The impact of computer aided architectural design programs on conceptual design in an educational context.

Little research has been undertaken concerning the manner in which students use computer aided architectural design (CAAD) programs for conceptual design. The research aim was to explore the potential impact of CAAD programs as conceptual design tools within architectural design methodologies. Therefore, the study aimed to understand the effect of CAAD on self-reflection using a think-aloud method. The findings demonstrate that participants used CAAD representations for concept development, information visualisation and presentation of design strategies. Results from the detailed analysis of design process are enlightening, particularly in terms of the cyclical nature of conceptual design. Furthermore, the use of a micro-detail protocol study within this context suggests an appropriate methodology for application in further study of the architectural design process

PEMANFAATAN VIDEO PEMBELAJARAN MENGGUNAKAN CANVA PADA PEMBELAJARAN IPS KELAS IV SEKOLAH DASAR

This study aims to find out related to the need to be able to develop animated video media from the nva application in Social Sciences (IPS) lessons. The instrument used in this study used a closed questionnaire with the type of quantitative data. This questionnaire is distributed through a google form. The results of this analysis show that from 10 educators and 163 fourth grade students (four) in nine elementary schools (SD) in Sungai Tarab, it proved that 90% of teachers stated the need and agreed that using animated video media based on the Canva application was interesting, 90% of educators said they needed and agreed to use Canva application-based animated video media is good and 83.4% of students said they needed to use Canva application video media in social science learning. Based on the research, it can be concluded that there must be the development of animated video media based on the Canva application in social studies science lesson

Perception and attitude of physicians toward local generic medicines in Saudi Arabia: A questionnaire-based study

AbstractObjectives: The current study aimed to explore the knowledge, perception, and attitude of physicians toward generic medicines in Saudi Arabia.Background: The local market of generic medicine share in Saudi Arabia is low compared to global and regional statistics. The reason for this low market share and the role of physicians has not previously been investigated. The purpose of this study was to assess health practitioner level of perceived knowledge, opinions and attitudes about local generic medication, and identify factors that influence infrequency of generic prescriptions.Methods: A random sample of 231 physicians was recruited from two hospitals in Riyadh (one government one private) and 178 (77%) responded. Information on the physicians’ perceived knowledge, opinions and attitude toward local generic medication was extracted, analyzed and interpreted. Factors that influence infrequent prescription of local generic drugs were identified.Results: Among the 178 participants in the physicians’ survey, 76% and 47% reported that they are knowledgeable about the terms “generic” and “bioequivalence” respectively, while 44% reported that they are able to explain bioequivalence to their patients. Approximately 52% of physicians reported that local generics should be substituted for brands if suitable for the case, and 21.9% reported that they believe SFDA approved local generics are therapeutically equivalent to their brands. Clinical effectiveness was reported by 71.9% of physicians as the most influential factor effecting prescription of brand over local generic medication. The three independent significant predictors for infrequent prescription of local generics among physicians: Government sector employment (OR=3.74, [95%CI 1.50–9.43]), consultant level (OR=3.94, [95%CI 1.50–10.31]) and low level of knowledge about local generics (OR=4.11, [95%CI 1.56–10.84]).Conclusion: The low market share of local generics medicines attributed to low prescription rates is significantly more among senior-level physicians working in governmental hospitals. Low level of knowledge about generic drugs among physicians was the strongest predictive factor for low prescription. Future bigger studies are needed to confirm these results

SINERGITAS PEMBERDAYAAN PONDOK PESANTREN

  The existence of pesantren in the midst of society has a very strategic meaning. Pesantren institutions that are rooted in the community, especially rural communities, are a separate force in arousing the enthusiasm and passion of the community for progress. One of the pesantren that has a long history of the Republic of Indonesia is pesantren Cijati Majalengka. Darul Falah Islamic Boarding School, Cijati. The Community Empowerment Program in Islamic Boarding Schools in terms of economic, social, psychological-counseling, religion, education and other aspects through community service cooperation between universities and partners is expected to provide optimal empowerment for the pesantren environment and the communities around the pesantren area. This service was carried out at the Darul Falah Islamic Boarding School which is located at Jl. K.H Mahfud No. 23 Kelurahan Cijati Kec / Kab. Majalengka with in-house training methods, in the form of socialization, training, and consultation. The conclusion of the community service carried out is the need for a holistic empowerment synergy to increase the potential of the pesantren

