The concordance of field-normalized scores based on Web of Science and Microsoft Academic data: A case study in computer sciences

In order to assess Microsoft Academic as a useful data source for evaluative bibliometrics it is crucial to know, if citation counts from Microsoft Academic could be used in common normalization procedures and whether the normalized scores agree with the scores calculated on the basis of established databases. To this end, we calculate the field-normalized citation scores of the publications of a computer science institute based on Microsoft Academic and the Web of Science and estimate the statistical concordance of the scores. Our results suggest that field-normalized citation scores can be calculated with Microsoft Academic and that these scores are in good agreement with the corresponding scores from the Web of Science.Comment: 10 pages, 2 figures, 1 tabl

Fabrication and electroosmotic flow measurements in micro- and nanofluidic channels

An easy method for fabricating micro- and nanofluidic channels, entirely made of a thermally grown silicon dioxide is presented. The nanochannels are up to 1-mm long and have widths and heights down to 200nm, whereas the microfluidic channels are 20-μm wide and 4.8-μm high. The nanochannels are created at the interface of two silicon wafers. Their fabrication is based on the expansion of growing silicon dioxide and the corresponding reduction in channel cross-section. The embedded silicon dioxide channels were released and are partially freestanding. The transparent and hydrophilic silicon dioxide channel system could be spontaneously filled with aqueous, fluorescent solution. The electrical resistances of the micro- and nanofluidic channel segments were calculated and the found values were confirmed by current measurements. Electrical field strengths up to 600V/cm were reached within the nanochannels when applying a potential of only 10V. Electroosmotic flow (EOF) measurements through micro- and nanofluidic channel systems resulted in electroosmotic mobilities in the same order of those encountered in regular, fused silica capillarie

Medication Review and Enhanced Information Transfer at Discharge of Older Patients with Polypharmacy: a Cluster-Randomized Controlled Trial in Swiss Hospitals

Background: Medication safety in patients with polypharmacy at transitions of care is a focus of the current Third WHO Global Patient Safety Challenge. Medication review and communication between health care professionals are key targets to reduce medication-related harm. Objective: To study whether a hospital discharge intervention combining medication review with enhanced information transfer between hospital and primary care physicians can delay hospital readmission and impact health care utilization or other health-related outcomes of older inpatients with polypharmacy. Design: Cluster-randomized controlled trial in 21 Swiss hospitals between January 2019 and September 2020, with 6 months follow-up. Participants: Sixty-eight senior physicians and their blinded junior physicians included 609 patients ≥ 60 years taking ≥ 5 drugs. Interventions: Participating hospitals were randomized to either integrate a checklist-guided medication review and communication stimulus into their discharge processes, or follow usual discharge routines. Main measures: Primary outcome was time-to-first-readmission to any hospital within 6 months, analyzed using a shared frailty model. Secondary outcomes covered readmission rates, emergency department visits, other medical consultations, mortality, drug numbers, proportions of patients with potentially inappropriate medication, and the patients' quality of life. Key results: At admission, 609 patients (mean age 77.5 (SD 8.6) years, 49.4% female) took a mean of 9.6 (4.2) drugs per patient. Time-to-first-readmission did not differ significantly between study arms (adjusted hazard ratio 1.14 (intervention vs. control arm), 95% CI [0.75-1.71], p = 0.54), nor did the 30-day hospital readmission rates (6.7% [3.3-10.1%] vs. 7.0% [3.6-10.3%]). Overall, there were no clinically relevant differences between study arms at 1, 3, and 6 months after discharge. Conclusions: The combination of a structured medication review with enhanced information transfer neither delayed hospital readmission nor improved other health-related outcomes of older inpatients with polypharmacy. Our results may help researchers in balancing practicality versus stringency of similar hospital discharge interventions. Study registration: ISRCTN18427377, https://doi.org/10.1186/ISRCTN18427377. Keywords: communication; health care quality improvement; hospital medicine; medication safety; primary care

Bacteria-on-a-bead: probing the hydrodynamic interplay of dynamic cell appendages during cell separation

