Triple Higgs coupling in the most general 2HDM at SM-like scenario

We consider the triple Higgs coupling for h(125) Higgs boson within the most general 2HDM. At moderate values of parameters of model, allowing by modern data, noticeable deviation of this coupling from its SM value is improbable. This deviation can be sizable only if some measurable parameters of the model are exotic

The phrase 'The Great War' in british discourse during world war one

The association of the term ‘The Great War’ with World War One, if it began 100 years ago, could be seen as telling, not only about attitudes at the time (and whether it meant ‘jolly big’ or ‘jolly good’), but about our retrospective attitudes to those who were involved. Through an examination of propaganda, periodicals, political statements and specific pre-war literature, an assumption that as a phrase it is indicative of jingoistic and bellicose hysteria generated by influential politicians for the gullible citizens of whichever participant nation, can be shown as a misleading simplification. Instead, with a concentration on Britain, a study of its use by statesmen such as Asquith and Lloyd George, the very particular circumstances under which it appeared in Punch magazine, and the overt zeal some advocates of war with Germany displayed from several years before 1914, is revealing of very different public standpoints among supporters of the war.info:eu-repo/semantics/publishedVersio

Randomised, Controlled, Assessor Blind Trial Comparing 4% Dimeticone Lotion with 0.5% Malathion Liquid for Head Louse Infestation

BACKGROUND:Malathion 0.5% has been the most prescribed pediculicide in the United Kingdom for around 10 years, and is widely used in Europe and North America. Anecdotal reports suggest malathion treatments are less effective than formerly, but this has not been confirmed clinically. This study was designed to determine whether malathion is still effective and if 4% dimeticone lotion is a more effective treatment for head louse infestation. METHODOLOGY/PRINCIPAL FINDINGS:We designed this study as an assessor blinded, randomised, controlled, parallel group trial involving 58 children and 15 adults with active head louse infestation. Each participant received two applications 7 days apart of either 4% dimeticone lotion, applied for 8 hours or overnight, or 0.5% malathion liquid applied for 12 hours or overnight. All treatment and check-up visits were conducted in participants' homes. Cure of infestation was defined as no evidence of head lice after the second treatment. Some people were found free from lice but later reinfested. Worst case, intention to treat, analysis found dimeticone was significantly more effective than malathion, with 30/43 (69.8%) participants cured using dimeticone compared with 10/30 (33.3%) using malathion (p<0.01, difference 36.4%, 95% confidence interval 14.7% to 58.2%). Per protocol analysis showed cure rates of 30/39 (76.9%) and 10/29 (34.5%) respectively. Irritant reactions were observed in only two participants, both treated with malathion. CONCLUSIONS/SIGNIFICANCE:We concluded that, although malathion liquid is still effective for some people, dimeticone lotion offers a significantly more effective alternative treatment for most people. TRIAL REGISTRATION:Controlled-Trials.com ISRCTN47755726

A highly efficacious pediculicide based on dimeticone: Randomized observer blinded comparative trial

BACKGROUND: Infestation with the human head louse (Pediculus humanus capitis) occurs worldwide. Existing treatment options are limited, and reports of resistance to commonly used pediculicides have been increasing. In this trial we assessed the efficacy of a product containing a high (92%) concentration of the silicone oil dimeticone (identical in composition to NYDA(R)), as compared to a 1% permethrin lotion. METHODS: Randomized, controlled, observer blinded clinical trial. Participants were recruited from a poor urban neighbourhood in Brazil where pediculosis capitis was highly prevalent. To minimize reinfestation during the trial, participants (145 children aged 5-15 years with head lice infestations) were transferred to a holiday resort outside the endemic area for a period of 9 days. Two applications of dimeticone or 1% permethrin were done, seven days apart. Outcome measures were defined as cure (absence of vital head lice) after first application and before and after second applications, degree of itching, cosmetic acceptability, and clinical pathology. RESULTS: Overall cure rates were: day 2 - dimeticone 94.5% (95% CI: 86.6% - 98.5%) and permethrin 66.7% (95% CI: 54.6% - 77.3%; p < 0.0001); day 7 - dimeticone 64.4% (95% CI: 53.3% - 75.3%) and permethrin 59.7% (95% CI: 47.5% - 71.1%; p = 0.5); day 9 - dimeticone 97.2% (95% CI: 90.3% - 99.7%) and permethrin 67.6% (95% CI: 55.4%-78.2%); p < 0.0001). Itching was reduced similarly in both groups. Cosmetic acceptability was significantly better in the dimeticone group as compared to the permethrin group (p = 0.01). Two mild product-related incidents occurred in the dimeticone group. CONCLUSION: The dimeticone product is a safe and highly efficacious pediculicide. Due to its physical mode of action (interruption of the lice's oxygen supply of the central nervous system), development of resistance is unlikely. TRIAL REGISTRATION: Current Controlled Trials ISRCTN15117709

