The Interplanetary Network Supplement to the BeppoSAX Gamma-Ray Burst Catalogs

Between 1996 July and 2002 April, one or more spacecraft of the interplanetary network detected 787 cosmic gamma-ray bursts that were also detected by the Gamma-Ray Burst Monitor and/or Wide-Field X-Ray Camera experiments aboard the BeppoSAX spacecraft. During this period, the network consisted of up to six spacecraft, and using triangulation, the localizations of 475 bursts were obtained. We present the localization data for these events.Comment: 89 pages, 3 figures. Submitted to the Astrophysical Journal Supplement Serie

A pertubative approach to the Kondo effect in magnetic atoms on nonmagnetic substrates

Recent experimental advances in scanning tunneling microscopy make the measurement of the conductance spectra of isolated and magnetically coupled atoms on nonmagnetic substrates possible. Notably these spectra are characterized by a competition between the Kondo effect and spin-flip inelastic electron tunneling. In particular they include Kondo resonances and a logarithmic enhancement of the conductance at voltages corresponding to magnetic excitations, two features that cannot be captured by second order perturbation theory in the electron-spin coupling. We have now derived a third order analytic expression for the electron-spin self-energy, which can be readily used in combination with the non-equilibrium Green's function scheme for electron transport at finite bias. We demonstrate that our method is capable of quantitative description the competition between Kondo resonances and spin-flip inelastic electron tunneling at a computational cost significantly lower than that of other approaches. The examples of Co and Fe on CuN are discussed in detail

De-blending Deep Herschel Surveys: A Multi-wavelength Approach

Cosmological surveys in the far infrared are known to suffer from confusion. The Bayesian de-blending tool, XID+, currently provides one of the best ways to de-confuse deep Herschel SPIRE images, using a flat flux density prior. This work is to demonstrate that existing multi-wavelength data sets can be exploited to improve XID+ by providing an informed prior, resulting in more accurate and precise extracted flux densities. Photometric data for galaxies in the COSMOS field were used to constrain spectral energy distributions (SEDs) using the fitting tool CIGALE. These SEDs were used to create Gaussian prior estimates in the SPIRE bands for XID+. The multi-wavelength photometry and the extracted SPIRE flux densities were run through CIGALE again to allow us to compare the performance of the two priors. Inferred ALMA flux densities (F$^i$), at 870$\mu$m and 1250$\mu$m, from the best fitting SEDs from the second CIGALE run were compared with measured ALMA flux densities (F$^m$) as an independent performance validation. Similar validations were conducted with the SED modelling and fitting tool MAGPHYS and modified black body functions to test for model dependency. We demonstrate a clear improvement in agreement between the flux densities extracted with XID+ and existing data at other wavelengths when using the new informed Gaussian prior over the original uninformed prior. The residuals between F$^m$ and F$^i$ were calculated. For the Gaussian prior, these residuals, expressed as a multiple of the ALMA error ($\sigma$), have a smaller standard deviation, 7.95$\sigma$ for the Gaussian prior compared to 12.21$\sigma$ for the flat prior, reduced mean, 1.83$\sigma$ compared to 3.44$\sigma$, and have reduced skew to positive values, 7.97 compared to 11.50. These results were determined to not be significantly model dependent. This results in statistically more reliable SPIRE flux densities.Comment: 8 pages, 7 figures, 3 tables. Accepted for publication in A&

Selective ALDH3A1 Inhibition by Benzimidazole Analogues Increase Mafosfamide Sensitivity in Cancer Cells

Aldehyde dehydrogenase enzymes irreversibly oxidize aldehydes generated from metabolism of amino acids, fatty acids, food, smoke, additives, and xenobiotic drugs. Cyclophosphamide is one such xenobiotic used in cancer therapies. Upon activation, cyclophosphamide forms an intermediate, aldophosphamide, which can be detoxified to carboxyphosphamide by aldehyde dehydrogenases (ALDH), especially ALDH1A1 and ALDH3A1. Consequently, selective inhibition of ALDH3A1 could increase chemosensitivity toward cyclophosphamide in ALDH3A1 expressing tumors. Here, we report detailed kinetics and structural characterization of a highly selective submicromolar inhibitor of ALDH3A1, 1-[(4-fluorophenyl)sulfonyl]-2-methyl-1H-benzimidazole (CB7, IC50 of 0.2 μM). CB7 does not inhibit ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2 activity. Structural, kinetics, and mutagenesis studies show that CB7 binds to the aldehyde binding pocket of ALDH3A1. ALDH3A1-expressing lung adenocarcinoma and glioblastoma cell lines are sensitized toward mafosfamide (MF) treatment in the presence analogues of CB7, whereas primary lung fibroblasts lacking ALDH3A1 expression, are not

The second Konus-Wind catalog of short gamma-ray bursts

In this catalog, we present the results of a systematic study of 295 short gamma-ray bursts (GRBs) detected by Konus-Wind (KW) from 1994 to 2010. From the temporal and spectral analyses of the sample, we provide the burst durations, the spectral lags, the results of spectral fits with three model functions, the total energy fluences and the peak energy fluxes of the bursts. We discuss evidence found for an additional power-law spectral component and the presence of extended emission in a fraction of the KW short GRBs. Finally, we consider the results obtained in the context of the Type I (merger-origin) / Type II (collapsar-origin) classifications.Comment: Accepted to the Astrophysical Journal Supplement Series (7 Figures, 8 Tables

X-Ray Light Curves of Gamma-ray Bursts Detected with the All-Sky Monitor on RXTE

We present X-ray light curves (1.5-12 keV) for fifteen gamma-ray bursts (GRBs) detected by the All-Sky Monitor on the Rossi X-ray Timing Explorer. We compare these soft X-ray light curves with count rate histories obtained by the high-energy (>12 keV) experiments BATSE, Konus-Wind, the BeppoSAX Gamma-Ray Burst Monitor, and the burst monitor on Ulysses. We discuss these light curves within the context of a simple relativistic fireball and synchrotron shock paradigm, and we address the possibility of having observed the transition between a GRB and its afterglow. The light curves show diverse morphologies, with striking differences between energy bands. In several bursts, intervals of significant emission are evident in the ASM energy range with little or no corresponding emission apparent in the high-energy light curves. For example, the final peak of GRB 970815 as recorded by the ASM is only detected in the softest BATSE energy bands. We also study the duration of bursts as a function of energy. Simple, singly-peaked bursts seem consistent with the E^{-0.5} power law expected from an origin in synchrotron radiation, but durations of bursts that exhibit complex temporal structure are not consistent with this prediction. Bursts such as GRB 970828 that show many short spikes of emission at high energies last significantly longer at low energies than the synchrotron cooling law would predict.Comment: 15 pages with 20 figures and 2 tables. In emulateapj format. Accepted by ApJ