El potencial de la economía creativa y el efecto catalizador futuro de Amazon HQ2 en el condado de Arlington

The supply and demand of vibrant places are often considered a luxurious goal for cities rather than an essential engine for business and talent attraction. With the ongoing development of Amazon HQ in Arlington and the potential jobs that will originate, the city must be prepared to fulfill the expectations of residents, workers, and investors. Through a qualitative analysis and interviews with relevant practitioners, this paper studies the potential gap between the current creative ecosystem by discussing the supply of cultural goods and services, Arlington’s proposal, and the benefits and risks of achieving the targets, based on lessons from Seattle. To maximize what is expected, it will be imperative to foster a coordinated and creative environment while celebrating the unique essence of Arlington’s communities and the potential risks these changes may bring.La oferta y la demanda de lugares dinámicos se consideran a menudo un objetivo de ostentación para las ciudades, y no un motor esencial para los negocios y la atracción de talento. Ante la próxima llegada de la sede de Amazon en Arlington y los posibles puestos de trabajo que se generarán, la ciudad debe prepararse para cumplir las expectativas de los residentes, los trabajadores y los inversores. Este artículo estudia, mediante un análisis cualitativo y entrevistas a profesionales relevantes, la brecha potencial entre el ecosistema creativo actual (analizando la oferta de bienes y servicios culturales), la propuesta de Arlington y los riesgos y beneficios de lograr los objetivos, teniendo en cuenta lo aprendido en Seattle. Para maximizar las expectativas, será necesario fomentar de coordinadamente el ambiente creativo a la vez que tener en cuenta la especificidad de las diferentes comunidades de Arlington y aquellos riesgos potenciales que estos cambios podrían acarrear

C12orf5 (chromosome 12 open reading frame 5)

Review on C12orf5, with data on DNA/RNA, on the protein encoded and where the gene is implicated

PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)

Review on PFKFB2, with data on DNA/RNA, on the protein encoded and where the gene is implicated

Assessment of the questionnaires module of the work environment Virtual UBU through Tecnological Acceptation Model

Una de las exigencias del Espacio Europeo de Educación Superior es el seguimiento individualizado del alumno y la evaluación continua, lo cual exige un incremento del tiempo dedicado a la actividad docente. Una posible solución para una mejor gestión de este tiempo es la integración de las tecnologías a los procesos de enseñanza-aprendizaje. En este artículo se analiza el grado de aceptación de los estudiantes del módulo de cuestionarios de UBUVirtual, a través del cual se ha realizado su evaluación continua. Para dicha evaluación se ha utilizado el Modelo de Aceptación Tecnológica (TAM), el cual especifica las relaciones causales entre la utilidad percibida, la facilidad de uso percibida y su comportamiento hacia el uso actual. Los resultados han mostrado que el módulo tiene una buena aceptación por parte de los estudiantes, si bien consideran que se deben introducir mejoras en el apartado de Soporte Técnico. Los resultados, finalmente, apoyan la idea de que TAM es un modelo útil para la evaluación de la aceptación de diferentes tipos de tecnologías por parte de los estudiantes.One of the requirements of the European Higher Education Space is the student's individualized monitoring and continuous evaluation, which requires an increase in time devoted to teaching. A possible solution for better management of time is the integration of new technologies into teaching-learning processes. This article discusses the acceptance degree of UBUVirtual questionnaire module by the students, through which it has made their continuous evaluation. For this evaluation the Technology Acceptance Model (TAM) has been used, which specifies the causal relationships between perceived usefulness, perceived ease of use and behaviour toward actual use. The results have shown that the module is well accepted by the students, although they consider to be improvements in the Technical Support section. The results eventually support the idea that TAM is a useful model for the evaluation of accepting different types of technologies by students.Grupo FORCE (HUM-386). Departamento de Didáctica y Organización Escolar de la Universidad de Granada

Discovering the Legacy of Hispanic/Spanish and South American Landscapes through Geohistorical Sources: The Geographical and Topographical Relations of Philip II

Landscapes have history and memory, which are eloquent generators of testimonies and traces on the processes of the landscape that take place today, and that will take place in the future. In recent years, numerous methods of analysing land and landscape patterns have been developed and evaluated, based on the multiplicity of these type of geographic and historical data sources, which have developed the concept of the geohistorical source. The goal of these sources of information allows us to historically reconstruct landscapes. With this in mind, the basic objective of the present research is to approach a geohistorical source with a wide spatial spectrum in Europe and America: the geographical and topographical relations of Philip II. This source has been chosen for the quality, quantity, variety and systematization of the data it provides on the territory and landscape of the crown of Castile. In addition, it ended up being the model of how to obtain organized and homogeneous knowledge of a large spatial area, considering the geographical, anthropological and historical data of the different territories. This geohistorical source is reliable, because the local authorities, both secular and ecclesiastical, are questioned, as they are the ones who inhabit, use, and, at different levels, govern the territory and its people

Scavenging Behaviour of Red Deer Cervus elaphus Linnaeus, 1758 (Artiodactyla: Cervidae) in Eastern Spain

A male red deer was repeatedly observed scavenging in eastern Spain. This is the first time this behaviour of the red deer being recorded by means of camera traps. Scavenging behaviour of herbivores may have implications for wildlife biologists and managers

Cost-utility of cognitive behavioral therapy versus U.S. Food and Drug Administration recommended drugs and usual care in the treatment of patients with fibromyalgia: an economic evaluation alongside a 6-month randomized controlled trial

