at day 21 post treatment (p = 0·24). Patients in the ivermectin group recovered earlier from hyposmia/anosmia (76 vs 158 patient-days; p < 0.001). Interpretation Among patients with non-severe COVID-19 and no risk factors for severe disease receiving a single 400 mcg/kg dose of ivermectin within 72 h of fever or cough onset there was no difference in the proportion of PCR positives. There was however a marked reduction of self-reported anosmia/hyposmia, a reduction of cough and a tendency to lower viral loads and lower IgG titers which warrants assessment in larger trials. Funding ISGlobal, Barcelona Institute for Global Health and Clínica Universidad de Navarra

Prevention of skin lesions after the use of personal protective equipment against infection.

Una de las grandes preocupaciones actuales que padecen los profesionales sanitarios que precisan del uso continuado de equipos de protección individual (EPI), sobre todo para el manejo del paciente con enfermedad COVID, es la protección y prevención de las lesiones en piel que dichos equipos producen como evento adverso. El presente artículo revisa esta afectación y sus causas: oclusión de la piel, evaporación del agua intradérmica, fricción, presión, humedad y reacciones químicas. Como conclusiones, la estrategia de prevención incluye abordar aspectos como el lavado e hidratación de la piel, prevención de la presión local y prevención de la humedad.One of the major concerns of today's healthcare professionals who require the continued use of personal protective equipment (PPE), especially for the management of patients with COVID disease, is the protection and prevention of skin injuries that such equipment produces as an ad-verse event. This article reviews this affectation and its causes: skin occlusion, intra-dermal water evaporation, friction, pressure, humidity and chemical reactions. As conclusions, the prevention strategy includes addressing aspects such as washing and moisturizing the skin, preventing local pressure and preventing moisture.Medicin