Putting the pieces together: Integration for forest landscape restoration implementation

© 2019 John Wiley & Sons, Ltd. The concept of forest landscape restoration (FLR) is being widely adopted around the globe by governmental, non-governmental agencies, and the private sector, all of whom see FLR as an approach that contributes to multiple global sustainability goals. Originally, FLR was designed with a clearly integrative dimension across sectors, stakeholders, space and time, and in particular across the natural and social sciences. Yet, in practice, this integration remains a challenge in many FLR efforts. Reflecting this lack of integration are the continued narrow sectoral and disciplinary approaches taken by forest restoration projects, often leading to marginalisation of the most vulnerable populations, including through land dispossessions. This article aims to assess what lessons can be learned from other associated fields of practice for FLR implementation. To do this, 35 scientists came together to review the key literature on these concepts to suggest relevant lessons and guidance for FLR. We explored the following large-scale land use frameworks or approaches: land sparing/land sharing, the landscape approach, agroecology, and socio-ecological systems. Also, to explore enabling conditions to promote integrated decision making, we reviewed the literature on understanding stakeholders and their motivations, tenure and property rights, polycentric governance, and integration of traditional and Western knowledge. We propose lessons and guidance for practitioners and policymakers on ways to improve integration in FLR planning and implementation. Our findings highlight the need for a change in decision-making processes for FLR, better understanding of stakeholder motivations and objectives for FLR, and balancing planning with flexibility to enhance social–ecological resilience.The Frank Jackson Foundatio

Comparative phylogeography of reef fishes from the Gulf of Aden to the Arabian Sea reveals two cryptic lineages

Arabian Sea is a heterogeneous region with high coral cover and warm stable conditions at the western end (Djibouti), in contrast to sparse coral cover, cooler temperatures, and upwelling at the eastern end (southern Oman). We tested for barriers to dispersal across this region (including the Gulf of Aden and Gulf of Oman), using mitochondrial DNA surveys of 11 reef fishes. Study species included seven taxa from six families with broad distributions across the Indo-Pacific and four species restricted to the Arabian Sea (and adjacent areas). Nine species showed no significant genetic partitions, indicating connectivity among contrasting environments spread across 2000 km. One butterflyfish (Chaetodon melannotus) and a snapper (Lutjanus kasmira) showed phylogenetic divergences of d = 0.008 and 0.048, respectively, possibly indicating cryptic species within these broadly distributed taxa. These genetic partitions at the western periphery of the Indo-Pacific reflect similar partitions recently discovered at the eastern periphery of the Indo-Pacific (the Hawaiian and the Marquesan Archipelagos), indicating that these disjunctive habitats at the ends of the range may serve as evolutionary incubators for coral reef organisms. © 2017 Springer-Verlag Berlin HeidelbergTh

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

A multicriteria analysis of groundwater development pathways in three river basins in Sub-Saharan Africa

Reliance on groundwater in Sub-Saharan Africa is growing and expected to rise as surface water resource variability increases under climate change. Major questions remain about how groundwater will be used, and who informs these decisions. We represent different visions of groundwater use by ‘pathways’: politically and environmentally embedded socio-technological regimes for governing and managing groundwater systems. We presented policy actors (9 sets), development and research stakeholders (4 sets), and water users (6 sets) in three river basins in Ethiopia, Niger and Tanzania with information on the social and environmental impacts of six ‘Groundwater Development Pathways’, before gathering their opinions on each, through Multicriteria Mapping (MCM). Participants preferred pathways of low-intensity use, incorporating multiple agricultural, pastoral and domestic purposes, to high-intensity single-use pathways. Water availability and environmental sustainability, including water quality, were central concerns. Participants recognised that all groundwater uses potentially impinge upon one another affecting both the quantity and quality of abstracted water. Across participant groups there was ambiguity about what the most important water use was; each expressed demands for more detailed, certain modelling data. Water users preferred community or municipal-scale management regimes, perceiving that water quality was more likely to be safeguarded by institutions at these levels, whereas policy and development actors preferred individual-scale management, viewed as more efficient in terms of operation and maintenance. We conclude that MCM, combined with more detailed modelling, can provide an effective framework for policy actors to understand other stakeholders’ perspectives on groundwater development futures, enabling equitable, inclusive decision-making and governance

Experiences from stakeholder dialogues in Tamale, northern Ghana

Tamale is the capital city of Ghana’s Northern Region. As the regional capital, Tamale is growing rapidly – the population has almost tripled to over 370,000 in the past 30 years, and the areal extent has increased up to sevenfold in the same period. Urban agriculture is an integral part of the food system, linked to resource management and spatial planning. In general one can say that backyard farming flourishes, but more formally organised production is threatened by urbanisation

Experiences from stakeholder dialogues in Tamale, northern Ghana

Tamale is the capital city of Ghana’s Northern Region. As the regional capital, Tamale is growing rapidly – the population has almost tripled to over 370,000 in the past 30 years, and the areal extent has increased up to sevenfold in the same period. Urban agriculture is an integral part of the food system, linked to resource management and spatial planning. In general one can say that backyard farming flourishes, but more formally organised production is threatened by urbanisation

Trading food across West African borders

West African cities depend also on food imported from the global market and on intra-regional trade to supplement national food supplies. However, barriers on the road and at borders make cross-border trade challenging and expensive. Find out more about cross-border trade in West Africa, the formal and informal barriers, and why traders and transporters of food produced and consumed in the region are affected more by these barriers than others. This documentary summarizes findings from a road trip on a truck from the port in Tema, Ghana, to Ouagadougou, Burkina Faso. For more information please visit: http://www.urbanfoodplus.org Full version of the video with more details on the mechanisms of cross-border trade is available here https://uni-kassel.cloud.panopto.eu/P..