Prescribing patterns of gastrointestinal drugs in private clinics in Benghazi-Libya

Background: Prescription analysis can pinpoint areas of improvement in encounters issued by prescribing physicians. The present study was carried out to analyze prescribing trends for outpatients among consultants in the city of Benghazi-Libya.Methods: A total of 4000 prescriptions were collected from private pharmacies around the city of Benghazi, Libya. Indicators addressed included the patient's name, age, sex, and address, and the physician's name, address, and signature. The percentage of prescriptions lacking this information was calculated. Drugs prescribed by dosage, duration of treatment were also considered. The study focused on the commonly prescribed classes of gastrointestinal drugs and the most frequently prescribed drug of each common class. No attempt was made to evaluate the incidence of various gastrointestinal disorders. Results are expressed as frequency and percentage of prescribed medicines.Results: Information present in prescriptions and pertaining to the patient were name (2972, 74.3%), age (468, 11.7%), date of visit (107, 2.7%) while those for prescriber were name (1902, 47.6%) and signature (3612, 90.3%). None of the prescriptions contained sex of patient, his/her address, or registration number of the prescriber. All prescribed drugs were in brand names. Polypharmacy was not evident as all prescriptions contained 1-2 drugs.The number of prescriptions with a gastrointestinal drug(s) counted to 421 (10.5%) out of the total 4000 prescriptions. The most commonly prescribed classes of gastrointestinal drugs include in order, anti-hyperacidity, anti-emetics, anti-spasmodic, laxatives and anti-diarrheal with the most frequently prescribed drug of each therapeutic class being omeprazole (67, 48.9%), metoclopramide (57, 57%), hyoscine-N-butyl bromide (42, 55.3%), bisacodyl (44, 59.5%) and loperamide (30, 88.3%) respectively.Conclusions: The results of the present study indicate the need to improve prescribing among physicians, a task that can be achieved through inclusion of related topics such as prescription writing and rational drug use in undergraduate curricula and continuing medical educational programs

Performance and Combustion Characteristics of an SI Engine Fueled With Fusel Oil-Gasoline at Different Water Content

The main objective of the current study is to investigate the impacts of fusel oil-gasoline blends with different water content on performance and combustion characteristics of an SI engine. The water content of fusel oil is reduced by employing rotary extractor method. The parameters examined in the current study are the effects of test fuels upon engine performance criteria, fuel combustion, location of CA50 and coefficient of variation of indicated mean effective pressure (COVIMEP). The experiments are conducted in a SI engine with two blending ratio of gasoline-fusel oil (FBWE10 and FAWE10) in addition to pure gasoline as a standard fuel under different engine speeds and constant 45% of WOT engine load. The study results reveal that engine power, torque, and brake thermal efficiency have slightly improved with fusel oil-gasoline blends that were obvious clearly after reduction of water content. On the other hand, though the brake specific fuel consumption of FAWE10 slightly improve compared to FBWE10 but still higher than gasoline. Furthermore, the peak in-cylinder pressure, rate of heat release, and rate of pressure rise enhanced with fusel oil-gasoline blends. The (CA 0–10) and (CA 10–90) duration could be simultaneously decreased by reducing the water content of fusel oil, all of that are helpful to improve the stability of combustion and thought to be reasons for the reduction in COVIMEP. As a conclusion, the reduction of fusel oil water content has played positively to enhance the combustion and performance characteristics of the fuel blend and result in more stable engine operation

Preparation, characterization and antibacterial effects of eco-friendly gold nanorods

