THE INFLUENCE OF FOLIAR FERTILIZATION WITH ORGANIC FERTILIZERS ON THE YIELD AND THE CHEMICAL CONTENT OF POTATOES GROWN IN STRUMICA REGION

The effect of foliar fertilization with organic fertilizers on the yield and the chemical content of potatoes grown in Strumica region were studied, in the period from the year of 2011-2012. The experiment was set in four variants and three repetitions. The variants in the experiment were: Control (no-fertilizing variant); Humusil (organic matter 1.86%; organic carbon 1.08%; humin acids 0.14%; N 224 mg/L; P2O5 71 mg/L; K2O 1024 mg/L; CaO 180 mg/L); Humustim (organic matter 58.63 %; dry matter 12.38 %; humin acids 20.40 %; fulvo acids 2.15%; N 3%; P2O5 1.02%; K2O 7.92%; Ca 3.70 %; Mg 1.03%); Ingrasamant foliar (N 0 %; P2O5 130 g/L; K2O 130 g/L; ME in helate form and plant extracts 0.005 g/L). The experiment was arranged in 12 rows and in each variant and repetition was involved 100 plants, total in all experiment were involved 1200 plants. The planting was made in rows at a distance of 60 cm row by row and 20 cm in the rows. The row’s length was 20 m. Three foliar treatments were applied with given above fertilizers at a concentration of 0.4%. The soil where the experiment was carried had a good fertility with nitrogen, phosphorus and potassium. The foliar fertilization had a positive influence on potatoes yield in all of the variants treated with different organic fertilizers. The highest potatoes yield of 54.62 t ha-1 was established in variant 4. The foliar fertilization had a positive influence on the chemical content of tubers potato, too. In three variants treated with different fertilizers, higher content of all tested parameters was found, compared to the control untreated variant. The highest average content of vitamin C (2.60 mg/100g), phosphorus (0.90 %), and potassium (1.30 %) was determined in the tubers potato in variant 3

О ДИНАМИКЕ РАСПРЕДЕЛЕНИЯ ВЛАЖНОСТИ В ПОПЕРЕЧНОМ СЕЧЕНИИ ПЛОСКИХ ОБРАЗЦОВ ФОРМОВОЧНЫХ МАСС В НАЧАЛЬНОМ ПЕРИОДЕ СУШКИ

It is proposed to use an exponential dependence for description of humidity distribution in cross-section of flat clay mass samples of plastic formation in an initial drying stage. Dependences of exponential curve indices on time from drying start-up and size of an «active» zone of clay mass dehydration have been determined. Analytical-experimental methodology for calculation of maximum permissible humidity differential of moulding mass under crack formation conditions has been developed on the basis of thermo-elasticity model. Some regularities for an estimation of thinning agent usage while making-up mixture.Предложено использовать экспоненциальную зависимость для описания распределения влажности в поперечном сечении плоских образцов глинистых масс пластического формования в начальном периоде сушки. Определены зависимости показателей экспоненты от времени с начала сушки и величины «активной» зоны обезвоживания глинистой массы. На основе модели термоупругости разработана аналитическо-экспериментальная методика расчета предельно допустимого перепада влажности формовочной массы по условиям трещинообразования. Получены некоторые закономерности для оценки использования отощителей при составлении шихты

Immunoblastic morphology as a possible prognostic indicator for the outcome of the patients with diffuse large B cell lymphoma in era of the rituximab based treatment: single centre experience

