A Reliability-Generalization Study of Journal Peer Reviews: A Multilevel Meta-Analysis of Inter-Rater Reliability and Its Determinants

Background: This paper presents the first meta-analysis for the inter-rater reliability (IRR) of journal peer reviews. IRR is defined as the extent to which two or more independent reviews of the same scientific document agree. Methodology/Principal Findings: Altogether, 70 reliability coefficients (Cohen’s Kappa, intra-class correlation [ICC], and Pearson product-moment correlation [r]) from 48 studies were taken into account in the meta-analysis. The studies were based on a total of 19,443 manuscripts; on average, each study had a sample size of 311 manuscripts (minimum: 28, maximum: 1983). The results of the meta-analysis confirmed the findings of the narrative literature reviews published to date: The level of IRR (mean ICC/r 2 =.34, mean Cohen’s Kappa =.17) was low. To explain the study-to-study variation of the IRR coefficients, meta-regression analyses were calculated using seven covariates. Two covariates that emerged in the metaregression analyses as statistically significant to gain an approximate homogeneity of the intra-class correlations indicated that, firstly, the more manuscripts that a study is based on, the smaller the reported IRR coefficients are. Secondly, if the information of the rating system for reviewers was reported in a study, then this was associated with a smaller IRR coefficient than if the information was not conveyed. Conclusions/Significance: Studies that report a high level of IRR are to be considered less credible than those with a low level o

RNA recombination in the genome of barley stripe mosaic virus.

Barley stripe mosaic Hordeivirus (BSMV) is a positive-strand RNA virus requiring three single-stranded RNAs (alpha, beta, and gamma) for infectivity. A terminal-sequence-dependent cloning strategy was used to clone the entire genome of the CV17 strain. Full-length gamma cDNA clones were obtained when oligonucleotides specific for the 5'-terminal sequence of RNA alpha were used in the cloning procedure, but not when RNA gamma-specific oligonucleotides were used. Sequence analysis of six putative gamma cDNA clones revealed that nucleotides 1-70 possess 89% homology with the first 70 nucleotides of RNA alpha. This leader region is separated from the gamma-specific coding region by an eight-base intervening sequence common to both CV17 RNAs alpha and gamma. Northern and Southern hybridization with oligonucleotide probes specific for either alpha or gamma leader sequences indicated that CV17 gamma cDNA clones are representative of native CV17 gamma RNAs. Furthermore, bioassays indicated that in vitro transcripts derived from these gamma cDNA clones were infectious when coinoculated with in vitro transcripts of full-length alpha and beta cDNA clones. Thus, the evidence suggests that RNA gamma of BSMV strain CV17 is a recombinant molecule which may have arisen as a result of natural recombination between RNAs alpha and gamma

RNA recombination in the genome of barley stripe mosaic virus.

Barley stripe mosaic Hordeivirus (BSMV) is a positive-strand RNA virus requiring three single-stranded RNAs (alpha, beta, and gamma) for infectivity. A terminal-sequence-dependent cloning strategy was used to clone the entire genome of the CV17 strain. Full-length gamma cDNA clones were obtained when oligonucleotides specific for the 5'-terminal sequence of RNA alpha were used in the cloning procedure, but not when RNA gamma-specific oligonucleotides were used. Sequence analysis of six putative gamma cDNA clones revealed that nucleotides 1-70 possess 89% homology with the first 70 nucleotides of RNA alpha. This leader region is separated from the gamma-specific coding region by an eight-base intervening sequence common to both CV17 RNAs alpha and gamma. Northern and Southern hybridization with oligonucleotide probes specific for either alpha or gamma leader sequences indicated that CV17 gamma cDNA clones are representative of native CV17 gamma RNAs. Furthermore, bioassays indicated that in vitro transcripts derived from these gamma cDNA clones were infectious when coinoculated with in vitro transcripts of full-length alpha and beta cDNA clones. Thus, the evidence suggests that RNA gamma of BSMV strain CV17 is a recombinant molecule which may have arisen as a result of natural recombination between RNAs alpha and gamma

Sawtooth control using electron cyclotron current drive in ITER demonstration plasmas in DIII-D

Sawtooth control using electron cyclotron current drive (ECCD) has been demonstrated in ITER-like plasmas with a large fast ion fraction, wide q=1 radius and long uncontrolled sawtooth period in DIII-D. The sawtooth period is minimized when the ECCD resonance is just inside the q=1 surface. Sawtooth destabilization using driven current inside q=1 avoids the triggering of performance-degrading neoclassical tearing modes (NTMs), even at much higher pressure than required in the ITER baseline scenario. Operation at =3 without 3/2 or 2/1 NTMs has been achieved in ITER demonstration plasmas when sawtooth control is applied using only modest ECCD power. Numerical modelling qualitatively confirms that the achieved driven current changes the local magnetic shear sufficiently to compensate for the stabilizing influence of the energetic particles in the plasma core. © 2012 IAEA, Vienna.

Wheat Mds-1 encodes a heat-shock protein and governs susceptibility towards the Hessian fly gall midge

Citation: Liu, X., . . . & Chen, M. (2013). Wheat Mds-1 encodes a heat-shock protein and governs susceptibility towards the Hessian fly gall midge. Nature Communication, 4(1), 2070. https://doi.org/10.1038/ncomms3070Gall midges induce formation of host nutritive cells and alter plant metabolism to utilize host resources. Here we show that the gene Mayetiola destructor susceptibility-1 (Mds-1) on wheat chromosome 3AS encodes a small heat-shock protein and is a major susceptibility gene for infestation of wheat by the gall midge M. destructor, commonly known as the Hessian fly. Transcription of Mds-1 and its homoeologs increases upon insect infestation. Ectopic expression of Mds-1 or induction by heat shock suppresses resistance of wheat mediated by the resistance gene H13 to Hessian fly. Silencing of Mds-1 by RNA interference confers immunity to all Hessian fly biotypes on normally susceptible wheat genotypes. Mds-1-silenced plants also show reduced lesion formation due to infection by the powdery mildew fungus Blumeria graminis f. sp. tritici. Modification of susceptibility genes may provide broad and durable sources of resistance to Hessian fly, B. graminis f. sp. tritici, and other pests

Percepción de la experiencia de violencia doméstica en mujeres víctimas de maltrato de pareja

This study aimed to understand the perceptions that domestic violence has a group of women victims of it. To this end we conducted a qualitative study on the technique of focus groups. The research participants were 9 women victims of domestic violence between the ages of 25 and 60 years served in an ONG of Bogotá city. It was found in women with a negative perception of themselves while minimizing many of the skills they possess, and evaluating their skills as inferior to men, which have learned from their families of origin.El presente estudio tuvo como objetivo comprender las percepciones que sobre la violencia doméstica tiene un grupo de mujeres víctimas de la misma. Para tal fin, se llevó a cabo una investigación de tipo cualitativo bajo la técnica de grupos focales. Las participantes de la investigación fueron nueve mujeres víctimas de la violencia doméstica, con edades comprendidas entre los 25 y 60 años, atendidas en una ONG de la ciudad de Bogotá. Se encontró que las mujeres tienen una percepción negativa de sí mismas, aprendida desde sus familias de origen, pues minimizan muchas de sus capacidades y evalúan sus habilidades como inferiores a las de los hombres