Natural Suppression of Higgsino-Mediated Proton Decay in Supersymmetric SO(10)

In supersymmetric Grand Unified Theories, proton decay mediated by the color--triplet higgsino is generally problematic and requires some fine--tuning of parameters. We present a mechanism which naturally suppresses such dimension 5 operators in the context of SUSY $SO(10)$. The mechanism, which implements natural doublet--triplet splitting using the adjoint higgs, converts these dimension 5 operators effectively into dimension 6. By explicitly computing the higgs spectrum and the resulting threshold uncertainties we show that the successful prediction of $\sin^2\theta_W$ is maintained {\it as a prediction} in this scheme. It is argued that only a weak suppression of the higgsino mediated proton decay is achievable within SUSY $SU(5)$ without fine--tuning, in contrast to a strong suppression in SUSY $SO(10)$.Comment: 39 pages (3 Feynman graphs not included), in Plain LaTeX, BA-93-2

World-Sheet Logarithmic Operators and Target Space Symmetries in String Theory

We discuss the target-space interpretation of the world-sheet logarithmic operators in string theory. These operators generate the normalizable zero modes (discrete states) in target space, which restore the symmetries of the theory broken by the background. The problem of the recoil in string theory is considered, as well as some general properties of string amplitudes containing logarithmic operators.Comment: 22 pages, LaTeX, some minor corrections and references adde

Rapid deglaciation during the Bølling-Allerød Interstadial in the Central Pyrenees and associated glacial and periglacial landforms

The Central Pyrenees hosted a large ice cap during the Late Pleistocene. The cirques under relatively low-altitude peaks (2200-2800 m) include the greatest variety of glacial landforms (moraines, fossil debris-covered glaciers and rock glaciers), but their age and formation process are poorly known. Here, we focus on the headwaters of the Garonne River, namely on the low-altitude Bacivèr Cirque (highest peaks at ~2600 m), with widespread erosive and depositional glacial and periglacial landforms. We reconstruct the pattern of deglaciation from geomorphological observations and a 17-sample dataset of 10Be Cosmic-Ray Exposure (CRE) ages. Ice thickness in the Bacivèr Cirque must have reached ~200 m during the maximum ice extent of the last glacial cycle, when it flowed down towards the Garonne paleoglacier. However, by ~15 ka, during the Bølling-Allerød (B-A) Interstadial, the mouth of the cirque was deglaciated as the tributary glacier shrank and disconnected from the Garonne paleoglacier. Glacial retreat was rapid, and the whole cirque was likely to have been deglaciated in only a few centuries, while paraglacial processes accelerated, leading to the transformation of debris-free glaciers into debriscovered and rock glaciers in their final stages. Climate conditions prevailing at the transition between the B-A and the Younger Dryas (YD) favored glacial growth and the likely development of small moraines within the slopes of the cirque walls by ~12.9 ka, but the dating uncertainties make it impossible to state whether these moraines formed during the B-A or the YD. The melting of these glaciers favored paraglacial dynamics, which promoted the development of rock glaciers as well as debris-covered glaciers. These remained active throughout the Early Holocene until at least ~7 ka. Since then, the landscape of the Bacivèr Cirque has seen a period of relative stability. A similar chronological sequence of deglaciation has been also detected in other cirques of the Pyrenees below 3000 m. As in other mid-latitude mountain regions, the B-A triggered the complete deglaciation of the Garonne paleoglacier and promoted the development of the wide variety of glacial and periglacial landforms existing in the Bacivèr cirque

Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome

Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest. The CHR sample was then followed clinically for a mean of 59.7 months (~5 y), when clinical outcomes were assessed in terms of transition (CHR-T) or non-transition (CHR-NT) to psychosis (CAARMS criteria): during this period, 13 individuals (17%) developed a psychotic disorder (CHR-T) and 63 did not. Functional activation and effective connectivity within a hippocampal-striatal-midbrain circuit were compared between groups. In CHR individuals compared to HC, hippocampal response to novel stimuli was significantly attenuated (P = .041 family-wise error corrected). Dynamic Causal Modelling revealed that stimulus novelty modulated effective connectivity from the hippocampus to the striatum, and from the midbrain to the hippocampus, significantly more in CHR participants than in HC. Conversely, stimulus novelty modulated connectivity from the midbrain to the striatum significantly less in CHR participants than in HC, and less in CHR participants who subsequently developed psychosis than in CHR individuals who did not become psychotic. Our findings are consistent with preclinical evidence implicating hippocampal-striatal-midbrain circuit dysfunction in altered salience processing and the onset of psychosis

Quantum Phase Space from String Solitons

In this paper we view the sigma-model couplings of appropriate vertex operators describing the interaction of string matter with a certain type of string solitons (0-branes) as the quantum phase space of a point particle. The sigma-model is slightly non critical, and therefore one should dress it with a Liouville mode. Quantization is achieved by summing over world-sheet genera (in the pinched approximation). To leading order in the coupling constant expansion, the quantization reproduces the usual quantum mechanical commutator. We attempt to go beyond leading order and we reproduce the generalized string uncertainty principle.Comment: 32 pages LATEX, correction of a minor typo in formula (88

Local habitat filtering shapes microbial community structure in four closely spaced lakes in the High Arctic

Arctic lakes are experiencing increasingly shorter periods of ice cover due to accelerated warming at northern high latitudes. Given the control of ice cover thickness and duration over many limnological processes, these changes will have pervasive effects. However, due to their remote and extreme locations even first-order data on lake ecology is lacking for many ecosystems. The aim of this study was to characterize and compare the microbial communities of four closely spaced lakes in Stuckberry Valley (northern Ellesmere Island, Canadian Arctic Archipelago), in the coastal margin zone of the Last Ice Area, that differed in their physicochemical, morphological and catchment characteristics. We performed high-throughput amplicon sequencing of the V4 16S rRNA gene to provide inter- and intra-lake comparisons. Two deep (>25 m) and mostly oxygenated lakes showed highly similar community assemblages that were distinct from those of two shallower lakes (<10 m) with anoxic bottom waters. Proteobacteria, Verrucomicrobia, and Planctomycetes were the major phyla present in the four water bodies. One deep lake contained elevated proportions of Cyanobacteria and Thaumarchaeota that distinguished it from the others, while the shallow lakes had abundant communities of predatory bacteria, as well as microbes in their bottom waters that contribute to sulfur and methane cycles. Despite their proximity, our data suggest that local habitat filtering is the primary determinant of microbial diversity in these systems. This study provides the first detailed examination of the microbial assemblages of the Stuckberry lakes system, resulting in new insights into the microbial ecology of the High Arctic

Financial crises and the attainment of the SDGs: an adjusted multidimensional poverty approach

This paper analyses the impact of financial crises on the Sustainable Development Goal of eradicating poverty. To do so, we develop an adjusted Multidimensional Poverty Framework (MPF) that includes 15 indicators that span across key poverty aspects related to income, basic needs, health, education and the environment. We then use an econometric model that allows us to examine the impact of financial crises on these indicators in 150 countries over the period 1980–2015. Our analysis produces new estimates on the impact of financial crises on poverty’s multiple social, economic and environmental aspects and equally important captures dynamic linkages between these aspects. Thus, we offer a better understanding of the potential impact of current debt dynamics on Multidimensional Poverty and demonstrate the need to move beyond the boundaries of SDG1, if we are to meet the target of eradicating poverty. Our results indicate that the current financial distress experienced by many low-income countries may reverse the progress that has been made hitherto in reducing poverty. We find that financial crises are associated with an approximately 10% increase of extreme poor in low-income countries. The impact is even stronger in some other poverty aspects. For instance, crises are associated with an average decrease of government spending in education by 17.72% in low-income countries. The dynamic linkages between most of the Multidimensional Poverty indicators, warn of a negative domino effect on a number of SDGs related to poverty, if there is a financial crisis shock. To pre-empt such a domino effect, the specific SDG target 17.4 on attaining long-term debt sustainability through coordinated policies plays a key role and requires urgent attention by the international community

Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction

Background: This study was designed to investigate the association of the 894G>T polymorphism in the eNOS gene with risk of acute myocardial infarction (AMI), extent of coronary artery disease (CAD) on coronary angiography, and in-hospital mortality after AMI. Methods: We studied 1602 consecutive patients who were enrolled in the GEMIG study. The control group was comprised by 727 individuals, who were randomly selected from the general adult population. Results: The prevalence of the Asp298 variant of eNOS was not found to be significantly and independently associated with risk of AMI (RR = 1.08, 95%CI = 0.77–1.51, P = 0.663), extent of CAD on angiography (OR = 1.18, 95%CI = 0.63–2.23, P = 0.605) and in-hospital mortality (RR = 1.08, 95%CI = 0.29–4.04, P = 0.908). Conclusion: In contrast to previous reports, homozygosity for the Asp298 variant of the 894G>T polymorphism in the eNOS gene was not found to be associated with risk of AMI, extent of CAD and in-hospital mortality after AM

Biodiversity patterns of Arctic diatom assemblages in lakes and streams: Current reference conditions and historical context for biomonitoring

Comprehensive assessments of contemporary diatom distributions across the Arctic remain scarce. Furthermore, studies tracking species compositional differences across space and time, as well as diatom responses to climate warming, are mainly limited to paleolimnological studies due to a lack of routine monitoring in lakes and streams across vast areas of the Arctic. The study aims to provide a spatial assessment of contemporary species distributions across the circum-Arctic, establish contemporary biodiversity patterns of diatom assemblages to use as reference conditions for future biomonitoring assessments, and determine pre-industrial baseline conditions to provide historical context for modern diatom distributions. Diatom assemblages were assessed using information from ongoing regulatory monitoring programmes, individual research projects, and from surface sediment layers obtained from lake cores. Pre-industrial baseline conditions as well as the nature, direction and magnitude of changes in diatom assemblages over the pastc.200 years were determined by comparing surface sediment samples (i.e. containing modern assemblages) with a sediment interval deposited prior to the onset of significant anthropogenic activities (i.e. containing pre-1850 assemblages), together with an examination of diatoms preserved in contiguous samples from dated sediment cores. We identified several biotypes with distinct diatom assemblages using contemporary diatom data from both lakes and streams, including a biotype typical for High Arctic regions. Differences in diatom assemblage composition across circum-Arctic regions were gradual rather than abrupt. Species richness was lowest in High Arctic regions compared to Low Arctic and sub-Arctic regions, and higher in lakes than in streams. Dominant diatom taxa were not endemic to the Arctic. Species richness in both lakes and streams reached maximum values between 60 degrees N and 75 degrees N but was highly variable, probably reflecting differences in local and regional environmental factors and possibly sampling effort. We found clear taxon-specific differences between contemporary and pre-industrial samples that were often specific to both ecozone and lake depth. Regional patterns of species turnover (beta-diversity) in the pastc.200 years revealed that regions of the Canadian High Arctic and the Hudson Bay Lowlands to the south showed most compositional change, whereas the easternmost regions of the Canadian Arctic changed least. As shown in previous Arctic diatom studies, global warming has already affected these remote high latitude ecosystems. Our results provide reference conditions for future environmental monitoring programmes in the Arctic. Furthermore, diatom taxa identification and harmonisation require improvement, starting with circum-Arctic intercalibrations. Despite the challenges posed by the remoteness of the Arctic, our study shows the need for routine monitoring programmes that have a wide geographical coverage for both streams and lakes

The Sliding-singlet Mechanism Revived

It is shown, using a modification of an idea of Sen, that completely realistic supersymmetric grand-unified theories based on SU(6) or larger unitary groups can be constructed using the sliding-singlet mechanism. These models have a simple structure, preserve the successful prediction of $\sin^2 \theta_W$, and can suppress Higgsino-mediated proton decay to an acceptable level in a simple way.Comment: xx pages, LaTeX. Note adde