Recently the results from one large prospective study indicated that immunoblastic morphology and not immunohistohemical features predict the outcome of the Diffuse large B lymphoma (DLBL). In order to investigate the prediction value of the immunoblastic morphology (IB) as a possible prognostic indicator for the outcome of our DLBL patient treated with the Rituximab (R)-CHOP regimen we conducted a retrospective study. Our study enrolled 192 DLBL patients diagnosed and treated at the University Clinic of Hematology in the period between February 2002 and December 2007. They were all treated with R-CHOP regimen and the median follow-up of the patient was 36 months. We analyzed the biopsy samples immunohistochemically for markers of germinal center (BCL6), post-germinal center (MUM1) and apoptosis (BCL2).The patients were categorized as DLBL(132; 68.7%), IB(60; 31.2). The median overall survival time (OS) were 59.3 months in DLBL group and 42.2 months in IB group, and time to treatment (TT) were 56.8 and 30.6 months respectively for the IB group. The DLBL and IB groups were comparable regarding the age, gender distributions and all others already established prognostic parameters as performance status, advanced IPI, albumin level except for the low IPI 0-2 which was statistically associated with the DLBL group (p=.024). Our results did not show any statistical survival advantage and better outcome for the patient classified as DLBL when treated with R-CHOP and indicate that immunohistohemical markers do not really reflect the molecular diversity of the tumor.  Our work shows that IB morphology is a major risk factor in DLBL patients treated with R-CHOP. Therefore this morphology appears to capture some adverse molecular events that a currently hard to detect with routine diagnostic procedures.

Severe peripheral joint laxity is a distinctive clinical feature of spondylodysplastic-ehlers-danlos syndrome (Eds)-b4galt7 and spondylodysplastic-eds-b3galt6

Variations in genes encoding for the enzymes responsible for synthesizing the linker region of proteoglycans may result in recessive conditions known as “linkeropathies”. The two phenotypes related to mutations in genes B4GALT7 and B3GALT6 (encoding for galactosyltransferase I and II respectively) are similar, characterized by short stature, hypotonia, joint hypermobility, skeletal features and a suggestive face with prominent forehead, thin soft tissue and prominent eyes. The most outstanding feature of these disorders is the combination of severe connective tissue involvement, often manifesting in newborns and infants, and skeletal dysplasia that becomes apparent during childhood. Here, we intend to more accurately define some of the clinical features of B4GALT7 and B3GALT6-related conditions and underline the extreme hypermobility of distal joints and the soft, doughy skin on the hands and feet as features that may be useful as the first clues for a correct diagnosis

Multiple sulfatase deficiency with neonatal manifestation.

Multiple Sulfatase Deficiency (MSD; OMIM 272200) is a rare autosomal recessive inborn error of metabolism caused by mutations in the sulfatase modifying factor 1 gene, encoding the formylglycine-generating enzyme (FGE), and resulting in tissue accumulation of sulfatides, sulphated glycosaminoglycans, sphingolipids and steroid sulfates. Less than 50 cases have been published so far. We report a new case of MSD presenting in the newborn period with hypotonia, apnoea, cyanosis and rolling eyes, hepato-splenomegaly and deafness. This patient was compound heterozygous for two so far undescribed SUMF1 mutations (c.191C > A; p.S64X and c.818A > G; p.D273G)

Models of Rosetta/OSIRIS 67P Dust Coma Phase Function

The phase function of the dust coma of comet 67P has been determined from Rosetta/OSIRIS images. This function shows a deep minimum at phase angles near 100°, and a strong backscattering enhancement. These two properties cannot be reproduced by regular models of cometary dust, most of them based on wavelength-sized and randomly oriented aggregate particles. We show, however, that an ensemble of oriented elongated particles of a wide variety of aspect ratios, with radii r 10 μm, and whose long axes are perpendicular to the direction of the solar radiation, are capable of reproducing the observed phase function. These particles must be absorbing, with an imaginary part of the refractive index of about 0.1 to match the expected geometric albedo, and with porosity in the 60%-70% range.© 2018. The American Astronomical Society. All rights reserved..OSIRIS was built by a consortium of the Max-Planck-Institut fur Sonnensystemforschung, in Gottingen, Germany, CISAS-University of Padova, Italy, the Laboratoire dAstrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politecnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB; grant No. 74/10: 2), and the ESA Technical Directorate is gratefully acknowledged. H.R. was also supported by grant No. 2011/01/B/ST9/05442 of the Polish National Science Center. We thank the ESA teams at ESAC, ESOC, and ESTEC for their work in support of the Rosetta mission We thank the Rosetta Science Ground Segment at ESAC, the Rosetta Mission Operations Centre at ESOC, and the Rosetta Project at ESTEC for their outstanding work enabling the science return of the Rosetta Mission. This work was supported by contracts AYA2015-67152-R and AYA2015-71975-REDT from the Spanish Ministerio de Economia y Competitividad

