Phytochemical composition, Antioxidant and Anti-inflammatory potential of bioactive fractions from extracts of three medicinal plants traditionally used to treat liver diseases in Burkina Faso

Our aim in this study concerning the ethyl acetate and dichloromethane fractions was to provide a scientific basis for the treatment of hepatitis B in Burkina Faso of these three ethnomedicinal plants. As a result, we evaluated polyphenol content, antioxidant and anti-inflammatory evaluated by lipoxygenase (LOX) inhibitory and Xanthine Oxidase (XO) activities of aqueous acetone bioactive fractions from three species of Malvaceae (Sida cordifolia, Sida rhombifolia, S. urens). Folin-ciocalteu; AlCl3 methods and tannic acid respectively were used for polyphenol content research. The antioxidant activity of the samples was evaluate using three separate methods, inhibition of free radical 2,2-diphenyl-1-picrylhydramzyl (DPPH), ABTS radical cation decolorization assay, Iron (III) to iron (II) reduction activity (FRAP). For anti-inflammatoty activity, lypoxygenase and xanthine oxidase inhibitory activities were used. Finally, in this study, the ethyl acetate fraction has shown the best results comparatively to the dichloromethane fraction. Keywords: Polyphenol, Antioxidant, anti-inflammatory, Medicinal plants, hepatitis B

Phytochemical composition, Antioxidant and Anti-inflammatory potential of bioactive fractions from extracts of three medicinal plants traditionally used to treat liver diseases in Burkina Faso

Our aim in this study concerning the ethyl acetate and dichloromethane fractions was to provide a scientific basis for the treatment of hepatitis B in Burkina Faso of these three ethnomedicinal plants. As a result, we evaluated polyphenol content, antioxidant and anti-inflammatory evaluated by lipoxygenase (LOX) inhibitory and Xanthine Oxidase (XO) activities of aqueous acetone bioactive fractions from three species of Malvaceae (Sida cordifolia, Sida rhombifolia, S. urens). Folin-ciocalteu; AlCl3 methods and tannic acid respectively were used for polyphenol content research. The antioxidant activity of the samples was evaluate using three separate methods, inhibition of free radical 2,2-diphenyl-1-picrylhydramzyl (DPPH), ABTS radical cation decolorization assay, Iron (III) to iron (II) reduction activity (FRAP). For anti-inflammatoty activity, lypoxygenase and xanthine oxidase inhibitory activities were used. Finally, in this study, the ethyl acetate fraction has shown the best results comparatively to the dichloromethane fraction. Keywords: Polyphenol, Antioxidant, anti-inflammatory, Medicinal plants, hepatitis B

Screening African rice (Oryza glaberrima) for tolerance to abiotic stresses: I. Fe toxicity

AbstractIron (Fe) toxicity is recognized as one of the most widely spread soil constraints for rice production especially in West Africa. Oryza glaberrima the cultivated rice species that originated from West Africa is well-adapted to its growing ecologies. The aim of this study was to identify the promising O. glaberrima accessions tolerant to Fe toxicity from the 2106 accessions held at the AfricaRice gene bank. The screenings were conducted over a four-year period and involved evaluating the entries under Fe-toxic field conditions in West Africa, selecting good yielding accessions and repeating the testing with newly selected lines. Three accessions (TOG 7206, TOG 6218-B and TOG 7250-A) were higher yielding than O. sativa checks under stress but with similar yields under control conditions. These accessions yielded over 300g/m2 under both Fe toxicity and control conditions. In conclusion, these materials could be used as donors in breeding programs for developing high yielding rice varieties suited to Fe toxicity affected areas in West Africa

Pityriasis Rosé de Gibert révélant une Hépatite virale B

Le pityriasis rosé, décrit par Gibert en 1860, est une dermatose fréquente, bénigne, transitoire, et d’étiologie inconnue qui atteint surtout les adultes jeunes. On pense qu'il s'agit d'une affection virale, mais sans argument bien probant. Nous rapportons un cas de Pityriasis Rosé de Gibert (PRG) révélant une hépatite virale B. Observation : Il s’agissait d’un adulte de 47 ans originaire de Diago (Commune de Kati), sans antécédents médicaux et chirurgicaux connus, qui consulte pour des macules rosées disséminées sur tout le tronc associées à du prurit chez qui le diagnostic de PRG a été retenu. Il a bénéficié de la vaseline à l’urée 5% et de la Mequitazine 10mg comme traitement. Devant la persistance du prurit un bilan biologique à la recherche d’une étiologie fut demandé et cela a conduit au diagnostic d’une infection par le virus de l’hépatite B. Conclusion : Cette observation devrait conduire les dermatologues à proposer systématiquement la recherche d’une infection virale à l’hépatite B devant des PRG très prurigineux et résistants aux traitements habituels

Dépistage du VIH en salle d’accouchement à la maternité du Centre de Santé de Référence de la commune V Bamako

