Design of Airsoft Weapon Selected Parts

Bakalářská práce se zabývá konstrukčním návrhem airsoftové elektrické zbraně a úpravou mechanismu. Úvod práce podává stručný přehled o problematice a provádí srovnání různých typů mechaboxů dostupných na trhu. V dalších částech práce je proveden výpočetní rozbor, který zahrnuje návrh a kontrolní výpočty vybraných konstrukčních prvků a uzlů. Součástí této práce je také řešení různých variant interních i externích komponent, které přispívají ke zlepšení výkonu a funkčnosti zbraně.The bachelor's thesis deals with the structural design of an electric airsoft weapon and the modification of the mechanism with the intention of increasing the rate of fire. The introduction of the thesis provides a brief overview of the issue and compares various types of mechaboxes available on the market. In the following parts of the thesis, a computational analysis is performed, including the design and control calculations of selected structural elements and assemblies. This work also addresses various variants of internal and external components contributing to the improvement of the gun's performance and functionality.340 - Katedra konstruovánívýborn

Application of organocatalytic approach for the synthesis of piperidine-2-ones, useful building blocks for the preparation of antidepresants

Tato bakalářská práce pojednává o využití organokatalytického konceptu pro přípravu enantiomerně čistých substituovaných piperidin-2-onů ze snadno synteticky dostupných výchozích látek za katalýzy komerčně dostupnými sekundárními aminy. Substituované piperidin-2-ony byly připraveny v dobrých výtěžcích (49-99 %) a s vynikající enantioselektivitou (93-96 % ee). Byla provedena syntéza klíčového intermediátu pro přípravu antidepresiva (+)-femoxetinu, čímž byla syntéza formálně dokončena v úhrnném výtěžku 23 % s enantiomerním přebytkem 95 % ee.This bachelor thesis is focused on the application of organocatalytic approach for the synthesis of enantiomerically pure substitued piperidine-2-ones from synthetically easily avaiable starting materials and commercially avaiable secondary amine. Substitued piperidine-2-ones are prepared in good yields (49-99 %) and excellent enantioselectivities (93-96 % ee). The key-intermediate in synthesis of (+)-femoxetine is prepared and the synthesis is formally finalised in the overall yield 23 % and enantiomeric excess of 95 %.Department of Organic ChemistryKatedra organické chemieFaculty of SciencePřírodovědecká fakult

Interprofessional Collaboration in a New Model of Transitional Care for Families with Preterm Infants – The Health Care Professional's Perspective

Background: Families with preterm infants find life after hospital discharge challenging and need tailored support to thrive. The “Transition to Home (TtH)”-model offers structured, individual support for families with preterm infants before and after hospital discharge. TtH improves parental mental health and competence, promotes child development and fosters interprofessional collaboration (IPC). Aim: Evaluate the TtH-models’ structure and implementation process and its associated interprofessional collaboration from the healthcare professional’s (HCP) perspective. Methods: This qualitative explorative study thematically analyzed four focus group inter- views (n=28 HCP) and an open-ended questionnaire with general pediatricians (n=8). Results: The main themes of the thematic analysis were the benefits of the TtH-model, tailored parental support, the challenges of changing interprofessional collaboration, facil- itators and barriers to successfully implementing the model, and feasibility and health economic limits. HCP acknowledge that continuous family-centered care led by an advanced practice nurse (APN) supports, strengthens, and relieves families with preterm infants in the transition from hospital to home. Families in complex situations benefit most. The TtH- model incorporates key aspects of integrated care like shared decision-making, considering family preferences, and defining the APN as the family’s main contact. HCP want network collaboration but found communication, cooperation, and reorganization challenging in the new IPC process. IPC challenges and involving many HCP in family care can create parental oversupply, negatively affect treatment outcomes, and raise health care costs. Conclusion: These challenges need to be addressed to ensure sustainable implementation of the model. The roles and tasks of HCP should be clearly distinguished from each other, and HCP must have time to learn this new form of IPC. Learning requires time, effective communication strategies, and leadership support. Political action is also required to imple- ment new models of care, including regulating advanced practice roles and developing new financing models

Enhancing Parents’ Well-Being after Preterm Birth—A Qualitative Evaluation of the “Transition to Home” Model of Care

There are few programs available aimed at preventing short- and long-term negative consequences after preterm birth and covering the entire care continuum. The “Transition to Home (TtH)” model is such a program, offering structured, individual support for families with preterm infants before and after hospital discharge. This study gathers and examines the parents’ views of receiving support from an interprofessional team under the TtH model of care during hospitalization and after discharge. Using a qualitative explorative design, 39 semi-structured interviews with parents were analyzed thematically. From this analysis, three main themes were identified: (1) TtH and the relevance of continuity of care; (2) Enhancement of parents’ autonomy and self-confidence; (3) Perception of interprofessional collaboration. Within these themes, the most relevant aspects identified were continuity of care and the appointment of a designated health care professional to anchor the entire care continuum. Emotional support complemented by non-medical approaches, along with strength-based and family resource-oriented communication, also emerged as key aspects. Continuous, family-centered care and well-organized interprofessional collaboration promote the well-being of the family after a premature birth. If the aspects identified in this study are applied, the transition from hospital to home will be smoothened for the benefit of affected families

Hemodynamic and prognostic impact of the diastolic pulmonary arterial pressure in children with pulmonary arterial hypertension-a registry-based analysis

