Studying the impact of a medication use evaluation for polymedicated older patients by the community pharmacist (SIMENON) : study protocol

Background: Aged polymedicated patients are particularly vulnerable for drug-related problems. A medication review aims to optimize the medication use of patients and improve health outcomes. In this study, the effect of a pharmacist-led medication use review is investigated for polymedicated ambulatory older patients with the aim of implementing this pharmaceutical care intervention across Belgium. Methods: This article describes the study protocol of the SIMENON study and reports the results of the feasibility study, which aimed to test and optimize this study protocol. In the SIMENON intervention study, 75 Belgian community pharmacies each recruit 12 patients for a medication use review. For each patient, the identified drug-related problems and subsequent interventions are registered using the PharmDISC classification. In a subset of Dutch speaking patients, a pretest-posttest single group design is used to measure the impact of this review on patient related outcomes using questionnaires. The main outcome of the study is the type and number of drug-related problems and related interventions. A second outcome is the impact of the medication use review on adherence, objectively measured with dispensing data. Evolution in medication related quality of life is another outcome, measured with the Living with Medicines Questionnaire version 3. Other patient reported outcomes include adherence, self-management, patient satisfaction, fall incidents and use of emergency healthcare services. Discussion: The findings of this study can provide data on the effectiveness of a medication use review in the Belgian primary care setting. Furthermore, it will provide insights in which patients benefit most of this intervention and therefore facilitate the implementation of medication review in Belgium

The KMOS^3D Survey: design, first results, and the evolution of galaxy kinematics from 0.7<z<2.7

We present the KMOS^3D survey, a new integral field survey of over 600 galaxies at 0.7<z<2.7 using KMOS at the Very Large Telescope (VLT). The KMOS^3D survey utilizes synergies with multi-wavelength ground and space-based surveys to trace the evolution of spatially-resolved kinematics and star formation from a homogeneous sample over 5 Gyrs of cosmic history. Targets, drawn from a mass-selected parent sample from the 3D-HST survey, cover the star formation-stellar mass ($M_*$) and rest-frame $(U-V)-M_*$ planes uniformly. We describe the selection of targets, the observations, and the data reduction. In the first year of data we detect Halpha emission in 191 $M_*=3\times10^{9}-7\times10^{11}$ Msun galaxies at z=0.7-1.1 and z=1.9-2.7. In the current sample 83% of the resolved galaxies are rotation-dominated, determined from a continuous velocity gradient and $v_{rot}/\sigma>1$, implying that the star-forming 'main sequence' (MS) is primarily composed of rotating galaxies at both redshift regimes. When considering additional stricter criteria, the Halpha kinematic maps indicate at least ~70% of the resolved galaxies are disk-like systems. Our high-quality KMOS data confirm the elevated velocity dispersions reported in previous IFS studies at z>0.7. For rotation-dominated disks, the average intrinsic velocity dispersion decreases by a factor of two from 50 km/s at z~2.3 to 25 km/s at z~0.9 while the rotational velocities at the two redshifts are comparable. Combined with existing results spanning z~0-3, disk velocity dispersions follow an approximate (1+z) evolution that is consistent with the dependence of velocity dispersion on gas fractions predicted by marginally-stable disk theory.Comment: 20 pages, 11 figures, 1 Appendix; Accepted to ApJ November 2

The Evolution of the Field and Cluster Morphology-Density Relation for Mass-Selected Samples of Galaxies

The Sloan Digital Sky Survey (SDSS) and photometric/spectroscopic surveys in the GOODS-South field (the Chandra Deep Field-South, CDFS) are used to construct volume-limited, stellar mass-selected samples of galaxies at redshifts 0<z<1. The CDFS sample at 0.6<z<1.0 contains 207 galaxies complete down to M=4x10^10 Msol (for a ``diet'' Salpeter IMF), corresponding to a luminosity limit for red galaxies of M_B=-20.1. The SDSS sample at 0.020<z<0.045 contains 2003 galaxies down to the same mass limit, which corresponds to M_B=-19.3 for red galaxies. Morphologies are determined with an automated method, using the Sersic parameter n and a measure of the residual from the model fits, called ``bumpiness'', to distinguish different morphologies. These classifications are verified with visual classifications. In agreement with previous studies, 65-70% of the galaxies are located on the red sequence, both at z~0.03 and at z~0.8. Similarly, 65-70% of the galaxies have n>2.5. The fraction of E+S0 galaxies is 43+/-3%$ at z~0.03 and 48+/-7% at z~0.8, i.e., it has not changed significantly since z~0.8. When combined with recent results for cluster galaxies in the same redshift range, we find that the morphology-density relation for galaxies more massive than 0.5M* has remained constant since at least z~0.8. This implies that galaxies evolve in mass, morphology and density such that the morphology-density relation does not change. In particular, the decline of star formation activity and the accompanying increase in the stellar mass density of red galaxies since z~1 must happen without large changes in the early-type galaxy fraction in a given environment.Comment: 16 pages, 13 figures, 2 tables. Updated to match journal version. Will appear in ApJ (vol. 670, p. 206

