1,087 research outputs found
Tailored for Real-World: A Whole Slide Image Classification System Validated on Uncurated Multi-Site Data Emulating the Prospective Pathology Workload.
Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin & eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency and diagnostic reproducibility. We present and validate a deep learning system which classifies digitized dermatopathology slides into 4 categories. The system is developed using 5,070 images from a single lab, and tested on an uncurated set of 13,537 images from 3 test labs, using whole slide scanners manufactured by 3 different vendors. The system\u27s use of deep-learning-based confidence scoring as a criterion to consider the result as accurate yields an accuracy of up to 98%, and makes it adoptable in a real-world setting. Without confidence scoring, the system achieved an accuracy of 78%. We anticipate that our deep learning system will serve as a foundation enabling faster diagnosis of skin cancer, identification of cases for specialist review, and targeted diagnostic classifications
Solar neutrino detection in a large volume double-phase liquid argon experiment
Precision measurements of solar neutrinos emitted by specific nuclear
reaction chains in the Sun are of great interest for developing an improved
understanding of star formation and evolution. Given the expected neutrino
fluxes and known detection reactions, such measurements require detectors
capable of collecting neutrino-electron scattering data in exposures on the
order of 1 ktonne yr, with good energy resolution and extremely low background.
Two-phase liquid argon time projection chambers (LAr TPCs) are under
development for direct Dark Matter WIMP searches, which possess very large
sensitive mass, high scintillation light yield, good energy resolution, and
good spatial resolution in all three cartesian directions. While enabling Dark
Matter searches with sensitivity extending to the "neutrino floor" (given by
the rate of nuclear recoil events from solar neutrino coherent scattering),
such detectors could also enable precision measurements of solar neutrino
fluxes using the neutrino-electron elastic scattering events. Modeling results
are presented for the cosmogenic and radiogenic backgrounds affecting solar
neutrino detection in a 300 tonne (100 tonne fiducial) LAr TPC operating at
LNGS depth (3,800 meters of water equivalent). The results show that such a
detector could measure the CNO neutrino rate with ~15% precision, and
significantly improve the precision of the 7Be and pep neutrino rates compared
to the currently available results from the Borexino organic liquid
scintillator detector.Comment: 21 pages, 7 figures, 6 table
The Nylon Scintillator Containment Vessels for the Borexino Solar Neutrino Experiment
Borexino is a solar neutrino experiment designed to observe the 0.86 MeV Be-7
neutrinos emitted in the pp cycle of the sun. Neutrinos will be detected by
their elastic scattering on electrons in 100 tons of liquid scintillator. The
neutrino event rate in the scintillator is expected to be low (~0.35 events per
day per ton), and the signals will be at energies below 1.5 MeV, where
background from natural radioactivity is prominent. Scintillation light
produced by the recoil electrons is observed by an array of 2240
photomultiplier tubes. Because of the intrinsic radioactive contaminants in
these PMTs, the liquid scintillator is shielded from them by a thick barrier of
buffer fluid. A spherical vessel made of thin nylon film contains the
scintillator, separating it from the surrounding buffer. The buffer region
itself is divided into two concentric shells by a second nylon vessel in order
to prevent inward diffusion of radon atoms. The radioactive background
requirements for Borexino are challenging to meet, especially for the
scintillator and these nylon vessels. Besides meeting requirements for low
radioactivity, the nylon vessels must also satisfy requirements for mechanical,
optical, and chemical properties. The present paper describes the research and
development, construction, and installation of the nylon vessels for the
Borexino experiment
Hydrodynamic Interactions in Two Dimensions
We measure hydrodynamic interactions between colloidal particles confined in
a thin sheet of fluid. The reduced dimensionality, compared to a bulk fluid,
increases dramatically the range of couplings. Using optical tweezers we force
a two body system along the eigenmodes of the mobility tensor and find that
eigen-mobilities change logarithmically with particle separation. At a hundred
radii distance, the mobilities for correlated and anti-correlated motions
differ by a factor of two, whereas in bulk fluids, they would be practically
indistinguishable. We derive the two dimensional counterpart of the Oseen
hydrodynamic tensor which quantitatively reproduces the observed behavior.
These results highlight the importance of dimensionality for transport and
interactions in colloidal systems and proteins in biological membranes.Comment: 5 pages, 3 figure
A Study of the Residual 39Ar Content in Argon from Underground Sources
The discovery of argon from underground sources with significantly less 39Ar
than atmospheric argon was an important step in the development of
direct-detection dark matter experiments using argon as the active target. We
report on the design and operation of a low background detector with a single
phase liquid argon target that was built to study the 39Ar content of the
underground argon. Underground argon from the Kinder Morgan CO2 plant in
Cortez, Colorado was determined to have less than 0.65% of the 39Ar activity in
atmospheric argon.Comment: 21 pages, 10 figure
Discovery of underground argon with low level of radioactive 39Ar and possible applications to WIMP dark matter detectors
We report on the first measurement of 39Ar in argon from underground natural
gas reservoirs. The gas stored in the US National Helium Reserve was found to
contain a low level of 39Ar. The ratio of 39Ar to stable argon was found to be
<=4x10-17 (84% C.L.), less than 5% the value in atmospheric argon
(39Ar/Ar=8x10-16). The total quantity of argon currently stored in the National
Helium Reserve is estimated at 1000 tons. 39Ar represents one of the most
important backgrounds in argon detectors for WIMP dark matter searches. The
findings reported demonstrate the possibility of constructing large multi-ton
argon detectors with low radioactivity suitable for WIMP dark matter searches.Comment: 6 pages, 2 figures, 2 table
On the stability of standing waves of Klein-Gordon equations in a semiclassical regime
We investigate the orbital stability and instability of standing waves for
two classes of Klein-Gordon equations in the semi-classical regime.Comment: 9 page
Constraining Non-Standard Interactions of the Neutrino with Borexino
We use the Borexino 153.6 ton.year data to place constraints on non-standard
neutrino-electron interactions, taking into account the uncertainty in the 7Be
solar neutrino flux, and backgrounds due to 85Kr and 210Bi beta-decay. We find
that the bounds are comparable to existing bounds from all other experiments.
Further improvement can be expected in Phase II of Borexino due to the
reduction in the 85Kr background.Comment: 21 pages, 16 pdf figures, 2 tables. Analysis updated including the
uncertainty in sin^2\theta_{23}. Accepted in JHE
Supernova Neutrino-Nucleus Astrophysics
In this brief review we explore the role of neutrino-nucleus interactions in
core-collapse supernovae and discuss open questions. In addition implications
of neutrino mass and mixings in such environments are summarized.Comment: Revtex 4 figure
Maximum likelihood analysis of the first KamLAND results
A maximum likelihood approach has been used to analize the first results from
KamLAND emphasizing the application of this method for low statistics samples.
The goodness of fit has been determined exploiting a simple Monte Carlo
approach in order to test two different null hytpotheses. It turns out that
with the present statistics the neutrino oscillation hypothesis has a
significance of about 90% (the best-fit for the oscillation parameters from
KamLAND are found to be: eV and
), while the no-oscillation hypothesis of
about 50%. Through the likelihood ratio the hypothesis of no disappearence is
rejected at about 99.9% C.L. with the present data from the positron spectrum.
A comparison with other analyses is presented.Comment: 14 pages, 5 figure
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