Purpose: To synthesize and characterize eco-friendly gold nanorods (Au-NRs) and to assess their effects against two bacterial strains.Methods: Synthesis of eco-friendly gold nanorods was done from an aqueous solution of chloroauric acid and cetyltrimethylammonium bromide by mixing Olea europaea fruit and Acacia nilotica husk extracts with the latter as a reducing agent. The synthesis was monitored by ultraviolet–visible (UV) spectrophotmetry and a zetasizer, while the morphology of the resulting nanorods was assessed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) coupled with an energy-dispersive spectrophotometer (EDS). The effect of the prepared eco-nanorods on growth of Escherichia coli and Staphylococcus aureus bacteria were investigated by agar diffusion method.Results: The synthesized Au-NRs were mostly rod-shaped, with mean size of 96 nm. They exhibited a potent antibacterial activity against Gram-positive and  Gram-negative microorganisms (Escherichia coli and Staphylococcus aureus).Conclusion: The findings suggest that the nanoformulation of the biomaterial mix of Olea europaea fruit and Acacia nilotica husk extracts is a cost-effective, eco-friendly, and non-toxic synthesis of Au- NRs which has therpeautic potential.Keywords: Olea europaea, Acacia nilotica, Gold nanorods, Eco-friendly synthesis, Gram-positive and Gram-negative microorganism

CLINICAL AND BIOCHEMICAL EFFECTS OF LIDIOCAINE HCL, KETAMINE HCL, AND THEIR COMBINATION FOR POSTERIOR EPIDURAL ANALGESIA IN BUFFALOES

ABSTRACT This study was performed to clarify the effects of lidiocaine Hcl, ketamine Hcl and their combination injected into the sacrococcygeal space for posterior epidural analgesia in buffaloes. Five adult buffaloes were randomly received 3 treatments with 2 week interval. The treatments were 7.5 ml of lidiocaine Hcl 2% (Group I), 7.5 ml of ketamine Hcl 2% (Group II) and 7.5 ml combination of lidiocaine Hcl 2% and ketamine Hcl 2% (Group III). Analgesic, sedative, ataxic, cardiopulmonary effects, rumen motility and biochemical parameters were observed and recorded. Average of onset and duration of analgesia were 4.8 & 77.0 min.; 3.8 & 25.8 min. and 5.2 & 90.0 min. in group I, II and III respectively. Analgesic areas were tail, perineum and the posterior aspect of hind limbs. There was no sedative effect in all groups. Slight ataxia was observed in one case in group I. The biochemical findings showed significant increase in serum glucose and cortisol in group III especially at 30 and 60 minutes from start of analegesia, while the creatnine level significantly increased in both group II and III at 15, 30, 60 minutes. However, these parameters fluctuated with in normal range and started to recover with in 90 min. Other examined parameters did not show any significant change. It could be concluded that, epidural administration of ketamine Hcl 2% had rapid onset and short duration of analgesia. Combination of lidiocaine Hcl and ketamine Hcl 2% treatment had rapid and long duration of analgesia like lidiocaine Hcl treatment. This study indicated also a possible additive analgesic interaction between epidurally administered lidiocaine Hcl and ketamine Hcl, with transient and minimal systemic effects in buffaloes

Conserved Charges in Even Dimensional Asymptotically locally Anti-de Sitter Space-times

Based on the recent paper hep-th/0503045, we derive a formula of calculating conserved charges in even dimensional asymptotically {\it locally} anti-de Sitter space-times by using the definition of Wald and Zoupas. This formula generalizes the one proposed by Ashtekar {\it et al}. Using the new formula we compute the masses of Taub-Bolt-AdS space-times by treating Taub-Nut-AdS space-times as the reference solution. Our result agrees with those resulting from "background subtraction" method or "boundary counterterm" method. We also calculate the conserved charges of Kerr-Taub-Nut-AdS solutions in four dimensions and higher dimensional Kerr-AdS solutions with Nut charges. The mass of (un)wrapped brane solutions in any dimension is given.Comment: Latex, 28 pages, v2: minor changes, to appear in JHE

Enhancement the removal capacity of heavy metals from aqueous solution using different aquatic organisms

