3,827 research outputs found
An opinion paper: emphasis on white muscle development and growth to improve farmed fish flesh quality
Due to rapid depletion of wild stocks, the necessity to cultivate fish is eminent. Current fish farming practices seek to improve flesh quality. The notion that white muscles are the main target of the fishing industry is emphasized. A novel approach is suggested based on the development of white muscles in wild fish from eggs to adults. A compilation of facts about white muscle structure, function and ontogeny is followed by an account of the changes in swimming behaviour and performance related to the use of white muscle during growth from larva to adult. Ecological data narrate early swimming performance with white muscle development and growth, unveiling some of the important natural selection factors eliminating weak swimmers and poor growers from the breeding stock. A comparison between fish culture practise and natural conditions reveals fundamental differences. New approaches following wild breeding processes promise several important advantages regarding the quality of white muscle
Wie verlässlich ist die Bestimmung von Procalcitonin als Entzündungsmarker auf Intensivstation?
The role of procalcitonin (PCT) plasma levels as a diagnostic tool for intensive care patients has been intensively investigated during the past years. In particular for recognition of bacterial infections, PCT levels have been shown to be superior to other clinical and biochemical markers. Furthermore, some very recent studies show that in patients with lower respiratory tract infections PCT guided antibiotic therapy reduces antibiotic use and thereby may also reduce duration of stay of patients in hospital and thus cut hospitalisation costs. However, various studies indicate that the value of PCT as a prognostic marker is limited because of false positive or negative values. Despite these limitations PCT plasma levels are currently measured in intensive care units. The present study summarises the possible clinical uses of this lab marker as a diagnostic tool for the assessment of critically of ill patients
Quantum Memories. A Review based on the European Integrated Project "Qubit Applications (QAP)"
We perform a review of various approaches to the implementation of quantum
memories, with an emphasis on activities within the quantum memory sub-project
of the EU Integrated Project "Qubit Applications". We begin with a brief
overview over different applications for quantum memories and different types
of quantum memories. We discuss the most important criteria for assessing
quantum memory performance and the most important physical requirements. Then
we review the different approaches represented in "Qubit Applications" in some
detail. They include solid-state atomic ensembles, NV centers, quantum dots,
single atoms, atomic gases and optical phonons in diamond. We compare the
different approaches using the discussed criteria.Comment: 22 pages, 12 figure
Reconstructions of deltaic environments from Holocene palynological records in the Volga delta, northern Caspian Sea
This article was made available through open access by the Brunel Open Access Publishing Fund.New palynological and ostracod data are presented from the Holocene Volga delta, obtained from short cores and surface samples collected in the Damchik region, near Astrakhan, Russian Federation in the northern Caspian Sea. Four phases of delta deposition are recognized and constrained by accelerated mass spectrometry (AMS) radiocarbon ages. Palynological records show that erosive channels, dunes (Baer hills) and inter-dune lakes were present during the period 11,500–8900 cal. BP at the time of the Mangyshlak Caspian lowstand. The period 8900–3770 cal. BP was characterized regionally by extensive steppe vegetation, with forest present at times with warmer, more humid climates, and with halophytic and xerophytic vegetation present at times of drought. The period 3770–2080 cal. BP was a time of active delta deposition, with forest or woodland close to the delta, indicating relatively warm and humid climates and variable Caspian Sea levels. From 2080 cal. BP to the present-day, aquatic pollen is frequent in highstand intervals and herbaceous pollen and fungal hyphae frequent in lowstand intervals. Soils and incised valley sediments are associated with the regional Derbent regression and may be time-equivalent with the ‘Medieval Warm Period’. Fungal spores are an indicator of erosional or aeolian processes, whereas fungal hyphae are associated with soil formation. Freshwater algae, ostracods and dinocysts indicate mainly freshwater conditions during the Holocene with minor brackish influences. Dinocysts present include Spiniferites cruciformis, Caspidinium rugosum, Impagidinium caspienense and Pterocysta cruciformis, the latter a new record for the Caspian Sea. The Holocene Volga delta is a partial analogue for the much larger oil and gas bearing Mio-Pliocene palaeo-Volga delta.Funding for the data collection and field work was provided from the following sources: 1 – IGCP-UNESCO 2003–2008 (Project 481 CASPAGE, Dating Caspian Sea Level Change); 2 – NWO, Netherlands Science Foundation and RFFI, Russian Science Foundation 2005–2008 (Programme: ‘VHR Seismic Stratigraphy and Paleoecology of the Holocene Volga Delta’); and 3 – BP Exploration (Caspian Sea) Sea Ltd. (Azeri-Chirag-Gunashli) 2005–2008 (‘Unravelling the Small-Scale Stratigraphy and Sediment Dynamics of the Modern Volga Delta Using VHR Marine Geophysics’). The palynological work was funded jointly by BP Exploration (Caspian Sea) Ltd., Delft University of Technology and KrA Stratigraphic Ltd. Ostracod analyses were funded by StrataData Ltd. and funding for two additional radiocarbon dates provided by Deltares
Harnessing nuclear spin polarization fluctuations in a semiconductor nanowire
Soon after the first measurements of nuclear magnetic resonance (NMR) in a
condensed matter system, Bloch predicted the presence of statistical
fluctuations proportional to in the polarization of an ensemble of
spins. First observed by Sleator et al., so-called "spin noise" has
recently emerged as a critical ingredient in nanometer-scale magnetic resonance
imaging (nanoMRI). This prominence is a direct result of MRI resolution
improving to better than 100 nm^3, a size-scale in which statistical spin
fluctuations begin to dominate the polarization dynamics. We demonstrate a
technique that creates spin order in nanometer-scale ensembles of nuclear spins
by harnessing these fluctuations to produce polarizations both larger and
narrower than the natural thermal distribution. We focus on ensembles
containing ~10^6 phosphorus and hydrogen spins associated with single InP and
GaP nanowires (NWs) and their hydrogen-containing adsorbate layers. We monitor,
control, and capture fluctuations in the ensemble's spin polarization in
real-time and store them for extended periods. This selective capture of large
polarization fluctuations may provide a route for enhancing the weak magnetic
signals produced by nanometer-scale volumes of nuclear spins. The scheme may
also prove useful for initializing the nuclear hyperfine field of electron spin
qubits in the solid-state.Comment: 18 pages, 5 figure
Selection for Replicases in Protocells
PMCID: PMC3649988This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.
