10 research outputs found
Association between lutein intake and lutein concentrations in human milk samples from lactating mothers in South Korea
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of Endobronchial Valve Therapy on Pulmonary Perfusion and Ventilation Distribution
- Author
- A D'Andrilli
- A Fishman
- AE Holland
- BJ Dykstra
- C Casanova
- C Martin
- Carmen Pizarro
- D Chandra
- DE O'Donnell
- Dirk Skowasch
- DM Mannino
- F Venuta
- FC Sciurba
- FJ Herth
- FJ Herth
- FJ Martinez
- Georg Nickenig
- Hojjat Ahmadzadehfar
- IY Wan
- Izabela Tuleta
- KF Rabe
- KS Naunheim
- Marco Idzko
- Markus Essler
- MS Brown
- N Sommer
- PW Jones
- RG Argula
- Rolf Fimmers
- S Mantri
- SC Chung
- SS Kon
- TP Toma
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Signal transduction mechanisms for members of the TGF-β family
- Author
- A Alevizopoulos
- A Atfi
- A Atfi
- A Bhushan
- A Gougos
- A Hata
- A Hollnagel
- A Ishisaki
- A Ishisaki
- A Jazwinska
- A Kon
- A Moustakas
- A Nakao
- A Nishihara
- AB Roberts
- AF Candia
- B Liu
- BA Hocevar
- BL Rosenzweig
- C Pouponnot
- C Savage
- C Sirard
- C Wong
- C-H Heldin
- CZ Song
- D Wotton
- E Kaufmann
- E Labbé
- E Piek
- F Liu
- F Liu
- F Liu
- F López-Casillas
- G Campbell
- GJ Riggins
- H Hayashi
- H Inoue
- H Shibuya
- H Shibuya
- HT Nguyen
- HY Lin
- I Mucsi
- IY Kim
- J Kim
- J Kleeff
- J Luo
- J Massagué
- J Yanagisawa
- J Yue
- J Yue
- J-M Li
- JA LeSuer
- JD Brown
- JD Thatcher
- JF DeCoteau
- JJ Lebrun
- JJ Sekelsky
- JL Wrana
- JM Li
- JM Yingling
- JN Topper
- JN Topper
- K Eppert
- K Kurozumi
- K Shirakabe
- K Tsuneizumi
- K Verschueren
- K Yagi
- K Yamaguchi
- K Yamaguchi
- KK Hunt
- L Attisano
- L Ulloa
- L Vindevoghel
- L Vindevoghel
- L Zawel
- LA Raftery
- LJC Jonk
- LS Mathews
- M Afrakhte
- M Goggins
- M Howell
- M Huse
- M Kawabata
- M Kretzschmar
- M Kretzschmar
- M Kretzschmar
- M Kurokawa
- M Minami
- M Takase
- MB Datto
- MB Datto
- MB Datto
- MM Matzuk
- MP Caestecker de
- MP Caestecker De
- MT Hartsough
- N Masuyama
- NA Armes
- NT Liberati
- P Dijke ten
- P Franzén
- P Greenwel
- R Casellas
- R Derynck
- R Janknecht
- R Janknecht
- R Wieser
- RG Riggins
- RS Frey
- RS Lo
- S Abdollah
- S Ammanamanchi
- S Dennler
- S Dennler
- S Eresh
- S Itoh
- S Lawler
- S Markowitz
- S Souchelnytskyi
- S Souchelnytskyi
- S Souchelnytskyi
- S Thiagalingam
- S Zhou
- SA Hahn
- SA Hahn
- SJ Tang
- SL Stroschein
- T Imamura
- T Nakayama
- T Nohno
- T Shioda
- T Tsukazaki
- T Wang
- TP Chen
- U Persson
- W Cui
- WR Waldrip
- X Chen
- X Chen
- X Shen
- X Shi
- X Xu
