De ontwikkeling van een zevental Professionele Leer Gemeenschappen (PLG-en) in beeld gebracht:gemeten veranderingen van vormgevende kenmerken en sturingsfactoren in de loop van twee jaar onderzoek

Op basis van een multidimensionaal concept is een vragenlijst ontwikkeld die in het kader van een longitudinaal onderzoeksproject twee keer is ingezet om de ontwikkeling van een zevental PLG-en inbeeld te brengen. Tijdens de papersessie worden de resultaten en een onderbouwde conclusie gepresenteerd

COMPARE LAAO: Rationale and design of the randomized controlled trial "COMPARing Effectiveness and safety of Left Atrial Appendage Occlusion to standard of care for atrial fibrillation patients at high stroke risk and ineligible to use oral anticoagulation therapy"

Contains fulltext : 252137.pdf (Publisher’s version ) (Open Access)BACKGROUND: Left atrial appendage occlusion (LAAO) provides an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). In patients with a long-term or permanent contraindication for OAC randomized controlled trial (RCT) data is lacking. STUDY OBJECTIVES: To assess the efficacy and safety of LAAO in AF patients who are ineligible to use OAC. The co-primary efficacy endpoint is (1) time to first occurrence of stroke (ischemic, hemorrhagic, or undetermined) and (2) time to first occurrence of the composite of stroke, transient ischemic attack (TIA), and systemic embolism (SE). The primary safety endpoint is the 30-day rate of peri-procedural complications. STUDY DESIGN: This is a multicenter, investigator-initiated, open-label, blinded endpoint (PROBE), superiority-driven RCT. Patients with AF, a CHA₂DS₂-VASc score ≥2 for men and ≥3 for women and a long-term or permanent contraindication for OAC will be randomized in a 2:1 fashion to the device- or control arm. Patients in the device arm will undergo percutaneous LAAO and will receive post-procedural dual antiplatelet therapy (DAPT) per protocol, while those in the control arm will continue their current treatment consisting of no antithrombotic therapy or (D)APT as deemed appropriate by the primary responsible physician. In this endpoint-driven trial design, assuming a 50% lower stroke risk of LAAO compared to conservative treatment, 609 patients will be followed for a minimum of 1 and a maximum of 5 years. Cost-effectiveness and budget impact analyses will be performed to allow decision-making on reimbursement of LAAO for the target population in the Netherlands. SUMMARY: The COMPARE LAAO trial will investigate the clinical superiority in preventing thromboembolic events and cost-effectiveness of LAAO in AF patients with a high thromboembolic risk and a contraindication for OAC use. NCT TRIAL NUMBER: NCT04676880

Factors influencing user acceptance of public sector big open data

In recent years Government departments and public/private organizations are becoming increasingly transparent with their data to establish the whole new paradigm of big open data. Increasing research interest arises from the claimed usability of big open data in improving public sector reforms, facilitating innovation, improving supplier and distribution networks and creating resilient supply chains that help improve the efficiency of public services. Despite the advantages of big open data for supply chain and operations management, there is severe shortage of empirical analyses in this field, especially with regards to its acceptance. To address this gap, in this paper we use an extended Technology Acceptance Model (TAM) to empirically examine the factors affecting users’ behavioural intentions towards public sector big open data. We outline the importance of our model for operations and supply chain managers, the limitations of the study, and future research directions

Narrative visualization of open data

Several governments around the globe have recently released significant amounts of open data to the public. The main motivation is that citizens or companies use these datasets and develop new data products and applications by either enriching their existing data stores or by smartly combining datasets from various open data portals. In this chapter, we first describe the development of open data over the last few years and briefly introduce the open data portals of the USA, the EU, and Switzerland. Next we will explain various methods for information visualization. Finally, we describe how we combined methods from open data and information visualization. In particular, we show how we developed visualization applications on top of the Swiss open data portal that enable web-based, interactive information visualization as well as a novel paradigm—narrative visualization

Professional Learning Communities (PLCs) as learning environments for teachers:An in-depth examination of the development of seven PLCs and influencing factors

This study focused on the development of seven within-school PLCs during two school years. A total of 139 interviews, and 82 observations of PLC meetings formed the base for in-depth explorations, distinguishing various development levels in PLC characteristics. Using two validated qualitative classification instruments, data were collected to identify changes in characteristics and to track and describe development. This study explores the multiple way(s) in which PLCs develop through time, and looks at school context factors that might influence their development. Results indicated that all PLCs developed over time, however differently. The way the learning activities Collaboration, Reflection, Feedback and Experimentation were performed, showed a cautious development from individual to collective performance. Development from an incidental towards a systematic way of performing was not found in any PLC. No patterns in the development of PLC characteristics could be distinguished that might explain the influence of school context factors on the development of PLCs. In terms of practical implications, school leaders and others responsible for PLCs can be effective in fostering PLC development by tailoring their actions specifically to the needs of the PLC and by deploying a facilitator, granting collective autonomy, providing time and space and offering sources