Arquitectura colectiva como transición

Artículo de investigaciónPara el proyecto en el barrio Egipto, se realizan dos tipos de intervención; una a nivel general que consistió en un ejercicio de acupuntura urbana y la otra en un desarrollo puntual de un dispositivo de apropiación colectiva. El dispositivo se plantea como punto de referencia y de desarrollo futuro para el barrio y la ciudad de Bogotá.1. RESUMEN 2. INTRODUCCIÓN 3. METODOLOGÍA 4. RESULTADOS 5. DISCUSIÓN 6. CONCLUSIONES 7. REFERENCIAS 8. ANEXOSPregradoArquitect

Neural signature of tDCS, tPCS and their combination: Comparing the effects on neural plasticity

Transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) are two noninvasive neuromodulatory brain stimulation techniques whose effects on human brain and behavior have been studied individually. In the present study we aimed to quantify the effects of tDCS and tPCS, individually and in combination, on cortical activity, sensitivity and pain-related assessments in healthy individuals in order to understand their neurophysiological mechanisms and potential applications in clinical populations. A total of 48 healthy individuals participated in this randomized double blind sham controlled study. Participants were randomized to receive a single stimulation session of either: active or sham tPCS and active or sham tDCS. Quantitative electroencephalography (qEEG), sensitivity and pain assessments were used before and after each stimulation session. We observed that tPCS had a higher effect on power, as compared to tDCS, in several bandwidths on various cortical regions: the theta band in the parietal region (p = 0.021), the alpha band in the temporal (p=0.009), parietal (p = 0.0063), and occipital (p < 0.0001) regions. We found that the combination of tPCS and tDCS significantly decreased power in the low beta bandwidth of the frontal (p = 0.0006), central (p = 0.0001), and occipital (p = 0.0003) regions, when compared to sham stimulation. Additionally, tDCS significantly increased power in high beta over the temporal (p = 0.0015) and parietal (p = 0.0007) regions, as compared to sham. We found no effect on sensitivity or pain-related assessments. We concluded that tPCS and tDCS have different neurophysiological mechanisms, elicit distinct signatures, and that the combination of the two leads to no effect or a decrease on qEEG power. Further studies are required to examine the effects of these techniques on clinical populations in which EEG signatures have been found altered. (C) 2016 Published by Elsevier Ireland Ltd.This research was supported by Labuschagne Foundation. Dr. Thibaut was founded by the Belgian American Educational Foundation (BAEF) and the Duesberg Foundation. Dr. Morales-Quezada received funding support from an Institutional National Research Service Award from the National Center for Complementary and Integrative Health grant T32AT000051, the Ryoichi Sasakawa Fellowship Fund, and by the Program in Placebo Studies at Beth Israel Deaconess Medical Center. Deitos, A. was founded by the Coordination for the Improvement of Higher Education Personnel - CAPES, International Cooperation General Program - PGCI (no 023/11). Prof. Fregni has been supported by NIH RO1 grant (1R01HD082302-01A1)

Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity

BackgroundThe cerebellum contributes to the precise timing of non-motor and motor functions, and cerebellum abnormalities have been implicated in psychosis pathophysiology. In this study, we explored the effects of cerebellar theta burst stimulation (TBS), an efficient transcranial magnetic stimulation protocol, on temporal discrimination and self-reported mood and psychotic symptoms.MethodsWe conducted a case-crossover study in which patients with psychosis (schizophrenias, schizoaffective disorders, or bipolar disorders with psychotic features) were assigned to three sessions of TBS to the cerebellar vermis: one session each of intermittent (iTBS), continuous (cTBS), and sham TBS. Of 28 enrolled patients, 26 underwent at least one TBS session, and 20 completed all three. Before and immediately following TBS, participants rated their mood and psychotic symptoms and performed a time interval discrimination task (IDT). We hypothesized that cerebellar iTBS and cTBS would modulate these measures in opposing directions, with iTBS being adaptive and cTBS maladaptive.ResultsReaction time (RT) in the IDT decreased significantly after iTBS vs. Sham (LS-mean difference = −73.3, p = 0.0001, Cohen’s d = 1.62), after iTBS vs. cTBS (LS-mean difference = −137.6, p &lt; 0.0001, d = 2.03), and after Sham vs. cTBS (LS-mean difference = −64.4, p &lt; 0.0001, d = 1.33). We found no effect on IDT accuracy. We did not observe any effects on symptom severity after correcting for multiple comparisons.ConclusionWe observed a frequency-dependent dissociation between the effects of iTBS vs. cTBS to the cerebellar midline on the reaction time of interval discrimination in patients with psychosis. iTBS showed improved (adaptive) while cTBS led to worsening (maladaptive) speed of response. These results demonstrate behavioral target engagement in a cognitive dimension of relevance to patients with psychosis and generate testable hypotheses about the potential therapeutic role of cerebellar iTBS in this clinical population.Clinical Trial Registrationclinicaltrials.gov, identifier NCT02642029

