Persistence and transmission of tick-borne viruses: Ixodes ricinus and louping-ill virus in red grouse populations

The population dynamics of tick-borne disease agents and in particular the mechanisms which influence their persistence are examined with reference to the flavivirus that causes louping-ill in red grouse and sheep. Pockets of infection cause heavy mortality and the infection probably persists as a consequence of immigration of susceptible hosts. Seroprevalence is positively associated with temporal variations in vectors per host, although variation between areas is associated with the abundance of mountain hares. The presence of alternative tick hosts, particularly large mammals, provides additional hosts for increasing tick abundance. Grouse alone can not support the vectors and the pathogen but both can persist when a non-viraemic mammalian host supports the tick population and a sufficiently high number of nymphs bite grouse. These alternative hosts may also amplify virus through non-viraemic transmission by the process of co-feeding, although the relative significance of this has yet to be determined. Another possible route of infection is through the ingestion of vectors when feeding or preening. Trans-ovarial transmission is a potentially important mechanism for virus persistence but has not been recorded with louping-ill and ixodes ricinus. The influence of non-viraemic hosts, both in the multiplication of vectors and the amplification of virus through non-viraemic transmission are considered significant for virus persistence

Legislative strengthening meets party support in international assistance: a closer relationship?

Recent reports recommend that international efforts to help strengthen legislatures in emerging democracies should work more closely with support for building stronger political parties and competitive party systems. This article locates the recommendations within international assistance more generally and reviews the arguments. It explores problems that must be addressed if the recommendations are to be implemented effectively. The article argues that an alternative, issue-based approach to strengthening legislatures and closer links with civil society could gain more traction. However, that is directed more centrally at promoting good governance for the purpose of furthering development than at democratisation goals sought by party aid and legislative strengtheners in the democracy assistance industry

Renal Stone Risk During Space Flight: Assessment and Countermeasure Validation

NASA has focused its future on exploration class missions including the goal of returning to the moon and landing on Mars. With these objectives, humans will experience an extended exposure to the harsh environment of microgravity and the associated negative effects on all the physiological systems of the body. Exposure to microgravity affects human physiology and results in changes to the urinary chemical composition during and after space flight. These changes are associated with an increased risk of renal stone formation. The development of a renal stone would have health consequences for the crewmember and negatively impact the success of the mission. As of January 2007, 15 known symptomatic medical events consistent with urinary calculi have been experienced by 13 U.S. astronauts and Russian cosmonauts. Previous results from both MIR and Shuttle missions have demonstrated an increased risk for renal stone formation. These data have shown decreased urine volume, urinary pH and citrate levels and increased urinary calcium. Citrate, an important urinary inhibitor of calcium-containing renal stones binds with calcium in the urine, thereby reducing the amount of calcium available to form calcium oxalate stones. Urinary citrate also prevents calcium oxalate crystals from aggregating into larger crystals and into renal stones. In addition, citrate makes the urine less acidic which inhibits the development of uric acid stones. Potassium citrate supplementation has been successfully used to treat patients who have formed renal stones. The evaluation of potassium citrate as a countermeasure has been performed during the ISS Expeditions 3-6, 8, 11-13 and is currently in progress during the ISS Expedition 14 mission. Together with the assessment of stone risk and the evaluation of a countermeasure, this investigation provides an educational opportunity to all crewmembers. Individual urinary biochemical profiles are generated and the risk of stone formation is estimated. Increasing fluid intake is recommended to all crewmembers. These results can be used to lower the risk for stone formation through lifestyle, diet changes or therapeutic administration to minimize the risk for stone development. With human presence in microgravity a continuing presence and exploration class missions being planned, maintaining the health and welfare of all crewmembers is critical to the exploration of space

Full phase stabilization of a Yb:fiber femtosecond frequency comb via high-bandwidth transducers

We present full phase stabilization of an amplified Yb:fiber femtosecond frequency comb using an intra-cavity electro-optic modulator and an acousto-optic modulator. These transducers provide high servo bandwidths of 580 kHz and 250 kHz for frep and fceo, producing a robust and low phase noise fiber frequency comb. The comb was self-referenced with an f - 2f interferometer and phase locked to an ultra-stable optical reference used for the JILA Sr optical clock at 698 nm, exhibiting 0.21 rad and 0.47 rad of integrated phase errors (over 1 mHz - 1 MHz) respectively. Alternatively, the comb was locked to two optical references at 698 nm and 1064 nm, obtaining 0.43 rad and 0.14 rad of integrated phase errors respectively

