Analgesic Comparison of Propiram Fumarate with Pentazocine, Codeine, and Placebo in Postsurgical Pain

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97240/1/j.1552-4604.1980.tb01688.x.pd

The ANOVA decomposition and generalized sparse grid methods for the high-dimensional backward Kolmogorov equation

In this thesis, we discuss numerical methods for the solution of the high-dimensional backward Kolmogorov equation, which arises in the pricing of options on multi-dimensional jump-diffusion processes. First, we apply the ANOVA decomposition and approximate the high-dimensional problem by a sum of lower-dimensional ones, which we then discretize by a θ-scheme and generalized sparse grids in time and space, respectively. We solve the resultant systems of linear equations by iterative methods, which requires both preconditioning and fast matrix-vector multiplication algorithms. We make use of a Linear Program and an algebraic formula to compute optimal diagonal scaling parameters. Furthermore, we employ the OptiCom as non-linear preconditioner. We generalize the unidirectional principle to non-local operators and develop a new matrix-vector multiplication algorithm for the OptiCom. As application we focus on the Kou model. Using a new recurrence formula, the computational complexity of the operator application remains linear in the number of degrees of freedom. The combination of the above-mentioned methods allows us to efficiently approximate the solution of the backward Kolmogorov equation for a ten-dimensional Kou model.Die ANOVA-Zerlegung und verallgemeinerte dünne Gitter für die hochdimensionale Kolmogorov-Rückwärtsgleichung In der vorliegenden Arbeit betrachten wir numerische Verfahren zur Lösung der hochdimensionalen Kolmogorov-Rückwärtsgleichung, die beispielsweise bei der Bewertung von Optionen auf mehrdimensionalen Sprung-Diffusionsprozessen auftritt. Zuerst wenden wir eine ANOVA-Zerlegung an und approximieren das hochdimensionale Problem mit einer Summe von niederdimensionalen Problemen, die wir mit einem θ-Verfahren in der Zeit und mit verallgemeinerten dünnen Gittern im Ort diskretisieren. Wir lösen die entstehenden linearen Gleichungssysteme mit iterativen Verfahren, wofür eine Vorkonditionierung als auch schnelle Matrix-Vektor-Multiplikationsalgorithmen nötig sind. Wir entwickeln ein Lineares Programm und eine algebraische Formel, um optimale Diagonalskalierungen zu finden. Des Weiteren setzen wir die OptiCom als nicht-lineares Vorkonditionierungsverfahren ein. Wir verallgemeinern das unidirektionale Prinzip auf nicht-lokale Operatoren und entwickeln einen für die OptiCom optimierten Matrix-Vektor-Multiplikationsalgorithmus. Als Anwendungsbeispiel betrachten wir das Kou-Modell. Mit einer neuen Rekurrenzformel bleibt die Gesamtkomplexität der Operatoranwendung linear in der Anzahl der Freiheitsgrade. Unter Einbeziehung aller genannten Methoden ist es nun möglich, die Lösung der Kolmogorov-Rückwärtsgleichung für ein zehndimensionales Kou-Modell effizient zu approximieren

Einfluss einer Komposition von Farben und Klängen auf Wahrnehmung und Lebensqualität demenzkranker Menschen

Im Zuge der schlechteren finanziellen Situation in der institutionellen Pflege und den dadurch entstehenden Personaleinschränkungen werden Rufe nach Interventionen, die sich von dieser Situation frei machen können, lauter. Darüber hinaus ist das herausfordernde Verhalten, wie Schreien und Rufen, sehr alltagsdominant auf den Stationen. Folglich sind Interventionen, die auf den Patienten eine beruhigende Wirkung haben und finanziell tragbar sind, die Mittel der Wahl. Lawton hat 1891 über die Wirkung des jeweiligen Umfeldes auf das Individuum gesprochen. Er geht davon aus, dass unsere Umwelt uns weniger beeinflusst, wenn wir sie stärker beeinflussen können. Im Laufe einer Demenzerkrankung wird dem Menschen die Möglichkeit der Einflussnahme auf seine Umwelt genommen. Dieses umgekehrt proportionale Verhältnis bzw. der hohe Einfluss der Umwelt auf den an Demenz Erkrankten ist eines der Leitmotive dieser Arbeit

