176 research outputs found
Zeldovich flow on cosmic vacuum background: new exact nonlinear analytical solution
A new exact nonlinear Newtonian solution for a plane matter flow superimposed
on the isotropic Hubble expansion is reported. The dynamical effect of cosmic
vacuum is taken into account. The solution describes the evolution of nonlinear
perturbations via gravitational instability of matter and the termination of
the perturbation growth by anti-gravity of vacuum at the epoch of transition
from matter domination to vacuum domination. On this basis, an `approximate' 3D
solution is suggested as an analog of the Zeldovich ansatz.Comment: 9 pages, 1 figure
Non-fungible token: a promising digital tool for business
This paper presents a review of the current status and development trends of the non-fungible tokensβ technology (NFT), which are digital rights to unique objects recorded in the blockchain. The object of the study is the non-interchangeable token technology. The subject of the study is the fields of practical application of NFT. The method is an analytical review of scientific publications. The current state and socio-cultural sources of the NFT market related to works of art and media objects are analysed. The technological and legal problems preventing the wide spread of NFT in the business environment are identified. The prospects for the use of non-fungible tokens in the field of protection and commercialization of patent law objects are considered
The conceptual model of sustainable development of the rubal sector
On the one hand, the relevance of the studied issue is determined by growing lag of rural territorial units in socioeconomic development, and one the other by their significance in such important aspects of the country, as ensuring food supply security, preservation of the available land, production, ecological, demographic and human potential. The aim of the article is to develop the conceptual model of sustainable development of rural areas, which is based on the system of indicators of quality of living of rural population. The leading method for studying this issue is modeling, which allows to consider it as a targeted and organized process of formation of the concept of sustainable development of the rural sector of the regional economy using the example of the studies of experience of sustainable development of the Kinel-Cherkassky municipal district of the Samara region. The results: the analysis of consistence and tendencies of development of agrarian potential of rural areas of the Samara region was carried out for the purpose of implementation of the conceptual model of sustainable development and assessment of further prospects in the production sphere of the village; the main reasons for disproportion in sustainable development of rural areas of the Samara region are identified. The materials of this article can be used for theoretical conclusions, methodological developments and working knowledge in activities of bodies of the regional government and local self-government when developing the concept and programs of sustainable development of rural municipalities. Β© 2016 Belyaeva et al
Novel data about association of the functionally significant polymorphisms of the MMP9 gene with exfoliation glaucoma in the caucasian population of Central Russia
This study aimed to investigate the role of functionally significant polymorphisms of the MMP1, MMP3, and MMP9 genes in the development of exfoliation glaucoma in the Caucasian population of Central Russi
The role of the national community in the adaptation and education of students from Kyrgyzstan in university
ΠΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΈ Π°Π½Π°Π»ΠΈΠ· ΠΏΡΠΎΠ±Π»Π΅ΠΌ Π² ΠΡΡΠ³ΡΠ·ΡΠΊΠΎΠΌ Π·Π΅ΠΌΠ»ΡΡΠ΅ΡΡΠ²Π΅ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Π² Π£ΡΠ°Π»ΡΡΠΊΠΎΠΌ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ΅ ΠΈΠΌΠ΅Π½ΠΈ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΠΡΠ΅Π·ΠΈΠ΄Π΅Π½ΡΠ° Π ΠΎΡΡΠΈΠΈ Π. Π. ΠΠ»ΡΡΠΈΠ½Π°. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΡΠΎΡΠΎΠΏΡΠΎΡ ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² Π² Π·Π΅ΠΌΠ»ΡΡΠ΅ΡΡΠ²Π΅, Π° ΡΠ°ΠΊΠΆΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ Π°Π΄Π°ΠΏΡΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΠΏΡΠΎΡΠ΅ΡΡ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΈΠ· ΠΡΡΠ³ΡΠ·ΡΡΠ°Π½Π° Π² ΠΠΊΠ°ΡΠ΅ΡΠΈΠ½Π±ΡΡΠ³Π΅Identification and analysis of problems in the Kyrgyz student community in the Ural Federal University of the first President of Russia B. Yeltsin. Conducted a public opinion poll and study the interaction of students in fraternities, as well as the impact of factors on the adaptive learning process
Quality of life in headache patients with analgesic overuse and therapy efficiency
Patients satisfying the IHS criteria for analgesic-overuse headache (AOH) were investigated in during the withdrawal therapy: 25 of them received amitriptyline 25 mg twice a day and 10,0 ml of Cerebrolysin daily (20 intravenous infusions). The group of comparison consisted of 12 age-and sex-matched patients with the headache of the same type treated with amitriptyline only. The methods included Spilbergerβs questionnaire, Beckβs inventory, Goetheborg quality of life (QoL) inventory, Attention Test Score, 100-point pain visual analogous scale. Results: QoL was reduced in AOH patients, inversely significantly correlating with "pain daysβ per week (R=0,714; p=0,004), analgesic intake frequency (R=0,760; p=0,001), with anxiety (p=0,022-0,005) and depression (R=0,543; p=0,044) scores. After 20-days treatment frequency and intensity of headaches reduced in both groups as well as the analgesic intake. The attention score worsened in group of comparison (possibly because of side effect of amitriptiline) and improved in the group of combined therapy. In both groups a tendency to QoL improvement was found which reached the significance borderline (p=0,048) in group of amitriptiline + cerebrolisine therapy.ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Ρ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΌΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΡΠΌΠΈ Π±ΠΎΠ»ΡΠΌΠΈ, ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΡΠΌΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠΌ Π°Π±ΡΠ·ΡΡΠΎΠΌ: 25 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π½Π° ΡΠΎΠ½Π΅ ΠΎΡΠΌΠ΅Π½Ρ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠΎΠ² ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΡ (25 ΠΌΠ³ Π°ΠΌΠΈΡΡΠΈΠΏΡΠΈΠ»ΠΈΠ½Π° Π΄Π²Π°ΠΆΠ΄Ρ Π² Π΄Π΅Π½Ρ ΠΈ 10,0 ΠΌΠ» ΡΠ΅ΡΠ΅Π±ΡΠΎΠ»ΠΈΠ·ΠΈΠ½Π° Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ): Π³ΡΡΠΏΠΏΡ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 12 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΠ΅ ΡΠΎΠ»ΡΠΊΠΎ Π°ΠΌΠΈΡΡΠΈΠΏΡΠΈΠ»ΠΈΠ½. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊΠΈ Π‘ΠΏΠΈΠ»Π±Π΅ΡΠ³Π΅ΡΠ°, ΠΠ΅ΠΊΠ°, ΠΠ΅ΡΠ΅Π±ΠΎΡΠ³ΡΠΊΠΈΠΉ ΠΎΠΏΡΠΎΡΠ½ΠΈΠΊ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΆΠΈΠ·Π½ΠΈ, 100-Π±Π°Π»Π»ΡΠ½Π°Ρ Π²ΠΈΠ·ΡΠ°Π»ΡΠ½Π°Ρ Π°Π½Π°Π»ΠΎΠ³ΠΎΠ²Π°Ρ ΡΠΊΠ°Π»Π°, ΡΠ΅ΡΡ Β«ΠΏΠ΅ΡΠ΅ΠΏΡΡΠ°Π½Π½ΡΡ
Π»ΠΈΠ½ΠΈΠΉΒ» Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π°Π±ΡΠ·ΡΡΠ½ΠΎΠΉ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠΉ Π±ΠΎΠ»ΡΡ ΠΎΠΊΠ°Π·Π°Π»ΠΎΡΡ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΡΠΌ. ΠΡΡΠ²Π»Π΅Π½Π° ΠΎΠ±ΡΠ°ΡΠ½Π°Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΠΠ Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎΠΌ Β«Π±ΠΎΠ»Π΅Π²ΡΡ
