Circulating intercellular adhesion molecule-1 and E-selectin levels in gastric cancer.

A diversity of adhesive interactions occur between the cancer cell and host extracellular matrix which potentiate neoplastic expansion and metastatic dissemination. In miscellaneous malignant diseases, tumour progression has been observed to be associated with alterations in adhesion molecule expression. Recently, circulating soluble intercellular adhesion molecules have been identified. In this study, serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) were determined in patients with gastric cancer. The study group consisted of 27 patients with previously untreated gastric adenocarcinoma. Four patients had stage II, two patients stage III and 21 patients stage IV disease according to the TNM classification. Nineteen patients had distant metastasis. The sera obtained from 18 healthy volunteers served as controls. Serum sICAM-1 and sE-selectin concentrations were determined by enzyme-linked immunosorbent assay (ELISA). In addition, we also studied other tumour-associated antigens, i.e. CEA and CA 19-9. Serum sICAM-1 levels were significantly increased in patients with gastric cancer (P < 0.0001). However, sE-selectin levels did not differ from the controls. sICAM-1 concentrations were also significantly higher in patients with distant metastasis and peritoneal spread (P = 0.0045 and P = 0.0157 respectively), whereas sE-Selectin levels were elevated only in patients with peritoneal metastasis (P = 0.033). Serum concentrations of sICAM-1 and sE-selectin correlated with CEA levels (P = 0.0013 and P = 0.003 respectively). Elevated levels of sE-selectin were associated with poorer prognosis (P = 0.0099), whereas sICAM-1 had no significant impact on survival. Our results suggest that increased sICAM-1 serum levels may reflect widespread disease and contribute directly to the progression of gastric cancer. Further investigation of the molecular mechanisms of adhesive tumour-host interactions may lead to a better understanding of the natural history of gastric cancer

Effect of acetic acid on telomerase activity in premalignant and malignant cervical lesions

PubMe

Neural Network-Based Equations for Predicting PGA and PGV in Texas, Oklahoma, and Kansas

Parts of Texas, Oklahoma, and Kansas have experienced increased rates of seismicity in recent years, providing new datasets of earthquake recordings to develop ground motion prediction models for this particular region of the Central and Eastern North America (CENA). This paper outlines a framework for using Artificial Neural Networks (ANNs) to develop attenuation models from the ground motion recordings in this region. While attenuation models exist for the CENA, concerns over the increased rate of seismicity in this region necessitate investigation of ground motions prediction models particular to these states. To do so, an ANN-based framework is proposed to predict peak ground acceleration (PGA) and peak ground velocity (PGV) given magnitude, earthquake source-to-site distance, and shear wave velocity. In this framework, approximately 4,500 ground motions with magnitude greater than 3.0 recorded in these three states (Texas, Oklahoma, and Kansas) since 2005 are considered. Results from this study suggest that existing ground motion prediction models developed for CENA do not accurately predict the ground motion intensity measures for earthquakes in this region, especially for those with low source-to-site distances or on very soft soil conditions. The proposed ANN models provide much more accurate prediction of the ground motion intensity measures at all distances and magnitudes. The proposed ANN models are also converted to relatively simple mathematical equations so that engineers can easily use them to predict the ground motion intensity measures for future events. Finally, through a sensitivity analysis, the contributions of the predictive parameters to the prediction of the considered intensity measures are investigated.Comment: 5th Geotechnical Earthquake Engineering and Soil Dynamics Conference, Austin, TX, USA, June 10-13. (2018

On asymptotically AdS-like solutions of three dimensional massive gravity

In this paper we have added Maxwell, Maxwell-Chern-Simons and gravitational Chern-Simons terms to Born-Infeld extended new massive gravity and we have found different types of (non)extremal charged black holes. For each black hole we find mass, angular momentum, entropy and temperature. Since our solutions are asymptotically AdS or warped-AdS, we infer central charges of dual CFTs by using Cardy's formula. Computing conserved charges associated to asymptotic symmetry transformations confirms calculation of central charges. For CFTs dual to asymptotically AdS solutions we find left central charges from Cardy's formula, while conserved charge approach gives both left and right central charges. For CFTs dual to asymptotically warped-AdS solutions, left and right central charges are equal when we have Maxwell-Chern-Simons term but they have different values when gravitational Chern-Simons term is included.Comment: 30 pages, 11 tables. Improved version (two new sections added for asymptotic conserved charges). Accepted in JHE

Flux vacua in DBI type Einstein-Maxwell theory

We study compactification of extra dimensions in a theory of Dirac-Born-Infeld (DBI) type gravity. We investigate the solution for Minkowski spacetime with an $S^2$ extra space as well as that for de Sitter spacetime ($S^4$) with an $S^2$ extra space. They are derived by the effective potential method in the presence of the magnetic flux on the extra sphere. We also consider the higher dimensional generalization of the solutions. We find that, in a certain model, the radius of the extra space has a minimum value independent of the higher-dimensional Newton constant in weak-field limit.Comment: 13 pages, no figure. A reference added, typos fixe

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access