Raised frequency of microcephaly related to zika virus infection in two birth defects surveillance systems in Bogotá and Cali, Colombia

Q2Q1Informes breves1017-1019Zika virus infection during pregnancy is now known to cause congenital microcephaly and severe brain defects. In 2016, rates of microcephaly appeared to start increasing around May, peaking in July, and declining through December. The occurrence of microcephaly appears to have increased nearly 4-fold in 2 large cities in Colombia, concurrently with the reported Zika virus epidemic in the country

Gestión de exámenes online. Base de datos de preguntas y desarrollo de software

Depto. de Farmacología y ToxicologíaFac. de MedicinaFALSEsubmitte

Base de datos de preguntas y actualización del software. Herramientas para la generación de exámenes presenciales u online

Depto. de Farmacología y ToxicologíaFac. de MedicinaFALSEsubmitte

Sistema de diálogo para el Proyecto DIHANA

En este trabajo se describe un sistema de diálogo desarrollado para el Proyecto DIHANA. El sistema está compuesto por siete módulos: un reconocedor automático del habla, un módulo de comprensión del habla, un gestor del diálogo, un módulo de consulta a la base de datos, un generador de respuestas en lenguaje natural, un sintetizador de texto a voz y finalmente por un gestor central de comunicaciones. Para la implementación del sistema se ha optado por una arquitectura siguiendo el paradigma cliente-servidor, donde el gestor central actúa como cliente, gestionando las comunicaciones, y el resto de módulos actúan como servidores.In this work we describe a dialog system developed into the DIHANA project. This system consists of seven modules: an automatic speech recognizer, a language understanding module, a dialog manager, a module that manages the queries to the database, a natural language answer generator, a text-to-speech converter and, finally, a central communication manager. For the implementation of the system, we built an architecture based on the client-server paradigm, where the central communication manager works as the client and manages the communications, and the other modules work as servers

Novedades de Cavanillesia chicamochae Fern. Alonso (Bombacaceae) en Piedecuesta y Girón (Santander-Colombia)

Peer reviewe

The role of Nursing against COVID-19

A vision of the role performed against the COVID-19 pandemic, is presented, from the Nursing profession. The main aspects related to the nursing situation in the region of the Americas and Cuba, their contribution to confronting the pandemic, their leadership in the surveillance and health care of the population as well as of prevention and health education related to this disease were analyzed

Creating a research idea: steps and challenges

BACKGROUND: This article is part of a special series designed to help health professionals in the process of developing a research project and writing a manuscript. The research question is the keystone in this process, and represents the first step of every research project. However, its importance is frequently neglected. OBJECTIVE: To highlight important considerations in the development and formulation of a research idea, with the purpose of identifying main guiding elements, in order to prevent errors in one of the most important stages of an experiment. METHODS: The authors performed a non-systematic literature review (PubMed.gov - U.S. National Library of Medicine/National Institute of Health) to retrieve papers that addressed the main steps to build a research question. RESULTS: The construction process includes the conception of the research idea, seeking an appropriate environment and resources, performing a literature review, then crafting and refining the research question, while being aware of potential challenges and pitfalls that may be encountered. The FINER and PICOT criteria can be useful tools in this process. CONCLUSION: It is essential to invest time, energy, and resources in the construction of the research question prior to detailing the study design, thus supporting the further development of the research project on a solid initial foundation.</p