151-162The Eichhornia sp had high ability for bioremoval of Pb and Cd (97.15 and 97.48%) during 15 min with some ultrastructure changes of the leaf such as, ruptured or disappeared plasma membrane, swollen mitochondria and malformation chloroplast and some anatomical studies; thickness of upper epidermis and mesophyll decreased with presences number of raphide crystals in treated leaf but it not found in untreated plants. It was noticed that treated with Pb was more effect on histological leaf than treated with Cd. While, Gelidium pectinatum had highest efficiency for removal of Cd but during 0.5 hr. The bioremoval efficiency of lead by Gelidium pectinatum increased with Epichlorohydrin 1 from 28.84 to 90.18 % during 240 min contact time and from 77.34 in raw (untreated) algae to 99.58% in case of cadmium during the same contact time

Assessment of knowledge, attitude and practice of diabetic people in Najran, Kingdom of Saudi Arabia

Background: This cross-sectional hospital based study aimed at determining the level of knowledge, attitude and practice of diabetes among local people of Najran, Saudi Arabia.Methods: We aimed to investigate the levels of knowledge, attitude and practice among diabetic people in Najran area.Results: 10% of the participants scored >7, 28% scored >5 and 62% scored 5 and less in Knowledge questionnaire. None [0.00%] of the participants scored 7 or more out of the attitude questionnaire. 100% of the participants scored 5 and less out of 12. 100% of the participants scored >6 and 0% scored 12 or more in the practice questionnaire.Conclusions: Our study revealed that the level of knowledge, attitude and practice of diabetes in the area of Najran is very poor. We suggest that a structured educational program to be adopted by the health authorities in Saudi Arabia

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

<p>Abstract</p> <p>Background</p> <p><it>Asclepias curassavica </it>Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours. We have determined the protective effect of β-sitosterol isolated from <it>A. curassavica </it>in colon cancer, using <it>in vitro </it>and <it>in vivo </it>models.</p> <p>Methods</p> <p>The active molecule was isolated, based upon bioassay guided fractionation, and identified as β-sitosterol on spectral evidence. The ability to induce apoptosis was determined by its <it>in vitro </it>antiradical activity, cytotoxic studies using human colon adenocarcinoma and normal monkey kidney cell lines, and the expression of β-catenin and proliferating cell nuclear antigen (PCNA) in human colon cancer cell lines (COLO 320 DM). The chemopreventive potential of β-sitosterol in colon carcinogenesis was assessed by injecting 1,2-dimethylhydrazine (DMH, 20 mg/kg b.w.) into male Wistar rats and supplementing this with β-sitosterol throughout the experimental period of 16 weeks at 5, 10, and 20 mg/kg b.w.</p> <p>Results</p> <p>β-sitosterol induced significant dose-dependent growth inhibition of COLO 320 DM cells (IC₅₀266.2 μM), induced apoptosis by scavenging reactive oxygen species, and suppressed the expression of β-catenin and PCNA antigens in human colon cancer cells. β-sitosterol supplementation reduced the number of aberrant crypt and crypt multiplicity in DMH-initiated rats in a dose-dependent manner with no toxic effects.</p> <p>Conclusion</p> <p>We found doses of 10-20 mg/kg b.w. β-sitosterol to be effective for future <it>in vivo </it>studies. β-sitosterol had chemopreventive potential by virtue of its radical quenching ability <it>in vitro</it>, with minimal toxicity to normal cells. It also attenuated β-catenin and PCNA expression, making it a potential anticancer drug for colon carcinogenesis.</p

Virtual prototyping of a semi-active transfemoral prosthetic leg

This article presents a virtual prototyping study of a semi-active lower limb prosthesis to improve the functionality of an amputee during prosthesis–environment interaction for level ground walking. Articulated ankle–foot prosthesis and a single-axis semi-active prosthetic knee with active and passive operating modes were considered. Data for level ground walking were collected using a photogrammetric method in order to develop a base-line simulation model and with the hip kinematics input to verify the proposed design. The simulated results show that the semi-active lower limb prosthesis is able to move efficiently in passive mode, and the activation time of the knee actuator can be reduced by approximately 50%. Therefore, this semi-active system has the potential to reduce the energy consumption of the actuators required during level ground walking and requires less compensation from the amputee due to lower deviation of the vertical excursion of body centre of mass