CP properties of symmetry-constrained two-Higgs-doublet models

The two-Higgs-doublet model can be constrained by imposing Higgs-family symmetries and/or generalized CP symmetries. It is known that there are only six independent classes of such symmetry-constrained models. We study the CP properties of all cases in the bilinear formalism. An exact symmetry implies CP conservation. We show that soft breaking of the symmetry can lead to spontaneous CP violation (CPV) in three of the classes.Comment: 14 pages, 2 tables, revised version adapted to the journal publicatio

Proposal for a multilevel university cybermetric analysis model

The final publication is available at Springer via http://dx.doi.org/10.1007/s11192-012-0868-5Universities’ online seats have gradually become complex systems of dynamic information where all their institutions and services are linked and potentially accessible. These online seats now constitute a central node around which universities construct and document their main activities and services. This information can be quantitative measured by cybermetric techniques in order to design university web rankings, taking the university as a global reference unit. However, previous research into web subunits shows that it is possible to carry out systemic web analyses, which open up the possibility of carrying out studies which address university diversity, necessary for both describing the university in greater detail and for establishing comparable ranking units. To address this issue, a multilevel university cybermetric analysis model is proposed, based on parts (core and satellite), levels (institutional and external) and sublevels (contour and internal), providing a deeper analysis of institutions. Finally the model is integrated into another which is independent of the technique used, and applied by analysing Harvard University as an example of use.Orduña Malea, E.; Ontalba Ruipérez, JA. (2013). Proposal for a multilevel university cybermetric analysis model. Scientometrics. 95(3):863-884. doi:10.1007/s11192-012-0868-5S863884953Acosta Márquez, T., Igartua Perosanz, J.J. & Gómez Isla, J. (2009). Páginas web de las universidades españolas. Enred: revista digital de la Universidad de Salamanca, 5 [online; discontinued].Aguillo, I. F. (1998). Hacia un concepto documental de sede web. El Profesional de la Información, 7(1–2), 45–46.Aguillo, I. F. (2009). Measuring the institutions’ footprint in the web. 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Journal of the American Society for Information Science and Technology, 55(14), 1216–1227.Buenadicha, M., Chamorro, A., Miranda, F. J., & González, O. R. (2001). A new web assessment index: Spanish Universities Analysis. Internet Research, 11(3), 226–234.Castells, M. (2001). La galaxia Internet. Barcelona: Plaza y Janés.Chu, H., He, S., & Thelwall, M. (2002). Library and Information Science Schools in Canada and USA: a Webometric perspective. Journal of Education for Library and Information Science, 43(2), 110–125.Crowston, K., & Williams, M. (2000). Reproduced and Emergent Genres of Communication on the World Wide Web. The Information Society: an International Journal, 16(3), 201–215.Goldfarb, A. (2006). The (teaching) role of universities in the diffusion of the Internet. International Journal of Industrial Organization, 24(2), 203–225.Ingwersen, P. (1998). The calculation of web impact factors. Journal of Documentation, 54(2), 236–243.Katz, R. N. (2008a). The tower and the cloud: Higher education in the age of cloud computing. USA: Educause.Katz, R. N. (2008b). The gathering cloud: is this the end of the middle. In R. N. Katz (Ed.), The tower and the cloud: Higher education in the age of cloud computing (p. 2008). USA: Educause.Li, X. (2005). National and international university departmental Web site interlinking: a webometric analysis. [Unpublished doctoral dissertation]. Wolverhampton, UK: University of Wolverhampton.Li, X., Thelwall, M., Musgrove, P., & Wilkinson, D. (2003). The relationship between the links/Web Impact Factors of computer science departments in UK and their RAE (Research Assessment Exercise) ranking in 2001. Scientometrics, 57(2), 239–255.Middleton, I., McConnell, M., & Davidson, G. (1999). Presenting a model for the structure and content of a University World Wide Web site. Journal of Information Science, 25(3), 217–219.Orduña-Malea, E. (2012). Propuesta de un modelo de análisis redinformétrico multinivel para el estudio sistémico de las universidades españolas (2010). Valencia: Polytechnic University of Valencia.Ortega, J. L., & Aguillo, Isidro. F. (2007). La web académica española en el contexto del Espacio Europeo de Educación Superior: estudio exploratorio. El profesional de la información, 16(5), 417–425.Pareja, V. M., Ortega, J. L., Prieto, J. A., Arroyo, N., & Aguillo, I. F. (2005). Desarrollo y aplicación del concepto de sede web como unidad documental de análisis en Cibermetría. Jornadas Españolas de Documentación, 9, 325–340.Saorín, T. (2012). Arquitectura de la dispersión: gestionar los riesgos cíclicos de fragmentación de las webs corporativas. Anuario ThinkEPI, 6, 281–287.Tang, R., & Thelwall, M. (2003). U.S. academic departmental Web-site interlinking: disciplinary differences. Library & Information Science Research, 25(4), 437–458.Tang, R., & Thelwall, M. (2004). 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Use of news articles and announcements on official websites of universities. Turkish Online Journal of Educational Technology, 10(2), 287–296