HST and Spitzer imaging of red and blue galaxies at z~2.5: A correlation between size and star formation activity from compact quiescent galaxies to extended star forming galaxies

We present HST NICMOS+ACS and Spitzer IRAC+MIPS observations of 41 galaxies at 2<z<3.5 in the FIRES MS1054 field with red and blue rest-frame optical colors. About half of the galaxies are very compact (effective radii r_e < 1 kpc) at rest-frame optical wavelengths, the others are extended (1< r_e < 10 kpc). For reference, 1 kpc corresponds to 0.12 arcsec at z=2.5 in the adopted cosmology. We separate actively star forming galaxies from quiescent galaxies by modeling their rest-frame UV-NIR SEDs. The star forming galaxies span the full range of sizes, while the quiescent galaxies all have r_e<2kpc. In the redshift range where MIPS 24 micron imaging is a sensitive probe of re-radiated dust emission (z<2.5), the 24 micron fluxes confirm that the light of the small quiescent galaxies is dominated by old stars, rather than dust-enshrouded star formation or AGN activity. The inferred surface mass densities and velocity dispersions for the quiescent galaxies are very high compared to those in local galaxies. The galaxies follow a Kormendy relation (between surface brightness and size) with approximately the same slope as locally, but shifted to brighter surface brightnesses, consistent with a mean stellar formation redshift of z_f~5. This paper demonstrates a direct relation between star formation activity and size at z~2.5, and the existence of a significant population of massive, extremely dense, old stellar systems without readily identifiable counterparts in the local universe.Comment: Accepted for publication in Ap

The far-infrared/radio correlation and radio spectral index of galaxies in the SFR-M* plane up to z 2

[Abridged] We study the evolution of the radio spectral index and far-infrared/radio correlation (FRC) across the star-formation rate-stellar masse (i.e. SFR-M*) plane up to z 2. We start from a M*-selected sample of galaxies with reliable SFR and redshift estimates. We then grid the SFR-M* plane in several redshift ranges and measure the infrared luminosity, radio luminosity, radio spectral index, and ultimately the FRC index (i.e. qFIR) of each SFR-M*-z bin. The infrared luminosities of our SFR-M*-z bins are estimated using their stacked far-infrared flux densities inferred from observations obtained with Herschel. Their radio luminosities and radio spectral indices (i.e. alpha, where Snu nu^-alpha) are estimated using their stacked 1.4GHz and 610MHz flux densities from the VLA and GMRT, respectively. Our far-infrared and radio observations include the most widely studied blank extragalactic fields -GOODS-N/S, ECDFS, and COSMOS- covering a sky area of 2deg^2. Using this methodology, we constrain the radio spectral index and FRC index of star-forming galaxies with M*>10^10Msun and 0<z<2.3. We find that alpha^1.4GHz_610MHz does not evolve significantly with redshift or with the distance of a galaxy with respect to the main sequence (MS) of the SFR-M* plane (i.e. Delta_log(SSFR)_MS=log[SSFR(galaxy)/SSFR_MS(M*,z)]). Instead, star-forming galaxies have a radio spectral index consistent with a canonical value of 0.8, which suggests that their radio spectra are dominated by non-thermal optically thin synchrotron emission. We find that qFIR displays a moderate but statistically significant redshift evolution as qFIR(z)=(2.35+/-0.08)*(1+z)^(-0.12+/-0.04), consistent with some previous literature. Finally, we find no significant correlation between qFIR and Delta_log(SSFR)_MS, though a weak positive trend, as observed in one of our redshift bins, cannot be firmly ruled out using our dataset.Comment: Accepted for publication in A&A; 18 pages, 10 figure

Panchromatic spectral energy distributions of Herschel sources

(abridged) Far-infrared Herschel photometry from the PEP and HerMES programs is combined with ancillary datasets in the GOODS-N, GOODS-S, and COSMOS fields. Based on this rich dataset, we reproduce the restframe UV to FIR ten-colors distribution of galaxies using a superposition of multi-variate Gaussian modes. The median SED of each mode is then fitted with a modified version of the MAGPHYS code that combines stellar light, emission from dust heated by stars and a possible warm dust contribution heated by an AGN. The defined Gaussian grouping is also used to identify rare sources. The zoology of outliers includes Herschel-detected ellipticals, very blue z~1 Ly-break galaxies, quiescent spirals, and torus-dominated AGN with star formation. Out of these groups and outliers, a new template library is assembled, consisting of 32 SEDs describing the intrinsic scatter in the restframe UV-to-submm colors of infrared galaxies. This library is tested against L(IR) estimates with and without Herschel data included, and compared to eight other popular methods often adopted in the literature. When implementing Herschel photometry, these approaches produce L(IR) values consistent with each other within a median absolute deviation of 10-20%, the scatter being dominated more by fine tuning of the codes, rather than by the choice of SED templates. Finally, the library is used to classify 24 micron detected sources in PEP GOODS fields. AGN appear to be distributed in the stellar mass (M*) vs. star formation rate (SFR) space along with all other galaxies, regardless of the amount of infrared luminosity they are powering, with the tendency to lie on the high SFR side of the "main sequence". The incidence of warmer star-forming sources grows for objects with higher specific star formation rates (sSFR), and they tend to populate the "off-sequence" region of the M*-SFR-z space.Comment: Accepted for publication in A&A. Some figures are presented in low resolution. The new galaxy templates are available for download at the address http://www.mpe.mpg.de/ir/Research/PEP/uvfir_temp

