Geo-neutrinos

We review a new interdisciplinary field between Geology and Physics: the study of the Earth's geo-neutrino flux. We describe competing models for the composition of the Earth, present geological insights into the make up of the continental and oceanic crust, those parts of the Earth that concentrate Th and U, the heat producing elements, and provide details of the regional settings in the continents and oceans where operating and planned detectors are sited. Details are presented for the only two operating detectors that are capable of measuring the Earth's geo-neutrinos flux: Borexino and KamLAND; results achieved to date are presented, along with their impacts on geophysical and geochemical models of the Earth. Finally, future planned experiments are highlighted

The likelihood for supernova neutrino analyses

We derive the event-by-event likelihood that allows to extract the complete information contained in the energy, time and direction of supernova neutrinos, and specify it in the case of SN1987A data. We resolve discrepancies in the previous literature, numerically relevant already in the concrete case of SN1987A data.Comment: 7 pages, 2 figures. Accepted for publication in PR

Evaluation of chemical composition and meat quality of breast muscle in broilers reared under light-emitting diode

The present study was designed to investigate the role of three different light-emitting diode (LED) light color temperatures on the growth performance, carcass characteristics, and breast meat quality of broilers. In our experimental condition, 180 chicks were randomly distributed into four environmentally controlled rooms (three replicates/treatment). The experimental design consisted of four light sources: neon (Control), Neutral (Neutral LED; K = 3500–3700), Cool (Cool LED; K = 5500–6000), and Warm (Warm LED; K = 3000–2500). Upon reaching the commercial weight (3.30 ± 0.20 kg live weight), 30 birds from each group were randomly selected, and live and carcass weight were evaluated to determinate the carcass yield. Following the slaughtering, samples of hemibreast meat were collected from each group and analyzed for physical and chemical properties, fatty acids composition, and volatile compounds. Live weight and carcass weight were negatively influenced by the Warm LED; however, no significant differences were observed in carcass yield in any of the experimental conditions. Higher drip loss values were detected in breast meat samples obtained by broilers reared under Neutral and Cool LEDs. In regard to the meat fatty acids profiles, higher polyunsaturated fatty acids (PUFA) values were detected with the Warm LED; however, the ratio of PUFA/saturated fatty acids (SFA) did not change in any group. The evaluation of volatile profiles in cooked chicken meat led to the identification of 18 compounds belonging to the family of aldehydes, alcohols, ketones, and phenolic compounds, both at 0 (T0) and 7 (T7) d after the cooking. The results of the present study suggest that the LED represents an alternative technology that is cheaper and more sustainable than traditional light sources, since it allows economic savings for poultry farming without significant alterations on the production parameters or the quality of the product

New forms of distinction: how contemporary cultural elites understand ‘good’ taste

Taste is a subject of longstanding academic interest. The question of how cultural interests and preferences are socially stratified is at the heart of the sociology of culture. This article adds to this literature by examining the tastes of a specific social fraction, those working in cultural and creative occupations (N = 203). The analysis finds that, in keeping with existing quantitative research on changing cultural hierarchies, cultural workers are open and eclectic in their expressions of taste. They are reflexive, able to play with, and question, ideas of taste alongside conceptions of artistic or cultural legitimacy, connecting their understandings to broader questions of social division and distinction. At the same time, this ‘emerging’ form of cultural capital is a new dividing line, substantiated by modes of consumption, depth of appreciation, and willingness to articulate commitments to engagement with culture. These distinctive tastes of cultural workers matter because, as creators, commissioners and curators of what ends up on stage, page and screen, cultural workers’ tastes shape the cultural hierarchies of which they are a part. In the context of cultural and creative industries, we can expect that these new forms of distinction will serve to create group identities, providing yet another way that cultural elites are socially closed, in addition to well-known exclusions based on demographics such as race, class, gender, age or disability

Thyroid ultrasonography reporting: consensus of Italian Thyroid Association (AIT), Italian Society of Endocrinology (SIE), Italian Society of Ultrasonography in Medicine and Biology (SIUMB) and Ultrasound Chapter of Italian Society of Medical Radiology (SIRM)