Objectifs : Evaluer l’impact du counseling pour le dépistage VIH en salle de travail chez les patientes n’ayant pas bénéficié de cette activité lors des CPN. Méthodes et matériels : L’étude s’est déroulée au CSRéf de la commune v de Bamako du 1er janvier au 31décembre 2014. L’échantillonnage était systématique, portait sur toutes les parturientes admises en salle de travail avec une dilatation cervicale à 4cm ou plus et dans le post- partum immédiat avec un âge gestationnel ≥ 28SA ou un poids fœtal ≥1000g. Le test par bandelette a été utilisé après consentement éclairé des patientes .La confirmation a été faite avec l’immunocomb II VIH1 et 2 Bi spot. Résultats :L’étude a rapporté que 4,34% (380) des parturientes n’ont pas fait le dépistage VIH lors du suivi prénatal. En salle d’accouchement, ces 380 parturientes ont bénéficié toutes d’un conseil dépistage volontaire au VIH. Nous avons enregistré 11 cas de refus. Sur les 369 parturientes ayant fait le test, 37 étaient positifs au VIH soit 10%. L’âge moyen était de 27ans ±07 ; non instruite (58,9%) vivant dans un régime polygamique (65,9) ; un suivi prénatal fait (95,12%) ; 93% suivi dans les structures citées PTME. Les antirétroviraux ont été administrés à toutes les mères et aux nouveau- nés vivants. Conclusion : Au regard de la fréquence élevée (10%) des cas positifs dans notre étude, il est nécessaire de poursuivre les activités de Conseil et Dépistage Volontaire en salle d’accouchement pour permettre à l’ensemble des femmes enceintes qui accouchent dans nos structures sanitaires de bénéficier des interventions de la PTM

Influence of basement heterogeneity on the architecture of low subsidence rate Paleozoic intracratonic basins (Reggane, Ahnet, Mouydir and Illizi basins, Hoggar Massif)

The Paleozoic intracratonic North African Platform is characterized by an association of arches (ridges, domes, swells, or paleo-highs) and low subsidence rate syncline basins of different wavelengths (75–620&thinsp;km). The Reggane, Ahnet, Mouydir and Illizi basins are successively delimited from east to west by the Amguid El Biod, Arak-Foum Belrem, and Azzel Matti arches. Through the analysis of new unpublished geological data (i.e., satellite images, well logs, seismic lines), the deposits associated with these arches and syncline basins exhibit thickness variations and facies changes ranging from continental to marine environments. The arches are characterized by thin amalgamated deposits with condensed and erosional surfaces, whereas the syncline basins exhibit thicker and well-preserved successions. In addition, the vertical facies succession evolves from thin Silurian to Givetian deposits into thick Upper Devonian sediments. Synsedimentary structures and major unconformities are related to several tectonic events such as the Cambrian–Ordovician extension, the Ordovician–Silurian glacial rebound, the Silurian–Devonian Caledonian extension/compression, the late Devonian extension/compression, and the Hercynian compression. Locally, deformation is characterized by near-vertical planar normal faults responsible for horst and graben structuring associated with folding during the Cambrian–Ordovician–Silurian period. These structures may have been inverted or reactivated during the Devonian (i.e., Caledonian, Mid–Late Devonian) compression and the Carboniferous (i.e., pre-Hercynian to Hercynian). Additionally, basement characterization from geological and geophysics data (aeromagnetic and gravity maps), shows an interesting age-dependent zonation of the terranes which are bounded by mega-shear zones within the arches–basins framework. The old terranes are situated under arches while the young terranes are located under the basins depocenter. This structural framework results from the accretion of Archean and Proterozoic terranes inherited from former orogeny (e.g., Pan-African orogeny 900–520&thinsp;Ma). Therefore, the sedimentary infilling pattern and the nature of deformation result from the repeated slow Paleozoic reactivation of Precambrian terranes bounded by subvertical lithospheric fault systems. Alternating periods of tectonic quiescence and low-rate subsidence acceleration associated with extension and local inversion tectonics correspond to a succession of Paleozoic geodynamic events (i.e., far-field orogenic belt, glaciation).</p

The intensification of thermal extremes in west Africa

International audienceThis study aims in filling the gap in understanding the relationship between trend and extreme in diurnal and nocturnal temperatures (Tx and Tn) over the Gulf of Guinea area and the Sahel. Time-evolution and trend of Tx and Tn anomalies, extreme temperatures and heat waves are examined using regional and station-based indices over the 1900–2012 and 1950–2012 periods respectively. In investigating extreme temperature anomalies and heat waves, a percentile method is used. At the regional and local scales, rising trends in Tx and Tn anomalies, which appear more pronounced over the past 60 years, are identified over the two regions. The trends are characterized by an intensification of: i) nocturnal/Tn warming over the second half of the 20th century; and ii) diurnal/Tx warming over the post-1980s. This is the same scheme with extreme warm days and warm nights. Finally annual number of diurnal and nocturnal heat waves has increase over the Gulf of Guinea coastal regions over the second half of the 20th century, and even more substantially over the post-1980s period. Although this trend in extreme warm days and nights is always overestimated in the simulations, from the Coupled Model Intercomparison Project Phase 5 (CMIP5), those models display rising trends whatever the scenario, which are likely to be more and more pronounced over the two regions in the next 50 years

Intermittent Preventive Treatment to Reduce the Burden of Malaria in Children: New Evidence on Integration and Delivery

James Beeson and colleagues discuss three new studies in PLoS Medicine that provide valuable evidence on how to delivery and integrate intermittent preventive reatment for malaria in children (IPTc)