Frequency dependent relaxation rate in the superconducting YBa2Cu3O{6+delta}

The submillimeter-wave 3 cm{-1} < nu < 35 cm{-1} complex conductivity of the reduced YBa2Cu3O{6+delta} film (Tc=56.5 K) was investigated for temperatures 4 K < T < 300 K and compared to the properties of the same film in the optimally doped state. The frequency dependence of the effective quasiparticle scattering rate 1/tau*(nu) was extracted from the spectra. 1/tau*(nu) is shown to be frequency independent at low frequencies and high temperatures. A gradual change to 1/tau*~nu^{1.5} law is observed as temperature decreases. In order to explain the observed temperature dependence of the low frequency spectral weight above Tc, the quasiparticle effective mass is supposed to be temperature dependent for T>Tc.Comment: 4 pages, 4 figure

Data protection risk modeling into business process analysis

We present a novel way to link business process model with data protection risk management. We use established body of knowledge regarding risk manager concepts and business process towards data protections. We try to contribute to the problems that today organizations should find a suitable data protection model that could be used in as a risk framework. The purpose of this document is to define a model to describe data protection in the context of risk. Our approach including the identification of the main concepts of data protection according to the scope of the with EU directive data protection regulation. We outline data protection model as a continuous way of protection valued organization information regarding personal identifiable information. Data protection encompass the preservation of personal data information from unauthorized access, use, modification, recording or destruction. Since this kind of service is offered in a continuous way, it is important to stablish a way to measure the effectiveness of awareness of data subject discloses regrading personal identifiable information.info:eu-repo/semantics/publishedVersio

Change of the Ground State upon Hole Doping Unveiled by Ni Impurity in High-TcT_{\rm c} Cuprates

The electronic ground state in high-$T_{\rm c}$ cuprates where the superconducting state is suppressed by Ni substitution has been investigated in La$_{2-x}$Sr$_x$Cu$_{1-y}$Ni$_y$O$_4$ from the specific heat and muon spin relaxation measurements. It has been found that the ground state changes from a magnetically ordered state with the strong hole-trapping by Ni to a metallic state with the Kondo effect of Ni with increasing hole-concentration. Moreover, the analysis of the results has revealed that a phase separation into the magnetically ordered phase and the metallic phase occurs around the boundary of two phases.Comment: 11pages, 4 figure

The Space Density and Colors of Massive Galaxies at 2<z<3: the Predominance of Distant Red Galaxies

Using the deep multi-wavelength MUSYC, GOODS, and FIRES surveys we construct a stellar mass-limited sample of galaxies at 2<z<3. The sample comprises 294 galaxies with M>10^11 Solar masses distributed over four independent fields with a total area of almost 400 sq arcmin. The mean number density of massive galaxies in this redshift range is (2.2+-0.6) x 10^-4 Mpc^-3. We present median values and 25th and 75th percentiles for the distributions of observed R mags, observed J-K colors, and rest-frame UV continuum slopes, M/L(V) ratios, and U-V colors. The galaxies show a large range in all these properties. The ``median galaxy'' is faint in the observer's optical (R=25.9), red in the observed near-IR (J-K=2.48), has a rest-frame UV spectrum which is relatively flat (beta=-0.4), and rest-frame optical colors resembling those of nearby spiral galaxies (U-V=0.62). We determine which galaxies would be selected as Lyman break galaxies (LBGs) or Distant Red Galaxies (DRGs, having J-K>2.3) in this mass-limited sample. By number DRGs make up 69% of the sample and LBGs 20%, with a small amount of overlap. By mass DRGs make up 77% and LBGs 17%. Neither technique provides a representative sample of massive galaxies at 2<z<3 as they only sample the extremes of the population. As we show here, multi-wavelength surveys with high quality photometry are essential for an unbiased census of massive galaxies in the early Universe. The main uncertainty in this analysis is our reliance on photometric redshifts; confirmation of the results presented here requires extensive near-infrared spectroscopy of optically-faint samples.Comment: Accepted for publication in ApJ Letter