The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the onset and progression of Alzheimer's disease. Although this observation has prompted an extensive search for therapeutic agents to modulate the concentration of Aβ or inhibit its aggregation, all clinical trials with these objectives have so far failed, at least in part because of a lack of understanding of the molecular mechanisms underlying the process of aggregation and its inhibition. To address this problem, we describe a chemical kinetics approach for rational drug discovery, in which the effects of small molecules on the rates of specific microscopic steps in the self-assembly of Aβ42, the most aggregation-prone variant of Aβ, are analyzed quantitatively. By applying this approach, we report that bexarotene, an anticancer drug approved by the U.S. Food and Drug Administration, selectively targets the primary nucleation step in Aβ42 aggregation, delays the formation of toxic species in neuroblastoma cells, and completely suppresses Aβ42 deposition and its consequences in a Caenorhabditis elegans model of Aβ42-mediated toxicity. These results suggest that the prevention of the primary nucleation of Aβ42 by compounds such as bexarotene could potentially reduce the risk of onset of Alzheimer's disease and, more generally, that our strategy provides a general framework for the rational identification of a range of candidate drugs directed against neurodegenerative disorders.This work was supported by the Centre for Misfolding Diseases, University
of Cambridge.This is the final published version. It first appeared at http://advances.sciencemag.org/content/2/2/e1501244
Multiferroicity in an organic charge-transfer salt: Electric-dipole-driven magnetism
Multiferroics, showing simultaneous ordering of electrical and magnetic
degrees of freedom, are remarkable materials as seen from both the academic and
technological points of view. A prominent mechanism of multiferroicity is the
spin-driven ferroelectricity, often found in frustrated antiferromagnets with
helical spin order. There, similar to conventional ferroelectrics, the
electrical dipoles arise from an off-centre displacement of ions. However,
recently a different mechanism, namely purely electronic ferroelectricity,
where charge order breaks inversion symmetry, has attracted considerable
interest. Here we provide evidence for this exotic type of ferroelectricity,
accompanied by antiferromagnetic spin order, in a two-dimensional organic
charge-transfer salt, thus representing a new class of multiferroics. Quite
unexpectedly for electronic ferroelectrics, dipolar and spin order arise nearly
simultaneously. This can be ascribed to the loss of spin frustration induced by
the ferroelectric ordering. Hence, here the spin order is driven by the
ferroelectricity, in marked contrast to the spin-driven ferroelectricity in
helical magnets.Comment: 8 pages, 9 figures (including 4 pages and 6 figures in supplementary
information). Version 2 with minor errors corrected (legend of Fig. 3c and
definition of vectors e and Q
Spatial and topological organization of DNA chains induced by gene co-localization
Transcriptional activity has been shown to relate to the organization of
chromosomes in the eukaryotic nucleus and in the bacterial nucleoid. In
particular, highly transcribed genes, RNA polymerases and transcription factors
gather into discrete spatial foci called transcription factories. However, the
mechanisms underlying the formation of these foci and the resulting topological
order of the chromosome remain to be elucidated. Here we consider a
thermodynamic framework based on a worm-like chain model of chromosomes where
sparse designated sites along the DNA are able to interact whenever they are
spatially close-by. This is motivated by recurrent evidence that there exists
physical interactions between genes that operate together. Three important
results come out of this simple framework. First, the resulting formation of
transcription foci can be viewed as a micro-phase separation of the interacting
sites from the rest of the DNA. In this respect, a thermodynamic analysis
suggests transcription factors to be appropriate candidates for mediating the
physical interactions between genes. Next, numerical simulations of the polymer
reveal a rich variety of phases that are associated with different topological
orderings, each providing a way to increase the local concentrations of the
interacting sites. Finally, the numerical results show that both
one-dimensional clustering and periodic location of the binding sites along the
DNA, which have been observed in several organisms, make the spatial
co-localization of multiple families of genes particularly efficient.Comment: Figures and Supplementary Material freely available on
http://dx.doi.org/10.1371/journal.pcbi.100067
Dosimetry during intramedullary nailing of the tibia: Patient and occupational exposure
Background Intramedullary nailing under fluoroscopic guidance is a common operation. We studied the intraoperative radiation dose received by both the patient and the personnel
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