- X Yang
- X Yang
- X-H Feng
- XH Feng
- XX Hua
- Y Kim
- Y Sano
- Y Shi
- Y Zhang
- Y Zhang
- Y Zhu
- YG Chen
- YG Chen
- YG Chen
- YG Shi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2001
- Field of study
Oxidant Stress and Drug-Induced Hepatotoxicity
- Author
- A Ashkenazi
- A Boveris
- A Chowdhury
- A Chowhury
- A Loguidice
- A Ramachandran
- A Ramachandran
- A Reuben
- A Wendel
- A Wendel
- AI Cederbaum
- AL Tappel
- AM Larson
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- BH Lauterburg
- BH Lauterburg
- BS Wilfond
- C Cover
- C Saito
- C Saito
- C Scaffidi
- CA Hubel
- CD Klaassen
- CD Klaassen
- CD Smith
- CJ Hsiao
- CK Sen
- CN Palmer
- CP Baines
- CV Smith
- CY Lee
- D Medan
- D Moquin
- D Vercammen
- D Vercammen
- DC Dahlin
- DJ Jollow
- DJ Reed
- DJ Singel
- DW Zhang
- E Gulbins
- E Norberg
- EA Meagher
- FC Fang
- G Bjelakovic
- G Dewson
- G Petrosillo
- GL Squadrito
- GM Kasof
- GW Burton
- GY Lam
- H Boujrad
- H Devarbhavi
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Jaeschke
- H Nakagawa
- H Ohshima
- HD Fahimi
- HM Yan
- IG Metushi
- IY Haddad
- J Allen
- J Huang
- J Jiang
- JA Hinson
- JA Hinson
- JJ Burns
- JJ Lemasters
- Jr Adams JD
- JS Beckman
- JS Gujral
- JS Gujral
- JS Gujral
- JY Hong
- K Bedard
- K Fujimoto
- K Katagiri
- K Kon
- K Kon
- L Cantoni
- L Conde de la Rosa
- L Delavallee
- L Flohé
- L Galluzzi
- L Wang
- LY Li
- M Arai
- M D’Alessio
- M Levine
- M Miki
- M Nishikimi
- M Reilly
- M Saitoh
- M Schrader
- MC Bernhard
- MD Miramar
- ME Peter
- MI Lucena
- ML Bajt
- ML Bajt
- ML Bajt
- ML Bajt
- ML Circu
- MM Berger
- MM Ong
- MM Ong
- MP Murphy
- MS Rao
- N Hanawa
- N Vahsen
- N Watanabe
- O Heizmann
- OM Bakke
- P Dammeyer
- P Olivier
- P Patrignani
- P Vandenabeele
- P Widlak
- PA Clavien
- PM Harrison
- Q Zhong
- R Agarwal
- R Brigelius-Flohé
- R Schlatter
- R Singh
- RA Jacob
- RC Zangar
- RJ Gryglewski
- RJ Schauer
- RJ Temple
- RP Kelly
- S Cagnol
- S Schüngel
- S Toppo
- S Win
- SB Bratton
- SD Nelson
- SG Rhee
- SK Acharya
- SK Powers
- T Hasegawa
- T Marar
- TH Tran
- TK Chang
- TR Knight
- TR Knight
- TR Knight
- UA Boelsterli
- UM Hanumegowda
- V Battaglia
- V Tong
- V Tong
- W Haeusgen
- W Korytowski
- W Martin
- WM Nauseef
- WX Ding
- X Liu
- X Saelens
- Y Masubuchi
- Y Zuo
- YS Huang
- Z Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Drug Treatments for Alzheimer’s Disease: Hopes and Challenges
- Author
- A Sharma
- A Walesiuk
- AC McKee
- ARA Ladiwala
- AS Fleisher
- AY Sun
- B McGuinness
- B Reisberg
- B Strooper De
- B Strooper De
- B Winblad