Role of Parenting Variables and Health-Related Quality of Life in Pediatric Cancer

The purpose of the current study was to assess the relationship between parenting capacity variables, namely parental overprotection, perceived child vulnerability, and parenting stress, and socioecological factors, including family socioeconomic status and parental marital status, and parent-proxy report of child health-related quality of life. Participants were 89 parents of children, ages two to 16 (M = 6.5 years, 57% male, 80.9% Caucasian), who were diagnosed with pediatric cancer. Parent participants completed a demographic form, the parent-proxy report of the Pediatric Quality of Life Inventory 3.0 Cancer Module (PedsQL), Parent Protection Scale (PPS), Child Vulnerability Scale (CVS), and Parenting Stress Index/Short Form (PSI/SF). A medical chart review was also conducted. Participants were recruited while attending outpatient appointments at the cancer center of a midwestern children's hospital. After controlling for theoretically important demographic factors, results revealed that parent-proxy report of health-related quality of life was negatively related to family socioeconomic status, parental overprotection, perceived child vulnerability, and parenting stress. No significant relationship was found between parent marital status and health-related quality of life. However, older child age also emerged as a significant predictor of poor child health-related quality of life. Overall, these results support the transactional relationship between parent and child adjustment to pediatric cancer. The evident contributions of socioeconomic status, parental overprotection, perceptions of vulnerability, and parenting stress to child disease-specific health-related quality of life may warrant assessment of these variables in parents of children who have been recently diagnosed with cancer.Department of Psycholog

FONTES DE FINANCIAMENTO DA UNIVERSIDADE FEDERAL DE SANTA CATARINA

O financiamento universitário é temática constantemente discutida, por sua importância na manutenção das atividades de ensino, pesquisa e extensão e na contribuição da universidade para a formação e prosperidade social dos indivíduos e da coletividade. Desde a falência do modelo de Estado de Bem-Estar Social no rico ocidente e o conseqüente desmonte de seu similar nacional, nascido na era Vargas, as universidades públicas buscam fontes alternativas de recursos, seja por diminuições nos repasses do fundo público federal, seja pelo desejo dos administradores universitários de contarem com recursos menos “amarrados” por legislação específica para exercerem suas atividades. Neste estudo exploratório, mas também descritivo, baseado em pesquisa bibliográfica e documental, auxiliada por entrevista por pautas junto à Secretaria de Planejamento da Universidade Federal de Santa Catarina, foram atingidos os objetivos de listar os entes financiadores da IES nos anos de 2009 e 2010, identificar quais recursos são oriundos de convênios e contratos e calcular sua importância relativa nos orçamentos dos dois anos, respectivamente 14,50% e 18,06%. Espera-se com isso subsidiar estudos futuros quanto às contrapartidas exigidas em tais convênios e desvendar como a universidade sucede em captar tais recursos

Differences in adjustment by child developmental stage among caregivers of children with disorders of sex development

<p>Abstract</p> <p>Background</p> <p>The current study sought to compare levels of overprotection and parenting stress reported by caregivers of children with disorders of sex development at four different developmental stages.</p> <p>Methods</p> <p>Caregivers (<it>N </it>= 59) of children with disorders of sex development were recruited from specialty clinics and were asked to complete the Parent Protection Scale and Parenting Stress Index/Short Form as measures of overprotective behaviors and parenting stress, respectively.</p> <p>Results</p> <p>Analyses of covariance (ANCOVAs) were conducted to examine differences between caregiver report of overprotection and parenting stress. Results revealed that caregivers of infants and toddlers exhibited more overprotective behaviors than caregivers of children in the other age groups. Further, caregivers of adolescents experienced significantly more parenting stress than caregivers of school-age children, and this effect was driven by personal distress and problematic parent-child interactions, rather than having a difficult child.</p> <p>Conclusions</p> <p>These results suggest that caregivers of children with disorders of sex development may have different psychosocial needs based upon their child's developmental stage and based upon the disorder-related challenges that are most salient at that developmental stage.</p

