12 research outputs found
Non-relativistic Matrix Inflation
We reconsider a string theoretic inflationary model, where inflation is
driven by multiple coincident -branes in the finite limit. We show
that the finite action can be continued to the limit of large , where it
converges to the action for a wrapped -brane with units of U(1) flux.
This provides an important consistency check of the scenario and allows for
more control over certain back-reaction effects. We determine the most general
form of the action for a specific sub-class of models and examine the
non-relativistic limits of the theory where the branes move at speeds much less
than the speed of light. The non-Abelian nature of the world-volume theory
implies that the inflaton field is matrix valued and this results in
modifications to the slow-roll parameters and Hubble-flow equations. A specific
small field model of inflation is investigated where the branes move out of an
AdS throat, and observational constraints are employed to place bounds on the
background fluxes.Comment: 25 page
Genetic variation in APOE, GRN, and TP53 are phenotype modifiers in frontotemporal dementia
Frontotemporal dementia (FTD) is a clinical, genetic, and pathologic heterogeneous group of neurodegenerative diseases. In this study, we investigated the role of APO\u1904, rs5848 in GRN, and rs1042522 in TP53 gene as disease risk factors and/or phenotype modifiers in 440 FTD patients, including 175 C9orf72 expansion carriers. We found that the C9orf72 expansion carriers showing an earlier age at onset (p < 0.001). Among the clinical groups, the FTD-MND (motoneuron disease) showed the lowest survival (hazard ratio [HR] = 4.12), and the progressive nonfluent aphasia group showed the highest onset age (p = 0.03). In our cohort, the rs1042522 in TP53 was associated with disease onset (p = 0.02) and survival (HR = 1.73) and rs5848 GRN with a significantly shorter survival in CC homozygous patients (HR = 1.98). The frequency of APO\u1904 carriers was significantly increased in the C9orf72 noncarriers (p = 0.022). Although validation of our findings is necessary, our results suggest that TP53, GRN, and APOE genes may act as phenotype modifiers in FTD and should be considered in future clinical trials
Vito Flaker@Boj za (2012): Direktno socialno delo, (Oranžna zbirka). Ljubljana: Založba /*cf. 372 str. ISBN 978-961-257-047-7
The
yields of NO from combustion of bituminous coal, lignite, and
biomass chars were investigated in O<sub>2</sub>/N<sub>2</sub> and
O<sub>2</sub>/CO<sub>2</sub> atmospheres. The experiments were performed
in a laboratory-scale fixed-bed reactor in the temperature range of
850–1150 °C. To minimize thermal deactivation during char
preparation, the chars were generated by in situ pyrolysis at the
reaction temperature. The NO yield clearly decreased and the CO yield
increased when the atmosphere was altered from O<sub>2</sub>/N<sub>2</sub> to O<sub>2</sub>/CO<sub>2</sub> at 850 °C, but only
small differences in NO and CO yields were observed between the two
atmospheres at 1050–1150 °C. To examine how CO influences
the NO yield, the effect of CO on NO reduction over char as well as
NO reduction by CO over ash was investigated in the fixed-bed reactor.
Furthermore, the influence of CO on the homogeneous oxidation of HCN,
possibly a product of the char-N oxidation, was evaluated using a
detailed chemical kinetic model. The results indicate that CO influences
the NO yield from char combustion through two paths at 850 °C:
(1) CO accelerates NO reduction over char and (2) CO accelerates HCN
oxidation, increasing the possibility of NO reduction over char. Both
effects were more pronounced at 850 °C than at 1050–1150
°C. The present work indicates that the effect of CO<sub>2</sub> on NO formation in oxy-fuel combustion in fluidized beds can partly
be attributed to heterogeneous reactions, whereas for high-temperature
pulverized fuel combustion, CO<sub>2</sub> mainly affects the volatile
chemistry
Effect of pyrolysis temperature on the char micro-structure and reactivity of NO reduction
<em>C9orf72</em>, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
Using large-scale whole-genome sequencing, Dewan et al. identify pathogenic HTT repeat expansions in patients diagnosed with FTD/ALS neurodegenerative disorders. Autopsies confirm the TDP-43 pathology expected in FTD/ALS and show polyglutamine inclusions within the frontal cortices but no striatal degeneration. These data broaden the phenotype resulting from HTT repeat expansions