- BL Wilkinson
- BM Schneider
- BN Ramesh
- BP Imbimbo
- BP Imbimbo
- BP Imbimbo
- BR Coleman
- C Ballard
- C Ballard
- C Carlson
- C Perdomo
- C Stough
- C Uluoglu
- CA Lasagna-Reeves
- CR Jack
- CY Shen
- D Albani
- D Weintraub
- DB Donoviel
- DR Lachno
- E Masliah
- E Steen
- ER Siemers
- F Panza
- G Pepeu
- H Fukumoto
- H Martinez-Coria
- H Massudi
- H Samadi
- H Takahashi
- HC Kales
- HH Feldman
- HJ Moebius
- HJ Moebius
- HS Sharma
- IR Chandrashekaran
- IY Tamboli
- J Attems
- J Feng
- J Fossey
- J Gotz
- J McLaurin
- J Neugroschl
- J Olazaran
- J Tang
- J Thome
- J Wang
- JF Quinn
- JL Cummings
- JM Geleijnse
- JM Orgogozo
- JM Reichert
- JW Zhou
- K Blennow
- K Samson
- K Uenaka
- KR Daffner
- KRR Krishnan
- LC Nord
- LS Schneider
- M Farlow
- M Kimura
- M Lee
- M Pettersson
- M Pohanka
- M Sano
- M Tabaton
- MC Morris
- MD Haag
- MJ Serby
- N Braidy
- N Herrmann
- N Herrmann
- N Marks
- N Okamura
- OL Lopez
- PB Rosenberg
- PJ Smith
- PK Menon
- PN Tariot
- PS Aisen
- PS Aisen
- PS Aisen
- RA Vazquez-Roque
- RC Petersen
- RC Petersen
- RF Allegri
- RS Black
- RS Naik
- SA Rosales-Corral
- SC Vlad
- SF Xiao
- SH Ferris
- T Frankiewicz
- T Hashimoto
- T Kon
- T Perry
- V Rocher-Ros
- VR Porter
- WD Heiss
- WP Chang
- X Gao
- XQ Ma
- Y Li
- Y Wei
- YD Ke
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Spectroscopy with Lasers
- Author
- A Corney
- A Crocker
- A Griffin
- A Haug
- A Javan
- A Javan
- A Javan
- A Kiel
- A Lauberau
- A Müller
- A Müller
- A Szöke
- A Weber
- AA Kaminskii
- AB Rosenberger
- AD Devir
- AD May
- AD White
- AE Hill
- AE Siegmann
- AG Maki
- AH Rosenthal
- AJ Alcock
- AJ Demaria
- AJ Goldsborough
- AK Mcquillan
- AL Bloom
- AL Bloom
- AL Schalow
- AM Bonch-Bruyevich
- AM Ronn
- AN Bondarenko
- AN Nesmeyanov
- AP Kanzantsev
- AR Evans
- B Budick
- B Chu
- B Hartmann
- B Kronast
- BB Snavely
- BC Fawcett
- BF Jacoby
- BF Levine
- BG Huth
- BH Soffer
- BI Stephanov
- BJ Berne
- BN Edwards
- BP Kibble
- BP Stoicheff
- BP Stoicheff
- BP Stoicheff
- BR Clemesha
- C Cohen-Tannoudjii
- C Demichelis
- C Ottinger
- C Wittig
- CB Moore
- CB Wheeler
- CB Wheeler
- CC Bradley
- CC Wang
- CG Garret
- CG Young
- Ch Bordé
- CH Gooch
- CH Townes
- CJ Chen
- CK Patel
- CK Patel
- CKN Patel
- CM Ferrar
- CP Christensen
- CR Giuliano
- CR Jeggo
- D Froehlich
- D Meyerhofer
- D Pohl
- D Rosenberger
- D Röss
- D Röss
- DC Smith
- DC Smith
- DE Ashby
- DE Mccumber
- DE Mccumber
- DE Setzer
- DH Rank
- DH Rank
- DH Rank
- DJ Bradley
- DJ Bradley
- DL Rosseau
- DM Hansen
- DN Klishko
- DP Akitt
- DR Lide Jr.