Key Food Hygiene Behaviors to Reduce Microbial Contamination of Complementary Foods in Rural Bangladesh

Microbial contamination of complementary foods puts young children at risk of developing intestinal infections and could be reduced by improved handwashing and food hygiene practices. We aimed to identify which promoted food hygiene practices are associated with reduced complementary food contamination in a rural population in Bangladesh. We collected cross-sectional data on reported and observed maternal food hygiene behaviors and measured Escherichia coli counts as an indicator of microbial contamination in complementary food samples from 342 children of women enrolled in the Food and Agricultural Approaches to Reducing Malnutrition trial in Sylhet, Bangladesh. We used multivariable logistic regression to examine associations of food hygiene behaviors with food contamination. Approximately 46%of complementary food samples had detectable levels of Escherichia coli. Handwashing with soap at critical times and fresh preparation of food before feeding were strongly associated with reduced odds of food sample contamination (odds ratio [OR]: 0.8, 95% confidence interval [CI]: 0.6-0.9 and OR: 0.3, 95% CI: 0.1-0.7, respectively); in contrast, there was no or only weak evidence that reheating of stored food, safe food storage, and cleanliness of feeding utensils reduced contamination. Reduction in food contamination could be more than halved only when several food hygiene behaviors were practiced in combination. In conclusion, single food hygiene practices showed limited potential and a combined practice of multiple food hygiene behaviors may be needed to achieve a substantial reduction of complementary food contamination

KEBERLANJUTAN PERIKANAN RAJUNGAN INDONESIA: PENDEKATAN MODEL BIOEKONOMI

Perikanan Rajungan (Portunus pelagicus) di Indonesia memberikan devisa sebesar US$246,14 juta dari ekspor pada tahun 2015 dan menghidupi 65.000 nelayan dan 130.000 pengupas rajungan di Indonesia. Berdasar nilai strategisnya ini, pemanfaatan perikanan rajungan perlu memperhatikan asas keberlanjutan sumber daya. Penelitian ini bertujuan menganalisa keberlanjutan pemanfaatan sumberdaya rajungan di Indonesia menggunakan model bioeokomi dari data hasil tangkapan rajungan di Wilayah Pengelolaan Perikanan (WPP) RI tahun 1977-2014. Hasil penelitian menunjukkan bahwa pemanfaatan sumberdaya rajungan di Indonesia memberikan rente ekonomi yang tinggi pada kondisi Maksimum Sustainale Yield (MSY) dan Maksimum Economic Yield (MEY) sedangkan pada rezim open access (OA) tidak memberikan rente ekonomi. Mengacu pada hasil penelitian maka pengaturan pemanfaatan sumberdaya rajungan dengan upaya dan produksi yang mendekati batas MEY diharapkan dapat menjamin keberlanjutan usaha rajungan baik secara biologi maupun ekonomi. Adapun pemanfaatan secara open access (OA) hendaknya dibatasi atau dihindari karena kondisi ini tidak dapat menjamin berkelanjutan perikanan rajungan baik secara biologi maupun ekonomi.The Blue Swimming Crab (BSC, Portunus pelagicus) fishery  in Indonesia provides revenue of US$ 246.14 million rom exports in 2015 and supports 65,000 fishermen and 130,000 pickers in Indonesia. Based on this value, the harvest of BSC fishery should consider the principle of resource sustainability. This study aims to analyze the sustainability of utilization of crab resources in Indonesia using bioeocomic model applied to the BSC catch data from all Fisheries Management Areas (FMA) in Indonesia from year 1977 until 2014. The results show that BSC harvest in Indonesia gives high economic rents under the conditions of Maximum Sustainale Yield (MSY) and Maximum Economic Yield (MEY) while the open access regime does not provide any economic rents. Referring to the results of the study, the arrangement of utilization of crab resources with efforts and production close to the limit of MEY is to be expected to ensure the continuity of the crab business both biologically and economically. The direction toward open access should be limited or avoided because this condition will lead to the unsustainable practices of the BSC fishery both biologically or economically.

IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients

Autoimmunity mediated by IgG4 subclass autoantibodies is an expanding field of research. Due to their structural characteristics a key feature of IgG4 antibodies is the ability to exchange Fab-arms with other, unrelated, IgG4 molecules, making the IgG4 molecule potentially monovalent for the specific antigen. However, whether those disease-associated antigen-specific IgG4 are mono- or divalent for their antigens is unknown. Myasthenia gravis (MG) with antibodies to muscle specific kinase (MuSK-MG) is a well-recognized disease in which the predominant pathogenic IgG4 antibody binds to extracellular epitopes on MuSK at the neuromuscular junction; this inhibits a pathway that clusters the acetylcholine (neurotransmitter) receptors and leads to failure of neuromuscular transmission. In vitro Fab-arm exchange-inducing conditions were applied to MuSK antibodies in sera, purified IgG4 and IgG1-3 sub-fractions. Solid-phase cross-linking assays were established to determine the extent of pre-existing and inducible Fab-arm exchange. Functional effects of the resulting populations of IgG4 antibodies were determined by measuring inhibition of agrin-induced AChR clustering in C2C12 cells. To confirm the results, κ/κ, λ/λ and hybrid κ/λ IgG4s were isolated and tested for MuSK antibodies. At least fifty percent of patients had IgG4, but not IgG1-3, MuSK antibodies that could undergo Fab-arm exchange in vitro under reducing conditions. Also MuSK antibodies were found in vivo that were divalent (monospecific for MuSK). Fab-arm exchange with normal human IgG4 did not prevent the inhibitory effect of serum derived MuSK antibodies on AChR clustering in C2C12 mouse myotubes. The results suggest that a considerable proportion of MuSK IgG4 could already be Fab-arm exchanged in vivo. This was confirmed by isolating endogenous IgG4 MuSK antibodies containing both κ and λ light chains, i.e. hybrid IgG4 molecules. These new findings demonstrate that Fab-arm exchanged antibodies are pathogenic. publisher: Elsevier articletitle: IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients journaltitle: Journal of Autoimmunity articlelink: http://dx.doi.org/10.1016/j.jaut.2016.11.005 content_type: article copyright: © 2016 The Authors. Published by Elsevier Ltd. ispartof: Journal of Autoimmunity vol:77 pages:104-115 ispartof: location:England status: publishe

Design, delivery, and determinants of uptake: findings from a food hygiene behavior change intervention in rural Bangladesh.