Evidence of unrelaxed IGM around IC1262

AIMS: A peculiar morphology of the hot gas was discovered at the center of IC1262 with the ROSAT HRI. Sensitive Chandra and XMM-Newton data were requested to investigate the characteristics of this structure to understand its nature. METHODS: We have exploited the high resolution and sensitivity of Chandra's ACIS-S to investigate the peculiar morphology and spectral characteristics of hot gas in the group around IC1262. XMM-Newton data are only partially usable due to very heavy high background contamination, but they are useful to confirm and strengthen the results from Chandra. RESULTS: The Chandra data show a quite dramatic view of the \object{IC1262} system: a sharp discontinuity east of the central galaxy, with steep drops and a relatively narrow feature over 100 kpc long, plus an arc/loop to the N, are all indicative of a turmoil in the high energy component. Their morphologies could suggest them to be tracers of shocked material caused either by peculiar motions in the system or by a recent merger process, but the spectral characteristics indicate that the structure is cooler than its surroundings. The lack of evidence of significant structures in the velocity distribution of the group members and the estimated scale of the phenomenon make the interpretation of its physical nature challenging. We review a few possible interpretations, in light of similar phenomena observed in clusters and groups. The ram pressure stripping of a bright spiral galaxy, now near the center of the group, is a promising interpretation for most of the features observed. The relation with the radio activity requires a better sampling of the radio parameters that can only be achieved with deeper and higher resolution observations.Comment: Accepted for pubblication in Astronomy & Astrophysics. Figs 1, 2, 3 and 9-12 are given as JPEG files due to the restrictions on space available on astro-p

Inverse Compton X-rays from relativistic flare electrons and positrons

<p><b>Context:</b> In solar flares, inverse Compton scattering (ICS) of photospheric photons might give rise to detectable hard X-ray photon fluxes from the corona where ambient densities are too low for significant bremsstrahlung or recombination. γ-ray lines and continuum in some large flares imply the presence of the necessary ~100 MeV electrons and positrons, the latter as by-products of GeV energy ions. Recent observations of coronal hard X-ray sources in particular prompt us to reconsider here the possible contribution of ICS.</p> <p><b>Aims:</b> We aim to evaluate the ICS X-ray fluxes to be expected from prescribed populations of relativistic electrons and positrons in the solar corona. The ultimate aim is to determine if ICS coronal X-ray sources might offer a new diagnostic window on relativistic electrons and ions in flares.</p> <p><b>Methods:</b> We use the complete formalism of ICS to calculate X-ray fluxes from possible populations of flare primary electrons and secondary positrons, paying attention to the incident photon angular distribution near the solar surface and thus improving on the assumption of isotropy made in previous solar discussions.</p> <p><b>Results:</b> Both primary electrons and secondary positrons produce very hard ICS X-ray spectra. The anisotropic primary radiation field results in pronounced centre-to-limb variation in predicted fluxes and spectra, with the most intense spectra, extending to the highest photon energies, expected from limb flares. Acceptable numbers of electrons or positrons could account for RHESSI coronal X/γ-ray sources.</p> <p><b>Conclusions:</b> Some coronal X-ray sources at least might be interpreted in terms of ICS by relativistic electrons or positrons, particularly when sources appear at such low ambient densities that bremsstrahlung appears implausible.</p&gt

Formation of ultracold dipolar molecules in the lowest vibrational levels by photoassociation

We recently reported the formation of ultracold LiCs molecules in the rovibrational ground state X1Sigma+,v''=0,J''=0 [J. Deiglmayr et al., PRL 101, 133004 (2008)]. Here we discuss details of the experimental setup and present a thorough analysis of the photoassociation step including the photoassociation line shape. We predict the distribution of produced ground state molecules using accurate potential nergy curves combined with an ab-initio dipole transition moment and compare this prediction with experimental ionization spectra. Additionally we improve the value of the dissociation energy for the X1Sigma+ state by high resolution spectroscopy of the vibrational ground state.Comment: Submitted to Faraday Discussions 142: Cold and Ultracold Molecules 18 pages, 8 figure

