Hepatitis B Virus, Hepatitis C Virus and Human Immunodeficiency Virus Infections among Pregnant Women in Central Sudan

Background: The epidemiology of viral hepatitis and Human immunodeficiency virus (HIV) during pregnancy is of great importance for health planners and program managers. However, few published data on viral hepatitis and HIV are available in Sudan especially during pregnancy.Objectives: The current study was conducted to investigate seropositivity of hepatitis B, hepatitis C, and HIV among pregnant women in central Sudan.Materials and methods: A cross sectional study was conducted where 396 pregnant women were investigated for the presence of hepatitis B, C and HIV. Enzyme linked immunosorbent assay (ELISA) was used to detect HBsAg and anti-HCV. Antibodies to HIV were detected by three different methods as per Strategy III of the National AIDS Control Organization by utilizing different systems of testing to make a diagnosis of HIV.Results: Twenty (5.1%), five (1.3%), and six (1.5%) women were seropositive for HBsAg anti- HCV antibodies and HIV, respectively. One (0.003 %) woman was seropositive for both HBsAg and anti-HCV antibodies. While age, parity, were not associated with seropostivtiy of HBsAg, home delivery was the only significant risk factor for seropostivtiy of HBsAg (OR=4.5 (95% CI=1.2-16.7)Conclusion: Prevalence of HBV and HCV among pregnant women in this setting is in the intermediate zone of endemicity. This is alarming and should draw medical authorities’ attention if vertical transmission is to be reduced.Key words: Sudan, hepatitis B, hepatitis C, HIV, seropositivity, Pregnancy

Ionospheric currents estimated simultaneously from CHAMP satelliteand IMAGE ground-based magnetic field measurements: a statisticalstudy at auroral latitudes

One important contribution to the magnetic field measured at satellite altitude and at ground level comes from the external currents. We used the total field data sampled by the Overhauser Magnetometer on CHAMP and the horizontal magnetic field measurements of the IMAGE ground-based magnetometer network to study the ionospheric Hall current system in the auroral regions. For the CHAMP data a current model consisting of a series of lines and placed at a height of 110km is fitted to the magnetic field signature sampled on the passage across the polar region. The derived current distributions depend, among others, on season and on the local time of the satellite track. At dawn/dusk the auroral electrojets can be detected most clearly in the auroral regions. Their intensity and location are evidently correlated with the <i>A E</i> activity index. For a period of almost two years the results obtained from space and the currents determined from ground-based observations are studied. For the full IMAGE station array a newly-developed method of spherical elementary current systems (SECS) is employed to compute the 2-D equivalent current distribution, which gives a detailed picture of an area covering latitudes 60° – 80° N and 10° – 30° E in the auroral region. Generally, the current estimates from satellite and ground are in good agreement. The results of this survey clearly show the average dependence of the auroral electrojet on season and local time. This is particularly true during periods of increased auroral activity. The correlation coefficient of the results is close to one in the region of sizeable ionospheric current densities. Also the ratio of the current densities, as determined from above and below the ionosphere, is close to unity. It is the first time that the method of Hall current estimate from a satellite has been validated quantitatively by ground-based observations. Among others, this result is of interest for magnetic main field modelling, since it demonstrates that ground-based observations can be used to predict electrojet signatures in satellite magnetic field scalar data.<br><br> <b>Key words.</b> Ionosphere (auroral Ionosphere; electric fields and currents; ionosphere-magnetosphere interactions

Epicatechin content and antioxidant capacity of cocoa beans from four different countries

Natural antioxidant has received more attention to be part of daily diet. Cocoa beans is one of the main sources of polyphenols especially epicatechin. This study was conducted to investigate the relationship between antioxidant potential and epicatechin content of raw cocoa beans from different countries, namely Malaysia, Ghana, Cote d’Ivoire and Sulawesi (Indonesia). Antioxidant potential was determined using trolox-equivalent antioxidant capacity (TEAC) and ferric reducing antioxidant power (FRAP) assays. Reversed-phase high performance liquid chromatography (HPLC) was used to quantify the amount of epicatechin. The epicatechin content of raw cocoa beans was in the range of 270 - 1235mg/100 g cocoa beans. Based on the two assays, Sulawesian beans exhibited the highest antioxidant capacity followed by Malaysian, Ghanaian and Cote d’Ivoirian beans for both extracts. Both ethanolic (r= 0.92) and water (r = 0.90) extracts of cocoa beans showed a significant positive and high correlation between epicatechin and TEAC value. Similarly, FRAP assay also showed a positive and high correlation with epicatechin for both ethanolic (r = 0.84) and water (r = 0.79) extracts. Results indicatedthat antioxidant capacity using two different antioxidant assays exhibited a positive and high correlation with epicatechin content in cocoa beans. Thus, epicatechin content in cocoa beans could be responsible for the antioxidant capacity

Temporal response to harmonic driving in electroconvection

The temporal evolution of the spatially periodic electroconvection (EC) patterns has been studied within the period of the driving ac voltage by monitoring the light intensity diffracted from the pattern. Measurements have been carried out on a variety of nematic systems, including those with negative dielectric and positive conductivity anisotropy, exhibiting "standard EC" (s-EC), those with both anisotropies negative exhibiting "non-standard EC" (ns-EC), as well as those with the two anisotropies positive. Theoretical predictions have been confirmed for stationary s-EC and ns-EC patterns. Transitions with Hopf bifurcation have also been studied. While traveling had no effect on the temporal evolution of dielectric s-EC, traveling conductive s-EC and ns-EC patterns exhibited a substantially altered temporal behavior with a dependence on the Hopf frequency. It has also been shown that in nematics with both anisotropies positive, the pattern develops and decays within an interval much shorter than the period, even at relatively large driving frequencies.Comment: 19 pages, 5 figure

