Surviving Unemployment without State Support: Unemployment and Household Formation in South Africa

High unemployment in many OECD countries is often attributed, at least in part, to the generosity and long duration of unemployment compensation. It is therefore instructive to examine a country where high unemployment exists despite the near complete absence of an unemployment insurance system. In South Africa unemployment stood at 23% in 1997 and the unemployed have no unemployment insurance nor informal sector activities to fall back on. This paper examines how the unemployed are able to get access to resources without support from unemployment compensation. Analysing a household survey from 1995, we find that the household formation response of the unemployed is the critical way in which they assure access to resources. In particular, unemployment delays the setting up of an individual household of young people, in some cases by decades. It also leads to the dissolution of existing households and a return of constituent members to parents and other relatives and friends. Access to state transfers (in particular, non¡ contributory old age pensions) increases the likelihood of attracting unemployed persons to a household. Some unemployed do not benefit from this safety net, and the presence of unemployed members pulls many households supporting them into poverty. We also show that the household formation responses draw some unemployed away from employment opportunities and thus lowers their employment prospects. The paper discusses the implications of these findings for debates about unemployment and social policy in South Africa and in OECD countries

High performance in hospital management: a guideline for developing and developed countries

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High Performance in Hospital Management: A Guideline for Developing and Developed Countries. By Edda Weimann and Peter Weimann. Berlin: Springer Publishing Company, 2017. ISBN: 978-3-662-49658-9, ISBN (e-book): 978-3-662-49660-2

This book provides a broad overview of what is needed to run hospitals and other health care facilities effectively and efficiently. All the skills and tools required to achieve this aim are elucidated, including business engineering and change management, strategic planning and the Balanced Scorecard, project management, integrative innovation management, social and ethical aspects of human resource management, communication and conflict management, staff development and leadership. The guidance offered is exceptional and applicable in both developed and developing countries. The relevant theoretical background is outlined and instructive case reports are included. Each chapter finishes with a summary and five reflective questions. Excellence can only be achieved when healthcare professionals show in addition to their medical skills a high level of managerial competence. High performance in hospital management assists managers of health care providers as well as doctors and nurses to engage in the successful management of healthcare facilities

Micro-Environment Causes Reversible Changes in DNA Methylation and mRNA Expression Profiles in Patient-Derived Glioma Stem Cells

In vitro and in vivo models are widely used in cancer research. Characterizing the similarities and differences between a patient\u27s tumor and corresponding in vitro and in vivo models is important for understanding the potential clinical relevance of experimental data generated with these models. Towards this aim, we analyzed the genomic aberrations, DNA methylation and transcriptome profiles of five parental tumors and their matched in vitro isolated glioma stem cell (GSC) lines and xenografts generated from these same GSCs using high-resolution platforms. We observed that the methylation and transcriptome profiles of in vitro GSCs were significantly different from their corresponding xenografts, which were actually more similar to their original parental tumors. This points to the potentially critical role of the brain microenvironment in influencing methylation and transcriptional patterns of GSCs. Consistent with this possibility, ex vivo cultured GSCs isolated from xenografts showed a tendency to return to their initial in vitro states even after a short time in culture, supporting a rapid dynamic adaptation to the in vitro microenvironment. These results show that methylation and transcriptome profiles are highly dependent on the microenvironment and growth in orthotopic sites partially reverse the changes caused by in vitro culturing

Interannual and interdecadal variability in the predominant Pacific region SST anomaly patterns and their impact on climate in the mid-Mississippi valley region