BACKGROUND: Microbial food contamination, although a known contributor to diarrheal disease and highly prevalent in low-income settings, has received relatively little attention in nutrition programs. Therefore, to address the critical pathway from food contamination to infection to child undernutrition, we adapted and integrated an innovative food hygiene intervention into a large-scale nutrition-sensitive agriculture trial in rural Bangladesh. In this article, we describe the intervention, analyze participation and uptake of the promoted food hygiene behaviors among intervention households, and examine the underlying determinants of behavior adoption. METHODS: The food hygiene intervention employed emotional drivers, engaging group activities, and household visits to improve six feeding and food hygiene behaviors. The program centered on an 'ideal family' competition. Households' attendance in each food hygiene session was documented. Uptake of promoted behaviors was assessed by project staff on seven 'ideal family' indicators using direct observations of practices and spot checks of household hygiene conditions during household visits. We used descriptive analysis and mixed-effect logistic regression to examine changes in household food hygiene practices and to identify determinants of uptake. RESULTS: Participation in the food hygiene intervention was high with more than 75% attendance at each session. Hygiene behavior practices increased from pre-intervention with success varying by behavior. Safe storage and fresh preparation or reheating of leftover foods were frequently practiced, while handwashing and cleaning of utensils was practiced by fewer participants. In total, 496 of 1275 participating households (39%) adopted at least 5 of 7 selected practices in all three assessment rounds and were awarded 'ideal family' titles at the end of the intervention. Being an 'ideal family' winner was associated with high participation in intervention activities [adjusted odds ratio (AOR): 11.4, 95% CI: 5.2-24.9], highest household wealth [AOR: 2.3, 95% CI: 1.4-3.6] and secondary education of participating women [AOR: 2.2, 95% CI: 1.4-3.4]. CONCLUSION: This intervention is an example of successful integration of a behavior change food hygiene component into an existing large-scale trial and achieved satisfactory coverage. Future analysis will show if the intervention was able to sustain improved behaviors over time and decrease food contamination and infection

COVID-19 vaccination in Sindh province, Pakistan: A modelling study of health impact and cost-effectiveness

Background: Multiple Coronavirus Disease 2019 (COVID-19) vaccines appear to be safe and efficacious, but only high-income countries have the resources to procure sufficient vaccine doses for most of their eligible populations. The World Health Organization has published guidelines for vaccine prioritisation, but most vaccine impact projections have focused on high-income countries, and few incorporate economic considerations. To address this evidence gap, we projected the health and economic impact of different vaccination scenarios in Sindh Province, Pakistan (population: 48 million).Methods and findings: We fitted a compartmental transmission model to COVID-19 cases and deaths in Sindh from 30 April to 15 September 2020. We then projected cases, deaths, and hospitalisation outcomes over 10 years under different vaccine scenarios. Finally, we combined these projections with a detailed economic model to estimate incremental costs (from healthcare and partial societal perspectives), disability-adjusted life years (DALYs), and incremental cost-effectiveness ratio (ICER) for each scenario. We project that 1 year of vaccine distribution, at delivery rates consistent with COVAX projections, using an infection-blocking vaccine at $3/dose with 70$27.9 per DALY averted from the health system perspective. Under a broad range of alternative scenarios, we find that initially prioritising the older (65+) population generally prevents more deaths. However, unprioritised distribution has almost the same cost-effectiveness when considering all outcomes, and both prioritised and unprioritised programmes can be cost-effective for low per-dose costs. High vaccine prices ($10/dose), however, may not be cost-effective, depending on the specifics of vaccine performance, distribution programme, and future pandemic trends. The principal drivers of the health outcomes are the fitted values for the overall transmission scaling parameter and disease natural history parameters from other studies, particularly age-specific probabilities of infection and symptomatic disease, as well as social contact rates. Other parameters are investigated in sensitivity analyses. This study is limited by model approximations, available data, and future uncertainty. Because the model is a single-population compartmental model, detailed impacts of nonpharmaceutical interventions (NPIs) such as household isolation cannot be practically represented or evaluated in combination with vaccine programmes. Similarly, the model cannot consider prioritising groups like healthcare or other essential workers. The model is only fitted to the reported case and death data, which are incomplete and not disaggregated by, e.g., age. Finally, because the future impact and implementation cost of NPIs are uncertain, how these would interact with vaccination remains an open question.Conclusions: COVID-19 vaccination can have a considerable health impact and is likely to be cost-effective if more optimistic vaccine scenarios apply. Preventing severe disease is an important contributor to this impact. However, the advantage of prioritising older, high-risk populations is smaller in generally younger populations. This reduction is especially true in populations with more past transmission, and if the vaccine is likely to further impede transmission rather than just disease. Those conditions are typical of many low- and middle-income countries