Metaphors and idioms that hurt

Amb aquest article pretenem mostrar la importància del context i de les emocions per tal de descodificar el significat de frases fetes construïdes principalment mitjançant metàfores centrades en parts del cos humà. A partir de la teoria de la Integració Conceptual de Fauconnier i Turner mostrarem com podem explicar que en determinades situacions activem el sentit literal originari de la frase feta descodificant cada una de les seves unitats per separat en comptes de, com succeeix normalment, tractar-la en bloc per accedir al seu significat metafòric o figurat.With this article we try to show the importance of the context and the emotions to decode the meaning of idioms principally constructed by means of metaphors centred on parts of the human body. From the theory of Conceptual Integration by Fauconnier and Turner we will show that we can explain that in certain situations we activate the literal original sense of the idiom decoding each of its units separately instead of, as it happens normally, treating it in a block to accede to its metaphorical or figurative meaning

Metaphors and idioms that hurt

Amb aquest article pretenem mostrar la importància del context i de les emocions per tal de descodificar el significat de frases fetes construïdes principalment mitjançant metàfores centrades en parts del cos humà. A partir de la teoria de la Integració Conceptual de Fauconnier i Turner mostrarem com podem explicar que en determinades situacions activem el sentit literal originari de la frase feta descodificant cada una de les seves unitats per separat en comptes de, com succeeix normalment, tractar-la en bloc per accedir al seu significat metafòric o figurat.With this article we try to show the importance of the context and the emotions to decode the meaning of idioms principally constructed by means of metaphors centred on parts of the human body. From the theory of Conceptual Integration by Fauconnier and Turner we will show that we can explain that in certain situations we activate the literal original sense of the idiom decoding each of its units separately instead of, as it happens normally, treating it in a block to accede to its metaphorical or figurative meaning

Evolución de la mortalidad por cáncer de mama y diseminación de la mamografía de cribado en Cataluña: un análisis por regiones sanitarias

Fundamento: El descenso de las tasas de mortalidad por cáncer de mama (CM) se ha atribuido a la implantación de programas de cribado y a avances terapéuticos. El objetivo de este trabajo es comparar la evolución de su mortalidad en las regiones sanitarias de Cataluña en el periodo 1993-2007. Paralelamente, se ha analizado la diseminación de la mamografía periódica en las regiones sanitarias. Métodos: Se analizaron los datos del registro de mortalidad y encuestas de salud. Se utilizaron regresiones de Poisson y «joinpoint» para comparar las tasas de mortalidad por CM y analizar su evolución temporal. Se utilizaron modelos de efectos mixtos para comparar el nivel y la evolución de la mortalidad por regiones. Resultados. La tasa de mortalidad por CM descendió un 3% anual en Cataluña. Entre 1993 y 2007, la tasa estandarizada varió de 34,8 a 23,3 por 100.000 mujeres. Barcelona ciutat presentó unas tasas de mortalidad más elevadas que las regiones Centre (ratio de tasas (RT)=0,87), Costa de Ponent (RT=0,89), Tarragona (RT=0,9) y Lleida (RT=0,915), pero estas diferencias tendieron a desaparecer. No se observaron cambios de tendencia en la evolución de la mortalidad de las regiones, excepto en la región Centre. Durante los años 1990 Barcelona ciutat presentó unos porcentajes de utilización de mamografía periódica del 36,1% de las mujeres de 40-74 años, en la encuesta de 1994, la región Centre (23,7%) y Costa de Ponent (25,2%). Conclusiones: La progresiva utilización de mamografía periódica y la disminución de la mortalidad por CM fueron similares en las regiones sanitarias de Cataluña.Background: The decrease of breast cancer (BC) mortality rates has been attributed to early detection programs and therapeutic advances. The objective is to compare BC mortality trend in health regions of Catalonia during the period 1993-2007. In parallel, dissemination of periodic mammography in the health regions has been analyzed. Methods: Mortality and health surveys data were used. Poisson and «joinpoint» regression analyses were used to compare regional BC mortality rates and quantify their temporal evolution. Mixed effects models were used to compare the rates and their evolution by region. Results: The BC mortality rate decreased 3% annually in Cataluña. Between 1993 and 2007, the standard mortality rate changed from 34.8 to 23.3 per 100,000 women. Barcelona ciutat showed higher mortality rates than the Centre (rate ratio (RR)=0.873), Costa de Ponent (RR=0.885), Tarragona (RR=0.9) and Lleida regions (RR=0.915), but these differences tend to disappear over time. There were no observed trend changes in the evolution of the regional mortality rates, except in the Centre region. The use of periodic mammography was similar across health regions. During the 90s, Barcelona ciutat had a 36.1% utilization of periodic mammography in women aged 40-74, in the 1994 survey, the Centre 23.7 and Costa de Ponent 25.2%. Conclusions: The progressive increase in the use of periodic mammography and the decrease of BC mortality were similar in the eight health regions of Catalonia