- DR White
- DW Feldman
- DW Gregg
- DW Gregg
- E Lippincott
- E Snitzer
- E Yarmire
- EB Hooper
- EE Salpeter
- EJ Woodbury
- EM Logothetis
- EO Ammann
- F Rasetti
- F Shimizu
- F Shimizu
- F Shimizu
- FG Gebhardt
- FH Crawford
- FJ Mcclung
- FJ Mcclung
- FM Ryan
- FV Kitaeva
- G Baumgartner
- G Duxbury
- G Eckhardt
- G Gobeli
- G Grau
- G Günther
- G Herzberg
- G Hubert
- G Mayer
- G Placek
- G Porter
- G Racah
- GC Baldwin
- GC Pimentel
- GD Boyd
- GD Boyd
- GE Notkin
- GE Walrafen
- GH Megrue
- GH Winstel
- GI Zaitsev
- GN Vinokurov
- GR Hanes
- GS Voronov
- GW Day
- GW Flynn
- H Becker
- H Becker
- H Brunet
- H Hotop
- H Moenke
- H Röhr
- H Vogt
- HC Koons
- HJ Gerritsen
- HJ Gerritsen
- HK Holt
- HL Chen
- HM Gerritsen
- HN Barton
- HP Broida
- HR Schloßberg
- HR Schloßberg
- HW Mocker
- HW Moos
- HW Schrötter
- I Tamaka
- ID Abella
- IY Chang
- J Berkowitz
- J Brandmüller
- J Brandmüller
- J Haisma
- J Hougon
- J Oubieux
- J Tulip
- JA Fejer
- JA Giordmaine
- JA Giordmaine
- JA Koningstein
- JA Koningstein
- JA Koningstein
- JA Sousa
- JB Gerardo
- JB Gerardo
- JB Gerardo
- JC Stephensen
- JC Stephenson
- JD Knox
- JD Shipman
- JE Bjorkholm
- JF Scott
- JH Parker
- JI Steinfeld
- JK Link
- JK Thomas
- JK Wright
- JL Hall
- JL Hall
- JM Besson
- JM Besson
- JP Kotthaus
- JR Airey
- JR Airey
- JR Izatt
- JR Novak
- JR Novak
- JS Levine
- JS Shirk
- JT Yardley
- JT Yardley
- JT Yardley
- JT Yardley
- JV Kasper
- JV Kasper
- JW Strojek
- K Banse
- K Banse
- K Banse
- K Boersch
- K Gürs
- K Gürs
- K Sakurai
- K Sakurai
- K Sakurai
- K Sakurai
- K Sakurai
- K Uehara
- K Uehara
- K Weiser
- KL Kompa
- Kleen-Müller
- KT Hecht
- L Allen
- L Huff
- Landau-Lifshitz
- LB Kreuzer
- LC Lee
- LF Johnson
- LG Shazer
- LG Vitert
- LM Osterink
- LN Pyatnitskii
- LO Heflinger
- LO Hocker
- M Di-Domenico Jr
- M Domenico Jr
- M Goeppert-Maier
- M Hercher
- M Hercher
- M Mcclintock
- M Mcclintock
- M Mcclintock
- M Michon
- M Michon
- M Pilkuhn
- MA Duguay
- MA Duguay
- MA Kovacs
- MA Pollack
- MA Pollack
- ME Mack
- ME Mack
- MI Nathan
- MI Nathan
- MJ Feld
- MM Litvak
- MS Feld
- MS Feld
- MS Feld
- MS Lipsett
- MV Evans
- MV Klein
- MV Klein
- MW Dowley
- N Bloembergen
- N Bloembergen
- N Cohen
- N Dieu
- NC Ford Jr.