Communicating breast cancer risk information to young adult women: A pilot study

Objective To examine the effectiveness of a health promotion flyer to increase awareness of breast cancer risk and physical activity as a risk reduction strategy in young adult women. Methods Young adult women (N = 123) viewed one of five health promotion flyers online and then completed measures of perceived breast cancer risk (PR) and perceived informativeness (PI) and a qualitative thought-listing activity. Results Differences were observed in PI such that the control and low risk/low information messages were significantly less informative than the others. Qualitative analyses revealed two general themes: message content and flyer design. Additional analyses of the flyer design comments revealed four sub-themes: negative thoughts about the image, positive thoughts about the image, misunderstanding breast cancer risk information, and social comparison. Exploratory analyses controlling for message type indicated that image appraisal predicted PI such that those who commented on the image found the flyer to be less informative. Discussion Results suggest that the flyer was informative but did not impact young women’s breast cancer risk perceptions. Additionally, the image may have distracted young women from the intended message. Evaluating the acceptability of images used in health promotion materials is recommended before testing the effectiveness of the intervention

Проектирование электроснабжения токарно-автоматного цеха конденсаторного завода

Объект исследования – конденсаторный завод, токарно-автоматный цех. Цель работы: проектирование электроснабжения конденсаторного завода.The object of study is a capacitor factory, an automatic machine shop. The purpose of the work: the design of power supply of a capacitor factor

Phase I of the Detecting and Evaluating Childhood Anxiety and Depression Effectively in Subspecialties (DECADES) Study: Development of an Integrated Mental Health Care Model for Pediatric Gastroenterology

Background: Children with gastrointestinal symptoms have a very high rate of anxiety and depression. Rapid identification of comorbid anxiety and depression is essential for effective treatment of a wide variety of functional gastrointestinal disorders. Objective: The objective of our study was to determine patient and parent attitudes toward depression, anxiety, and mental health screening during gastroenterology (GI) visits and to determine patient and parent preferences for communication of results and referral to mental health providers after a positive screen. Methods: We augmented standard qualitative group session methods with patient-centered design methods to assess patient and parent preferences. We used a variety of specific design methods in these sessions, including card sorting, projective methods, experience mapping, and constructive methods. Results: Overall, 11 families (11 patients and 14 parents) participated in 2 group sessions. Overall, patients and their parents found integrated mental health care to be acceptable in the subspecialty setting. Patients’ primary concerns were for the privacy and confidentiality of their screening results. Patients and their parents emphasized the importance of mental health services not interfering with the GI visit and collaboration between the GI physician, psychologist, and primary care provider. Conclusions: Patients and their families are open to integrated mental health care in the pediatric subspecialty clinic. The next phase of the DECADES study will translate patient and parent preferences into an integrated mental health care system and test its efficacy in the pediatric GI office. [J Participat Med 2018;10(3):e10655

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process.

G protein-Coupled Receptors (GPCRs) kinases (GRKs) play a crucial role in regulating cardiac hypertrophy. Recent data from our lab has shown that, following ventricular pressure overload, GRK5, a primary cardiac GRK, facilitates maladaptive myocyte growth via novel nuclear localization. In the nucleus, GRK5\u27s newly discovered kinase activity on histone deacetylase 5 induces hypertrophic gene transcription. The mechanisms governing the nuclear targeting of GRK5 are unknown. We report here that GRK5 nuclear accumulation is dependent on Ca(2+)/calmodulin (CaM) binding to a specific site within the amino terminus of GRK5 and this interaction occurs after selective activation of hypertrophic Gq-coupled receptors. Stimulation of myocytes with phenylephrine or angiotensinII causes GRK5 to leave the sarcolemmal membrane and accumulate in the nucleus, while the endothelin-1 does not cause nuclear GRK5 localization. A mutation within the amino-terminus of GRK5 negating CaM binding attenuates GRK5 movement from the sarcolemma to the nucleus and, importantly, overexpression of this mutant does not facilitate cardiac hypertrophy and related gene transcription in vitro and in vivo. Our data reveal that CaM binding to GRK5 is a physiologically relevant event that is absolutely required for nuclear GRK5 localization downstream of hypertrophic stimuli, thus facilitating GRK5-dependent regulation of maladaptive hypertrophy