3D characterization of a Boston Ivy double-skin green building facade using a LiDAR system

On the way to more sustainable and resilient urban environments, the incorporation of urban green infrastructure (UGI) systems, such as green roofs and vertical greening systems, must be encouraged. Unfortunately, given their variable nature, these nature-based systems are difficult to geometrically characterize, and therefore there is a lack of 3D objects that adequately reflect their geometry and analytical properties to be used in design processes based on Building Information Modelling (BIM) technologies. This fact can be a disadvantage, during the building's design phase, of UGIs over traditional grey solutions. Areas of knowledge such as precision agriculture, have developed technologies and methodologies that characterize the geometry of vegetation using point cloud capture. The main aim of this research was to create the 3D characterization of an experimental double-skin green facade, using LiDAR technologies. From the results it could be confirmed that the methodology used was precise and robust, enabling the 3D reconstruction of the green facade's outer envelope. Detailed results were that foliage volume differences in height were linked to plant growth, whereas differences in the horizontal distribution of greenery were related to the influence of the local microclimate and specific plant diseases on the south orientation. From this research, along with complementary previous research, it could be concluded that, generally speaking, with vegetation volumes of 0.2 m3/m2, using Boston Ivy (Parthenocissus Tricuspidata) under Mediterranean climate, reductions in external building surface temperatures of around 13 °C can be obtained and used as analytic parameter in a future 3D-BIM-object.The authors at GREiA research group would like to thank the Catalan Government for the quality accreditation given to their research group (2017 SGR 1537). GREiA is a certified agent TECNIO in the category of technology developers from the Government of Catalonia. The authors at GRAP research group would like to thank the Secretaria d’Universitats i Recerca del Departament d’Empresa i Coneixement de la Generalitat de Catalunya (grant 2017 SGR 646), the Spanish Ministry of Economy and Competitiveness (project AGL2013-464 48297-C2-2-R) and the Spanish Ministry of Science, Innovation and Universities (project RTI2018-094222-B-I00). This work is partially supported by ICREA under the ICREA Academia programme. The authors also wish to thank Dr. Jaume Arnó for his contribution in the statistical analysis of the results

Nitrate pollution of groundwater, all right... but nothing else?

Contamination from agricultural sources and, in particular, nitrate pollution, is one of the main concerns in groundwater management. However, this type of pollution entails the entrance of other substances into the aquifer, as well as it may promote other processes. In this study, we deal with hydrochemical and isotopic analysis of groundwater samples from four distinct zones in Catalonia (NE Spain), which include different lithological units, to investigate the influence of manure fertilization on the overall hydrochemical composition of groundwater. Results indicate that high nitrate concentrations, resulting from intense manure application, homogenize the contents of the major dissolved ions (i.e.; Cl-, SO42-, Ca2+, Na+, K+, and Mg2+). Moreover, positive linear relationships between nitrate and some ions are found indicating the magnitude of the fertilization impact on groundwater hydrochemistry. Nevertheless, the increasing concentration of specific ions is not only attributed to the manure input, but to the enhancing effect of manure and slurry upon the biogeochemical processes that control water-rock interactions. Such results raise awareness that such processes should be evaluated in advance in order to assess adequate groundwater resources assessmen

Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFβ1

Background Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of unknown aetiology and poor prognosis, characterized by altered tissue repair and fibrosis. The extracellular matrix (ECM) is a critical component in regulating cellular homeostasis and appropriate wound healing. The aim of our study was to determine the expression profile of highlighted ECM proteins in IPF lungs. Methods ECM gene and protein expression was analyzed by cDNA microarrays, rt-PCR, immunohistochemistry and western-blot in lungs from idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP), categorized as chronic (cHP) and subacute (saHP), and healthy lung tissue. Primary fibroblast cultures from normal subjects and fibrotic patients were studied to evaluate tenascin-C (TNC) synthesis. Results A total of 20 ECM proteins were upregulated and 6 proteins downregulated in IPF. TNC was almost undetected in normal lungs and significantly upregulated in fibrotic lungs (IPF and cHP) compared to saHP. Furthermore, it was located specifically in the fibroblastic foci areas of the fibrotic lung with a subepithelial gradient pattern. TNC levels were correlated with fibroblastic foci content in cHP lungs. Versican and fibronectin glycoproteins were associated with TNC, mainly in fibroblastic foci of fibrotic lungs. Fibroblasts from IPF patients constitutively synthesized higher levels of TNC than normal fibroblasts. TNC and α-sma was induced by TGF-β1 in both fibrotic and normal fibroblasts. TNC treatment of normal and fibrotic fibroblasts induced a non-significant increased α-sma mRNA. Conclusions The difference in ECM glycoprotein content in interstitial lung diseases could contribute to the development of lung fibrosis. The increase of TNC in interstitial areas of fibrotic activity could play a key role in the altered wound healing