- NG Basov
- NG Basov
- NG Basov
- NG Basov
- NG Basov
- NG Basov
- NG Basov
- NG Basov
- NG Basov
- NM Kroll
- NV Karlov
- OG Peterson
- OR Wood
- OS Mortensen
- P Franken
- P Görlich
- P Görlich
- P Heller
- P Langer
- P Pringsheim
- P Sorokin
- P Zory
- PD Maker
- PD Maker
- PH Lee
- PK Yin
- PP Sorokin
- PW Smith
- PW Smith
- R Bonneau
- R Mcleary
- R Müller
- R Paananen
- R Rabinowitz
- R Velasco
- RA Alpher
- RA Fisher
- RA Jeffries
- RA Lilly
- RA Mcfarlane
- RA Mcfarlane
- RA Mclaren
- RC Leite
- RC Leite
- RC Leite
- RD Bates
- RD Mountain
- RD Watson
- RE Drullinger
- RE Honig
- RE Popham
- RG Bennett
- RG Brewer
- RG Brewer
- RG Kepler
- RG Meyerand
- RG Norrish
- RG Smith
- RG Smith
- RG Tomlinson
- RI Scarlet
- RL Abrams
- RL Abrams
- RL Barger
- RL Byer
- RL Byer
- RL Fork
- RL Fork
- RM Danzinger
- RM Measures
- RM Measures
- RN Hall
- RN Zare
- RN Zare
- RN Zare
- RS Lawrence
- RS Lawrence
- RW Gross
- RW Hellwarth
- RW Hellwarth
- RW Minck
- RW Minck
- RW Minck
- RY Chiao
- S Ezekiel
- S Kon
- S Speiser
- S Yoshikava
- SA Ahmed
- SA Akhmanov
- SE Harris
- SG Rantran
- SK Freeman
- SK Kurtz
- SL Shapiro
- SL Shapiro
- SL Shapiro
- SL Shapiro
- SM Sze
- SP Porto
- T Hänsch
- T Hänsch
- T Kushida
- T Sakurai
- TA Cool
- TA Cool
- TA Wiggins
- TG Pavlopoulos
- TG Roberts
- TH Maiman
- THE Cottrell
- TJ Bridges
- TL Cotrell
- TL Cotrell
- TM Quist
- TS Jaseja
- TS Jaseja
- TW Hänsch
- TW Hänsch
- TY Chang
- V Hizhnyakov
- VA Zubov
- VA Zubov
- VL Sedov
- VN Lisitsyn
- VP Belyaiev
- VP Kurnosov
- VP Oppenheim
- VP Oppenheim
- VP Tychinskii
- VS Letokhov
- VS Letokhov
- VS Svorov
- W Demtröder
- W Demtröder
- W Demtröder
- W Demtröder
- W Hanle
- W Holzer
- W Kaiser
- W Krassev
- W Lamb
- W Quillfeldt
- W Schmidt
- W Smith
- W Tango
- W Tango
- WA Nordland
- WB Bendo
- WB Davenport
- WH Blackburn
- WH Smith
- WJ Jones
- WJ Tomlinson
- WJ Wittemann
- WL Peticolas
- WL Peticolas
- WR Bennet Jr.
- WR Bennet Jr.
- WR Bennett Jr
- WR Bennett Jr
- WR Bennett Jr
- WR Bennett Jr.
- WR Bennett Jr.
- WS Benedict
- WS Benedict
- WS Benedict
- WT Silfast
- WW Holzer
- YA Prozhbin
- YH Pao
- YI Zaitsev
- YP Raizer
- YT Yardley
- YV Brzhazovsky
- Z Gelder
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1971
- Field of study
Effects of empagliflozin on progression of chronic kidney disease: a prespecified secondary analysis from the empa-kidney trial
- Author
- Abat S
- Abd Rahman R
- Abdul Cader R
- Abdul Hafidz MI
- Abdul Wahab MZ
- Abdul-Samad T
- Abdullah NK
- Abe M
- Abraham N
- Acheampong S
- Achiri P
- Acosta JA
- Adeleke A
- Adell V
- Adewuyi-Dalton R
- Adnan N
- Africano A
- Agharazii M
- Aguilar F
- Aguilera A
- Ahmad Miswan N
- Ahmad Rosdi H
- Ahmad M
- Ahmad MK
- Ahmad NA
- Ahmad NH
- Ahmad NI
- Ahmed I
- Ahmed S
- Ahmed S
- Aiello J
- Aitken A
- AitSadi R
- Aker S
- Akimoto S
- Akinfolarin A
- Akram S
- Al-Rabadi L
- Al-Zeer B
- Alberici F
- Albert C
- Aldrich L
- Alegata M
- Alexander L
- Alfaress S
- Alhadj Ali M
- Ali A
- Ali A
- Alicic R
- Aliu A
- Almaraz R
- Almasarwah R
- Almeida J
- Aloisi A
- Alscher D
- Alvarez P
- Amat M
- Ambrose C
- Ammar H
- An Y
- Andriaccio L
- Ansu K
- Apostolidi A
- Arai N
- Araki H
- Araki S
- Arbi A
- Arechiga O
- Armstrong S
- Arnold T
- Aronoff S
- Arriaga W
- Arroyo J
- Arteaga D
- Asahara S
- Asai A
- Asai N
- Asano S
- Asawa M
- Asmee MF
- Aucella F
- Augustin M
- Avery A
- Awad A
- Awang IY
- Awazawa M
- Axler A
- Ayub W
- Azhari Z
- Baccaro R
- Badin C
- Bagwell B
- Bahlmann-Kroll E
- Bahtar AZ
- Baigent C
- Baigent C