Introduction:- Cognitive behavioral therapy (CBT) and U.S. Food and Drug Administration (FDA)-recommended pharmacologic treatments (RPTs; pregabalin, duloxetine, and milnacipran) are effective treatment options for fibromyalgia (FM) syndrome and are currently recommended by clinical guidelines. We compared the cost-utility from the healthcare and societal perspectives of CBT versus RPT (combination of pregabalin + duloxetine) and usual care (TAU) groups in the treatment of FM. Methods:- The economic evaluation was conducted alongside a 6-month, multicenter, randomized, blinded, parallel group, controlled trial. In total, 168 FM patients from 41 general practices in Zaragoza (Spain) were randomized to CBT (n = 57), RPT (n = 56), or TAU (n = 55). The main outcome measures were Quality-Adjusted Life Years (QALYs, assessed by using the EuroQoL-5D questionnaire) and improvements in health-related quality of life (HRQoL, assessed by using EuroQoL-5D visual analogue scale, EQ-VAS). The costs of healthcare use were estimated from patient self-reports (Client Service Receipt Inventory). Cost-utility was assessed by using the net-benefit approach and cost-effectiveness acceptability curves (CEACs). Results:- On average, the total costs per patient in the CBT group (1,847€) were significantly lower than those in patients receiving RPT (3,664€) or TAU (3,124€). Patients receiving CBT reported a higher quality of life (QALYs and EQ-VAS scores); the differences between groups were significant only for EQ-VAS. From a complete case-analysis approach (base case), the point estimates of the cost-effectiveness ratios resulted in dominance for the CBT group in all of the comparisons performed, by using both QALYs and EQ-VAS as outcomes. These findings were confirmed by bootstrap analyses, net-benefit curves, and CEACs. Two additional sensitivity analyses (intention-to-treat analysis and per-protocol analysis) indicated that the results were robust. The comparison of RPT with TAU yielded no clear preference for either treatment when using QALYs, although RPT was determined to be more cost-effective than TAU when evaluating EQ-VAS. Conclusions:- Because of lower costs, CBT is the most cost-effective treatment for adult FM patients. Implementation in routine medical care would require policymakers to develop more-widespread public access to trained and experienced therapists in group-based forms of CBT. Trial registration:- Current Controlled Trials ISRCTN10804772. Registered 29 September 2008

Fructose 2,6-bisphosphate in cancer cell metabolism

For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have focused on the idea that tumor cells maintain high glycolytic rates even with adequate oxygen supply, in what is known as aerobic glycolysis or the Warburg effect. Recent studies have reported a more complex situation, where the tumor ecosystem plays a more critical role in cancer progression. Cancer cells display extraordinary plasticity in adapting to changes in their tumor microenvironment, developing strategies to survive and proliferate. The proliferation of cancer cells needs a high rate of energy and metabolic substrates for biosynthesis of biomolecules. These requirements are met by the metabolic reprogramming of cancer cells and others present in the tumor microenvironment, which is essential for tumor survival and spread. Metabolic reprogramming involves a complex interplay between oncogenes, tumor suppressors, growth factors and local factors in the tumor microenvironment. These factors can induce overexpression and increased activity of glycolytic isoenzymes and proteins in stromal and cancer cells which are different from those expressed in normal cells. The fructose-6-phosphate/fructose-1,6-bisphosphate cycle, catalyzed by 6-phosphofructo-1-kinase/fructose 1,6-bisphosphatase (PFK1/FBPase1) isoenzymes, plays a key role in controlling glycolytic rates. PFK1/FBpase1 activities are allosterically regulated by fructose-2,6-bisphosphate, the product of the enzymatic activity of the dual kinase/phosphatase family of enzymes: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFKFB1-4) and TP53-induced glycolysis and apoptosis regulator (TIGAR), which show increased expression in a significant number of tumor types. In this review, the function of these isoenzymes in the regulation of metabolism, as well as the regulatory factors modulating their expression and activity in the tumor ecosystem are discussed. Targeting these isoenzymes, either directly or by inhibiting their activating factors, could be a promising approach for treating cancers

Revisiting the thiosemicarbazonecopper(II) reaction with glutathione. Activity against colorectal carcinoma cell lines

Thiosemicarbazones (TSCs), and their copper derivatives, have been extensively studied mainly due to the potential applications as antitumor compounds. A part of the biological activity of the TSC-CuII complexes rests on their reactivity against cell reductants, as glutathione (GSH). The present paper describes the structure of the [Cu(PTSC)(ONO2)]n compound (1) (HPTSC =pyridine-2-carbaldehyde thiosemicarbazone) and its spectroscopic and magnetic properties. ESI studies performed on the reaction of GSH with 1 and the analogous [{Cu (PTSC*)(ONO2)}2] derivative (2, HPTSC* =pyridine-2-carbaldehyde 4N-methylthiosemicarbazone) show the absence of peaks related with TSC-Cu-GSH species. However GSH-Cu ones are detected, in good agreement with the release of CuI ions after reduction in the experimental conditions. The reactivity of 1 and 2 with cytochrome c and myoglobin and their activities against HT-29 and SW-480 colon carcinoma cell lines are compared with those shown by the free HPTSC and HPTSC* ligands.Obra Social “la Caixa” (OSLC-2012-007), Ministerio de Economía y Competitividad and FEDER funds (CTQ2013-48937-C2-1-P, CTQ2015-70371-REDT, MAT2015-66441-P, BIO2015-67358-C2-2-P), Junta de Castilla y León (BU237U13), Gerencia Regional de Salud, Consejería de Sanidad, Junta de Castilla y León (GRS 1023/A/14), the Basque Government (project IT-779-13