Pathological macromolecular crystallographic data affected by twinning, partial-disorder and exhibiting multiple lattices for testing of data processing and refinement tools

Twinning is a crystal growth anomaly, which has posed a challenge in macromolecular crystallography (MX) since the earliest days. Many approaches have been used to treat twinned data in order to extract structural information. However, in most cases it is usually simpler to rescreen for new crystallization conditions that yield an untwinned crystal form or, if possible, collect data from non-twinned parts of the crystal. Here, we report 11 structures of engineered variants of the E. coli enzyme N-acetyl-neuraminic lyase which, despite twinning and incommensurate modulation, have been successfully indexed, solved and deposited. These structures span a resolution range of 1.45–2.30 Å, which is unusually high for datasets presenting such lattice disorders in MX and therefore these data provide an excellent test set for improving and challenging MX data processing programs

Ionospheric conductances derived from satellite measurements of auroral UV and X-ray emissions, and ground-based electromagnetic data: a comparison

International audienceGlobal instantaneous conductance maps can be derived from remote sensing of UV and X-ray emissions by the UVI and PIXIE cameras on board the Polar satellite. Another technique called the 1-D method of characteristics provides mesoscale instantaneous conductance profiles from the MIRACLE ground-based network in Northern Scandinavia, using electric field measurements from the STARE coherent scatter radar and ground magnetometer data from the IMAGE network. The method based on UVI and PIXIE data gives conductance maps with a resolution of ~800km in space and ~4.5min in time, while the 1-D method of characteristics establishes conductances every 20s and with a spatial resolution of ~50km. In this study, we examine three periods with substorm activity in 1998 to investigate whether the two techniques converge when the results from the 1-D method of characteristics are averaged over the spatial and temporal resolution of the UVI/PIXIE data. In general, we find that the calculated conductance sets do not correlate. However, a fairly good agreement may be reached when the ionosphere is in a state that does not exhibit strong local turbulence. By defining a certain tolerance level of turbulence, we show that 14 of the 15 calculated conductance pairs during relatively uniform ionospheric conditions differ less than ±30%. The same is true for only 4 of the 9 data points derived when the ionosphere is in a highly turbulent state. A correlation coefficient between the two conductance sets of 0.27 is derived when all the measurements are included. By removing the data points from time periods when too much ionospheric turbulence occurs, the correlation coefficient raises to 0.57. Considering the two very different techniques used in this study to derive the conductances, with different assumptions, limitations and scale sizes, our results indicate that simple averaging of mesoscale results allows a continuous transition to large-scale results. Therefore, it is possible to use a combined approach to study ionospheric events with satellite optical and ground-based electrodynamic data of different spatial and temporal resolutions. We must be careful, though, when using these two techniques during disturbed conditions. The two methods will only give results that systematically converge when relatively uniform conditions exist

EISCAT and Cluster observations in the vicinity of the dynamical polar cap boundary

The dynamics of the polar cap boundary and auroral oval in the nightside ionosphere are studied during late expansion and recovery of a substorm from the region between Tromsø (66.6° cgmLat) and Longyearbyen (75.2° cgmLat) on 27 February 2004 by using the coordinated EISCAT incoherent scatter radar, MIRACLE magnetometer and Cluster satellite measurements. During the late substorm expansion/early recovery phase, the polar cap boundary (PCB) made zig-zag-type motion with amplitude of 2.5° cgmLat and period of about 30 min near magnetic midnight. We suggest that the poleward motions of the PCB were produced by bursts of enhanced reconnection at the near-Earth neutral line (NENL). The subsequent equatorward motions of the PCB would then represent the recovery of the merging line towards the equilibrium state (Cowley and Lockwood, 1992). The observed bursts of enhanced westward electrojet just equatorward of the polar cap boundary during poleward expansions were produced plausibly by particles accelerated in the vicinity of the neutral line and thus lend evidence to the Cowley-Lockwood paradigm. <br><br> During the substorm recovery phase, the footpoints of the Cluster satellites at a geocentric distance of 4.4 <I>R<sub>E</sub></I> mapped in the vicinity of EISCAT measurements. Cluster data indicate that outflow of H<sup>+</sup> and O<sup>+</sup> ions took place within the plasma sheet boundary layer (PSBL) as noted in some earlier studies as well. We show that in this case the PSBL corresponded to a region of enhanced electron temperature in the ionospheric F region. It is suggested that the ion outflow originates from the F region as a result of increased ambipolar diffusion. At higher altitudes, the ions could be further energized by waves, which at Cluster altitudes were observed as BBELF (broad band extra low frequency) fluctuations. <br><br> The four-satellite configuration of Cluster revealed a sudden poleward expansion of the PSBL by 2° during ~5 min. The beginning of the poleward motion of the PCB was associated with an intensification of the downward FAC at the boundary. We suggest that the downward FAC sheet at the PCB is the high-altitude counterpart of the Earthward flowing FAC produced in the vicinity of the magnetotail neutral line by the Hall effect (Sonnerup, 1979) during a short-lived reconnection pulse

Direct observation of twist mode in electroconvection in I52

I report on the direct observation of a uniform twist mode of the director field in electroconvection in I52. Recent theoretical work suggests that such a uniform twist mode of the director field is responsible for a number of secondary bifurcations in both electroconvection and thermal convection in nematics. I show here evidence that the proposed mechanisms are consistent with being the source of the previously reported SO2 state of electroconvection in I52. The same mechanisms also contribute to a tertiary Hopf bifurcation that I observe in electroconvection in I52. There are quantitative differences between the experiment and calculations that only include the twist mode. These differences suggest that a complete description must include effects described by the weak-electrolyte model of electroconvection

IMF effect on the polar cap contraction and expansion during a period of substorms

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