- Bains D
- Bajaj H
- Baker R
- Baldini E
- Banas B
- Banerjee D
- Banno S
- Bansal S
- Barberi S
- Barnes S
- Barnini C
- Barot C
- Barrett K
- Barrios R
- Bartolomei Mecatti B
- Barton I
- Barton J
- Basily W
- Bavanandan S
- Baxter A
- Becker L
- Beddhu S
- Beige J
- Beigh S
- Bell S
- Benck U
- Beneat A
- Bennett A
- Bennett D
- Benyon S
- Berdeprado J
- Bergler T
- Bergner A
- Berry M
- Bevilacqua M
- Bhairoo J
- Bhandari S
- Bhandary N
- Bhatt A
- Bhattarai M
- Bhavsar M
- Bian W
- Bianchini F
- Bianco S
- Bilous R
- Bilton J
- Bilucaglia D
- Bird C
- Birudaraju D
- Biscoveanu M
- Blake C
- Bleakley N
- Bocchicchia K
- Bodine S
- Bodington R
- Boedecker S
- Bolduc M
- Bolton S
- Bond C
- Boreky F
- Boren K
- Bouchi R
- Bough L
- Bovan D
- Bowler C
- Bowman L
- Brar N
- Braun C
- Breach A
- Breitenfeldt M
- Brenner S
- Brenner S
- Brettschneider B
- Brewer A
- Brewer G
- Brindle V
- Brioni E
- Brown C
- Brown H
- Brown L
- Brown R
- Brown S
- Browne D
- Bruce K
- Brueckmann M
- Brunskill N
- Bryant M
- Brzoska M
- Bu Y
- Buckman C
- Budoff M
- Bullen M
- Burke A
- Burnette S
- Burston C
- Busch M
- Bushnell J
- Butler S
- Byrne C
- Büttner C
- Caamano A
- Cadorna J
- Cafiero C
- Cagle M
- Cai J
- Calabrese K
- Calvi C
- Camilleri B
- Camp S
- Campbell D
- Campbell R
- Cao H
- Capelli I
- Caple M
- Caplin B
- Cardone A
- Carle J
- Carnall V
- Caroppo M
- Carr S
- Carraro G
- Carson M
- Casares P
- Castillo C
- Castro C
- Caudill B
- Cejka V
- Ceseri M
- Cham L
- Chamberlain A
- Chambers J
- Chan CBT
- Chan JYM
- Chan YC
- Chang E
- Chang E
- Chant T
- Chavagnon T
- Chellamuthu P
- Chen F
- Chen J
- Chen P
- Chen TM
- Chen Y
- Chen Y
- Cheng C
- Cheng H
- Cheng MC
- Cherney D
- Cherney D
- Cheung AK
- Cheung AK
- Ching CH
- Chitalia N
- Choksi R
- Chukwu C
- Chung K
- Cianciolo G
- Cipressa L
- Clark S
- Clarke H
- Clarke R
- Clarke S
- Cleveland B
- Cole E
- Coles H
- Condurache L
- Connor A
- Convery K
- Cooper A
- Cooper N
- Cooper Z
- Cooperman L
- Cosgrove L
- Coutts P
- Cowley A
- Craik R
- Cui G
- Cummins T
- D'Amelio A
- Dahl N
- Dai H
- Dajani L
- Damian E
- Damianik K
- Danel L
- Daniels C
- Daniels T
- Darbeau S
- Darius H
- Dasgupta T
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- Zhu D
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- Zippo M
- Zirino F
- Zulkipli FH
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce progression of chronic kidney disease and the risk of cardiovascular morbidity and mortality in a wide range of patients. However, their effects on kidney disease progression in some patients with chronic kidney disease are unclear because few clinical kidney outcomes occurred among such patients in the completed trials. In particular, some guidelines stratify their level of recommendation about who should be treated with SGLT2 inhibitors based on diabetes status and albuminuria. We aimed to assess the effects of empagliflozin on progression of chronic kidney disease both overall and among specific types of participants in the EMPA-KIDNEY trial. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA), and included individuals aged 18 years or older with an estimated glomerular filtration rate (eGFR) of 20 to less than 45 mL/min per 1·73 m2, or with an eGFR of 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher. We explored the effects of 10 mg oral empagliflozin once daily versus placebo on the annualised rate of change in estimated glomerular filtration rate (eGFR slope), a tertiary outcome. We studied the acute slope (from randomisation to 2 months) and chronic slope (from 2 months onwards) separately, using shared parameter models to estimate the latter. Analyses were done in all randomly assigned participants by intention to treat. EMPA-KIDNEY is registered at ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and then followed up for a median of 2·0 years (IQR 1·5-2·4). Prespecified subgroups of eGFR included 2282 (34·5%) participants with an eGFR of less than 30 mL/min per 1·73 m2, 2928 (44·3%) with an eGFR of 30 to less than 45 mL/min per 1·73 m2, and 1399 (21·2%) with an eGFR 45 mL/min per 1·73 m2 or higher. Prespecified subgroups of uACR included 1328 (20·1%) with a uACR of less than 30 mg/g, 1864 (28·2%) with a uACR of 30 to 300 mg/g, and 3417 (51·7%) with a uACR of more than 300 mg/g. Overall, allocation to empagliflozin caused an acute 2·12 mL/min per 1·73 m2 (95% CI 1·83-2·41) reduction in eGFR, equivalent to a 6% (5-6) dip in the first 2 months. After this, it halved the chronic slope from -2·75 to -1·37 mL/min per 1·73 m2 per year (relative difference 50%, 95% CI 42-58). The absolute and relative benefits of empagliflozin on the magnitude of the chronic slope varied significantly depending on diabetes status and baseline levels of eGFR and uACR. In particular, the absolute difference in chronic slopes was lower in patients with lower baseline uACR, but because this group progressed more slowly than those with higher uACR, this translated to a larger relative difference in chronic slopes in this group (86% [36-136] reduction in the chronic slope among those with baseline uACR <30 mg/g compared with a 29% [19-38] reduction for those with baseline uACR ≥2000 mg/g; ptrend<0·0001). Interpretation: Empagliflozin slowed the rate of progression of chronic kidney disease among all types of participant in the EMPA-KIDNEY trial, including those with little albuminuria. Albuminuria alone should not be used to determine whether to treat with an SGLT2 inhibitor. Funding: Boehringer Ingelheim and Eli Lilly
Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial
- Author
- Abat S
- Abd Rahman R
- Abdul Cader R
- Abdul Hafidz MI
- Abdul Wahab MZ
- Abdul-Samad T
- Abdullah NK
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: The EMPA-KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5-2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62-0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16-1·59), representing a 50% (42-58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council
Notes for genera – Ascomycota
- Author
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- T Kowalsky
- T Luangsuphabool
- T Lumbsch
- T Læssøe
- T Martinović
- T Matos
- T Mitrovic
- T Musvuugwa
- T Nagahama
- T Osono
- T Pisani
- T Randlane
- T Rämä
- T Shirouzu
- T Sivakumar
- T Spribille
- T Spribille
- T Spribille
- T Spribille
- T Spribille
- T Spribille
- T Trakunyingcharoen
- T Trakunyingcharoen
- T Tsuge
- T Tønsberg
- T Valadbeigi
- T Valadbeigi
- T Valadbeigi
- T Valadbeigi
- T Valadbeigi
- T Vaupotič
- T Wen
- T Yang
- T Yazawa
- TA Doherty
- TA Duong
- TA Gulder
- TA Hofmann
- TA Naumann
- TAM Jagadeesh Ram
- TC Harrington
- TC Harrington
- TC Harrington
- TC Harrington
- TC Harrington
- TC Wen
- TC Wen
- TC Wen
- TC Wen
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- TE Ahti
- TE Twaroch
- Teixeira M Melo de
- TF Elliott
- TH Hofton
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- TI Sanjuan
- TJ Dreaden
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- TK Goh
