288 research outputs found
Shark tooth regeneration reveals common stem cell characters in both human rested lamina and ameloblastoma
The human dentition is a typical diphyodont mammalian system with tooth replacement of most positions. However, after dental replacement and sequential molar development, the dental lamina undergoes apoptosis and fragments, leaving scattered epithelial units (dental lamina rests; DLRs). DLRs in adult humans are considered inactive epithelia, thought to possess limited capacity for further regeneration. However, we show that these tissues contain a small proportion of proliferating cells (assessed by both Ki67 and PCNA) but also express a number of common dental stem cell markers (Sox2, Bmi1, β-catenin and PH3) similar to that observed in many vertebrates that actively, and continuously regenerate their dentition. We compared these human tissues with the dental lamina of sharks that regenerate their dentition throughout life, providing evidence that human tissues have the capacity for further and undocumented regeneration. We also assessed cases of human ameloblastoma to characterise further the proliferative signature of dental lamina rests. Ameloblastomas are assumed to derive from aberrant lamina rests that undergo changes, which are not well understood, to form a benign tumour. We suggest that dental lamina rests can offer a potential source of important dental stem cells for future dental regenerative therapy. The combined developmental genetic data from the shark dental lamina and ameloblastoma may lead to the development of novel methods to utilise these rested populations of adult lamina stem cells for controlled tooth replacement in humans
The Maximum Mass of Star Clusters
When an universal untruncated star cluster initial mass function (CIMF)
described by a power-law distribution is assumed, the mass of the most massive
star cluster in a galaxy (M_max) is the result of the size-of-sample (SoS)
effect. This implies a dependence of M_max on the total number of star clusters
(N). The SoS effect also implies that M_max within a cluster population
increases with equal logarithmic intervals of age. This is because the number
of clusters formed in logarithmic age intervals increases (assuming a constant
cluster formation rate). This effect has been observed in the SMC and LMC.
Based on the maximum pressure (P_int) inside molecular clouds, it has been
suggested that a physical maximum mass (M_max[phys]) should exist. The theory
predicts that M_max[phys] should be observable, i.e. lower than M_max that
follows from statistical arguments, in big galaxies with a high star formation
rate. We compare the SoS relations in the SMC and LMC with the ones in M51 and
model the integrated cluster luminosity function (CLF) for two cases: 1) M_max
is determined by the SoS effect and 2) M_max=M_max[phys]=constant. The observed
CLF of M51 and the comparison of the SoS relations with the SMC and LMC both
suggest that there exists a M_max[phys] of 5*10^5 M_sun in M51. The CLF of M51
looks very similar to the one observed in the ``Antennae'' galaxies. A direct
comparison with our model suggests that there M_max[phys]=2*10^6 M_sun.Comment: 4 pages, contribution to "Globular Clusters: Guides to Galaxies",
March 6th-10th, 200
Assessment of Current Jet Noise Prediction Capabilities
An assessment was made of the capability of jet noise prediction codes over a broad range of jet flows, with the objective of quantifying current capabilities and identifying areas requiring future research investment. Three separate codes in NASA s possession, representative of two classes of jet noise prediction codes, were evaluated, one empirical and two statistical. The empirical code is the Stone Jet Noise Module (ST2JET) contained within the ANOPP aircraft noise prediction code. It is well documented, and represents the state of the art in semi-empirical acoustic prediction codes where virtual sources are attributed to various aspects of noise generation in each jet. These sources, in combination, predict the spectral directivity of a jet plume. A total of 258 jet noise cases were examined on the ST2JET code, each run requiring only fractions of a second to complete. Two statistical jet noise prediction codes were also evaluated, JeNo v1, and Jet3D. Fewer cases were run for the statistical prediction methods because they require substantially more resources, typically a Reynolds-Averaged Navier-Stokes solution of the jet, volume integration