Reabilitação Protética Em Pacientes Totalmente Edêntulos Com Prótese Em Carga Imediata

O tratamento de pacientes totalmente edentulos com sistemas de carga imediata ou precoce difere apenas pelo tempo de espera para completar o trabalho. O objetivo principal deste trabalho foi uma Revisão Bibliográfica da técnica de carga imediata e analisar as diferenças do procedimento com carga precoce para pacientes desdentados totais. Este trabalho foi baseado numa Revisão Bibliográfica. Para tal foi realizada uma pesquisa nas seguintes base de dados , PubMed, Medline, Scielo, ISI Web of Knowledge, Google scholar nas quais pesquisei 1100 artigos de interesse, 39 correspondiam aos critérios de inclusão préviamente definidos. Os resultados permitem concluir que com uma seleção cuidadosa dos pacientes e o uso de implantes com superfícies tratados, o carregamento imediato com próteses fixas em pacientes desdentados parecem ter os mesmos efeitos sobre a taxa de sobrevida, falha e complicações do implante com o carregamento precoce e convencional na maxila e mandibular

Untargeted NMR Metabolomics Reveals Alternative Biomarkers and Pathways in Alkaptonuria

Alkaptonuria (AKU) is an ultra-rare metabolic disease caused by the accumulation of homogentisic acid (HGA), an intermediate product of phenylalanine and tyrosine degradation. AKU patients carry variants within the gene coding for homogentisate-1,2-dioxygenase (HGD), which are responsible for reducing the enzyme catalytic activity and the consequent accumulation of HGA and formation of a dark pigment called the ochronotic pigment. In individuals with alkaptonuria, ochronotic pigmentation of connective tissues occurs, leading to inflammation, degeneration, and eventually osteoarthritis. The molecular mechanisms underlying the multisystemic development of the disease severity are still not fully understood and are mostly limited to the metabolic pathway segment involving HGA. In this view, untargeted metabolomics of biofluids in metabolic diseases allows the direct investigation of molecular species involved in pathways alterations and their interplay. Here, we present the untargeted metabolomics study of AKU through the nuclear magnetic resonance of urine from a cohort of Italian patients; the study aims to unravel molecular species and mechanisms underlying the AKU metabolic disorder. Dysregulation of metabolic pathways other than the HGD route and new potential biomarkers beyond homogentisate are suggested, contributing to a more comprehensive molecular signature definition for AKU and the development of future adjuvant treatment. © 2022 by the authors

Glucagon-Like Peptide-1 Receptor Agonists and Cardiovascular Events: A Meta-Analysis of Randomized Clinical Trials

Objective. Data from randomized clinical trials with metabolic outcomes can be used to address concerns about potential issues of cardiovascular safety for newer drugs for type 2 diabetes. This meta-analysis was designed to assess cardiovascular safety of GLP-1 receptor agonists. Design and Methods. MEDLINE, Embase, and Cochrane databases were searched for randomized trials of GLP-1 receptor agonists (versus placebo or other comparators) with a duration ≥12 weeks, performed in type 2 diabetic patients. Mantel-Haenszel odds ratio with 95% confidence interval (MH-OR) was calculated for major cardiovascular events (MACE), on an intention-to-treat basis, excluding trials with zero events. Results. Out of 36 trials, 20 reported at least one MACE. The MH-OR for all GLP-1 receptor agonists was 0.74 (0.50–1.08), P = .12 (0.85 (0.50–1.45), P = .55, and 0.69 (0.40–1.22), P = .20, for exenatide and liraglutide, resp.). Corresponding figures for placebo-controlled and active comparator studies were 0.46 (0.25–0.83), P = .009, and 1.05 (0.63–1.76), P = .84, respectively. Conclusions. To date, results of randomized trials do not suggest any detrimental effect of GLP-1 receptor agonists on cardiovascular events. Specifically designed longer-term trials are needed to verify the possibility of a beneficial effect

Is Quantum Chaos Weaker Than Classical Chaos?

We investigate chaotic behavior in a 2-D Hamiltonian system - oscillators with anharmonic coupling. We compare the classical system with quantum system. Via the quantum action, we construct Poincar\'{e} sections and compute Lyapunov exponents for the quantum system. We find that the quantum system is globally less chaotic than the classical system. We also observe with increasing energy the distribution of Lyapunov exponts approaching a Gaussian with a strong correlation between its mean value and energy.Comment: text (LaTeX) + 7 figs.(ps

Quantum Chaos at Finite Temperature

We use the quantum action to study quantum chaos at finite temperature. We present a numerical study of a classically chaotic 2-D Hamiltonian system - harmonic oscillators with anharmonic coupling. We construct the quantum action non-perturbatively and find temperature dependent quantum corrections in the action parameters. We compare Poincar\'{e} sections of the quantum action at finite temperature with those of the classical action.Comment: Text (LaTeX), Figs. (ps

Anopheline mosquito saliva contains bacteria that are transferred to a mammalian host through blood feeding

Introduction: Malaria transmission occurs when Plasmodium sporozoites are transferred from the salivary glands of anopheline mosquitoes to a human host through the injection of saliva. The need for better understanding, as well as novel modes of inhibiting, this key event in transmission has driven intense study of the protein and miRNA content of saliva. Until now the possibility that mosquito saliva may also contain bacteria has remained an open question despite the well documented presence of a rich microbiome in salivary glands. MethodsUsing both 16S rRNA sequencing and MALDI-TOF approaches, we characterized the composition of the saliva microbiome of An. gambiae and An. stephensi mosquitoes which respectively represent two of the most important vectors for the major malaria-causing parasites P. falciparum and P. vivax. ResultsTo eliminate the possible detection of non-mosquito-derived bacteria, we used a transgenic, fluorescent strain of one of the identified bacteria, Serratiamarcescens, to infect mosquitoes and detect its presence in mosquito salivary glands as well as its transfer to, and colonization of, mammalian host tissues following a mosquito bite. We also showed that Plasmodium infection modified the mosquito microbiota, increasing the presence of Serratia while diminishing the presence of Elizabethkingia and that both P. berghei and Serratia were transferred to, and colonized mammalian tissues. DiscussionThese data thus document the presence of bacteria in mosquito saliva, their transfer to, and growth in a mammalian host as well as possible interactions with Plasmodium transmission. Together they raise the possible role of mosquitoes as vectors of bacterial infection and the utility of commensal mosquito bacteria for the development of transmission-blocking strategies within a mammalian host

Quantum Chaos Versus Classical Chaos: Why is Quantum Chaos Weaker?

We discuss the questions: How to compare quantitatively classical chaos with quantum chaos? Which one is stronger? What are the underlying physical reasons

Lyapunov exponent in quantum mechanics. A phase-space approach

Using the symplectic tomography map, both for the probability distributions in classical phase space and for the Wigner functions of its quantum counterpart, we discuss a notion of Lyapunov exponent for quantum dynamics. Because the marginal distributions, obtained by the tomography map, are always well defined probabilities, the correspondence between classical and quantum notions is very clear. Then we also obtain the corresponding expressions in Hilbert space. Some examples are worked out. Classical and quantum exponents are seen to coincide for local and non-local time-dependent quadratic potentials. For non-quadratic potentials classical and quantum exponents are different and some insight is obtained on the taming effect of quantum mechanics on classical chaos. A detailed analysis is made for the standard map. Providing an unambiguous extension of the notion of Lyapunov exponent to quantum mechnics, the method that is developed is also computationally efficient in obtaining analytical results for the Lyapunov exponent, both classical and quantum.Comment: 30 pages Late