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- TM Kharpukhaeva
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- TS Santa-Izabel
- TT Liu
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- VB Hosagoudar
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- VE Masiulionis
- VF Consolo
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- VL Castroagudín
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- VO Ntui
- VP Heluta
- VP Hustad
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- YC Chang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YD Zhang
- YF Han
- YH Geng
- YJ Choi
- YJ Zhao
- YL Chen
- YL Jiang
- YL Jiang
- YL Jiang
- YL Wang
- YL Zhang
- YM Li
- YM Shabana
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Wu
- YM Zhang
- YM Zhang
- Yong-Zhong Lu
- YP Ge
- YP Tan
- YQ Du
- YR Ma
- YR Ma
- YR Ma
- YT Huang
- YW Lim
- YX Liu
- YY Chen
- YY Su
- YZ Lu
- YZ Lu
- YZ Lu
- YZ Wang
- YZ Wang
- Z Du
- Z Fangyan
- Z Ferencova
- Z Jurjevic
- Z Jurjevic
- Z Zakeri
- Z Zhang
- ZA Dyer
- ZA Randriamanantany
- ZF Yu
- ZJ Li
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Luo
- ZL Yuan
- Zong-Long Luo
- ZQ Liang
- ZQ Zeng
- ZQ Zeng
- ZW Beer de
- ZW Beer de
- ZW Beer de
- ZW Ge
- Å Kruys
- Å Kruys
- Å Kruys
- Ö Tufan-Çetin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Knowledge of the relationships and thus the classification of fungi, has developed rapidly with increasingly widespread use of molecular techniques, over the past 10--15 years, and continues to accelerate. Several genera have been found to be polyphyletic, and their generic concepts have subsequently been emended. New names have thus been introduced for species which are phylogenetically distinct from the type species of particular genera. The ending of the separate naming of morphs of the same species in 2011, has also caused changes in fungal generic names. In order to facilitate access to all important changes, it was desirable to compile these in a single document. The present article provides a list of generic names of Ascomycota (approximately 6500 accepted names published to the end of 2016), including those which are lichen-forming. Notes and summaries of the changes since the last edition of `Ainsworth Bisby's Dictionary of the Fungi' in 2008 are provided. The notes include the number of accepted species, classification, type species (with location of the type material), culture availability, life-styles, distribution, and selected publications that have appeared since 2008. This work is intended to provide the foundation for updating the ascomycete component of the ``Without prejudice list of generic names of Fungi'' published in 2013, which will be developed into a list of protected generic names. This will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists, and scrutiny by procedures determined by the Nomenclature Committee for Fungi (NCF). The previously invalidly published generic names Barriopsis, Collophora (as Collophorina), Cryomyces, Dematiopleospora, Heterospora (as Heterosporicola), Lithophila, Palmomyces (as Palmaria) and Saxomyces are validated, as are two previously invalid family names, Bartaliniaceae and Wiesneriomycetaceae. Four species of Lalaria, which were invalidly published are transferred to Taphrina and validated as new combinations. Catenomycopsis Tibell Constant. is reduced under Chaenothecopsis Vain., while Dichomera Cooke is reduced under Botryosphaeria Ces. De Not. (Art. 59)
Retinal Glia
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