Death receptor 5 expression is inversely correlated with prostate cancer progression.

Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic tool as its sensitivity may be too low to reduce morbidity and mortality. Consequently, there is a demand for additional robust biomarkers for prostate cancer. Death receptor 5 (DR5) has been implicated in the prognosis of several cancers and it has been previously shown that it is negatively regulated by Yin Yang 1 (YY1) in prostate cancer cell lines. The present study investigated the clinical significance of DR5 expression in a prostate cancer patient cohort and its correlation with YY1 expression. Immunohistochemical analysis of protein expression distribution was performed using tissue microarray constructs from 54 primary PCa and 39 prostatic intraepithelial neoplasia (PIN) specimens. DR5 expression was dramatically reduced as a function of higher tumor grade. By contrast, YY1 expression was elevated in PCa tumors as compared with that in PIN, and was increased with higher tumor grade. DR5 had an inverse correlation with YY1 expression. Bioinformatic analyses corroborated these data. The present findings suggested that DR5 and YY1 expression levels may serve as progression biomarkers for prostate cancer

Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications

In this work, a hybrid copolymer consisting of poly(3-hydroxybutyrate) grafted to hyaluronic acid (HA) was synthesised and characterised. Once formed, the P(3HB)-g-HA copolymer was soluble in water allowing a green electrospinning process. The diameters of nanofibres can be tailored by simply varying the Mw of polymer. The optimization of the process allowed to produce fibres of average diameter in the range of 100-150 nm and low polydispersity. The hydrophobic modification has not only increased the fibre diameter, but also the obtained layers were homogenous. At the nanoscale, the hybrid copolymer exhibited an unusual hairy topography. Moreover, the hardness and tensile properties of the hybrid were found to be superior compared to fibres made of unmodified HA. Particularly, this reinforcement was achieved at the longitudinal direction. Additionally, this work reports the use in the composition of a water-soluble copolymer containing photo cross-linkable moieties to produce insoluble materials post-electrospinning. The derivatives as well as their nanofibrous mats retain the biocompatibility of the natural polymers used for the fabrication

Synthesis of graft copolymers based on hyaluronan and poly(3-hydroxyalkanoates)

This work reports the synthesis and characterisation of new amphiphilic hyaluronan (HA) grafted with poly(3-hydroxyalkanoates) (PHAs) conjugates. Hydrolytic depolymerisation of PHAs was used for the synthesis of defined oligo(3-hydroxyalkanoates)-containing carboxylic terminal moieties. A kinetic study of the depolymerisation was followed to prepare oligomers of required molecular weight. PHAs were coupled with hydroxyl groups of HA mediated by N, N'-carbonyldiimidazole (CDI) or HSTU Tetramethyl-O-(N-succinimidyl) uronium hexafluorophosphate. For the first time, the covalent bonding of oligo derivatives of P(3-hydroxybutyrate), P(3-hydroxyoctanoate), P(3-hydroxyoctanoate-co-3-hydroxydecanoate) and P(3-hydroxyoctanoate-co-3-hydroxydecanoate-co-3-hydroxydodecanoate) and HA was achieved by “grafting to” strategy. Achieved grafting degree was a function of hydrophobicity of PHA, Mw and polarity of the solvent. The most suitable reaction conditions were observed for oligo (3-hydroxybutyrate) grafted to HA (grafting degree of 14%). Graft copolymers were characterized by FT-IR, NMR, DSC and SEC-MALLS. Graft copolymers can be physically loaded with hydrophobic drugs and may serve as drug delivery system

Emotional intelligence in students in the 1st and 5th semesters of a nursing degree.