Previous research has demonstrated that Pacific Region SSTs and SST anomalies can be separated into seven general synoptic classifications (“clusters”) (A-G). Clusters B and G (C, D, and F) [A and E] were shown to be generally representative of La Niña (El Niño) [neutral] type SST distributions. Further, an analysis of the SST patterns from 1955 - 1993 demonstrated that clusters A - D were prominent from 1955-1977, while types E and F dominated the later period. Type G clusters were comparatively rare, but occurred during both periods. In retrospect, this shift during 1977 corresponds roughly with a change in phase of the Pacific Decadal Oscillation (PDO). After updating the analysis to include the 1994 to 2005 period, there was a corresponding change in the predominant SSTs associated with a change in phase of the PDO during 1999 and 2000. The results show that SST patterns did evolve from predominantly E and F-type anomalies in 1994 to A, B, D, and G-type anomalies through 2005. Thus, these results suggest that A through D-type (C, E, and F-type) SST clusters are characteristic of the negative (positive) phase of the PDO. Also, using a modified technique for generating phase diagrams, it is shown that there are interannual and interdecadal variations in the mid-Mississippi region monthly mean surface temperature and precipitation records that can be associated with the ENSO and PDO. Additionally, an analysis was performed to see if there was any statistical association between temperature and precipitation anomalies in the mid-Mississippi region and prolonged SST regimes. B, D and G anomalies were associated with warmer-than-normal conditions, while C and E type anomalies tended to be associated with cooler-than-normal conditions across the region. C, D, F, and G anomalies were associated with drier than normal conditions

Performance evaluation of a lossy transmission lines based diode detector at cryogenic temperature

This work is focused on the design, fabrication, and performance analysis of a square-law Schottky diodedetector based on lossy transmission lines working under cryogenic temperature (15 K). The design analysis of a microwave detector, based on a planar gallium-arsenide low effective Schottky barrier height diode, is reported, which is aimed for achieving large input return loss as well as flat sensitivity versus frequency. The designed circuit demonstrates good sensitivity, as well as a good return loss in a wide bandwidth at Ka-band, at both room (300 K) and cryogenic (15 K) temperatures. A good sensitivity of 1000 mV/mW and input return loss better than 12 dB have been achieved when it works as a zero-bias Schottky diodedetector at room temperature, increasing the sensitivity up to a minimum of 2200 mV/mW, with the need of a DC bias current, at cryogenic temperature.This work has been funded by the Spanish Ministry for Economy and Competitiveness under the CONSOLIDER-INGENIO 2010 programme under the Reference No. CSD2010-00064. The authors would like to thank Eva Cuerno and Ana Pérez for the assistance in the assembly of the circuit

Just use it! Linguistic conversion and identities of resistance amongst Galician new speakers

In recent years there has been a focus in language policy research on understanding how national policies are interpreted and negotiated by social actors on the ground. This paper looks at the interplay between government and grassroots initiatives to create Galician-speaking spaces in predominantly Spanish-speaking urban settings. While official language policies in Galicia since the 1980s have increased the potential for language use through bilingual educational policies, these policies have failed to convert the large pool of potential speakers amongst a younger generation of Galicians into active language users. Drawing on ethnographic fieldwork and in-depth interviews with Galician neofalantes (new speakers) this paper looks at instances where such policies seem to have worked and where the linguistic capacity created through the education system has been converted into active language use. The article examines how such speakers rationalise their practice of linguistic conversion not as success stories of language policy but as reactions to and dissatisfaction with what is perceived as ‘top-down’ governmentality through a reflexive process in which existing power structures are brought into question. The article looks specifically as the ideologies underpinning their decisions to become active speakers and the role they play as language planners in contemporary Galicia

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.

Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes. Malignant transformation is associated with aberrant accumulation of repressive histone modifications, such as polycomb mediated histone 3 lysine 27 (H3K27me3) resulting in a histone methylation mediated block to differentiation. The relevance, however, of histone demethylases in cancer remains less clear. We report that JMJD3, a H3K27me3 demethylase, is induced during differentiation of glioblastoma stem cells (GSCs), where it promotes a differentiation-like phenotype via chromatin dependent (INK4A/ARF locus activation) and chromatin independent (nuclear p53 protein stabilization) mechanisms. Our findings indicate that deregulation of JMJD3 may contribute to gliomagenesis via inhibition of the p53 pathway resulting in a block to terminal differentiation