On Scaling Solutions with a Dissipative Fluid

We study the asymptotic behaviour of scaling solutions with a dissipative fluid and we show that, contrary to recent claims, the existence of stable accelerating attractor solution which solves the `energy' coincidence problem depends crucially on the chosen equations of state for the thermodynamical variables. We discuss two types of equations of state, one which contradicts this claim, and one which supports it.Comment: 8 pages and 5 figures; to appear in Class. Quantum Gra

Plasticity induced by pairing brain stimulation with motor-related states only targets a subset of cortical neurones

Movement-related brain stimulation (MRBS) interventions associate endogenously generated movement-related brain states with external brain stimuli to induce targeted plastic changes in the motor cortex (M1) [[1], [2], [3], [4]]. These studies have emphasised the importance of the timing of stimulation relative to movement onset. However, none has examined whether the effects are specific to the cortical circuits activated by the stimuli. The question arises because previous work has shown that different sets of inputs to corticospinal neurones can be activated using TMS. Stimulation with a posterior-anterior (PA) direction activates a set of neurones that have a shorter latency connection to corticospinal neurones than those activated with an anterior-posterior (AP) current [5]. Previous MRBS studies have paired movement onset with PA pulses [1]. The present work tests whether the after-effects of MRBS are specific to PA-sensitive neurones, or whether those activated by AP pulses are also affected. Here we applied AP or PA TMS pulses applied just prior to the onset of volitional index finger movements in two experiments conducted on separate days in the same group of individuals [3]. Corticospinal excitability changes induced by these interventions were assessed using AP and PA TMS pulses in the effector muscle and in a control muscle

A Single Nucleotide Polymorphism in STK11 Influences Insulin Sensitivity and Metformin Efficacy in Hyperinsulinemic Girls With Androgen Excess

status: publishe

Plan de negocio para determinar la viabilidad de una tienda minorista digital para la venta de productos org?nicos y de primera necesidad

El E-commerce es un fen?meno que tom? gran impulso durante la pandemia COVID-19, ya que permiti? que las familias lograran adquirir bienes sin la necesidad de exponerse a contagiarse debido al m?nimo contacto f?sico que se requer?a por este canal. Asimismo, se viene presentando un fen?meno de cambios de h?bitos de los consumidores al preferir productos saludables org?nicos. El presente plan de negocio pretende determinar la viabilidad de crear un Marketplace para la venta y despacho de productos org?nicos y de primera necesidad en seis distritos de Lima Metropolitana: San Isidro, San Borja, Surquillo, Miraflores, Barranco y Santiago de Surco. Se desarroll? un an?lisis estrat?gico y se hizo investigaci?n de mercado con estudios cuantitativos. Adem?s se dise?aron los planes de marketing y comercial (describiendo estrategias de marca), un plan operativo (bas?ndonos en la atenci?n a tiempo y en la calidad de entrega cuidando de la huella de carbono), acompa?ado y soportado por un plan de Administracion y Recursos Humanos, para que finalmente concluyamos que el plan de negocio es econ?mica y financieramente viable y rentable para los accionistas

Predictions of SUSY Masses in the Minimal SUSY GUT

The MSSM distinguishes itself from other GUT's by a successful prediction of many unrelated phenomena with a minimum number of parameters. Among them: a) Unification of the couplings constants; b)Unification of the masses; c) Proton decay; d) Electroweak symmetry breaking. A combined fit of the free parameters in the MSSM to these low energy constraints shows that the MSSM model can satisfy these constraints simultaneously. From the fitted parameters the masses of the as yet unobserved superpartners of the SM particles are predicted. The 2nd order QCD coupling constant is required to be between 0.108 and 0.132. It is shown that a top mass of $174\pm16$ GeV, as suggested recently by the CDF Collaboration, constrains the mixing angle between the Higgs doublets in the MSSM to: 1.2<\tb<5.5 at the 90% C.L.. The most probable value corresponds to \tb = 1.56, which leads to a stop mass below the top mass. In this case the stop production in $p\bar{p}$ collisions would contribute to the top signature. This could be an explanation for the large effective $t\bar{t}$ cross section observed by CDF.Comment: latex + eps fig IEKP-KA/94-0

In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep

Epidemiological studies of the impact of environmental chemicals on reproductive health demonstrate consequences of exposure but establishing causative links requires animal models using ‘real life’ in utero exposures. We aimed to determine whether prolonged, low-dose, exposure of pregnant sheep to a mixture of environmental chemicals affects fetal ovarian development. Exposure of treated ewes (n = 7) to pollutants was maximized by surface application of processed sewage sludge to pasture. Control ewes (n = 10) were reared on pasture treated with inorganic fertilizer. Ovaries and blood were collected from fetuses (n = 15 control and n = 8 treated) on Day 110 of gestation for investigation of fetal endocrinology, ovarian follicle/oocyte numbers and ovarian proteome. Treated fetuses were 14% lighter than controls but fetal ovary weights were unchanged. Prolactin (48% lower) was the only measured hormone significantly affected by treatment. Treatment reduced numbers of growth differentiation factor (GDF9) and induced myeloid leukaemia cell differentiation protein (MCL1) positive oocytes by 25–26% and increased pro-apoptotic BAX by 65% and 42% of protein spots in the treated ovarian proteome were differently expressed compared with controls. Nineteen spots were identified and included proteins involved in gene expression/transcription, protein synthesis, phosphorylation and receptor activity. Fetal exposure to environmental chemicals, via the mother, significantly perturbs fetal ovarian development. If such effects are replicated in humans, premature menopause could be an outcome