Introducción. La inteligencia emocional [IE], se relaciona con el éxito académico y quienes la poseen tienen reacciones favorables al control de las emociones, y son conscientes de como éstas pueden afectarles (Quiliano & Quiliano, 2020). Es deseable que los estudiantes de ciencias de la salud aprendan a manejar sus emociones, por las repercusiones durante la interacción con las personas de su entorno personal y laboral (Liébana-Presa, 2017).  Objetivo general: Analizar las diferencias de las dimensiones de Inteligencia emocional, en estudiantes de 1ero y 5to semestres por cada variable sociodemográfica. Metodología: Estudio descriptivo-transversal comparativo, la muestra 175 estudiantes. Instrumento: Autopercepción de inteligencia emocional (Treit Meta-Mood Scale) de Fernández-Berrocal et al. (2004). Se utilizó Shapiro-Wilks y U de Mann-Whitney y Kruskal-Wallis, y la prueba de Ji cuadrada para determinar asociación de la IE. Resultados: Se identificaron diferencias en las dimensiones de inteligencia emocional y los datos sociodemográficos. Conclusiones: Los estudiantes de primer semestre presentan, mayor desarrollo en las dimensiones de atención, claridad y reparación emocional, comparativamente con los estudiantes de quinto semestre.Introduction. Emotional intelligence [EI] is related to academic success and those who possess it have favorable reactions to the control of emotions, and are aware of how these can affect them (Quiliano & Quiliano, 2020). It is desirable that health sciences students learn to manage their emotions, due to the repercussions during interaction with people in their personal and work environment (Liébana-Presa, 2017). General objective: Analyze the differences in the dimensions of emotional intelligence in 1st and 5th semester students for each sociodemographic variable. Methodology: Comparative descriptive-cross-sectional study, sample 175 students. Instrument: Self-perception of emotional intelligence (Treit Meta-Mood Scale) by Fernández-Berrocal et al. (2004). Shapiro-Wilks and Mann-Whitney U and Kruskal-Wallis, and the Chi-square test were used to determine the association of EI. Results: Differences were identified in the dimensions of emotional intelligence and sociodemographic data. Conclusions: First semester students present greater development in the dimensions of attention, clarity and emotional repair, compared to fifth semester students

Toward Molecular Nanowires Self-Assembled on an Insulating Substrate: Heptahelicene-2-carboxylic acid on Calcite (1014)

Rahe P, Nimmrich M, Greuling A, et al. Toward Molecular Nanowires Self-Assembled on an Insulating Substrate: Heptahelicene-2-carboxylic acid on Calcite (1014). Journal of Physical Chemistry C. 2010;114(3):1547-1552.Molecular self-assembly is employed for creating unidirectional molecular nanostructures on a truly insulating substrate, namely the (10 (1) over bar4) cleavage plane of calcite. The molecule used is racemic heptahelicene-2-carboxylic acid, which forms structures, well-aligned along the [010] crystallographic direction and stable at room temperature. Precise control of both molecule-substrate and molecule-molecule interaction is required, leading to the formation of such wire-like structures of well-defined width and lengths exceeding 100 nm. This subtle balance is governed by the heptahelicene-2-carboxylic acid used in this study, allowing for both hydrogen bond formation as well pi-pi stacking

Estilo de vida y su asociación con variables sociodemográficas en universitarios

Introduction: Lifestyles are defined as the set of personal characteristics and daily behavior at home, work, daily activities, diet, physical activity, among others. According to the WHO, healthy lifestyles prevent the onset of NCDs. Objective: To identify the lifestyle and its association with the sociodemographic variables of the nursing students of the FET-UAT. Methodology: Cross-sectional, correlational descriptive design, with a random sample of 134 students. Lifestyle was measured with the FANTASTIC questionnaire. Results: The reliability of the instrument was .77. Students mostly have a "good job, you're on the right track" lifestyle (46.3). In the association between the lifestyle with the age, sex, shift and academic period of the students, greater affectation was found in the dimensions of family, alcohol and tobacco, with men and those over 21 years of age consuming more alcohol and being the evening shift who smokes the most. Conclusions: It was determined that the lifestyle is mostly "good", but the students showed greater consumption of alcohol and tobacco and have a poor relationship with the family.Introducción: Los estilos de vida se definen cómo el conjunto de características personales y comportamiento diario en el hogar, trabajo, actividades cotidianas, dieta, actividad física, entre otros. Según la OMS, los estilos de vida saludable previenen la aparición de ECNT. Objetivo: Identificar el estilo de vida y su asociación con las variables sociodemográficas de los estudiantes de enfermería de la FET-UAT. Metodología: El diseño descriptivo transversal, correlacional, con una muestra al azar de 134 estudiantes. El estilo de vida se midió con el cuestionario FANTÁSTICO. Resultados: La confiabilidad del instrumento fue de .77. Los estudiantes en su mayoría tienen un estilo de vida de “buen trabajo, estás en buen camino” (46.3%). En la asociación entre el estilo de vida con la edad, sexo, turno y periodo académico de los estudiantes se encontró mayor afectación a las dimensiones de familia, alcohol y tabaco, siendo los hombres y los mayores de 21 años quien consumen más alcohol y es el turno vespertino quien más fuma. Conclusiones: Se determinó que el estilo de vida en su mayoría es “bueno”, pero los estudiantes mostraron mayor consumo de alcohol y tabaco y tener mala relación con la familia