Utilisation of an operative difficulty grading scale for laparoscopic cholecystectomy

Background A reliable system for grading operative difficulty of laparoscopic cholecystectomy would standardise description of findings and reporting of outcomes. The aim of this study was to validate a difficulty grading system (Nassar scale), testing its applicability and consistency in two large prospective datasets. Methods Patient and disease-related variables and 30-day outcomes were identified in two prospective cholecystectomy databases: the multi-centre prospective cohort of 8820 patients from the recent CholeS Study and the single-surgeon series containing 4089 patients. Operative data and patient outcomes were correlated with Nassar operative difficultly scale, using Kendall’s tau for dichotomous variables, or Jonckheere–Terpstra tests for continuous variables. A ROC curve analysis was performed, to quantify the predictive accuracy of the scale for each outcome, with continuous outcomes dichotomised, prior to analysis. Results A higher operative difficulty grade was consistently associated with worse outcomes for the patients in both the reference and CholeS cohorts. The median length of stay increased from 0 to 4 days, and the 30-day complication rate from 7.6 to 24.4% as the difficulty grade increased from 1 to 4/5 (both p < 0.001). In the CholeS cohort, a higher difficulty grade was found to be most strongly associated with conversion to open and 30-day mortality (AUROC = 0.903, 0.822, respectively). On multivariable analysis, the Nassar operative difficultly scale was found to be a significant independent predictor of operative duration, conversion to open surgery, 30-day complications and 30-day reintervention (all p < 0.001). Conclusion We have shown that an operative difficulty scale can standardise the description of operative findings by multiple grades of surgeons to facilitate audit, training assessment and research. It provides a tool for reporting operative findings, disease severity and technical difficulty and can be utilised in future research to reliably compare outcomes according to case mix and intra-operative difficulty

Mowat-Wilson syndrome: growth charts

Background Mowat-Wilson syndrome (MWS; OMIM #235730) is a genetic condition caused by heterozygous mutations or deletions of theZEB2gene. It is characterized by moderate-severe intellectual disability, epilepsy, Hirschsprung disease and multiple organ malformations of which congenital heart defects and urogenital anomalies are the most frequent ones. To date, a clear description of the physical development of MWS patients does not exist. The aim of this study is to provide up-to-date growth charts specific for infants and children with MWS. Charts for males and females aged from 0 to 16 years were generated using a total of 2865 measurements from 99 MWS patients of different ancestries. All data were collected through extensive collaborations with the Italian MWS association (AIMW) and the MWS Foundation. The GAMLSS package for the R statistical computing software was used to model the growth charts. Height, weight, body mass index (BMI) and head circumference were compared to those from standard international growth charts for healthy children. Results In newborns, weight and length were distributed as in the general population, while head circumference was slightly smaller, with an average below the 30th centile. Up to the age of 7 years, weight and height distribution was shifted to slightly lower values than in the general population; after that, the difference increased further, with 50% of the affected children below the 5th centile of the general population. BMI distribution was similar to that of non-affected children until the age of 7 years, at which point values in MWS children increased with a less steep slope, particularly in males. Microcephaly was sometimes present at birth, but in most cases it developed gradually during infancy; many children had a small head circumference, between the 3rd and the 10th centile, rather than being truly microcephalic (at least 2 SD below the mean). Most patients were of slender build. Conclusions These charts contribute to the understanding of the natural history of MWS and should assist pediatricians and other caregivers in providing optimal care to MWS individuals who show problems related to physical growth. This is the first study on growth in patients with MWS

