Trophic mechanisms underlying bentho-demersal community recovery in the north-east Atlantic

En prens

In vivo stem cell tracking using scintigraphy in a canine model of DMD

One of the main challenges in cell therapy for muscle diseases is to efficiently target the muscle. To address this issue and achieve better understanding of in vivo cell fate, we evaluated the relevance of a non-invasive cell tracking method in the Golden Retriever Muscular Dystrophy (GRMD) model, a well-recognised model of Duchenne Muscular Dystrophy (DMD). Mesoangioblasts were directly labelled with 111In-oxine, and injected through one of the femoral arteries. The scintigraphy images obtained provided the first quantitative mapping of the immediate biodistribution of mesoangioblasts in a large animal model of DMD. The results revealed that cells were trapped by the first capillary filters: the injected limb and the lung. During the days following injection, radioactivity was redistributed to the liver. In vitro studies, performed with the same cells prepared for injecting the animal, revealed prominent cell death and 111In release. In vivo, cell death resulted in 111In release into the vasculature that was taken up by the liver, resulting in a non-specific and non-cell-bound radioactive signal. Indirect labelling methods would be an attractive alternative to track cells on the mid- and long-term

Shifts in the seasonal trophic ecology of larvae and juveniles of European hake (Merluccius merluccius): From the Galician upwelling system (NW Spain).

The trophic ecology of European hake (Merluccius merluccius) larvae and early-juveniles from the Iberian shelf off Galicia (NW Spain) are assessed by means of stable isotopes (SIA) and nutritional condition in conjunction with hydrobiological variations observed during the winter and summer season of 2012. Hake early-juveniles (18–47 mm SL) showed higher δ15N than larvae (3–11 mm SL) together with the microzooplankton (55–200 μm) and mesozooplankton (>200 μm) during both seasons. Low δ15N values and high variability in both zooplankton and hake larvae were found during winter coinciding with an unusually strong upwelling event. Inversely, high δ15N content in zooplankton in summer suggests strong nitrogen reutilization. However, hake larvae sampled in summer had a higher RNA:DNA ratio in line with higher Fulton condition factors than those sampled in winter. Higher δ13C values for microzooplankton and mesozooplankton and hake larvae in summer compared to late winter point to prey availability differences. The relationship between nitrogen and carbon stable isotopes versus size or weight suggests an ontogenetic shift in the diet of hake larvae. Early-juveniles had a lower isotopic niche width compared to larvae in both late winter and summer, indicating a trophic specialization related to changes following settlement process from planktonic life to demersal habitat. Higher trophic specialization was observed in summer, which recorded a narrower isotopic niche and higher trophic position estimations.En prensa2,04

Fasciola and fasciolosis in ruminants in Europe: Identifying research needs

18 páginas, 1 figura, 2 tablas.Fasciola hepatica is a trematode parasite with a global distribution, which is responsible for considerable disease and production losses in a range of food producing species. It is also identified by WHO as a re-emerging neglected tropical disease associated with endemic and epidemic outbreaks of disease in human populations. In Europe, F. hepatica is mostly associated with disease in sheep, cattle and goats. This study reviews the most recent advances in our understanding of the transmission, diagnosis, epidemiology and the economic impact of fasciolosis. We also focus on the impact of the spread of resistance to anthelmintics used to control F. hepatica and consider how vaccines might be developed and applied in the context of the immune-modulation driven by the parasite. Several major research gaps are identified which, when addressed, will contribute to providing focussed and where possible, bespoke, advice for farmers on how to integrate stock management and diagnosis with vaccination and/or targeted treatment to more effectively control the parasite in the face of increasing the prevalence of infection and spread of anthelmintic resistance that are likely to be exacerbated by climate change.All authors are members of the Livestock Helminth Research Alliance (LiHRA), whose vision is to improve the health, wealth and productivity of European livestock by providing sustainable helminth control options. This review was commissioned by DISCONTOOLS (www.discontools.eu) as part of the process of identifying research gaps which impinge on effective and sustainable control of fasciolosis in food producing animals in Europe. DJLW, JC, LR, CC, JPA, AMM all received funding from the European Union through the following awards: FPVI‐FOOD‐CT‐200X‐023025‐DELIVER; FPVII‐KBBE‐2011‐5‐288975‐GLOWORM; FPVII‐KBBE‐2010‐4‐265862‐PARAVAC; H2020‐635408‐PARAGONE. DJLW, JEH, NJB received funding from the Biotechnology and Biological Sciences Research Council (BBSRC) through awards: BB/K015591/1 and BBI002480/1, and RJF was supported by BBSRC award BB/M018520/1. MMV was funded by the Spanish “Ramón y Cajal” Programme of the Ministry of Economy and Competitiveness (RYC‐2015‐18368). CC was funded by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE) and Liverpool School of Tropical Medicine (LSTM). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, the Department of Health or PHE.Peer reviewe

Mjesto izvedbe i stvaranje grada

Ovaj je zbornik rezultat projekta Mjesto izvedbe i stvaranje grada, koji je ostvaren u suradnji znanstveno-istraživačkog projekta Stvaranje grada: prostor, kultura i identitet (Hrvatska zaklada za znanost, Institut za etnologiju i folkloristiku) te umjetničkog projekta Creart (Hrvatsko društvo likovnih umjetnika, EU). Navedeni projekti ukratko su opisani u prvom dijelu knjige. U drugom dijelu zbornika objavljeni su znanstveni radovi prethodno izloženi na skupu Mjesto izvedbe i stvaranje grada, održanom u Zagrebu 4. travnja 2016. godine. Autori tekstova svojim profesionalnim određenjem pripadaju područjima etnologije i kulturne antropologije, folkloristike, izvedbenih studija, urbanih studija, primijenjene antropologije, teatrologije i kazališne produkcije. U trećem dijelu zbornika slijede radovi studenata etnologije i kulturne antropologije koji su bili istraživački angažirani u praćenju umjetničkih intervencija u javnim prostorima Zagreba početkom 2016. godine. U umjetničkim intervencijama sudjelovalo je petero umjetnika, a 21. ožujka 2016. godine, povodom obilježavanja Europskog dana kreativnosti, organizirana je i javno oglašena šetalačka tura slijedom lokacija konkretnih intervencija. Na kraju zbornika nalazi se tekst na engleskom jeziku o projektnoj suradnji, istraživanju izvedbi i stvaranju grada te konkretnim umjetničkim intervencijama u Zagrebu

Proyecto de urbanización del sector SU-8 de Peñíscola (Comunidad Valenciana)

El objetivo del Proyecto de Urbanización del sector SU-8 de Peñíscola es diseñar un espacio urbano atendiendo a los criterios establecidos en el Plan General de Ordenación Urbanística de Peñíscola y las consideraciones del entorno, sirviendo este proyecto para realizar una ordenación viaria de ese espacio, dotándola de todos los servicios necesarios para un desarrollo funcional independiente, mediante la conexión de los mismos a las infraestructuras generales existentes.<br /