Thyroid ultrasonography (US) is the gold standard for thyroid imaging and its widespread use is due to an optimal spatial resolution for superficial anatomic structures, a low cost and the lack of health risks. Thyroid US is a pivotal tool for the diagnosis and follow-up of autoimmune thyroid diseases, for assessing nodule size and echostructure and defining the risk of malignancy in thyroid nodules. The main limitation of US is the poor reproducibility, due to the variable experience of the operators and the different performance and settings of the equipments. Aim of this consensus statement is to standardize the report of thyroid US through the definition of common minimum requirements and a correct terminology. US patterns of autoimmune thyroid diseases are defined. US signs of malignancy in thyroid nodules are classified and scored in each nodule. We also propose a simplified nodule risk stratification, based on the predictive value of each US sign, classified and scored according to the strength of association with malignancy, but also to the estimated reproducibility among different operators

Solar neutrino detection in a large volume double-phase liquid argon experiment

Precision measurements of solar neutrinos emitted by specific nuclear reaction chains in the Sun are of great interest for developing an improved understanding of star formation and evolution. Given the expected neutrino fluxes and known detection reactions, such measurements require detectors capable of collecting neutrino-electron scattering data in exposures on the order of 1 ktonne yr, with good energy resolution and extremely low background. Two-phase liquid argon time projection chambers (LAr TPCs) are under development for direct Dark Matter WIMP searches, which possess very large sensitive mass, high scintillation light yield, good energy resolution, and good spatial resolution in all three cartesian directions. While enabling Dark Matter searches with sensitivity extending to the "neutrino floor" (given by the rate of nuclear recoil events from solar neutrino coherent scattering), such detectors could also enable precision measurements of solar neutrino fluxes using the neutrino-electron elastic scattering events. Modeling results are presented for the cosmogenic and radiogenic backgrounds affecting solar neutrino detection in a 300 tonne (100 tonne fiducial) LAr TPC operating at LNGS depth (3,800 meters of water equivalent). The results show that such a detector could measure the CNO neutrino rate with ~15% precision, and significantly improve the precision of the 7Be and pep neutrino rates compared to the currently available results from the Borexino organic liquid scintillator detector.Comment: 21 pages, 7 figures, 6 table

Seasonal and Feeding System Effects on Qualitative Parameters of Bovine Milk Produced in the Abruzzo Region (Italy)

The aim of this study was to examine variations in cow milk composition as a function of breeding system and seasonality. This study was carried out in 16 dairy farms located in the Abruzzo region (Central Italy), equally distributed between farms that adopt grazing in the spring and summer months, and farms where the intensive system is exploited. Milk was sampled in all seasons in each of the farms involved and was analyzed with particular attention given to the quality of the lipid and protein fractions. A lower concentration of saturated fatty acids and an increase in rumenic, vaccenic and oleic acids were registered for milk samples coming from outdoor grazing, in which was also observed the greatest presence of and caseins. The opposite result was instead observed for casein, which showed the highest values from intensive farming. Evaluations also focused on retinol, which significantly increased in concentration during summer in both breeding systems. The present results suggest positive insights into the role of the outdoor breeding system in improving the main qualitative trait of bovine milk in warm seasons

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells

mTOR kinase and the A isoform of lactate dehydrogenase (LDH-A) are key players controlling the metabolic characteristics of cancer cells. By using cultured human breast cells as a \u201cmetabolic tumor\u201d model, we attempted to explore the correlation between these two factors. \u201cMetabolic tumors\u201d are defined as neoplastic conditions frequently associated with features of the metabolic syndrome, such as hyper-insulinemia and hyper-glycemia. MCF-7 cells (a well differentiated carcinoma) and MCF-10A cells (a widely used model for studying normal breast cell transformation) were used in this study. These cells were exposed to known factors triggering mTOR activation. In both treated cultures, we evaluated the link between mTOR kinase activity and the level of LDH expression / function. Furthermore, we elaborated the metabolic changes produced in cells by the mTOR-directed LDH-A up-regulation. Interestingly, we observed that in the non-neoplastic MCF-10A culture, mTOR-directed up-regulation of LDH-A was followed by a reprogramming of cell metabolism, which showed an increased dependence on glycolysis rather than on oxidative reactions. As a consequence, lactate production appeared to be enhanced and cells began to display increased self-renewal and clonogenic power: signals suggestive of neoplastic change. Enhanced clono-genicity of cells was abolished by rapamycin treatment, and furthermore heavily reduced by LDH enzymatic inhibition. These results highlighted a mechanistic link between metabolic alterations and tumorigenesis, whereby suggesting LDH inhibition as a possible chemo-preventive measure to target the metabolic alterations driving neoplastic change