After DART: Using the First Full-scale Test of a Kinetic Impactor to Inform a Future Planetary Defense Mission

NASA’s Double Asteroid Redirection Test (DART) is the first full-scale test of an asteroid deflection technology. Results from the hypervelocity kinetic impact and Earth-based observations, coupled with LICIACube and the later Hera mission, will result in measurement of the momentum transfer efficiency accurate to ∼10% and characterization of the Didymos binary system. But DART is a single experiment; how could these results be used in a future planetary defense necessity involving a different asteroid? We examine what aspects of Dimorphos’s response to kinetic impact will be constrained by DART results; how these constraints will help refine knowledge of the physical properties of asteroidal materials and predictive power of impact simulations; what information about a potential Earth impactor could be acquired before a deflection effort; and how design of a deflection mission should be informed by this understanding. We generalize the momentum enhancement factor β, showing that a particular direction-specific β will be directly determined by the DART results, and that a related direction-specific β is a figure of merit for a kinetic impact mission. The DART β determination constrains the ejecta momentum vector, which, with hydrodynamic simulations, constrains the physical properties of Dimorphos’s near-surface. In a hypothetical planetary defense exigency, extrapolating these constraints to a newly discovered asteroid will require Earth-based observations and benefit from in situ reconnaissance. We show representative predictions for momentum transfer based on different levels of reconnaissance and discuss strategic targeting to optimize the deflection and reduce the risk of a counterproductive deflection in the wrong direction

Reappraisal of Vipera aspis Venom Neurotoxicity

BACKGROUND: The variation of venom composition with geography is an important aspect of intraspecific variability in the Vipera genus, although causes of this variability remain unclear. The diversity of snake venom is important both for our understanding of venomous snake evolution and for the preparation of relevant antivenoms to treat envenomations. A geographic intraspecific variation in snake venom composition was recently reported for Vipera aspis aspis venom in France. Since 1992, cases of human envenomation after Vipera aspis aspis bites in south-east France involving unexpected neurological signs were regularly reported. The presence of genes encoding PLA(2) neurotoxins in the Vaa snake genome led us to investigate any neurological symptom associated with snake bites in other regions of France and in neighboring countries. In parallel, we used several approaches to characterize the venom PLA(2) composition of the snakes captured in the same areas. [br/] METHODOLOGY/PRINCIPAL FINDINGS: We conducted an epidemiological survey of snake bites in various regions of France. In parallel, we carried out the analysis of the genes and the transcripts encoding venom PLA(2)s. We used SELDI technology to study the diversity of PLA(2) in various venom samples. Neurological signs (mainly cranial nerve disturbances) were reported after snake bites in three regions of France: Languedoc-Roussillon, Midi-Pyrénées and Provence-Alpes-Côte d'Azur. Genomes of Vipera aspis snakes from south-east France were shown to contain ammodytoxin isoforms never described in the genome of Vipera aspis from other French regions. Surprisingly, transcripts encoding venom neurotoxic PLA(2)s were found in snakes of Massif Central region. Accordingly, SELDI analysis of PLA(2) venom composition confirmed the existence of population of neurotoxic Vipera aspis snakes in the west part of the Massif Central mountains. [br/] CONCLUSIONS/SIGNIFICANCE: The association of epidemiological studies to genetic, biochemical and immunochemical analyses of snake venoms allowed a good evaluation of the potential neurotoxicity of snake bites. A correlation was found between the expression of neurological symptoms in humans and the intensity of the cross-reaction of venoms with anti-ammodytoxin antibodies, which is correlated with the level of neurotoxin (vaspin and/or ammodytoxin) expression in the venom. The origin of the two recently identified neurotoxic snake populations is discussed according to venom PLA(2) genome and transcriptome data