On the Radio Polarization Signature of Efficient and Inefficient Particle Acceleration in Supernova Remnant SN 1006

We present a radio polarization study of SN 1006, based on combined VLA and ATCA observations at 20 cm that resulted in sensitive images with an angular resolution of 10 arcsec. The fractional polarization in the two bright radio and X-ray lobes of the SNR is measured to be 0.17, while in the southeastern sector, where the radio and non-thermal X-ray emission are much weaker, the polarization fraction reaches a value of 0.6 +- 0.2, close to the theoretical limit of 0.7. We interpret this result as evidence of a disordered, turbulent magnetic field in the lobes, where particle acceleration is believed to be efficient, and a highly ordered field in the southeast, where the acceleration efficiency has been shown to be very low. Utilizing the frequency coverage of our observations, an average rotation measure of ~12 rad/m2 is determined from the combined data set, which is then used to obtain the intrinsic direction of the magnetic field vectors. While the orientation of magnetic field vectors across the SNR shell appear radial, a large fraction of the magnetic vectors lie parallel to the Galactic Plane. Along the highly polarized southeastern rim, the field is aligned tangent to the shock, and therefore also nearly parallel to the Galactic Plane. These results strongly suggest that the ambient field surrounding SN 1006 is aligned with this direction (i.e., from northeast to southwest) and that the bright lobes are due to a polar cap geometry. Our study establishes that the most efficient particle acceleration and generation of magnetic turbulence in SN 1006 is attained for shocks in which the magnetic field direction and shock normal are quasi-parallel, while inefficient acceleration and little to no generation of magnetic turbulence obtains for the quasi-perpendicular case.Comment: Accepted for publication in Astronomical Journa

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.

Amyloid protein aggregates are associated with dozens of devastating diseases including Alzheimer's, Parkinson's, ALS, and diabetes type 2. While structure-based discovery of compounds has been effective in combating numerous infectious and metabolic diseases, ignorance of amyloid structure has hindered similar approaches to amyloid disease. Here we show that knowledge of the atomic structure of one of the adhesive, steric-zipper segments of the amyloid-beta (Aβ) protein of Alzheimer's disease, when coupled with computational methods, identifies eight diverse but mainly flat compounds and three compound derivatives that reduce Aβ cytotoxicity against mammalian cells by up to 90%. Although these compounds bind to Aβ fibers, they do not reduce fiber formation of Aβ. Structure-activity relationship studies of the fiber-binding compounds and their derivatives suggest that compound binding increases fiber stability and decreases fiber toxicity, perhaps by shifting the equilibrium of Aβ from oligomers to fibers. DOI:http://dx.doi.org/10.7554/eLife.00857.001

Artefactual structure from least squares multidimensional scaling

We consider the problem of illusory or artefactual structure from the visualisation of high-dimensional structureless data. In particular we examine the role of the distance metric in the use of topographic mappings based on the statistical field of multidimensional scaling. We show that the use of a squared Euclidean metric (i.e. the SSTRESs measure) gives rise to an annular structure when the input data is drawn from a high-dimensional isotropic distribution, and we provide a theoretical justification for this observation

Professional Reading: Of Tactics, Doctrine and Rules Made to be Broken

Fleet Tactics: Theory and Practic

Economic Implications of Forest Products Sector Industry Development in Northwest Louisiana (Bulletin #874)

In this study, industry development opportunities specific to northwestern Louisiana were examined. This publication focuses on the economic impacts of forest products industry development in this region.https://digitalcommons.lsu.edu/agcenter_bulletins/1028/thumbnail.jp