DERMATOPOLYMYOSITES PARANEOPLASIQUES. A PROPOS DE 06 CAS

Introduction: Adult dermatopolymyositis is associated with cancer in 15 to 50% of cases. The aim of our study was to search for predictive factors of cancer among adults with dermatomyositis. Methods: We made a retrospective survey of 1981 to 2005 to the department of Dermatology Ibn Sina of Rabat. We collected 44 cases of DM. The parameters assessed were: age, gender, cutaneous extension lesion, cutaneous necrosis, muscular weakness, articular reach, muscular enzymes, intensity of the inflammatory syndrome, electromyographic abnormalitis and the improvement or not with the corticothérapie. Results: cancers were diagnosed in six cases. Mean age was of 65 years and sex-ratio (F/H) was 2.the beginning was brutal with muscular weakness in 1/3 of cases, none of our patients didn't have a skin necrosis. The 2 / 3 of our patients had normal muscular enzymes. The VS was accelerated for 04 of our patients. Our patients didn't improve whith the corticothérapie. Conclusion: In our limited set, the advanced age, muscular weakness, articular reach, inflammatory syndrome, electromyographic abnormalities, the no improvement with the corticothérapie seemed to be prédictive.Introduction : Les dermatopolymyosites de l’adulte sont associées à une néoplasie dans 15 à 50% des cas. L’objectif de notre étude était de rechercher les signes cliniques et paracliniques prédictifs  de l’association DM et néoplasie. Matériel et méthodes: Nous avons réalisé une étude rétrospective de 1981 à 2005 au service de dermatologie du CHU Ibn Sina de Rabat. Nous avons collecté 44 cas de DM. Les critères évalués étaient : l’âge, le sexe, l’extension des lésions cutanées, la nécrose cutanée, l’intensité de l’atteinte musculaire, l’atteinte articulaire, les enzymes musculaires, l’intensité du syndrome inflammatoire,  anomalies eléctromyographiques et l’absence ou la réponse à la corticothérapie. Résultats : Six  malades sur 44 étudiés avait une néoplasie associée, soit 14,28% .L’âge moyen était  de 65 ans, Le sexe ratio H/F était de deux .Le mode de début était brutal avec une atteinte musculaire intense dans un tiers des cas, aucun de nos malades n’avait une nécrose cutanée. Les deux tiers de nos patients avaient un taux d’enzymes musculaires normal. La vitesse de sédimentation (VS) était accélérée pour quatre de nos malades. Nos malades n’ont pas répondu à la corticothérapie. Conclusion : Dans notre série limitée, l’âge avancé, l’intensité de l’atteinte musculaire, l’atteinte articulaire, le syndrome inflammatoire, les anomalies électromyographiques, et la non réponse à la corticothérapie semblaient être prédictifs

Evaluation of the psychometric properties of the SF-36 health survey for use among Turkish and Moroccan ethnic minority populations in the Netherlands

Purpose: To evaluate the psychometrics of the SF-36 Health Survey among Turkish and Moroccan ethnic minority populations in the Netherlands and to compare the results to those based on the indigenous Dutch population. Methods: Data were derived from the Second Dutch National Survey of General Practice. In total, SF-36 data were available for 409 Turkish, 377 Moroccan, and 9,628 Dutch respondents. Language subgroup analyses were performed for the Turkish (n = 162) and Moroccan-Arabic (n = 52) versions of the SF-36. Psychometric properties were evaluated by descriptive statistics, factor analysis, internal consistency estimates, known-group comparisons, and differential item function (DIF) analysis. Results Low levels of missing SF-36 data were observed across all groups. Confirmatory factor analysis supported the hypothesized SF-36 scale structure for the Dutch and Turkish group, but high correlations between the MH and VT factors were observed in the Moroccan group. All Cronbach’s alpha coefficients were above 0.70, except for the Vitality scale in the Moroccan group and the Vitality and Social Functioning scales in the Moroccan-Arabic language subgroup. Known-groups validity was found across samples using age, sex, education, and comorbidity as grouping variables, but not marital status. Some evidence for DIF was found in both ethnic group samples. Conclusions: The results generally support the use of the SF-36 for general population research among Turkish and Moroccan ethnic minorities in the Netherlands. Additional studies are needed to confirm the psychometrics of the questionnaire when used among these populations in other Western European countries. (aut. ref.

Sedimentology and geochemistry of lacustrine terraces of three Middle Atlas lakes: Paleohydrological changes for the last 2300 cal BP in Morocco (western Mediterranean region)

International audienceIn the Moroccan Middle Atlas Mountains, three lakes were used to characterize climate variability in the late Holocene. The methodology is based on sedimentological, geochemical, and mineralogical analysis of lacustrine terraces. Lake Ifrah is a natural lake. Waters are calc-magnesian, relatively very alkaline and oxygenated. Lake Afourgagh is of karst origin, with maximum depth 1.5 m. Lake Iffer is a smaller lake, sub-circular and relatively deep. Its area is 3.5 ha. Its maximum depth is 6.5 m at the center of the lake. Seven terraces located in the borders of the lakes were sampled and studied. Seven radiocarbon dates were obtained on organic matter and shells. The time period concerned is between 2300 cal BP and 400 cal BP. The results show high lake levels at about 2300 cal BP related probably to the wetter Iberian - Roman period in northern Mediterranean. Lake Iffer was deeper by about 30 m from its current level. 1000 cal BP probably marks the beginning of the decline with a drop in lake level of 20 m, which is ongoing in connection with drier climate and the beginning of the medieval climate anomaly. (C) 2015 Elsevier Ltd and INQUA. All rights reserved

Bilan d'hospitalisation du service de dermatologie-v&#233n&3233rologie du CHU Ibn Sina Rabat Maroc

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Historical epidemiology of hepatitis C virus in select countries-volume 4

Due to the introduction of newer, more efficacious treatment options, there is a pressing need for policy makers and public health officials to develop or adapt national hepatitis C virus (HCV) control strategies to the changing epidemiological landscape. To do so, detailed, country-specific data are needed to characterize the burden of chronic HCV infection. In this study of 17 countries, a literature review of published and unpublished data on HCV prevalence, viraemia, genotype, age and gender distribution, liver transplants and diagnosis and treatment rates was conducted, and inputs were validated by expert consensus in each country. Viraemic prevalence in this study ranged from 0.2% in Hong Kong to 2.4% in Taiwan, while the largest viraemic populations were in Nigeria (2 597 000 cases) and Taiwan (569 000 cases). Diagnosis, treatment and liver transplant rates varied widely across the countries included in this analysis, as did the availability of reliable data. Addressing data gaps will be critical for the development of future strategies to manage and minimize the disease burden of hepatitis