DISTURBANCES OF THE VASCULAR THROMBOCYTE MECHANISM OF HEMOSTASIS IN PATHOGENESIS OF THE MICROCIRCULATORY DISORDERS IN RAPIDLY PROGRESSIVE PERIODONTITIS

In modern stomatology the problem ofatypicalforms ofinflammatoryperiodontaldiseases origination, namely of rapidly progressive periodontitis (RPP), has got special importance due to its widespread. The article presents one of the impotant parts of the pathogenesis- the disturbance of microcirculation processes caused by the decrease of blood clot resistencyofa vascularwall in pathogenesis ofmicrocirculatori disorders in patients with RPP. These disturbances are predetermined by endothelial dysfunction with the subsequent degradation of the clinical presentation of disease, the stomatologic status and quality of patients life

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Intensification of the process of decomposition of oil-water emulsions stabilized with hydrochloric acid

The major goal of oil and gas companies working in the oilfields on the late stages of development is to maintain a high level of hydrocarbon production. Analysis of well intervention techniques (WITs) in the oilfields of the Samara Region shows that most often the bottomhole area is treated with reagents containing hydrochloric acid, which significantly effects the efficiency of well fluid preparation processes. The paper summarizes the results of studies of the impact of hydrochloric acid on the rheological and near-surface properties of water-in-oil emulsions (WOEs). It is shown that the presence of acid and/or products of its reaction with the oil increases the stability of the water-in-oil emulsion. To enhance the process of decomposition of the water-in-oil emulsion stabilized with hydrochloric acid, a reagent was developed based on the non-ionic surfactants, alkaline agent and solvent, providing a significant reduction of the viscosity of water-in-oil emulsions and improving the efficiency of their decomposition

Destruction of powder-activated concrete with fixation of destruction by a laser interferometer

The article is devoted to the identification of the patterns of deformation and destruction of powder-activated concrete under the action of power loads. As research concrete, powder-activated concrete of a new generation was considered in comparison with materials of the old and transitional generations. To carry out such studies, laser holographic interferometry methods were used, the physical essence of which consists in recording wave fields synchronously with the application of the load reflected by the surface under study at various points in time and then comparing these wave fields with each other. Using the complete equilibrium deformation diagrams and 3D graphs, we determined the parameters of the diagram (cyclicity, ultimate tensile strength), and the parameters of surface deformation (photographs with waves of strains and cracks). Using laser interferometry methods, it was found that the introduction of microquartz, especially in combination with amorphous active silica fume, significantly delays the onset of microcrack formation in cement samples, which exhibit a uniform deformation field up to a stress level of 0.90–0.95 from destructive. A sample based on a cement-sand mortar without finely dispersed fillers distinguishes a lower level of crack formation, corresponding to a stress level of 0.5–0.6 from destructive ones, and with an increase in load, the fracture of the sample has a block character. © Travush V.I.,Karpenko N.I.,Erofeev V.T.,Vatin N.,Erofeeva I.V.,Maksimova I.N., Kondrashchenko V.I.,Kesarijskij A.G., 202