Activation of EGFR/ERBB2 via Pathways Involving ERK1/2, P38 MAPK, AKT and FOXO Enhances Recovery of Diabetic Hearts from Ischemia-Reperfusion Injury

This study characterized the effects of diabetes and/or ischemia on epidermal growth factor receptor, EGFR, and/or erbB2 signaling pathways on cardiac function. Isolated heart perfusion model of global ischemia was used to study the effect of chronic inhibition or acute activation of EGFR/erbB2 signaling on cardiac function in a rat model of type-1 diabetes. Induction of diabetes with streptozotocin impaired recovery of cardiac function (cardiac contractility and hemodynamics) following 40 minutes of global ischemia in isolated hearts. Chronic treatment with AG825 or AG1478, selective inhibitors of erbB2 and EGFR respectively, did not affect hyperglycemia but led to an exacerbation whereas acute administration of the EGFR ligand, epidermal growth factor (EGF), led to an improvement in cardiac recovery in diabetic hearts. Diabetes led to attenuated dimerization and phosphorylation of cardiac erbB2 and EGFR receptors that was associated with reduced signaling via extracellular-signal-regulated kinase 1/2 (ERK1/2), p38 mitogen activated protein (MAP) kinase and AKT (protein kinase B). Ischemia was also associated with reduced cardiac signaling via these molecules whereas EGF-treatment opposed diabetes and/or ischemia induced changes in ERK1/2, p38 MAP kinase, and AKT-FOXO signaling. Losartan treatment improved cardiac function in diabetes but also impaired EGFR phosphorylation in diabetic heart. Co-administration of EGF rescued Losartan-mediated reduction in EGFR phosphorylation and significantly improved cardiac recovery more than with either agent alone. EGFR/erbB2 signaling is an important cardiac survival pathway whose activation, particularly in diabetes, ischemia or following treatment with drugs that inhibit this cascade, significantly improves cardiac function. These findings may have clinical relevance particularly in the treatment of diabetes-induced cardiac dysfunction

Bridge-specific fragility analysis: when is it really necessary?

In seismic assessment of bridges the research focus has recently shifted on the derivation of bridge-specific fragility curves that account for the effect of different geometry, structural system, component and soil properties, on the seismic behaviour. In this context, a new, component-based methodology for the derivation of bridge-specific fragility curves has been recently proposed by the authors, with a view to overcoming the inherent difficulties in assessing all bridges of a road network and the drawbacks of existing methodologies, which use the same group of fragility curves for bridges within the same typological class. The main objective of this paper is to critically assess the necessity of bridge-specific fragility analysis, starting from the effect of structure-specific parameters on component capacity (limit state thresholds), seismic demand, and fragility curves. The aforementioned methodology is used to derive fragility curves for all bridges within an actual road network, with a view to investigating the consistency of adopting generic fragility curves for bridges that fall within the same class and quantifying the degree of over- or under-estimation of the probability of damage when generic bridge classes are considered. Moreover, fragility curves for all representative bridges of the analysed concrete bridge classes are presented to illustrate the differentiation in bridge fragility for varying structural systems, bridge geometry, total bridge length and maximum pier height. Based on the above, the relevance of bridge-specific fragility analysis is assessed, and pertinent conclusions are drawn