Estrategias de conservación para Cotoneaster granatensis (Rosaceae), especie catalogada En Peligro de Extinción en la Comunitat Valenciana (España)

Cotoneaster granatensis (Rosaceae) is an endangered species in the Valencian Community with two natural populations known and 37 wild plants located in Alicante province. The strategy applied for conservation of this species comprises three steps in a cyclical method: in situ (first step) - ex situ - in situ (second step). Current conservation status for this species has been evaluated as a part of the first step in situ actions. Ex situ conservation activities consisted of germplasm conservation on seed banks, creation and maintenance of collections of livings plants and production of new plants in order to develop reintroductions (in situ actions: second step) in natural populations. The seed germination is a complex issue, but an effective protocol has been established reaching values over 60% of germination. The plant propagation by cuttings has not been successful. In situ actions such as reducing the threat of herbivory has been also essential to enhance natural populations. The initial results on plantations in the natural habitat show high survival rates of specimens

Angioma esplénico de células litorales

A 62-year-old man with a medical history of a painful abdominal mass in left upper quadrant and general symptoms, who was classified initially as an unresectable sarcoma. He received chemotherapy and radiotherapy with no response, so he underwent a new surgery, finding a heterogeneous tumor with immunohistochemical consistent with littoral cell angioma. Littoral cell angioma (LCA) is a rare splenic lesion that presents general symptoms, so there are not many reports, which requires surgical management. Is usually an asymptomatic neoplasm of incidental finding, affecting both sexes equally, whose diagnosis is histological and immunohistochemical with a good prognosis always after a surgical approach.Presentamos el caso de un paciente varón de 62 años con masa dolorosa en hipocondrio izquierdo catalogado inicialmente como sarcoma irresecable, recibió quimioterapia y radioterapia sin respuesta, motivo por el cual se reintervino quirúrgicamente hallándose un tumor dependiente de bazo heterogéneo con perfil inmunohistoquímico de angioma de células litorales. El angioma de células litorales (ACL) es una lesión esplénica poco frecuente que se presenta asociado a síntomas genéricos como astenia, dolor regional y baja de peso, que requiere como manejo principal un abordaje quirúrgico. Suele ser una neoplasia asintomática de hallazgo incidental, afecta a ambos sexos por igual, cuyo diagnóstico es básicamente histológico e inmunohistoquímico con buen pronóstico luego de un abordaje quirúrgico inicial

Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells.

Background and aim: Extracellular matrix (ECM) components released during excessive fat mass expansion are considered potential endogenous danger/alarm signals contributing to innate immune system activation. The aim of the current study was to specifically measure plasma levels of low molecular weight (LMW) hyaluronan (HA) and to evaluate its role as pro-inflammatory damage-associated molecular pattern (DAMP) on leukocyte response in the context of human obesity. Subjects and methods: Participants were selected according to their body mass index (BMI, kg/m2) as non-obese (BMI 29.9, n = 33). Plasma samples were size-dependent fractionated using ion-exchange chromatography to specifically obtain LMW HA fractions that were subsequently quantified by ELISA. Cell incubation experiments with synthetic HA molecules were performed on freshly Ficoll-isolated neutrophils (PMN) and peripheral blood monocytes (PBMC). Leukocyte and adipose tissue gene expression was assessed by real-time PCR and NF-κB activation by western blot. Plasma cytokine levels were measured by fluorescent bead-based (Luminex) immunoassay. Results: We observed a statistically significant increase in the circulating levels of HA fragments of LMW in individuals with obesity which were consistent with significant up-regulated expression of the LMW HA synthesizing enzyme hyaluronan synthase-1 (HAS-1) in obese adipose tissue. Gene expression assessment of HA receptors revealed up-regulated levels for TLR2 in both obese PMN and PBMC. Synthetic HA molecules of different sizes were tested on leukocytes from healthy donors. LMW HA fragments (15-40 kDa) and not those from intermediate molecular sizes (75-350 kDa) induced a significant up-regulation of the expression of major pro-inflammatory cytokines such as IL-1β, MCP-1 and IL-8 in PBMC. Importantly, LMW HA was able to induce the phosphorylation of IKK α/β complex supporting its pro-inflammatory role through NF-κB activation. Conclusion: Circulating LMW HA molecules are elevated in obesity and may play an important role in triggering low-grade inflammation and the development of metabolic complications