Surface attachment of bacteria is the first step of biofilm formation and is often mediated and coordinated by the extracellular appendages, flagellum and pili. The model organism Caulobacter crescentus undergoes an asymmetric division cycle, giving rise to a motile "swarmer cell" and a sessile "stalked cell", which is attached to the surface. In the highly polarized predivisional cell, pili and flagellum, which are assembled at the pole opposite the stalk, are both activated before and during the process of cell separation. We explored the interplay of flagellum and active pili by growing predivisional cells on colloidal beads, creating a bacteria-on-a-bead system. Using this set-up, we were able to simultaneously visualize the bacterial motility and analyze the dynamics of the flagellum and pili during cell separation. The observed activities of flagellum and pili at the new cell pole of the predivisional cell result in a cooperating interplay of the appendages during approaching and attaching to a surface. Even in presence of a functioning flagellum, pili are capable of surface attachment and keeping the cell in position. Moreover, while flagellar rotation decreases the average attachment time of a single pilus, it increases the overall attachment rate of pili in a synergetic manner

Second messenger-mediated tactile response by a bacterial rotary motor

When bacteria encounter surfaces, they respond with surface colonization and virulence induction. The mechanisms of bacterial mechanosensation and downstream signaling remain poorly understood. Here, we describe a tactile sensing cascade in Caulobacter crescentus in which the flagellar motor acts as sensor. Surface-induced motor interference stimulated the production of the second messenger cyclic diguanylate by the motor-associated diguanylate cyclase DgcB. This led to the allosteric activation of the glycosyltransferase HfsJ to promote rapid synthesis of a polysaccharide adhesin and surface anchoring. Although the membrane-embedded motor unit was essential for surface sensing, mutants that lack external flagellar structures were hypersensitive to mechanical stimuli. Thus, the bacterial flagellar motor acts as a tetherless sensor reminiscent of mechanosensitive channels

Semaine d'Etude Mathématiques et Entreprises 6 : Analyse et filtrage temps-fréquence de "bursts" ultrasonores : identification, classification, séparation

Ce rapport est une présentation de nos résultats et de nos réflexions à propos du problème proposé par IFP Énergies Nouvelles pendant la sixième édition de la Semaine d'Étude Maths-Entreprises. Nous disposions d'enregistrements de bursts ultrasonores issus d'un problème physique de corrosion d'éprouvettes en métal. Le but était de donner une classification des signaux acoustiques visant à identifier les différentes typologies de corrosion. En Section 1 on trouve une présentation plus détaillée de la problématique enquêtée. Tous les approches considérées sont développées dans la Section 3, alors que dans la Section 2 on a passé en revue les outils mathématiques nécessaires

Arbeit und Krankheit : Berufliche Wiedereingliederung von Personen mit länger andauernder Arbeitsunfähigkeit - Eine Untersuchung zur Rolle des Rechts und des sozialen Umfelds

Weshalb gelingt es einigen Erwerbspersonen besser als andern, sich nach einer länger andauernden Arbeitsunfähigkeitsphase wieder in den Erwerbsprozess zu integrieren? In einem mehrjährigen Forschungsprojekt (2008-2012) wurde das komplexe Wechselspiel zwischen Individuen, sozialen, rechtlichen und gesellschaftlichen Kontextbedingungen und den beteiligten Betrieben und Institutionen analysiert. Vorschläge für Massnahmen zur Verhinderung der Desintegration runden die Studie ab. Das Projekt wurde vom schweizerischen Nationalfonds (SNF) unterstützt und gemeinsam vom Büro für arbeits- und sozialpolitische Studien BASS und der ZHAW – Zentrum für Sozialrecht durchgeführt

Characterizing digital microstructures by the Minkowski‐based quadratic normal tensor

For material modeling of microstructured media, an accurate characterization of the underlying microstructure is indispensable. Mathematically speaking, the overall goal of microstructure characterization is to find simple functionals which describe the geometric shape as well as the composition of the microstructures under consideration and enable distinguishing microstructures with distinct effective material behavior. For this purpose, we propose using Minkowski tensors, in general, and the quadratic normal tensor, in particular, and introduce a computational algorithm applicable to voxel-based microstructure representations. Rooted in the mathematical field of integral geometry, Minkowski tensors associate a tensor to rather general geometric shapes, which make them suitable for a wide range of microstructured material classes. Furthermore, they satisfy additivity and continuity properties, which makes them suitable and robust for large-scale applications. We present a modular algorithm for computing the quadratic normal tensor of digital microstructures. We demonstrate multigrid convergence for selected numerical examples and apply our approach to a variety of microstructures. Strikingly, the presented algorithm remains unaffected by inaccurate computation of the interface area. The quadratic normal tensor may be used for engineering purposes, such as mean field homogenization or as target value for generating synthetic microstructures