Measurement of the Crab Nebula Spectrum Past 100 TeV with HAWC

We present TeV gamma-ray observations of the Crab Nebula, the standard reference source in ground-based gamma-ray astronomy, using data from the High Altitude Water Cherenkov (HAWC) Gamma-Ray Observatory. In this analysis we use two independent energy-estimation methods that utilize extensive air shower variables such as the core position, shower angle, and shower lateral energy distribution. In contrast, the previously published HAWC energy spectrum roughly estimated the shower energy with only the number of photomultipliers triggered. This new methodology yields a much improved energy resolution over the previous analysis and extends HAWC's ability to accurately measure gamma-ray energies well beyond 100 TeV. The energy spectrum of the Crab Nebula is well fit to a log parabola shape $\left(\frac{dN}{dE} = \phi_0 \left(E/\textrm{7 TeV}\right)^{-\alpha-\beta\ln\left(E/\textrm{7 TeV}\right)}\right)$ with emission up to at least 100 TeV. For the first estimator, a ground parameter that utilizes fits to the lateral distribution function to measure the charge density 40 meters from the shower axis, the best-fit values are $\phi_o$=(2.35$\pm$0.04$^{+0.20}_{-0.21}$)$\times$10$^{-13}$ (TeV cm$^2$ s)$^{-1}$, $\alpha$=2.79$\pm$0.02$^{+0.01}_{-0.03}$, and $\beta$=0.10$\pm$0.01$^{+0.01}_{-0.03}$. For the second estimator, a neural network which uses the charge distribution in annuli around the core and other variables, these values are $\phi_o$=(2.31$\pm$0.02$^{+0.32}_{-0.17}$)$\times$10$^{-13}$ (TeV cm$^2$ s)$^{-1}$, $\alpha$=2.73$\pm$0.02$^{+0.03}_{-0.02}$, and $\beta$=0.06$\pm$0.01$\pm$0.02. The first set of uncertainties are statistical; the second set are systematic. Both methods yield compatible results. These measurements are the highest-energy observation of a gamma-ray source to date.Comment: published in Ap

Proposal of a Framework for Innovation Competencies Development and Assessment (FINCODA)

[EN] In this article we propose a model of innovation competence of people, based on the existing literature to integrate and complement the existing models. The main contribution of this work consists in demonstrating the differences and similarities of current models and in providing a conceptual definition for each model element. In this way, both researchers and people in charge of Human Resources in companies can obtain a framework to design measuring instruments to assess the innovation competence, which can fulfil the twofold demand requirement of validity and reliability.This work has been conducted as part of a European project financed by the European Union ["FINCODA" Project 554493-EPP-1-2014-1-FI-EPPKA2-KA] (http://bit.ly/FINCODA-EUsite01). (The European Commission support for the production of this publication does not constitute an endorsement of the contents which reflects the views only of the authors, and the Commission cannot be held responsible for any use which may be made of the information contained therein); and by the Universitat Politénica de Valencia PIME 2015-2016 A/09 “Evaluación de los indicadores del comportamiento innovador en el alumno universitario”.Marín García, JA.; Andreu Andrés, MA.; Atarés Huerta, LM.; Aznar Más, L.; García Carbonell, A.; González-Ladrón-De-Guevara, F.; Montero Fleta, MB.... (2016). Proposal of a Framework for Innovation Competencies Development and Assessment (FINCODA). Working Papers on Operations Management. 7(2):119-126. https://doi.org/10.4995/wpom.v7i2.6472SWORD1191267