of the source statistical models over the entire plume, and a numerical solution of the governing propagation equation within the jet. In the evaluation process, substantial justification of experimental datasets used in the evaluations was made. In the end, none of the current codes can predict jet noise within experimental uncertainty. The empirical code came within 2dB on a 1/3 octave spectral basis for a wide range of flows. The statistical code Jet3D was within experimental uncertainty at broadside angles for hot supersonic jets, but errors in peak frequency and amplitude put it out of experimental uncertainty at cooler, lower speed conditions. Jet3D did not predict changes in directivity in the downstream angles. The statistical code JeNo,v1 was within experimental uncertainty predicting noise from cold subsonic jets at all angles, but did not predict changes with heating of the jet and did not account for directivity changes at supersonic conditions. Shortcomings addressed here give direction for future work relevant to the statistical-based prediction methods. A full report will be released as a chapter in a NASA publication assessing the state of the art in aircraft noise prediction
Cytonuclear discordance in the Florida Everglades invasive Burmese python (Python bivittatus) population reveals possible hybridization with the Indian python (P. molurus)
The invasive Burmese python (Python bivittatus) has been reproducing in the Florida Everglades since the 1980s. These giant constrictor snakes have caused a precipitous decline in small mammal populations in southern Florida following escapes or releases from the commercial pet trade. To better understand the invasion pathway and genetic composition of the population, two mitochondrial (mtDNA) loci across 1,398 base pairs were sequenced on 426 snakes and 22 microsatellites were assessed on 389 snakes. Concatenated mtDNA sequences produced six haplotypes with an average nucleotide and haplotype diversity of π = 0.002 and h = 0.097, respectively. Samples collected in Florida from morphologically identified P. bivittatus snakes were similar to published cytochrome oxidase 1 and cytochrome b sequences from both P. bivittatus and Python molurus and were highly divergent (genetic distances of 5.4% and 4.3%, respectively). The average number of microsatellite alleles and expected heterozygosity were NA = 5.50 and HE = 0.60, respectively. Nuclear Bayesian assignment tests supported two genetically distinct groups and an admixed group, not geographically differentiated. The effective population size (NE = 315.1) was lower than expected for a population this large, but reflected the low genetic diversity overall. The patterns of genetic diversity between mtDNA and microsatellites were disparate, indicating nuclear introgression of separate mtDNA lineages corresponding to cytonuclear discordance. The introgression likely occurred prior to the invasion, but genetic information on the native range and commercial trade is needed for verification. Our finding that the Florida python population is comprised of distinct lineages suggests greater standing variation for adaptation and the potential for broader areas of suitable habitat in the invaded range
The young star cluster system of the Antennae galaxies
“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10509-009-0103-xThe study of young star cluster (YSC) systems, preferentially in starburst and merging galaxies, has seen great interest in the recent past, as it provides important input to models of star formation. However, even some basic properties (such as the luminosity function; LF) of YSC systems are still being debated. Here, we study the photometric properties of the YSC system in the nearest major merger system, the Antennae galaxies. We find evidence for the existence of a statistically significant turnover in the LF.Peer reviewe
Surface Terms as Counterterms in the AdS/CFT Correspondence
We examine the recently proposed technique of adding boundary counterterms to
the gravitational action for spacetimes which are locally asymptotic to anti-de
Sitter. In particular, we explicitly identify higher order counterterms, which
allow us to consider spacetimes of dimensions d<=7. As the counterterms
eliminate the need of ``background subtraction'' in calculating the action, we
apply this technique to study examples where the appropriate background was
ambiguous or unknown: topological black holes, Taub-NUT-AdS and Taub-Bolt-AdS.
