COMPARE LAAO: Rationale and design of the randomized controlled trial "COMPARing Effectiveness and safety of Left Atrial Appendage Occlusion to standard of care for atrial fibrillation patients at high stroke risk and ineligible to use oral anticoagulation therapy"

Contains fulltext : 252137.pdf (Publisher’s version ) (Open Access)BACKGROUND: Left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). In patients with a long-term or permanent contraindication for OAC randomized controlled trial (RCT) data is lacking. STUDY OBJECTIVES: To assess the efficacy and safety of LAAO in AF patients who are ineligible to use OAC. The co-primary efficacy endpoint is (1) time to first occurrence of stroke (ischemic, hemorrhagic, or undetermined) and (2) time to first occurrence of the composite of stroke, transient ischemic attack (TIA), and systemic embolism (SE). The primary safety endpoint is the 30-day rate of peri-procedural complications. STUDY DESIGN: This is a multicenter, investigator-initiated, open-label, blinded endpoint (PROBE), superiority-driven RCT. Patients with AF, a CHA₂DS₂-VASc score ≥2 for men and ≥3 for women and a long-term or permanent contraindication for OAC will be randomized in a 2:1 fashion to the device- or control arm. Patients in the device arm will undergo percutaneous LAAO and will receive post-procedural dual antiplatelet therapy (DAPT) per protocol, while those in the control arm will continue their current treatment consisting of no antithrombotic therapy or (D)APT as deemed appropriate by the primary responsible physician. In this endpoint-driven trial design, assuming a 50% lower stroke risk of LAAO compared to conservative treatment, 609 patients will be followed for a minimum of 1 and a maximum of 5 years. Cost-effectiveness and budget impact analyses will be performed to allow decision-making on reimbursement of LAAO for the target population in the Netherlands. SUMMARY: The COMPARE LAAO trial will investigate the clinical superiority in preventing thromboembolic events and cost-effectiveness of LAAO in AF patients with a high thromboembolic risk and a contraindication for OAC use. NCT TRIAL NUMBER: NCT04676880

Factors influencing user acceptance of public sector big open data

In recent years Government departments and public/private organizations are becoming increasingly transparent with their data to establish the whole new paradigm of big open data. Increasing research interest arises from the claimed usability of big open data in improving public sector reforms, facilitating innovation, improving supplier and distribution networks and creating resilient supply chains that help improve the efficiency of public services. Despite the advantages of big open data for supply chain and operations management, there is severe shortage of empirical analyses in this field, especially with regards to its acceptance. To address this gap, in this paper we use an extended Technology Acceptance Model (TAM) to empirically examine the factors affecting users’ behavioural intentions towards public sector big open data. We outline the importance of our model for operations and supply chain managers, the limitations of the study, and future research directions

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Several governments around the globe have recently released significant amounts of open data to the public. The main motivation is that citizens or companies use these datasets and develop new data products and applications by either enriching their existing data stores or by smartly combining datasets from various open data portals. In this chapter, we first describe the development of open data over the last few years and briefly introduce the open data portals of the USA, the EU, and Switzerland. Next we will explain various methods for information visualization. Finally, we describe how we combined methods from open data and information visualization. In particular, we show how we developed visualization applications on top of the Swiss open data portal that enable web-based, interactive information visualization as well as a novel paradigm—narrative visualization

The Future of eGovernment. An exploration of ICT-driven models of eGovernment for the EU in 2020 : Executive Summary

Dit onderzoeksproject is uitgevoerd door the Danish Technological Institute en TNO. Het project is uitgevoerd in opdracht van the Institute for Prospective Technological Studies

How to create public value through open data driven Co-creation: A survey of the literature

The drive for openness in government, with open data as a key component, has seen governments around the world devote a large amount of resources to publishing government collected and held data. Scarce resources are being devoted to this goal with the primary goals designated as economic growth and increased innovation. A somewhat overlooked aim is the creation of public value which can be deployed as an openness and trust enhancing apparatus. This preliminary work addresses this gap by aiming to develop the core knowledge of how public value can be co-created with open data. Through an extensive survey of the relevant literature, this research seeks to build an initial framework of public value as applied to co-created open data. Grounded in the structured literature review technique, the authors surveyed the pertinent literature to identify the primary factors that enable value co-creation from the citizens point of view. Furthermore, this research proposes an adapted collection of public values as they relate to open data

Public Services 2.0: The Impact of Social Computing on Public Services

Since 2003, the Internet has seen impressive growth in user-driven applications such as blogs, podcasts, wikis and social networking sites. This trend is referred to here as ‘social computing’ as online applications increasingly support the creation of value by social networks of people. The social computing trend has been recognised and monitored by the Institute for Prospective and Technological Studies (IPTS) over the past few years. IPTS observed a viral take up of social computing applications but – at the same time – a limited provision of citizen-centred public services by governments. Based on this observation, IPTS raised the question of what role social computing could play in generating public value. To answer this question, a more profound understanding of the impact of social computing on the public sector was required. Consequently, the key goal of the present research, commissioned by IPTS, is “to collect and analyse solid evidence, in order to qualify and quantify the significance of the social computing impact and to understand its implications.”5 A review of the literature on social computing shows that the phenomenon continues to grow in popularity and penetration across the globe. Users all over the world blog, network, tag and review. Social networking sites have entered the mainstream and now attract users across all generations and levels of society. Most users seem to assume a relatively passive role, although recent research shows that the number of active users may be significantly larger than the 1% rule used in most studies. The immense take up of social computing applications has clearly started to impact upon the private sector. New players have entered the news and entertainment 5 IPTS, Technical specifications, Call for Tenders J04/013/2007, Public Services 2.0: Social Computing and its implications for future public services. markets, and new business models are emerging rapidly. Current research shows that, in the public sector too, considerable impacts can be found. However, these impacts seem to be broader and more diverse, in line with the multifaceted character of government. The study identifies four categories of impact: political, socio-cultural, organisational and legal