Β» Π΄Π½Π΅ΠΉ Π² Π½Π΅Π΄Π΅Π»Ρ (R=0,714; Ρ=0,004), Ρ ΡΠ°ΡΡΠΎΡΠΎΠΉ ΠΏΡΠΈΠ΅ΠΌΠ° Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠΎΠ² (R=0,760; Ρ=0,001), Π° ΡΠ°ΠΊΠΆΠ΅ Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡΡ ΡΠΌΠΎΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ: Ρ ΡΡΠΎΠ²Π½Π΅ΠΌ ΡΠ΅Π°ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠ΅Π²ΠΎΠ³ΠΈ (R=0,622; Ρ=0,022), Π»ΠΈΡΠ½ΠΎΡΡΠ½ΠΎΠΉ ΡΡΠ΅Π²ΠΎΠ³ΠΈ (R=0,716; Ρ=0,005), Π΄Π΅ΠΏΡΠ΅ΡΡΠΈΠΈ (R=0,543; Ρ=0,044). Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΡ Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎ ΡΠΌΠ΅Π½ΡΡΠΈΠ»ΠΎΡΡ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Β«Π±ΠΎΠ»Π΅Π²ΡΡ
Β» Π΄Π½Π΅ΠΉ Π² Π½Π΅Π΄Π΅Π»Ρ, ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΠ°Π»Π³ΠΈΠΉ ΠΈ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΡΠΈΠ½ΠΈΠΌΠ°Π΅ΠΌΡΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Π°Π½Π°Π»ΡΠ³Π΅ΡΠΈΠΊΠΎΠ². ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΡΡ
ΡΠ΄ΡΠΈΠ»ΡΡ Π² Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ, ΡΡΠΎ Π±ΡΠ»ΠΎ ΡΠ°ΡΡΠ΅Π½Π΅Π½ΠΎ ΠΊΠ°ΠΊ ΠΏΠΎΠ±ΠΎΡΠ½ΡΠΉ ΡΡΡΠ΅ΠΊΡ Π°ΠΌΠΈΡΡΠΈΠΏΡΠΈΠ»ΠΈΠ½Π°, ΠΈ ΡΠ»ΡΡΡΠΈΠ»ΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ. Π ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
ΠΈΠΌΠ΅Π»Π°ΡΡ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΡ ΠΊ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΆΠΈΠ·Π½ΠΈ, Π΄ΠΎΡΡΠΈΠ³ΡΠ°Ρ Π² Π³ΡΡΠΏΠΏΠ΅ Π°ΠΌΠΈΡΡΠΈΠΏΡΠΈΠ»ΠΈΠ½ + ΡΠ΅ΡΠ΅Π±ΡΠΎΠ»ΠΈΠ·ΠΈΠ½ ΠΏΠΎΠ³ΡΠ°Π½ΠΈΡΠ½ΡΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ (Ρ=0,048)
IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low pH at the site of infection or in phagolysosome, as well as in anaerobic conditions, and also leads to deficiency of arginine. Metabolism of arginine plays an important role in regulating the functions of immune system cells in mammals. Arginine is a substrate of enzymes NOS and arginase. Arginine depletion, potentially contributs to immunosuppression. The review analyzed the literature data on the effect of streptococcal arginine deiminase on the metabolism of arginine eukaryotic cells, and discusses immunosuppressive action of the enzyme
Why 'scaffolding' is the wrong metaphor : the cognitive usefulness of mathematical representations.
The metaphor of scaffolding has become current in discussions of the cognitive help we get from artefacts, environmental affordances and each other. Consideration of mathematical tools and representations indicates that in these cases at least (and plausibly for others), scaffolding is the wrong picture, because scaffolding in good order is immobile, temporary and crude. Mathematical representations can be manipulated, are not temporary structures to aid development, and are refined. Reflection on examples from elementary algebra indicates that Menary is on the right track with his βenculturationβ view of mathematical cognition. Moreover, these examples allow us to elaborate his remarks on the uniqueness of mathematical representations and their role in the emergence of new thoughts.Peer reviewe
The study of the associations of polymorphism of matrix metalloproteinases with multifactorial human diseases and in silico assessment of their functional effects
The objective of this study is to identify the associations of polymorphism of matrix metalloproteinase genes with multifactorial diseases and evaluate in silico their functional effects. The material for the study was genomic DNA isolated from venous blood samples by the standard phenol-chloroform extraction method. The rs2250889 MMP9, rs11568818 MMP7 and rs17576 MMP9 polymorphic loci were studied using the polymerase chain reaction on a CFX-96 Real-Time System thermal cycler (Bio-Rad Laboratories, Inc., US) using oligonucleotide primers and probes synthesized by Syntol
LLC, Russia
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