We also identify certain cases where the covariant counterterms fail to render
the action finite, and we comment on the dual field theory interpretation of
this result. In some examples, the case of vanishing cosmological constant may
be recovered in a limit, which allows us to check results and resolve
ambiguities in certain asymptotically flat spacetime computations in the
literature.Comment: Revtex, 18 pages. References updated and few typo's fixed. Final
versio
Charged BTZ-like Black Holes in Higher Dimensions
Motivated by many worthwhile paper about (2 + 1)-dimensional BTZ black holes,
we generalize them to to (n + 1)-dimensional solutions, so called BTZ-like
solutions. We show that the electric field of BTZ-like solutions is the same as
(2 + 1)-dimensional BTZ black holes, and also their lapse functions are
approximately the same, too. By these similarities, it is also interesting to
investigate the geometric and thermodynamics properties of the BTZ-like
solutions. We find that, depending on the metric parameters, the BTZ-like
solutions may be interpreted as black hole solutions with inner (Cauchy) and
outer (event) horizons, an extreme black hole or naked singularity. Then, we
calculate thermodynamics quantities and conserved quantities, and show that
they satisfy the first law of thermodynamics. Finally, we perform a stability
analysis in the canonical ensemble and show that the BTZ-like solutions are
stable in the whole phase space.Comment: 5 pages, two column format, one figur
Thermodynamics of higher dimensional topological charged AdS black branes in dilaton gravity
In this paper, we study topological AdS black branes of -dimensional
Einstein-Maxwell-dilaton theory and investigate their properties. We use the
area law, surface gravity and Gauss law interpretations to find entropy,
temperature and electrical charge, respectively. We also employ the modified
Brown and York subtraction method to calculate the quasilocal mass of the
solutions. We obtain a Smarr-type formula for the mass as a function of the
entropy and the charge, compute the temperature and the electric potential
through the Smarr-type formula and show that these thermodynamic quantities
coincide with their values which are calculated through using the geometry.
Finally, we perform a stability analysis in the canonical ensemble and
investigate the effects of the dilaton field and the size of black brane on the
thermal stability of the solutions. We find that large black branes are stable
but for small black brane, depending on the value of dilaton field and type of
horizon, we encounter with some unstable phases.Comment: 21 pages, 21 figures, references updated, minor editing, accepted in
EPJC (DOI: 10.1140/epjc/s10052-010-1483-3
Rotating Black Branes in the presence of nonlinear electromagnetic field
In this paper, we consider a class of gravity whose action represents itself
as a sum of the usual Einstein-Hilbert action with cosmological constant and an
gauge field for which the action is given by a power of the Maxwell
invariant. We present a class of the rotating black branes with Ricci flat
horizon and show that the presented solutions may be interpreted as black brane
solutions with two event horizons, extreme black hole and naked singularity
provided the parameters of the solutions are chosen suitably. We investigate
the properties of the solutions and find that for the special values of the
nonlinear parameter, the solutions are not asymptotically anti-deSitter. At
last, we obtain the conserved quantities of the rotating black branes and find
that the nonlinear source effects on the electric field, the behavior of
spacetime, type of singularity and other quantities.Comment: 7 pages, 5 figures, to appear in EPJ
The long-term survival chances of young massive star clusters
We review the long-term survival chances of young massive star clusters
(YMCs), hallmarks of intense starburst episodes often associated with violent
galaxy interactions. We address the key question as to whether at least some of
these YMCs can be considered proto-globular clusters (GCs), in which case these
would be expected to evolve into counterparts of the ubiquitous old GCs
believed to be among the oldest galactic building blocks. In the absence of
significant external perturbations, the key factor determining a cluster's
long-term survival chances is the shape of its stellar initial mass function
(IMF). It is, however, not straightforward to assess the IMF shape in
unresolved extragalactic YMCs. We discuss in detail the promise of using
high-resolution spectroscopy to make progress towards this goal, as well as the
numerous pitfalls associated with this approach. We also discuss the latest
progress in worldwide efforts to better understand the evolution of entire
cluster systems, the disruption processes they are affected by, and whether we
can use recently gained insights to determine the nature of at least some of
the YMCs observed in extragalactic starbursts as proto-GCs. We conclude that
there is an increasing body of evidence that GC formation appears to be
continuing until today; their long-term evolution crucially depends on their
environmental conditions, however.Comment: invited refereed review article; ChJA&A, in press; 33 pages LaTeX (2
postscript figures); requires chjaa.cls style fil
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