‘What are you going to do, confiscate their passports?’ Professional perspectives on cross-border reproductive travel

Objective: This article reports findings from a UK-based study which explored the phenomenon of overseas travel for fertility treatment. The first phase of this project aimed to explore how infertility clinicians and others professionally involved in fertility treatment understand the nature and consequences of cross-border reproductive travel. Background: There are indications that, for a variety of reasons, people from the UK are increasingly travelling across national borders to access assisted reproductive technologies. While research with patients is growing, little is known about how ‘fertility tourism’ is perceived by health professionals and others with a close association with infertility patients. Methods: Using an interpretivist approach, this exploratory research included focussed discussions with 20 people professionally knowledgeable about patients who had either been abroad or were considering having treatment outside the UK. Semi-structured interviews were recorded, transcribed verbatim and subjected to a thematic analysis. Results: Three conceptual categories are developed from the data: ‘the autonomous patient’; ‘cross-border travel as risk’, and ‘professional responsibilities in harm minimisation’. Professionals construct nuanced, complex and sometimes contradictory narratives of the ‘fertility traveller’, as vulnerable and knowledgeable; as engaged in risky behaviour and in its active minimisation. Conclusions: There is little support for the suggestion that states should seek to prevent cross-border treatment. Rather, an argument is made for less direct strategies to safeguard patient interests. Further research is required to assess the impact of professional views and actions on patient choices and patient experiences of treatment, before, during and after travelling abroad

Literature

Literature has been proposed as a means to enrich an understanding of ethical issues within medicine and health care and as a resource in medical education. Its proponents argue for the value of understanding human suffering, and the experience of health care, through literature, rather than solely through the more abstract and analytic philosophical methods of bioethics. Literature is claimed to serve as a corrective to the rational and individualist approaches of bioethics, by drawing attention to ‘our vulnerable and interdependent human existence.’ In this essay the history of a relationship between ethics and literature is discussed, along with more recent scholarship on the ethical relevance of literature, and research focusing on the constitution of ethics as literary form. It is apparent that literature, and especially futurist writing and science fiction, has an influence on the construction and understanding of ethical issues for both specialist practitioners and the lay public. It is concluded that literature enhances understanding of ethical issues in health care and research, and the manner in which it does so needs to be better understood through the skills of literary analysis as a necessary complement to bioethical analysis

A catalogue of galaxies behind the southern Milky Way. - II. The Crux and Great Attractor regions (l = 289deg - 338deg)

In this second paper of the catalogue series of galaxies behind the southern Milky Way, we report on the deep optical galaxy search in the Crux region (289deg <= l <= 318deg and -10deg <= b <= 10deg) and the Great Attractor region (316deg <= l <= 338deg and -10deg <= b <= 10deg). The galaxy catalogues are presented, a brief description of the galaxy search given, as well as a discussion on the distribution and characteristics of the uncovered galaxies. A total of 8182 galaxies with major diameters D >= 0.2 arcmin were identified in this ~850 square degree area: 3759 galaxies in the Crux region and 4423 galaxies in the Great Attractor region. Of the 8182 galaxies, 229 (2.8%) were catalogued before in the optical (3 in radio) and 251 galaxies have a reliable (159), or likely (92) cross-identification in the IRAS Point Source Catalogue (3.1%). A number of prominent overdensities and filaments of galaxies are identified. They are not correlated with the Galactic foreground extinction and hence indicative of extragalactic large-scale structures. Redshifts obtained at the South African Astronomical Observatory (SAAO) for 518 of the newly catalogued galaxies in the Crux and Great Attractor regions (Fairall et al. 1998; Woudt et al. 1999) confirm distinct voids and clusters in the area here surveyed. With this optical galaxy search, we have reduced the width of the optical `Zone of Avoidance' for galaxies with extinction-corrected diameters larger than 1.3 arcmin from extinction levels A_B >= 1.0 mag to A_B >= 3.0 mag: the remaining optical Zone of Avoidance is now limited by |b| <= 3deg (see Fig. 16).Comment: 19 pages, 16 figures, accepted for publication in A&A. Tables will shortly be available in electronic version at the CDS. Full resolution (colour) copies of Figures 1, 2, 3 and 16 are available at http://mensa.ast.uct.ac.za/~pwoud