BACKGROUND: Diastolic pulmonary arterial pressure (dPAP) is regarded to be less sensitive to flow metrics as compared to mean PAP (mPAP), and was therefore proposed for the assessment of a precapillary component in patients with postcapillary pulmonary hypertension (PH). To analyze the diagnostic and prognostic impact of dPAP in patients with pure precapillary PH, we purposed to compare the correlation between dPAP and mPAP, as well as hemodynamically-derived calculations [ratio of PAP to systemic arterial pressure (PAP/SAP), pulmonary vascular resistance index (PVRI), transpulmonary gradient (TPG)], using both dPAP and mPAP, at rest and during acute vasoreactivity testing (AVT) in children with idiopathic or heritable pulmonary arterial hypertension (IPAH/HPAH). Furthermore, we aimed to assess the association of these metrics (at baseline and changes after AVT) with transplant-free survival. METHODS: We conducted a retrospective analysis of the TOPP (Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension) registry including 246 IPAH/HPAH patients. Of these, 45 children (18.3%) died, and 13 (5.3%) received lung transplantation during the observation period. RESULTS: dPAP and mPAP-derived variables showed almost linear relationship. Higher mPAP/mSAP, and dPAP-/mPAP-derived PVRI at rest was associated with time to death/transplantation. At maximum AVT-response, the decrease of dPAP and mPAP, diastolic pulmonary gradient (DPG) and TPG, as well as dPAP/dSAP and mPAP/mSAP was associated with time to death/transplantation, showing higher significance than corresponding baseline values. Remarkably, no predictive value was found for PVRI-reduction during AVT, neither dPAP- nor mPAP-derived. CONCLUSIONS: There is a strong relationship between dPAP and mPAP-derived variables. According to our results, hemodynamics during AVT (irrespectively of dPAP- or mPAP-derived) may have more prognostic implications than resting hemodynamics in children with IPAH/HPAH, except for PVRI

Long-term Outcome of Children with Newly Diagnosed Pulmonary Arterial Hypertension:Results From the Global TOPP-registry

BACKGROUND AND AIMS: The Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) registry is a global network established to gain insights into the disease course and long-term outcomes of pediatric pulmonary arterial hypertension (PAH). Previously published cohorts in pediatric PAH are obscured by survival bias due to the inclusion of both prevalent (previously diagnosed) and incident (newly diagnosed) patients. The current study aims to describe long-term outcome and its predictors in pediatric PAH, exclusively of newly diagnosed patients.METHODS AND RESULTS: 531 children with confirmed pulmonary hypertension, aged ≥3 months and &lt;18 years were enrolled in the real-world TOPP registry at 33 centers in 20 countries, from 2008 to 2015. Of these, 242 children with newly diagnosed PAH with at least one follow-up visit were included in the current outcome analyses. During long-term follow-up, 42 (17.4%) children died, 9 (3.7%) underwent lung transplantation, 3 (1.2%) atrial septostomy and 9 (3.7%) Potts shunt palliation (event rates: 6.2, 1.3, 0.4, and 1.4 events per 100 person-years, respectively). One, 3-, and 5-year survival free from adverse outcome was 83.9%, 75.2% and 71.8%, respectively. Overall, children with open (unrepaired or residual) cardiac shunts had the best survival rates. Younger age, worse World Health Organization functional class and higher pulmonary vascular resistance index were identified as independent predictors of long-term adverse outcome. Younger age, higher mean right atrial pressure and lower systemic venous oxygen saturation were specifically identified as independent predictors of early adverse outcome (within 12 months after enrolment).CONCLUSIONS: This comprehensive analysis of survival from time of diagnosis in a large exclusive cohort of children newly diagnosed with PAH describes current era outcome and its predictors.</p

Evaluierung der Zugangsregelungen nach § 71b, § 71c, § 71d UG 2002

Seit rund 15 Jahren gibt es an öffentlichen Universitäten in Österreich quantitative Zugangsregelungen. Diese Zugangsregelungen sind gemäß § 143 Abs. 42 Universitätsgesetz 2002 zu evaluieren

Application of a modified clinical classification for pulmonary arterial hypertension associated with congenital heart disease in children: emphasis on atrial septal defects and transposition of the great arteries. An analysis from the TOPP registry

AimsA proportion of patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) do not fit in the current classification. We aimed to analyse the applicability of an adapted clinical classification of PAH-CHD to pediatric patients using the TOPP-1 registry (Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension) and focus on atrial septal defects (ASD) and transposition of the great arteries (TGA).Methods and resultsHemodynamic and clinical data of all patients with PAH-CHD in the TOPP cohort were reviewed. Patients were classified according to predefined ABCDE categories (A: Eisenmenger syndrome, B: left-to-right shunt, C: coincidental defects, including all ASDs, D: corrected CHD, E: TGA), or as complex CHD (group 5), by 2 independent investigators. In case of disagreement, a third reviewer could either settle a final decision, or the patient was deemed not classifiable. Survival curves were calculated for each group and compared to idiopathic PAH patients of the registry. A total of 223 out of 531 patients in the registry had PAH-CHD, and 193 were categorized to the following groups: A 39(20%), B 27(14%), C 62(32%) including 43 ASDs, D 58(30%), E 7(4%), whereas 6 patients were categorized as group 5, and 10 patients were unable to be classified. No survival difference could be demonstrated between the groups.ConclusionsThis modified classification seems to be more applicable to pediatric PAH-CHD patients than the previous classification, but some patients with PAH-CHD who never had a shunt remain unclassifiable. The role of ASD in pediatric PH should be reconsidered